2,2-DICHLOROPROPIONIC ACID supplier

Name
2,2-Dichloropropionic acid
EINECS 200-923-0
CAS No. 75-99-0
Article Data37
CAS DataBase
Density 1.497 g/cm³
Solubility 50.2 g/100 mL
Melting Point 166 °C (dec.)
Formula C₃H₄Cl₂O₂
Boiling Point 187.5 °C at 760 mmHg
Molecular Weight 142.97
Flash Point 76.1 °C
Transport Information UN 1760/3265
Appearance A colorless liquid.
Safety 26-39-61
Risk Codes 22-38-41-52/53
Molecular Structure
Hazard Symbols Xn
Synonyms Propionicacid, 2,2-dichloro- (8CI);2,2-DPA;2,2-Dichloropropanoic acid;2,2-Dichloropropionic acid;Alatex;Basinex P;DPA;Dalapon;Dalascam;NSC56352;Proprop;S 1315;S 95;S 95 (herbicide);Tripon;a,a-Dichloropropanoic acid;a,a-Dichloropropionic acid;
PSA 37.30000
LogP 1.26480

Synthetic route

2,2-dichloropropanal: 2,2-dichloropropanal

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride; picoline hydrochloride; chlorine In chloroform at 65 - 70℃; for 24h; Oxidation;	95%
With nitric acid; sodium nitrite In dichloromethane at 20℃; for 192h;	66%

: 4-nitrosotetrahydro-2H-pyran-4-yl 2,2-dichloropropanoate

A: 29943-42-8
Tetrahydro-4H-pyran-4-one

B: 75-99-0
2,2-Dichloropropionic acid

C: 10024-97-2
dinitrogen monoxide

Conditions

Conditions	Yield
With water In methanol; aq. phosphate buffer at 20℃; for 24h; pH=7.4; Kinetics; Reagent/catalyst; Sealed tube;	A n/a B n/a C 92%

...Expand

: 802294-64-0
propionic acid

A: 75-99-0
2,2-Dichloropropionic acid

B: 598-78-7
(R,S)-2-chloropropionic acid

Conditions

Conditions	Yield
With chlorine; pyrographite; propionic acid anhydride at 130℃; under 760.051 Torr; for 2.5h;	A 10.47% B 68.23%

: pyruvic acid-(2,2-dichloro-propionic acid )-anhydride

A: 75-99-0
2,2-Dichloropropionic acid

B: 127-17-3
2-oxo-propionic acid

Conditions

Conditions	Yield
Zieht schon an der Luft rasch Wasser an und zerfaellt;

: 598-78-7
(R,S)-2-chloropropionic acid

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With chlorine; phosphorus trichloride at 180℃;
With phosphonic acid; chlorine at 180℃;

: 56511-21-8
2,2-dichloro-propionic acid anilide

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride at 140℃;

: 75265-14-4
p-methoxyphenyl 2,2-dichloropropanoate

A: 75-99-0
2,2-Dichloropropionic acid

B: 150-76-5
4-methoxy-phenol

Conditions

Conditions	Yield
With hydrogenchloride; water In various solvent(s) at 25℃; Rate constant; Thermodynamic data; Kinetics; var. temps.; ΔG(activ.), ΔH(activ.), ΔS(activ.), ΔCp(activ.);
With hydrogenchloride; water In various solvent(s) at 25℃; Mechanism;
With 2-Butoxyethanol; water at 20 - 48℃; Rate constant; Thermodynamic data; ΔG<>, ΔH<>, ΔS<>, ΔCp<>; reagents ratio;
With water at 25℃; under 750.06 Torr; Rate constant; Thermodynamic data; hydrolysis, ΔGp(excit.), ΔHp(excit.), ΔSp(excit.), ΔUv(excit.), ΔSv(excit.),solvent and pressure dependence;

: 75265-14-4
2,2-Dichloro-propionic acid p-tolyl ester

A: 75-99-0
2,2-Dichloropropionic acid

B: 150-76-5
4-methoxy-phenol

Conditions

Conditions	Yield
With at-poly(methacrylic acid) In water at 25℃; Rate constant; Thermodynamic data; Kinetics; ΔG+, ΔH+; further inhibitors;

: 79-43-6
dichloro-acetic acid

: 77-78-1
dimethyl sulfate

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With n-butyllithium; lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 5 min., 2.) room temp., 1 h; Yield given. Multistep reaction;

: 598-78-7
(R,S)-2-chloropropionic acid

A: 75-99-0
2,2-Dichloropropionic acid

B: 3278-46-4
chloropon

C: 39881-29-3
2,2,3,3-tetrachloropropanoic acid

Conditions

Conditions	Yield
With chlorine; phosphorus trichloride for 4h; Heating; Yields of byproduct given;	A 9.38 g B n/a C n/a
With chlorine; phosphorus trichloride for 4h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With chlorine; phosphorus trichloride for 4h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 2,2-Dichloro-propionic acid 1-phenoxy-ethyl ester

A: 75-99-0
2,2-Dichloropropionic acid

B: 75-07-0
acetaldehyde

C: 108-95-2
phenol

Conditions

Conditions	Yield
With water In acetonitrile Rate constant; var. pH;

...Expand

: 17640-02-7
methyl 2,2-dichloropropionate

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With lithium hydroxide In water; isopropyl alcohol at -7℃; for 0.25h;

: 7664-93-9
sulfuric acid

: 30362-74-4
tris-(1,1-dichloro-ethyl)-[1,3,5]triazine

: 75-99-0
2,2-Dichloropropionic acid

: 594-40-1
2,2-dichloropropionitrile

: 7664-93-9
sulfuric acid

: 75-99-0
2,2-Dichloropropionic acid

nitrile of/the/ 2.2-dichloro-propanoic acid (1): nitrile of/the/ 2.2-dichloro-propanoic acid (1)

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With sulfuric acid; water at 120℃;

: 27313-32-2
2,2-dichloropropanal

: 7782-50-5
chlorine

A: 75-44-5
phosgene

B: 71-55-6
1,1,1-trichloroethane

C: 26073-26-7
2,2-dichloropropionyl chloride

D: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
im UV-Licht;

...Expand

: 27313-32-2
2,2-dichloropropanal

: 3179-56-4
acetyl cyclohexanesulfonyl peroxide

: 7782-50-5
chlorine

A: 75-44-5
phosgene

B: 71-55-6
1,1,1-trichloroethane

C: 26073-26-7
2,2-dichloropropionyl chloride

D: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
at 50 - 60℃;

...Expand

: 7647-01-0
hydrogenchloride

: 56511-21-8
2,2-dichloro-propionic acid anilide

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
at 140℃;

: 7732-18-5
water

: 2,2-dichloro-propionic acid ; silver salt

A: 75-99-0
2,2-Dichloropropionic acid

B: 127-17-3
2-oxo-propionic acid

C chloro silver: chloro silver

...Expand

: 21400-25-9
1,1,2-trichloropropene

H2O, O2: H2O, O2

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

D: 97985-62-1
2,3-Dichloro-propionic acid 2,3,3-trichloro-propyl ester

Conditions

Conditions	Yield
for 17h; Heating; Irradiation; Further byproducts given. Title compound not separated from byproducts;

...Expand

: 75-99-0
2,2-Dichloropropionic acid

: 26073-26-7
2,2-dichloropropionyl chloride

Conditions

Conditions	Yield
With thionyl chloride In N-methyl-acetamide	92%
With thionyl chloride
With thionyl chloride for 3h; Heating;	3.8 g

: 50-67-9
3-(2-aminoethyl)-1H-indol-5-ol

: 75-99-0
2,2-Dichloropropionic acid

: 1388185-92-9
C13H14Cl2N2O2

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 24h;	89%

: 75-99-0
2,2-Dichloropropionic acid

: 153-98-0
serotonin hydrochloride

: 1388185-92-9
C13H14Cl2N2O2

Conditions

Conditions	Yield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 24h;	88%

: 107-46-0
Hexamethyldisiloxane

: 75-99-0
2,2-Dichloropropionic acid

: 72406-98-5
C6H12Cl2O2Si

Conditions

Conditions	Yield
With sulfuric acid In toluene for 4h; Heating;	78%

: 27313-32-2
2,2-dichloropropanal

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride; picoline hydrochloride; chlorine In chloroform at 65 - 70℃; for 24h; Oxidation;	95%
With nitric acid; sodium nitrite In dichloromethane at 20℃; for 192h;	66%

: 17437-57-9
(1,1,2,2-tetrachloro-propyl)-phosphorimidic acid trichloride

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With water

: 27992-53-6
1,1,3,3-tetrachloro-butan-2-one

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate

: 64697-39-8
1,1,1,3,3-pentachlorobutanone

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 21400-25-9
1,1,2-trichloropropene

: 103-19-5
di(p-tolyl) disulfide

: 75-99-0
2,2-Dichloropropionic acid

Conditions

Conditions	Yield
for 20.5h; Product distribution; Heating; Irradiation; molybdenum glass flask, effect of glass composition;

: 21400-25-9
1,1,2-trichloropropene

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-56-3
(Z)-1,1,2,4,5-Pentachloro-hexa-1,4-diene

D: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

Conditions

Conditions	Yield
With water; oxygen for 17h; Heating; Irradiation; Further byproducts given;
for 17h; Heating; Irradiation; Further byproducts given. Title compound not separated from byproducts;

...Expand

: 21400-25-9
1,1,2-trichloropropene

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-57-4
(Z)-1,2,4,4,5-Pentachloro-hexa-1,5-diene

D: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

Conditions

Conditions	Yield
for 17h; Heating; Irradiation; Further byproducts given. Title compound not separated from byproducts;

...Expand

: 21400-25-9
1,1,2-trichloropropene

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

D: 97985-59-6
1,1,2,4,6,6-Hexachloro-hexa-1,5-diene

Conditions

Conditions	Yield
for 17h; Heating; Irradiation; Further byproducts given. Title compound not separated from byproducts;

...Expand

: 21400-25-9
1,1,2-trichloropropene

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

D: 97985-58-5
1,1,2,4,4,5-Hexachloro-hexa-1,5-diene

Conditions

Conditions	Yield
for 17h; Heating; Irradiation; Further byproducts given. Title compound not separated from byproducts;

...Expand

: 21400-25-9
1,1,2-trichloropropene

A: 26073-26-7
2,2-dichloropropionyl chloride

B: 75-99-0
2,2-Dichloropropionic acid

C: 97985-55-2
(1Z,3Z)-1,2,3,5,5-Pentachloro-hexa-1,3-diene

D: 101414-14-6
1,1,2,4,5,6-hexachloro-1,4-hexadiene

Conditions

Conditions	Yield
for 17h; Heating; Irradiation; Yield given. Further byproducts given. Title compound not separated from byproducts;

...Expand

: 75-99-0
2,2-Dichloropropionic acid

: 5625-99-0
N,N'-diphenylphosphorodiamidic chloride

A: 1445-36-9
N-phenylamidophosphoric acid

B: 56511-21-8
2,2-dichloro-propionic acid anilide

Conditions

Conditions	Yield
In benzene for 8h; Heating;	A n/a B 75%

...Expand

: 75-99-0
2,2-Dichloropropionic acid

: 766-94-9
vinyl phenyl ether

: 2,2-Dichloro-propionic acid 1-phenoxy-ethyl ester

Conditions

Conditions	Yield
With phosphoric acid for 0.5h; Ambient temperature;	65%

: 75-99-0
2,2-Dichloropropionic acid

: 107-18-6
allyl alcohol

: 100114-38-3
allyl 2,2-dichloropropionate

Conditions

Conditions	Yield
With thionyl chloride at -10 - 20℃; for 4h; Esterification;	60%

: 61128-73-2
tetrahydropyran-4-one oxime

: 75-99-0
2,2-Dichloropropionic acid

: 4-nitrosotetrahydro-2H-pyran-4-yl 2,2-dichloropropanoate

Conditions

Conditions	Yield
With lead(IV) tetraacetate In dichloromethane at 0 - 20℃; for 4h;	58%

: 1-[({[3,3'-difluoro-2'-(methoxycarbonyl)-1,1'-biphenyl-4-yl]methyl}amino)carbonyl]cyclopropanaminium chloride

: 75-99-0
2,2-Dichloropropionic acid

: 4'-({[1-(2,2-dichloro-propionylamino)-cyclopropanecarbonyl]-amino}-methyl)-3,3'-difluoro-biphenyl-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	23%

: 67-56-1
methanol

: 75-99-0
2,2-Dichloropropionic acid

: 17640-02-7
methyl 2,2-dichloropropionate

Conditions

Conditions	Yield
With hydrogenchloride

: 4752-64-1
2,3,5-trichloro-6-hydroxy-benzyl alcohol

: 75-99-0
2,2-Dichloropropionic acid

: 101080-80-2
2,2-dichloro-propionic acid-(2,3,5-trichloro-6-hydroxy-benzyl ester)

: 57-55-6
propylene glycol

: 75-99-0
2,2-Dichloropropionic acid

: 90560-79-5
1,2-bis-(2,2-dichloro-propionyloxy)-propane

Conditions

Conditions	Yield
With 1,2-dichloro-ethane at 100℃;

: 110-98-5
1,1'-oxydipropan-2-ol

: 75-99-0
2,2-Dichloropropionic acid

: 1-[2-(2,2-dichloro-propionyloxy)-propoxy]-propan-2-ol

Conditions

Conditions	Yield
With ethylene glycol at 100℃;

: 64-17-5
ethanol

: 75-99-0
2,2-Dichloropropionic acid

: 6192-01-4
3-ethoxyprop-2-enoic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 64-17-5
ethanol

: 75-99-0
2,2-Dichloropropionic acid

: 17640-03-8
ethyl 2,2-dichloropropionate

Conditions

Conditions	Yield
With hydrogenchloride

: 594-40-1
2,2-dichloropropionitrile

: 75-99-0
2,2-Dichloropropionic acid

: bis-(2,2-dichloro-propionyl)-amine

Conditions

Conditions	Yield
at 130℃;

: 75-99-0
2,2-Dichloropropionic acid

: 17849-38-6
2-Chlorobenzyl alcohol

: 103263-91-8
2,2-dichloro-propionic acid-(2-chloro-benzyl ester)

Conditions

Conditions	Yield
With 1,2-dichloro-ethane

: 75-99-0
2,2-Dichloropropionic acid

: 120-67-2
2-(2,4-dichlorophenoxy)ethanol

: 99984-25-5
1-(2,4-dichloro-phenoxy)-2-(2,2-dichloro-propionyloxy)-ethane

Conditions

Conditions	Yield
With sulfuric acid; 1,2-dichloro-ethane Entfernen des entstehenden Wassers;

: 75-99-0
2,2-Dichloropropionic acid

: 2122-77-2
2-(2,4,5-trichloro-phenoxy)-ethanol

: 136-25-4
2,2-dichloro-propionic acid-[2-(2,4,5-trichloro-phenoxy)-ethyl ester]

Conditions

Conditions	Yield
With sulfuric acid; 1,2-dichloro-ethane Entfernen des entstehenden Wassers;

: 75-99-0
2,2-Dichloropropionic acid

: 34743-88-9
2-(4-bromophenoxy)ethanol

: 99852-98-9
2,2-dichloro-propionic acid-[2-(4-bromo-phenoxy)-ethyl ester]

Conditions

Conditions	Yield
With 1,2-dichloro-ethane Entfernen des entstehenden Wassers;

: 75-99-0
2,2-Dichloropropionic acid

: 6641-02-7
3,5-dichloro-2-hydroxybenzyl alcohol

: 103501-36-6
2,2-dichloro-propionic acid-(3,5-dichloro-2-hydroxy-benzyl ester)

: 75-99-0
2,2-Dichloropropionic acid

: 36220-29-8
2-(4-chloro-2-methylphenoxy)ethanol

: 100120-21-6
1-(4-chloro-2-methyl-phenoxy)-2-(2,2-dichloro-propionyloxy)-ethane

Conditions

Conditions	Yield
With 1,2-dichloro-ethane unter Entfernen des entstehenden H2O;

: 75-99-0
2,2-Dichloropropionic acid

: 1080-25-7, 17280-40-9, 64577-08-8
rac-((1R,2S,4S)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-en-2-yl)methanol

: 118659-28-2
(+/-)-2,2-dichloro-propionic acid-(1,4,5,6,7,7-hexachloro-norborn-5-ene-2endo-ylmethyl ester)

Conditions

Conditions	Yield
With 1,2-dichloro-ethane unter Entfernen des entstehenden Wassers;

: 75-99-0
2,2-Dichloropropionic acid

: 100960-29-0
2,3,6-trichloro-benzyl alcohol

: 1444-82-2
2,2-dichloro-propionic acid-(2,3,6-trichloro-benzyl ester)

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; 1,2-dichloro-ethane

: 75-99-0
2,2-Dichloropropionic acid

: 873-55-2
sodium benzenesulfonate

: 599-94-0
1,2-bis(phenylsulfonyl)ethane

Conditions

Conditions	Yield
With sodium carbonate

2,2-DICHLOROPROPIONIC ACID Chemical Properties

Product Name: 2,2-Dichloropropionic acid (CAS NO.75-99-0)

Molecular Formula: C₃H₄Cl₂O₂
Molecular Weight: 142.97g/mol
Mol File: 75-99-0.mol
Einecs: 200-923-0
Appearance: Clear yellow liquid
Melting Point: 166°C (dec.)
Boiling point: 187.5 °C at 760 mmHg
Storage Temperature: 0-6°C
Flash Point: 76.1 °C
Density: 1.497 g/cm³
Refractive index: 1.4544
Water Solubility: 50.2 g/100 mL
Sensitive: Moisture Sensitive
Surface Tension: 43.5 dyne/cm
Enthalpy of Vaporization: 46.71 kJ/mol
Vapour Pressure: 0.282 mmHg at 25°C
XLogP3-AA: 1.3
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: API intermediates; Aliphatic halogenatedAlphabetic; D; DA - DH; Herbicides; Pesticides&Metabolites

2,2-DICHLOROPROPIONIC ACID Toxicity Data With Reference

1.	skn-rbt 100 µg/24H open	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
2.	mmo-omi 500 ppm	IJEBA6 Indian Journal of Experimental Biology. 11 (1973),114.
3.	skn-rat LD50:>5 g/kg	FAATDF Fundamental and Applied Toxicology. 7 (1986),299.

2,2-DICHLOROPROPIONIC ACID Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

2,2-DICHLOROPROPIONIC ACID Safety Profile

A corrosive with low toxicity by skin contact. A skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻.
Safety Information of 2,2-Dichloropropionic acid (CAS NO.75-99-0):
Hazard Codes: Xn,Xi,F
Risk Statements: 22-38-41-52/53-40-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
41: Risk of serious damage to eyes
53: May cause long-term adverse effects in the aquatic environment
Safety Statements: 26-39-61-36-16
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
39: Wear eye/face protection
61: Avoid release to the environment. Refer to special instructions safety data sheet

2,2-DICHLOROPROPIONIC ACID Standards and Recommendations

OSHA PEL: TWA 1 ppm
ACGIH TLV: TWA 5 ppm, Not Classifiable as a Human Carcinogen
DFG MAK: 1 ppm (5.9 mg/m³)

2,2-DICHLOROPROPIONIC ACID Specification

2,2-Dichloropropionic acid ,its CAS NO. is 75-99-0,the synonyms is Dichloropropionicacid ; 2,2-Dichloropropanoic acid ; 2,2-Dichloro-propanoicaci ; 2,2-Dichloropropanoicacid ; 2,2-Dichloro-propionicaci ; 2,2-DPA ; Acide2,2-Dichloropropionique ; Alatex .

Product Name

2,2-Dichloropropionic acid

Synthetic route

2,2-DICHLOROPROPIONIC ACID Chemical Properties

2,2-DICHLOROPROPIONIC ACID Toxicity Data With Reference

2,2-DICHLOROPROPIONIC ACID Consensus Reports

2,2-DICHLOROPROPIONIC ACID Safety Profile

2,2-DICHLOROPROPIONIC ACID Standards and Recommendations

2,2-DICHLOROPROPIONIC ACID Specification

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