2,3-Dihydrobenzofuran supplier

Name
2,3-Dihydrobenzofuran
EINECS 207-817-3
CAS No. 496-16-2
Article Data110
CAS DataBase
Density 1.096 g/cm³
Solubility
Melting Point -21 °C
Formula C₈H₈O
Boiling Point 188.2 °C at 760 mmHg
Molecular Weight 120.151
Flash Point 66.7 °C
Transport Information
Appearance colorless to light yellow liquid
Safety 23-24/25-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzofuran,1,2-dihydro- (3CI);2,3-Dihydro-1-benzofuran;2,3-Dihydrobenzo[b]furan;Benzofuran,2,3-dihydro-;Benzodihydrofuran;Coumaran;Dihydrobenzofuran;Kumaran;
PSA 9.23000
LogP 1.62150

Synthetic route

: 271-89-6
1-benzofurane

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With methanol; palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In dichloromethane at 25℃; for 12h; Sealed tube; Inert atmosphere; chemoselective reaction;	99%
With hydrogen In methanol at 80 - 90℃; under 750.075 - 22502.3 Torr; Reagent/catalyst; Autoclave;	97.8%
With ethanol; (BQ‑NCOP)IrHCl; sodium t-butanolate at 60℃; for 5h; Inert atmosphere; Schlenk technique; Sealed tube; chemoselective reaction;	96%

: 26059-40-5
2-(2-iodophenyl)ethan-1-ol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With copper(l) iodide; sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Schlenk technique; Inert atmosphere; Molecular sieve;	99%
Multi-step reaction with 3 steps 1.1: triphenylphosphine; iodine; 1H-imidazole / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Darkness 2.1: silver(l) oxide / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere View Scheme

: 19819-95-5
2-(2-chlorophenyl)-1-ethanol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With Ru/Al2O3; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1.5h; Temperature; Microwave irradiation;	96.2%
With copper(l) iodide; 8-quinolinol; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 20 - 120℃; Inert atmosphere;	82%
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 23h;	72%
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 23h;	72%
With potassium phosphate; C22H28NP; palladium diacetate In toluene at 60℃; for 20h;	51 % Chromat.

: 1074-16-4
2-bromophenylethyl alcohol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With copper(l) iodide; lithium tert-butoxide In 1,4-dioxane at 100℃;	96%
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 26h;	87%
With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate In toluene at 50℃; for 26h;	87%

: 7768-28-7
2-(2-hydroxyphenyl)ethanol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With sodium methylate In carbonic acid dimethyl ester; acetonitrile for 2h; Inert atmosphere;	95%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; carbonic acid dimethyl ester at 90℃; for 8h; Reagent/catalyst; Time;	93%
Stage #1: 2-(2-hydroxyphenyl)ethanol With sodium hydride In mineral oil at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With trimethyl phosphite In mineral oil at 20℃; for 24h; Inert atmosphere;	90%

: 271-89-6
1-benzofurane

: 52652-40-1
1,4,4a,9a-tetrahydro-fluorene

A: 496-16-2
2,3-Dihydrobenzofuran

B: 86-73-7
9H-fluorene

Conditions

Conditions	Yield
palladium on activated carbon at 250℃; for 2h;	A 92% B 95%

...Expand

: 271-89-6
1-benzofurane

: 17057-95-3
1,2,3,4-tetrahydro-9H-fluorene

A: 496-16-2
2,3-Dihydrobenzofuran

B: 86-73-7
9H-fluorene

Conditions

Conditions	Yield
	A 92% B n/a

...Expand

: 1-iodo-2-(2-iodo-ethoxy)-benzene

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
Stage #1: 1-iodo-2-(2-iodo-ethoxy)-benzene With isopropylmagnesium chloride In tetrahydrofuran at -30℃; for 1h; Stage #2: In tetrahydrofuran at 25℃; for 2h; Stage #3: In tetrahydrofuran	87%

: 57027-75-5
2-(2-Bromoethyl)phenol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 3h; Heating;	86%
With sodium hydroxide; benzene
With water

: 94897-00-4
2-(2-bromophenoxy)ethyl 4-methylbenzenesulfonate

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With copper(l) iodide; lithium methanolate; magnesium In tetrahydrofuran at 0℃; for 24h; Inert atmosphere; Schlenk technique;	85%

: 7768-28-7
2-(2-hydroxyphenyl)ethanol

: 3724-43-4, 149409-22-3
Vilsmeier reagent

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With triethylamine In dichloromethane Ambient temperature;	80%

: 57056-94-7
1-(2-bromoethoxy)-2-iodobenzene

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
Stage #1: 1-(2-bromoethoxy)-2-iodobenzene With isopropylmagnesium chloride In tetrahydrofuran at -30℃; for 1h; Stage #2: In tetrahydrofuran at 25℃; for 2h; Stage #3: In tetrahydrofuran	79%

: 64010-12-4
2-bromophenyl 2-chloroethyl ether

A: 496-16-2
2,3-Dihydrobenzofuran

B: 95-56-7
2-hydroxybromobenzene

C: 108-95-2
phenol

Conditions

Conditions	Yield
With magnesium; ethylene dibromide In tetrahydrofuran	A 76% B n/a C n/a

...Expand

: 3002-78-6
5-methyl-1,10-phenanthroline

: 1074-16-4
2-bromophenylethyl alcohol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With CuI; caesium carbonate In dodecane; toluene	72%

: 18800-28-7
1-(2-bromoethoxy)-2-bromobenzene

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -100 - -95℃; for 0.5h;	69%
With diethyl ether; sodium

: 553-86-6
benzofuran-2(3H)-one

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With aluminium(III) triflate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran at 160℃; under 45603.1 Torr; for 12h; Autoclave;	65%
Multi-step reaction with 2 steps 1: Lawesson's reagent / toluene / Heating 2: Raney nickel / diethyl ether / 1.) -15 deg C, 2.) -10 deg C, 2 min View Scheme

: 1592933-65-7
2-(2-iodophenyl)ethyl tert-butyl peroxide

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere;	58%

: 7768-28-7
2-(2-hydroxyphenyl)ethanol

: 616-38-6
carbonic acid dimethyl ester

A: 496-16-2
2,3-Dihydrobenzofuran

B: 2-(2'-hydrophenyl)ethyl methyl carbonate

Conditions

Conditions	Yield
With sodium methylate for 7h; Reflux; Inert atmosphere;	A 55% B 31%
With sodium methylate at 90℃; for 24h;	A 6% B 21%

...Expand

: 5339-85-5
2-aminophenethyl alcohol

A: 496-16-2
2,3-Dihydrobenzofuran

B: 7768-28-7
2-(2-hydroxyphenyl)ethanol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite at 0 - 50℃; for 1h;	A 35% B 50%

: 7417-18-7
2-methoxyphenethyl alcohol

A: 496-16-2
2,3-Dihydrobenzofuran

B: 57027-75-5
2-(2-Bromoethyl)phenol

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid	A 36% B 46%

: 271-89-6
1-benzofurane

A: 90-00-6
o-Hydroxyethylbenzene

B: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With 15-crown-5; sodium; isopropyl alcohol In tetrahydrofuran at 0℃; for 0.0833333h; Birch Reduction; chemoselective reaction;	A 42% B 39%
With ethanol; sodium
With ethanol; sodium
With 15-crown-5; sodium In tetrahydrofuran; isopropyl alcohol; mineral oil at 0℃; for 0.0833333h; Inert atmosphere; Overall yield = 75 %; Overall yield = 45 mg;

: 52200-69-8
1-bromo-2-methoxy-3-methylbenzene

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With palladium(0)bis(tricyclohexylphosphine); cesium pivalate In toluene at 140℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;	40%

: 271-89-6
1-benzofurane

A: 496-16-2
2,3-Dihydrobenzofuran

B: 99636-24-5
4,7-dihydrobenzofuran

Conditions

Conditions	Yield
With sodium In methanol; diethyl ether; ammonia for 0.166667h;	A 34% B 36%
With tetrabutylammonium tetrafluoroborate In tetrahydrofuran; water at 0℃; electrolysis (mercury cathode, platinum flag anode, silver wire reference electrode, constant current 4-32 mA cm-2); Yield given. Yields of byproduct given;

: 6538-94-9
3,4-epoxy-chroman

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
In cyclohexane for 6h; Ambient temperature; Irradiation;	36%

: 75311-63-6
(Trimethylsilyl)(o-methoxyphenyl)methanol

A: 271-89-6
1-benzofurane

B: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
In benzene at 600℃;	A 16% B 28%

: 134749-74-9
[(2-Methoxy-phenyl)-phenylmethanesulfonyl-methylene]-triphenyl-λ5-phosphane

A: 496-16-2
2,3-Dihydrobenzofuran

B: 52805-92-2
(E)-2-methoxystilbene

C: 1898-14-2
(Z)-1-(2-methoxyphenyl)-2-phenylethene

D: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

Conditions

Conditions	Yield
at 600℃; under 0.001 - 0.1 Torr; for 1h; Yields of byproduct given. Title compound not separated from byproducts;	A 7% B n/a C n/a D 11 % Spectr.

...Expand

: 122-99-6
2-Phenoxyethanol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With zinc(II) chloride
With manganese(ll) chloride; zinc(II) chloride at 200℃; for 3h; Temperature;

: 18800-26-5
1-(2-bromoethoxy)-2-chlorobenzene

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With diethyl ether; sodium

: 5339-85-5
2-aminophenethyl alcohol

: 496-16-2
2,3-Dihydrobenzofuran

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite Erwaermen der Diazoniumsalz-Loesung mit Natiumhydrogencabonat;
Multi-step reaction with 2 steps 1: 50 percent / aq. sodium nitrite, conc. sulfuric acid / 1 h / 0 - 50 °C 2: 75 percent / alumina-silica / 1,2-dimethoxy-ethane / 1 h / 250 °C View Scheme

: 496-16-2
2,3-Dihydrobenzofuran

: 66826-78-6
5-bromo-2,3-dihydrobenzo[b]furan

Conditions

Conditions	Yield
With bromine	100%
With iron(III) chloride; N-Bromosuccinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide In toluene at 40℃; regioselective reaction;	98%
With bromine In dichloromethane for 0.5h; Ambient temperature;	96%

: 496-16-2
2,3-Dihydrobenzofuran

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 55745-70-5
2,3-dihydro-benzofuran-5-carbaldehyde

Conditions

Conditions	Yield
With trichlorophosphate at 70 - 90℃; for 9.5h;	100%
With trichlorophosphate at 70 - 90℃; for 9.5h;	100%
Stage #1: 2.3-dihydrobenzofuran; N,N-dimethyl-formamide With trichlorophosphate at 30 - 70℃; Stage #2: With water In N,N-dimethyl-formamide at 20℃; for 1h;	98%

: 496-16-2
2,3-Dihydrobenzofuran

: 55745-70-5
2,3-dihydro-benzofuran-5-carbaldehyde

Conditions

Conditions	Yield
With trichlorophosphate In water; N,N-dimethyl-formamide	100%
With trichlorophosphate In water; N,N-dimethyl-formamide	100%
With sodium hydrogencarbonate; trichlorophosphate In N,N-dimethyl-formamide	94%
Multi-step reaction with 2 steps 1: 100 percent / Br2 2: 98 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C View Scheme

: 496-16-2
2,3-Dihydrobenzofuran

: 115010-11-2
2,3-dihydrobenzofuran-5-sulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 2.3-dihydrobenzofuran With sulfur trioxide-N,N-dimethylformamide complex In 1,2-dichloro-ethane at 85℃; for 1h; Stage #2: With thionyl chloride In 1,2-dichloro-ethane at 20 - 75℃; for 1h;	100%
Stage #1: 2.3-dihydrobenzofuran With sulfur trioxide-N,N-dimethylformamide complex In 1,2-dichloro-ethane at 85℃; for 1h; Stage #2: With thionyl chloride In 1,2-dichloro-ethane at 20 - 75℃; for 1h;	100%
In 1,2-dichloro-ethane	94%

: 496-16-2
2,3-Dihydrobenzofuran

: 75-36-5
acetyl chloride

: 90843-31-5
1-(2,3-dihydrobenzofuran-5-yl)ethanone

Conditions

Conditions	Yield
aluminum (III) chloride In dichloromethane at -10℃; for 0.5h;	99%
With aluminum (III) chloride In dichloromethane at -10℃; for 0.5h;	99%
With aluminum (III) chloride In dichloromethane at -10℃; for 3h;	97%

: 496-16-2
2,3-Dihydrobenzofuran

: 132464-84-7
5-iodo-2,3-dihydro-1-benzofuran

Conditions

Conditions	Yield
With N-iodo-succinimide; silver(I) triflimide In dichloromethane at 36℃; for 1h; Darkness;	99%
With indium(III) triflate; N-iodo-succinimide In acetonitrile at 23℃; for 8h; Inert atmosphere; Darkness;	92%
With iron(III) chloride; N-iodo-succinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide at 36℃; for 1h; Inert atmosphere;	91%

: 617-86-7
triethylsilane

: 496-16-2
2,3-Dihydrobenzofuran

: triethyl-(2-ethyl-phenoxy)-silane

Conditions

Conditions	Yield
With tris(pentafluorophenyl)borate In dichloromethane at 20℃; for 20h; silylation;	99%
With tris(pentafluorophenyl)borate In dichloromethane at 20℃; for 20h; Reduction; dehydrocondensation;	99%

: 496-16-2
2,3-Dihydrobenzofuran

: 107-06-2
1,2-dichloro-ethane

: 115010-11-2
2,3-dihydrobenzofuran-5-sulfonyl chloride

Conditions

Conditions	Yield
With thionyl chloride In water	99%

: 496-16-2
2,3-Dihydrobenzofuran

: 871949-46-1
2-trimethylsilyl ethane sulfonic acid azide

: C13H21NO3SSi

Conditions

Conditions	Yield
Stage #1: 2.3-dihydrobenzofuran; 2-trimethylsilyl ethane sulfonic acid azide In neat (no solvent) at -10℃; for 0.5h; Schlenk technique; Inert atmosphere; Molecular sieve; Stage #2: With C61H40F4N2O3Ru In neat (no solvent) at -10℃; for 2h; Schlenk technique; Inert atmosphere; Molecular sieve; enantioselective reaction;	99%

: 496-16-2
2,3-Dihydrobenzofuran

: 73183-34-3
bis(pinacol)diborane

: 402503-13-3
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan

Conditions

Conditions	Yield
With C25H40O2P2Ru In octane at 150℃; for 12h; Inert atmosphere;	99%

: 496-16-2
2,3-Dihydrobenzofuran

: 79-03-8
propionyl chloride

: 68660-11-7
1-(2,3-dihydrobenzofuran-5-yl)propan-1-one

Conditions

Conditions	Yield
Stage #1: propionyl chloride; aluminum (III) chloride In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 2.3-dihydrobenzofuran In dichloromethane at 0℃; Inert atmosphere;	98%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 1h;	80%
With tin(IV) chloride In benzene at 30℃; for 24h; Friedel-Crafts acylation;	66%
With carbon disulfide; aluminium trichloride

: 496-16-2
2,3-Dihydrobenzofuran

: 2,3-dihydrobenzofuran-5-sulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide In nitromethane at 0℃; for 1h;	98%
With sulfur trioxide In nitromethane at 0℃;

: 496-16-2
2,3-Dihydrobenzofuran

: 2,3-Dihydro-benzofuran-5,7-disulfonic acid

Conditions

Conditions	Yield
With sulfuric acid at 20℃; for 3600h; other reagent; other solvent; other temp;	98%
With sulfur trioxide In nitromethane at 0℃; excess of reagent;

: 496-16-2
2,3-Dihydrobenzofuran

: 498-66-8
norbornene

: 7-(bicyclo[2.2.1]hept-2-yl)-2,3-dihydro-1-benzofuran

Conditions

Conditions	Yield
With (C5H5)Y(CH2C6H4NMe2-o)2; trityl tetrakis(pentafluorophenyl)borate In toluene at 70℃; for 24h; Inert atmosphere; Glovebox; regioselective reaction;	98%

: 496-16-2
2,3-Dihydrobenzofuran

: 65-85-0
benzoic acid

: 115063-19-9
(2,3-dihydrobenzofuran-5-yl)(phenyl)methanone

Conditions

Conditions	Yield
With trifluoroacetic acid; trifluoroacetic anhydride at 20℃; for 12h; Friedel-Crafts Acylation; Inert atmosphere;	98%

: 496-16-2
2,3-Dihydrobenzofuran

: 696-63-9
4-Methoxybenzenethiol

: (2,3-dihydro-1-benzofuran-5-yl)(4′-methoxyphenyl)sulfane

Conditions

Conditions	Yield
With tetrabutylammonium acetate for 4.5h; Electrolysis; Inert atmosphere; Sealed tube; regioselective reaction;	97%

: 496-16-2
2,3-Dihydrobenzofuran

: 38858-02-5
bis(2,2,2-trichloroethyl) hydrazino-1,2-dicarboxylate

: 197590-43-5
1-(5-dihydrobenzofuranyl)-1,2-hydrazinedicarboxylic acid bis(2,2,2-trichloroethyl) ester

Conditions

Conditions	Yield
With zinc(II) chloride In dichloromethane at 20℃;	96.6%

: 496-16-2
2,3-Dihydrobenzofuran

: 76429-69-1
5-Chloro-2,3-dihydrobenzo[b]furan

Conditions

Conditions	Yield
With N-chloro-succinimide; 2,2,6,6-tetramethylpiperidin-1-oxoammonium trifluoromethanesulfonate In chloroform at 25℃; for 12h; Reagent/catalyst; Schlenk technique;	96%
With iron(III) chloride; N-chloro-succinimide; 1-butyl-3-methylimidazolium trifluoromethanesulfonimide In tetrahydrofuran at 60℃; for 18h; Inert atmosphere; regioselective reaction;	86%
With N-chloro-succinimide; zirconium(IV) chloride In dichloromethane at 20℃; for 12h;
With N-chloro-succinimide; zirconium(IV) chloride In dichloromethane at 20℃; for 12h; Conversion of starting material;
With N-chloro-succinimide; acetic acid In acetonitrile at 10 - 35℃; for 48h;	2.28 g

: 496-16-2
2,3-Dihydrobenzofuran

: 108-24-7
acetic anhydride

: 90843-31-5
1-(2,3-dihydrobenzofuran-5-yl)ethanone

Conditions

Conditions	Yield
With Hβ zeolite (Si:Al 12.5) at 120℃; for 1.5h;	95%
With trifluoroacetic acid at 20℃; for 1.5h; Friedel-Crafts Acylation;	91%
With zinc(II) chloride at 95 - 105℃; for 10h;
With zinc(II) chloride at 95 - 105℃; for 10h;

: 3,5-bis(trifluoromethyl)phenyl azide

: 496-16-2
2,3-Dihydrobenzofuran

: C16H11F6NO

Conditions

Conditions	Yield
With chloro[5,10,15,20-tetrakis(4-dimethylamino-2,3,5,6-tetrafluorophenyl)porphyrinate]iron(III) In 1,2-dichloro-ethane at 120℃; for 12h; Schlenk technique; Inert atmosphere; Molecular sieve; regioselective reaction;	95%

: 496-16-2
2,3-Dihydrobenzofuran

: 953408-82-7
2,3-dihydrobenzofuran-7-sulfonyl chloride

Conditions

Conditions	Yield
In 1,2-dichloro-ethane	94%

: 496-16-2
2,3-Dihydrobenzofuran

: 90843-31-5
1-(2,3-dihydrobenzofuran-5-yl)ethanone

Conditions

Conditions	Yield
Stage #1: acetyl chloride With aluminum (III) chloride In dichloromethane at -10℃; for 0.25h; Stage #2: 2.3-dihydrobenzofuran In dichloromethane at -10℃; for 0.5h; Stage #3: With hydrogenchloride In dichloromethane; water at 0℃; for 2h;	94%

: 496-16-2
2,3-Dihydrobenzofuran

: 123266-59-1
5,7-Dibromo-2,3-dihydrobenzofuran

Conditions

Conditions	Yield
With bromine; sodium thiosulfate In dichloromethane; acetic acid	93%
With iodine pentoxide; potassium bromide In water at 20℃; for 23h; regioselective reaction;	89%
With bromine; sodium thiosulfate In chloroform	87%

: 496-16-2
2,3-Dihydrobenzofuran

: 1575-61-7
5-Chlorovaleroyl chloride

: 5-Chloro-1-(2,3-dihydro-1-benzofuran-5-yl)-1-pentanone

Conditions

Conditions	Yield
Stage #1: 2.3-dihydrobenzofuran; aluminum (III) chloride In toluene at 20 - 30℃; for 0.5h; Stage #2: 5-Chlorovaleroyl chloride In toluene at -5 - 5℃; for 1h;	92.8%

2,3-Dihydrobenzofuran Chemical Properties

Molecular Structure of 2,3-Dihydrobenzofuran (CAS NO.496-16-2):

IUPAC Name: 2,3-Dihydro-1-benzofuran
Molecular Formula: C₈H₈O
Molecular Weight: 120.148520 g/mol
Molar Refractivity: 35.42 cm³
Molar Volume: 109.5 cm³
Surface Tension: 41.4 dyne/cm
Density: 1.096 g/cm³Melting Point: -21 °C
Flash Point: 66.7 °C
Boiling Point: 188.2 °C at 760 mmHg
Enthalpy of Vaporization: 40.7 kJ/mol
Vapour Pressure: 0.836 mmHg at 25 °C
XLogP3: 2.1
H-Bond Acceptor: 1
Exact Mass: 120.057515
MonoIsotopic Mass: 120.057515
Topological Polar Surface Area: 9.2
Heavy Atom Count: 9
Canonical SMILES: C1COC2=CC=CC=C21
InChI: InChI=1S/C8H8O/c1-2-4-8-7(3-1)5-6-9-8/h1-4H,5-6H2
InChIKey: HBEDSQVIWPRPAY-UHFFFAOYSA-N
EINECS: 207-817-3
Product Categories: Fluorobenzene; Benzodiozoles, Benzodioxines & Benzodioxepines; Furan&Benzofuran; Benzodiozoles, Benzodioxines & Benzodioxepines

2,3-Dihydrobenzofuran Safety Profile

Hazard Codes: Xi
Hazard Note: Irritant
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 23-24/25-26
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24/25: Avoid contact with skin and eyes
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
HS Code: 29329995

2,3-Dihydrobenzofuran Specification

2,3-Dihydrobenzofuran (CAS NO.496-16-2) is also named as Coumaran ; Benzofuran, 2,3-dihydro- ; 2,3-Dihydro-1-benzofuran ; Dihydrocoumarone . 2,3-Dihydrobenzofuran (CAS NO.496-16-2) is colorless to light yellow liquid.

Product Name

2,3-Dihydrobenzofuran

Synthetic route

2,3-Dihydrobenzofuran Chemical Properties

2,3-Dihydrobenzofuran Safety Profile

2,3-Dihydrobenzofuran Specification

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