2,4,6-Trichlorobenzoyl chloride supplier

Name
2,4,6-Trichlorobenzoyl chloride
EINECS
CAS No. 4136-95-2
Article Data10
CAS DataBase
Density 1.608 g/cm³
Solubility Reacts with water.
Melting Point 165-166 °C
Formula C₇H₂Cl₄O
Boiling Point 284.215 °C at 760 mmHg
Molecular Weight 243.904
Flash Point 118.47 °C
Transport Information UN 3265 8/PG 2
Appearance clear yellow liquid
Safety 26-27-28-36/37/39-45-25
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 2,4,6-Trichlorobenzoylchloride;2,4,6-Trichlorobenzoic acid chloride;2,4,6-Trichlorobenzoyl chloride,98%;2,4,6-Trichlorobenzoyl chloride;
PSA 17.07000
LogP 4.02580

Synthetic route

: 50-43-1
2,4,6-trichlorobenzoic acid

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride
With phosphorus pentachloride
With thionyl chloride

: 135365-02-5
2-Bromo-6-chloro-4-methyl-benzoyl chloride

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide for 3h; Heating;

: 135340-78-2
2-bromo-6-chloro-4-methylaniline

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) concd. H2SO4, NaNO2 / 1.) HOAc, 15 deg C, 3 h, 2.) H2O, 35-40 deg C, 1 h 2: 40.8 percent / concd. H2SO4 / 3 h / Heating 3: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 4: SOCl2, DMF / 3 h / Heating 5: SOCl2, DMF / 3 h / Heating View Scheme

: 135340-79-3
2-bromo-6-chloro-4-methylbenzonitrile

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 40.8 percent / concd. H2SO4 / 3 h / Heating 2: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 3: SOCl2, DMF / 3 h / Heating 4: SOCl2, DMF / 3 h / Heating View Scheme

: 135340-36-2
2-chloro-6-bromo-4-methylbenzoic acid

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2, DMF / 3 h / Heating 2: SOCl2, DMF / 3 h / Heating View Scheme

: 135340-80-6
2-bromo-6-chloro-4-methylbenzamide

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 2: SOCl2, DMF / 3 h / Heating 3: SOCl2, DMF / 3 h / Heating View Scheme

: 615-65-6
2-chloro-4-methyl-benzenamine

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) Br2, HOAc, 2.) 50percent aq. NaOH / 0.5 h / Ambient temperature 2: 1.) concd. H2SO4, NaNO2 / 1.) HOAc, 15 deg C, 3 h, 2.) H2O, 35-40 deg C, 1 h 3: 40.8 percent / concd. H2SO4 / 3 h / Heating 4: 77.4 percent / concd. HCl, NaNO2, HOAc / H2O / 1.) 5 deg C, 30 min, 2.) 85 deg C, 1 h 5: SOCl2, DMF / 3 h / Heating 6: SOCl2, DMF / 3 h / Heating View Scheme

: 6575-05-9
2,4,6-Trichlorobenzonitrile

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid; water 2: phosphorus (V)-chloride View Scheme

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 4469-06-1
<3-14C>-cinnamic acid

: C15(14)CH9Cl3O3

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 1h; Ambient temperature;	100%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 71989-31-6
Fmoc-Pro-OH

: 1160053-32-6
C27H20Cl3NO5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h;	100%
With N-ethyl-N,N-diisopropylamine In toluene at 20℃; for 0.166667h; Inert atmosphere;

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic acid

: 2,4,6-trichlorobenzoic 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic anhydride

Conditions

Conditions	Yield
With potassium carbonate In acetone at 25 - 30℃; for 3h; Product distribution / selectivity; Inert atmosphere;	100%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic acid

: C53H81NO14

: C68H103NO17

Conditions

Conditions	Yield
Stage #1: 2,4,6-trichlorobenzoyl chloride; 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic acid With triethylamine In dichloromethane at 0 - 5℃; for 2h; Inert atmosphere; Stage #2: C53H81NO14 With dmap In toluene at 20℃; Product distribution / selectivity;	100%

...Expand

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic acid

: C54H87NO13Si

: C69H109NO16Si

Conditions

Conditions	Yield
Stage #1: 2,4,6-trichlorobenzoyl chloride; 1,5',7,7-tetramethylspiro[bicyclo[2.2.1]heptane-2,2'-[1,3]dioxane]-5'-carboxylic acid With triethylamine In dichloromethane at 0 - 5℃; for 2h; Inert atmosphere; Stage #2: C54H87NO13Si With dmap In toluene at 20℃; Product distribution / selectivity;	100%

...Expand

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 4-iodo-9H-carbazole

: 9-(2,4,6-trichlorobenzoyl)-4-iodo-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	100%

: 22401-74-7
3-(1,1-dimethylethyl)-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-3-(1,1-dimethylethyl)-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	100%

: 3652-88-8
4-chloro-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-4-chloro-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	100%

: 57905-76-7
4-Nitro-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-4-nitro-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	100%

: 3652-89-9
4-bromo-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-4-bromo-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	100%

: 3710-84-7
N-ethyl-N-hydroxy-ethanamine

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: N,N-diethyl-O-(2,4,6-trichlorobenzoyl)hydroxylamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.333333h;	100%

: 875685-46-4
10-Nitrooleic Acid

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 2,4,6-Trichlorobenzoyl 10-nitrooleate

Conditions

Conditions	Yield
Stage #1: 10-Nitrooleic Acid With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 23℃; for 0.25h; Inert atmosphere; Stage #2: 2,4,6-trichlorobenzoyl chloride In tetrahydrofuran at 23℃; for 3h; Inert atmosphere;	100%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 50-43-1
2,4,6-trichlorobenzoic acid

Conditions

Conditions	Yield
With water; triethylamine In acetone at 20℃; for 18h;	99%
With water In acetone at 55℃; Kinetics; Mechanism; Concentration;

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 121441-39-2
(E)-((hex-3-en-1-yloxy)methyl)benzene

: C13H13Cl3O2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	99%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 927-74-2
1-butyn-4-ol

: C11H7Cl3O2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	99%

: 3077-85-8
3-Nitro-carbazol

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-3-nitro-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 23℃; for 2h; Inert atmosphere;	99%

: 256-96-2
dibenzoazepine

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 5-(2,4,6-trichlorobenzoyl)-5H-dibenz[b,f]azepine

Conditions

Conditions	Yield
Stage #1: dibenzoazepine With potassium hexamethylsilazane In tetrahydrofuran at 0℃; Inert atmosphere; Stage #2: 2,4,6-trichlorobenzoyl chloride In tetrahydrofuran at 0 - 23℃; for 1h; Inert atmosphere;	98%

: 544-12-7
3-hexen-1-ol

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: C13H13Cl3O2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	98%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 4-(trimethylsilyl)-9H-carbazole

: 9-(2,4,6-trichlorobenzoyl)-4-trimethylsilyl-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	98%

: 2467-83-6
3-(trifluoromethyl)-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-3-trifluoromethyl-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	98%

: 2305-21-7
2-hexen-1-ol

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: C13H13Cl3O2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	97%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 1280222-59-4
(S)-1-((4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl)octan-1-ol

: (R)-4-((tert-butyldimethylsilyl)oxy)hex-5-ynoic acid

: (R)-(S)-1-((4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl)octyl 4-((tert-butyldimethylsilyl)oxy)hex-5-ynoate

Conditions

Conditions	Yield
Stage #1: 2,4,6-trichlorobenzoyl chloride; (R)-4-((tert-butyldimethylsilyl)oxy)hex-5-ynoic acid With triethylamine In toluene for 1h; Inert atmosphere; Stage #2: (S)-1-[(4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]octan-1-ol With dmap In toluene for 5h; Inert atmosphere;	96%

...Expand

: 4698-11-7
10-methoxy-5H-dibenzo[b,f]azepine

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 10-methoxy-5-(2,4,6-trichlorobenzoyl)-5H-dibenz[b,f]azepine

Conditions

Conditions	Yield
Stage #1: 10-methoxy-5H-dibenzo[b,f]azepine With potassium hexamethylsilazane In tetrahydrofuran at 0℃; Inert atmosphere; Stage #2: 2,4,6-trichlorobenzoyl chloride In tetrahydrofuran at 0 - 23℃; for 1h; Inert atmosphere;	96%

: 16807-13-9
3-iodocarbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-3-iodo-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	96%

: 18992-85-3
3-methoxycarbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-3-methoxy-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	96%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 7588-36-5
methyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate

: 1267907-58-3
methyl [1-(2,4,6-trichlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

Conditions

Conditions	Yield
Stage #1: methyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate With potassium hexamethylsilazane In tetrahydrofuran; toluene at 20℃; for 0.0833333h; Stage #2: 2,4,6-trichlorobenzoyl chloride In tetrahydrofuran; toluene at 20℃; for 2h;	95%

: 865444-41-3
(E) and (Z)-4-cyclohexyl-3-buten-1-ol

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: C17H19Cl3O2

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	95%

: 3770-48-7
4-methyl-9H-carbazole

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 9-(2,4,6-trichlorobenzoyl)-4-methyl-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	95%

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 3-trimethylsilyl-9H-carbazole

: 9-(2,4,6-trichlorobenzoyl)-3-trimethylsilyl-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 23℃; for 2h; Inert atmosphere;	94%

: 75-91-2
tert.-butylhydroperoxide

: 4136-95-2
2,4,6-trichlorobenzoyl chloride

: 2,4,6-trichloro-benzenecarboperoxoic acid tert-butyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at -20 - 20℃; Oxidation;	93%

2,4,6-Trichlorobenzoyl chloride Chemical Properties

Molecular Structure of Benzoyl chloride,2,4,6-trichloro- (CAS NO.4136-95-2):

IUPAC Name: 2,4,6-trichlorobenzoyl chloride
mpirical Formula: C₇H₂Cl₄O
Molecular Weight: 243.9022
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.589
Molar Refractivity: 51.18 cm³
Molar Volume: 151.6 cm³
Surface Tension: 47.7 dyne/cm
Density: 1.607 g/cm³
Flash Point: 118.5 °C
Enthalpy of Vaporization: 52.32 kJ/mol
Boiling Point: 284.2 °C at 760 mmHg
Vapour Pressure: 0.00302 mmHg at 25°C
Sensitive: Moisture Sensitive
BRN: 2050280
Product Categories: Condensation & Active Esterification; Synthetic Organic Chemistry; Acid Halides; Carbonyl Compounds; Organic Building Blocks

2,4,6-Trichlorobenzoyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-27-28-36/37/39-45-25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25:Avoid contact with eyes.
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: II

2,4,6-Trichlorobenzoyl chloride Specification

Benzoyl chloride,2,4,6-trichloro- , with CAS number of 4136-95-2, can be called 2,4,6-Trichlorobenzoyl chloride ; 2,4,6-Trichlorbenzoylchlorid ; 2,4,6-TrichlorobenzoyChloride ; 2,4,6-Trichlorobenzoic acid chloride ; 2,4,6-Trichlorobenzoyl chloride,98% . It is a clear yellow liquid.

Product Name

2,4,6-Trichlorobenzoyl chloride

Synthetic route

2,4,6-Trichlorobenzoyl chloride Chemical Properties

2,4,6-Trichlorobenzoyl chloride Safety Profile

2,4,6-Trichlorobenzoyl chloride Specification

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