2,4-Dimethoxybenzaldehyde supplier

Name
2,4-Dimethoxybenzaldehyde
EINECS 210-342-4
CAS No. 613-45-6
Article Data164
CAS DataBase
Density 1.114 g/cm³
Solubility insoluble in water
Melting Point 67-69 °C(lit.)
Formula C₉H₁₀O₃
Boiling Point 307.8 °C at 760 mmHg
Molecular Weight 166.177
Flash Point 124.7 °C
Transport Information
Appearance white solid
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzaldehyde, 2,4-dimethoxy-;
PSA 35.53000
LogP 1.51630

Synthetic route

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 0.0333333h; Microwave irradiation;	100%
With C6H4MoNO7(1-)*C19H42N(1+); oxygen In water at 100℃; for 18h; Green chemistry; chemoselective reaction;	98%
With Merrifield's resin-bound N-aminoimidazolium chlorochromate In dichloromethane for 6.3h; Heating;	97%

: C10H13N3O3

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With caro's acid; silica gel In dichloromethane for 0.0833333h; Heating;	100%

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 74-88-4
methyl iodide

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	99%
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 3.5h;	95%
With potassium carbonate In acetone for 2.5h; Reflux;	94%

: 3030-94-2
2,4-dimethoxybenzaldehyde semicarbazone

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.166667h; Heating;	98%
With potassium permanganate; montmorillonite K-10 for 0.25h;	96%
With (Bu4N)2S2O8 In 1,2-dichloro-ethane at 80℃; for 0.5h; oxidative cleavage;	90%
With tribromo-isocyanuric acid In acetonitrile at 20℃; for 4h;	78%

: 135655-77-5
2-(2',4'-dimethoxyphenyl)-1,3-dithiane

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2-[2',4'-dimethoxyphenyl]-1,3-dithiane With acetyl chloride; sodium nitrite In dichloromethane at 0 - 5℃; for 0.25h; Stage #2: With water In dichloromethane at 0 - 20℃; for 0.5h;	97%

: 24575-92-6
2,4-dimethoxybenzaldehyde phenylhydrazone

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium permanganate; montmorillonite K-10 for 0.25h;	96%

: 258876-09-4
2,4-dimethoxybenzyl phenylacetate

A: 103-82-2
phenylacetic acid

B: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane for 18h; Ambient temperature; Yields of byproduct given;	A 95% B n/a

: 2-(2,4-dimethoxy-phenyl)-[1,3]oxathiolane

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2-(2,4-dimethoxy-phenyl)-[1,3]oxathiolane With acetyl chloride; sodium nitrite In dichloromethane at 0 - 5℃; for 0.25h; Stage #2: With water In dichloromethane at 0 - 20℃; for 0.25h;	95%
With ammonium bromide; dihydrogen peroxide; vanadia In dichloromethane at 0 - 5℃; for 1.25h;	85%
With perchloric acid; dihydrogen peroxide; ammonium bromide; molybdic acid In dichloromethane at 0 - 5℃; for 2.5h;	80%

: 6496-89-5
2,4-dimethoxyphenylacetic acid

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 25℃; for 10h; UV-irradiation;	95%
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.25h; Microwave irradiation;	88%

: 31874-34-7
2,4-dimethoxybenzaldoxime

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With silica gel; iron(III) chloride for 0.00833333h; microwave irradiation;	93%
With (Bu4N)2S2O8 In 1,2-dichloro-ethane for 1h; Heating;	91.8%
With pyridinium chlorochromate at 20℃; for 4.5h;	90%

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 917-54-4
methyllithium

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With oxygen; 2,2,6,6-tetramethyl-piperidine-N-oxyl; copper(I) bromide dimethylsulfide complex; bis(3-(perfluorooctyl)butyl)-2,2'-bipyridine In chlorobenzene at 90℃; for 3h; Oxidation;	93%

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 74-88-4
methyl iodide

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0℃; for 18h;	93%

: 91352-76-0
2,4-dimethoxybenzaldehyde dimethylacetal

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With aluminum oxide; Oxone for 0.025h; Hydrolysis; Microwave irradiation;	92%

: 2-(2,4-dimethoxy-benzyloxy)-tetrahydro-pyran

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With 1-n-butylpyridinium tetrachloroferrate; pyridinium chlorochromate at 50℃; for 0.233333h;	92%

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

A: 4107-65-7
2,4-dimethoxybenzonitrile

B: 613-45-6
2,4-Dimethoxybenzaldehyde

C: (2,4-Dimethoxy-benzyl)-[1-(2,4-dimethoxy-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With sodium hydroxide; sodium hypochlorite In ethanol for 0.25h; Ambient temperature;	A 89% B n/a C n/a

...Expand

: 83026-07-7
Decanoic acid 2,4-dimethoxy-benzyl ester

A: 334-48-5
1-decanoic acid

B: 4316-58-9
tri(p-bromophenyl)amine

C: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; 2a-radical-kation In water; acetonitrile oxidative electrolysis; Yield given;	A 86% B n/a C n/a

...Expand

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 151-10-0
1,3-Dimethoxybenzene

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With silica gel; trichlorophosphate for 0.025h; Formylation; Microwave irradiation (300 W);	85%
With trichlorophosphate
With sodium hydroxide; pyrophosphoryl chloride 1) 100 deg C, 4 h; Yield given. Multistep reaction;

: 114478-87-4
1-(bis(ethylthio)methyl)-2,4-dimethoxybenzene

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With cetyl(trimethyl)-ammonium tribromide In dichloromethane at 0 - 5℃; for 0.0833333h;	85%
With ammonium heptamolybdate; dihydrogen peroxide; ammonium bromide; perchloric acid In dichloromethane; water at 0 - 5℃; for 0.5h;	82%

: 151-10-0
1,3-Dimethoxybenzene

: 332047-72-0
tris(diformylamino)methane

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In nitromethane at 20℃; for 2.5h;	84%
With aluminium trichloride In 1,2-dichloro-ethane at 2℃; for 15h;	45%
Stage #1: 1,3-Dimethoxybenzene; tris(diformylamino)methane With aluminium trichloride In 1,2-dichloro-ethane at -13 - 2℃; for 15h; Stage #2: With water	45%
With aluminium trichloride In 1,2-dichloro-ethane at -13 - 2℃; for 15h;	45%

: 20469-63-0
1-iodo-2,4-dimethoxybenzene

: 82102-37-2
9-methyl-9H-fluorene-9-carbonyl chloride

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 80℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;	84%

: 93-61-8
N-methyl-N-phenylformamide

: 151-10-0
1,3-Dimethoxybenzene

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With trichlorophosphate In various solvent(s) at 100℃; for 1h; Vilsmeier formylation;	83%
With trichlorophosphate

: 91-52-1
2,4 dimethoxybenzoic acid

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine In toluene for 24h; Irradiation; Glovebox;	81%

: 40243-84-3
2,4-dimethoxystyrene

A: 50-00-0
formaldehyd

B: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 20℃; under 760.051 Torr; for 5h;	A n/a B 80%

: 1535-67-7
difluoromethyl phenyl sulfide

: 151-10-0
1,3-Dimethoxybenzene

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: difluoromethyl phenyl sulfide; 1,3-Dimethoxybenzene With tin(IV) chloride In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; dimethyl sulfoxide at 20℃; for 2h;	78%

: 83169-55-5, 84187-45-1, 88792-18-1, 88792-19-2, 90192-18-0, 97591-37-2
cis-3-benzyloxycarbonylamino-1-(2,4-dimethoxybenzyl)-4-methoxycarbonyl-2-azetidinone

A: 91-52-1
2,4 dimethoxybenzoic acid

: 80542-47-8
cis-4-(methoxycarbonyl)-2-oxo-3-<<(phenylmethoxy)carbonyl>amino>-1-azetidine

: 92973-54-1
cis-3-benzyloxycarbonylamino-1-(2,4-dimethoxybenzoyl)-4-methoxycarbonyl-2-azetidinone

D: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; dipotassium peroxodisulfate In water; acetonitrile for 2h; Heating;	A 68 mg B 62% C 4.5% D 75%

...Expand

: 13398-65-7
2,4-dimethoxy-phenethyl alcohol

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With molecular sieve; pyridinium chlorochromate In dichloromethane at 20℃; for 8h;	73%

: N-(2,4-dinitrophenyl)-N'-(2',4'-dimethoxybenzylidene)hydrazone

: 613-45-6
2,4-Dimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium permanganate at 40℃; for 4.2h; Ionic liquid; chemoselective reaction;	69%

: 4885-02-3
Dichloromethyl methyl ether

: 151-10-0
1,3-Dimethoxybenzene

A: 613-45-6
2,4-Dimethoxybenzaldehyde

B: 3392-97-0
2,6-dimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,3-Dimethoxybenzene With titanium tetrachloride In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: Dichloromethyl methyl ether In dichloromethane at 0℃; for 0.75h; Inert atmosphere; Overall yield = 79 %;	A 61% B 18%

...Expand

: 552-41-0
1-(2-hydroxy-4-methoxyphenyl)ethanone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 36685-67-3, 84426-23-3
(E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 16h; Claisen-Schmidt Condensation;	100%
With sodium hydroxide In ethanol at 20℃; for 16h;	94%
With potassium hydroxide In ethanol at 20℃; Claisen Schmidt condensation;	90%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 13330-65-9
2,4-dimethoxyphenol

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide In methanol; water at 20℃; for 20h;	100%
With sulfuric acid; dihydrogen peroxide In methanol at 20℃; for 20h;	94%
With dihydrogen peroxide; sulfuric acid In methanol for 14h; Ambient temperature;	90%

: 623-33-6
glycine ethyl ester hydrochloride

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 95218-34-1
ethyl 2-{[(2,4-dimethoxyphenyl)methyl]amino}acetate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane for 17h;	100%
With sodium tetrahydroborate; triethylamine In methanol; ethanol for 1h; Ambient temperature;	59%
Stage #1: glycine ethyl ester hydrochloride; 2,4-Dimethoxybenzaldehyde With triethylamine In acetonitrile at 20℃; for 1h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride at 20℃; for 18h; Inert atmosphere;	49%
Stage #1: glycine ethyl ester hydrochloride; 2,4-Dimethoxybenzaldehyde With triethylamine In 1,1-dichloroethane for 1h; Stage #2: With water; sodium tris(acetoxy)borohydride In 1,1-dichloroethane for 72h; Stage #3: With sodium hydrogencarbonate In 1,1-dichloroethane; water

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; phenylboronic acid In dichloromethane at 20℃; for 16h;	100%
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	100%
With water; nickel dichloride; zinc In N,N-dimethyl-formamide for 1.5h; Ambient temperature;	98%

: 26138-64-7
3-acetyl-2,4-dihydroxyquinoline

: 613-45-6
2,4-Dimethoxybenzaldehyde

: (E)-1-(2,4-Dihydroxy-quinolin-3-yl)-3-(2,4-dimethoxy-phenyl)-propenone

Conditions

Conditions	Yield
	100%

: 104-94-9
4-methoxy-aniline

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 123794-61-6
N-(2,4-dimethoxybenzylidene)-4-methoxyaniline

Conditions

Conditions	Yield
In toluene for 40h; Heating;	100%
In toluene at 165℃; for 18h;
In chlorobenzene for 1h; Reflux;

: 109-80-8
1.3-propanedithiol

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 135655-77-5
2-(2',4'-dimethoxyphenyl)-1,3-dithiane

Conditions

Conditions	Yield
With Lewis acid	100%
With acetyl chloride at 20℃; for 0.0666667h;	98%
With nickel dichloride In methanol; dichloromethane at 20℃; for 0.2h;	96%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: (4S,5R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((E)-4,8-dimethyl-nona-3,7-dienyl)-5-methyl-dihydro-furan-2-one

: (3R,4R,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[(2,4-dimethoxy-phenyl)-hydroxy-methyl]-5-((E)-4,8-dimethyl-nona-3,7-dienyl)-5-methyl-dihydro-furan-2-one

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃;	100%

: 24470-78-8
isopropyltriphenylphosphonium iodide

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 798559-93-0
2,4-dimethoxy-1-(2-methyl-propenyl)-benzene

Conditions

Conditions	Yield
Stage #1: isopropyltriphenylphosphonium iodide With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.5h; Stage #2: 2,4-Dimethoxybenzaldehyde In tetrahydrofuran; hexane at 20℃; for 4h;	100%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 616-34-2
methoxycarbonylmethylamine

: 20839-81-0
(2,4-dimethoxybenzylamino)acetic acid methyl ester

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃; for 24h;	100%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: (E)-bis(2,4-dimethoxyphenyl)ethene

Conditions

Conditions	Yield
With woollins’ reagent In toluene for 20h; Heating;	100%

: 2987-53-3
2-(Methylthio)aniline

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 2-methylthio-N-(2,4-dimethoxybenzylidene)aniline

Conditions

Conditions	Yield
In toluene Heating;	100%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 74-89-5
methylamine

: 102503-23-1
1-(2,4-dimethoxyphenyl)-N-methylmethanamine

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol for 2h;	100%
Stage #1: 2,4-Dimethoxybenzaldehyde; methylamine In methanol at 0 - 20℃; for 1h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 12h;	92%
Stage #1: 2,4-Dimethoxybenzaldehyde; methylamine In methanol at 20℃; for 1h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 2℃; for 3h; Stage #3: With hydrogenchloride; water; sodium hydrogencarbonate more than 3 stages;	81%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 25℃;

: 35613-44-6
2-aminophenylacetic acid methyl ester

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1198328-58-3
C18H19NO4

Conditions

Conditions	Yield
In methanol at 20℃; for 16h; Inert atmosphere;	100%

: 41580-73-8
2'-(propargyloxy)acetophenone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1227420-52-1
3-(2,4-dimethoxy-phenyl)-1-(2-prop-2-ynyloxy-phenyl)-propenone

Conditions

Conditions	Yield
Stage #1: 2'-(propargyloxy)acetophenone With sodium hydroxide In methanol at 25℃; for 0.5h; Claisen-Schmidt condensation; Stage #2: 2,4-Dimethoxybenzaldehyde In methanol at 25℃; Claisen-Schmidt condensation;	100%

: 2508-29-4
5-hydroxypentylamine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 932176-57-3
5-((2,4-dimethoxybenzyl)amino)pentan-1-ol

Conditions

Conditions	Yield
Stage #1: 5-hydroxypentylamine; 2,4-Dimethoxybenzaldehyde In toluene for 4h; Reflux; Dean-Stark; Stage #2: With sodium tetrahydroborate In methanol at 0℃; for 0.166667h;	100%
Stage #1: 5-hydroxypentylamine; 2,4-Dimethoxybenzaldehyde With acetic acid In methanol at 10℃; for 0.5h; Stage #2: With sodium tetrahydroborate In methanol at -10 - 10℃; for 1.66667h; Stage #3: With sodium hydrogencarbonate In methanol for 0.5h;

: 106-47-8
4-chloro-aniline

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 38608-00-3
4-chloro-N-(2,4-dimethoxybenzylidene)aniline

Conditions

Conditions	Yield
In toluene at 80℃; for 12h; Inert atmosphere;	100%

: 2622-05-1
allylmagnesium bromide

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1023294-87-2
1-(2,4-dimethoxyphenyl)but-3-en-1-ol

Conditions

Conditions	Yield
In diethyl ether at 0 - 20℃;	100%
In tetrahydrofuran; diethyl ether at 0 - 20℃;

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1003-03-8
Cyclopentamine

: 356092-74-5
N-cyclopentyl-N-(2,4-dimethoxybenzyl)amine

Conditions

Conditions	Yield
Stage #1: 2,4-Dimethoxybenzaldehyde; Cyclopentamine In methanol at 20℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol for 0.5h;	100%

: 4-(2-cyclohexylethoxy)-2-fluoroaniline

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 4-(2-cyclohexylethoxy)-N-(2,4-dimethoxybenzyl)-2-fluoroaniline

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃;	100%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 2,4-dimethoxybenzaldehyde O-benzyloxime

Conditions

Conditions	Yield
With pyrrolidine In tetrahydrofuran at 20℃; for 4h; Reagent/catalyst; Solvent;	100%

: 35161-71-8
N-methylpropargylamine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 56862-22-7
N-(2,4-dimethoxybenzyl)-N-methylprop-2-yn-1-amine

Conditions

Conditions	Yield
Stage #1: 2,4-Dimethoxybenzaldehyde With acetic acid In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: methyl(propargyl)amine In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #3: With sodium tris(acetoxy)borohydride In dichloromethane at 0℃; Inert atmosphere;	100%

: 83-33-0
inden-1-one

: 613-45-6
2,4-Dimethoxybenzaldehyde

: (E)-2-(2,4-dimethoxybenzyliden)-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 20℃; for 24h;	99.1%
basic condition;
Claisen-Schmidt Condensation; Alkaline conditions;

: 141-82-2
malonic acid

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 16909-09-4
(E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid

Conditions

Conditions	Yield
With piperidine; pyridine at 80 - 115℃; for 4h; Knoevenagel Condensation;	99%
With piperidine; pyridine at 125℃; for 3.5h;	98%
Stage #1: malonic acid; 2,4-Dimethoxybenzaldehyde With pyridine; 3-amino propanoic acid for 1.5h; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In water at 0℃; Inert atmosphere;	90%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 24533-49-1
(E)-3-(2,4-dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one

Conditions

Conditions	Yield
Stage #1: 2,4-Dimethoxybenzaldehyde; 1-(4-methoxyphenyl)ethanone With potassium hydroxide In ethanol; water at 20℃; for 12h; Claisen Schmidt condensation; Stage #2: With hydrogenchloride In ethanol; water pH=3 - 4;	99%
With sodium hydroxide In ethanol; water at 0 - 20℃; for 12h; Claisen-Schmidt Condensation;	98%
With sodium hydroxide In ethanol; water at 0 - 20℃; for 15h; Claisen-Schmidt Condensation;	41%

: 20781-20-8
2,4-Dimethoxybenzylamine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 20781-23-1
bis(2,4-dimethoxybenzyl)amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃;	99%
With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 2h;	92%
(i) TsOH, toluene, (ii) aq. NaBH4; Multistep reaction;
Stage #1: 2,4-Dimethoxybenzylamine; 2,4-Dimethoxybenzaldehyde In ethanol at 20℃; for 2h; Stage #2: With sodium tris(acetoxy)borohydride In ethanol at 20℃; for 1h;	8 g
Stage #1: 2,4-Dimethoxybenzylamine; 2,4-Dimethoxybenzaldehyde In methanol at 20℃; for 1h; Stage #2: With methanol; sodium tetrahydroborate at 20℃;

: 85914-42-7
N-(3-Chloro-phenyl)-2-hydrazono-N'-hydroxy-propionamidine

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 126389-68-2
N-(3-Chloro-phenyl)-2-{[1-(2,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-hydrazono}-N'-hydroxy-propionamidine

Conditions

Conditions	Yield
In ethanol 1.) reflux, 2 to 5 min, 2.) RT;	99%

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 55991-67-8
5-phenylfuran-2,3-dione

: 77092-04-7
2-(2,4-Dimethoxy-phenyl)-6-phenyl-[1,3]dioxin-4-one

Conditions

Conditions	Yield
In benzene for 3h; Heating;	99%

2,4-Dimethoxybenzaldehyde Chemical Properties

The molecular structure of 2,4-Dimethoxybenzaldehyde (CAS NO.613-45-6):

IUPAC Name: 2,4-Dimethoxybenzaldehyde
Molecular Weight: 166.1739 g/mol
Molecular Formula: C₉H₁₀O₃
Density: 1.114 g/cm³
Melting Point: 67-69 °C(lit.)
Boiling Point: 307.8 °C at 760 mmHg
Flash Point: 124.7 °C
Index of Refraction: 1.534
Molar Refractivity: 46.36 cm³
Molar Volume: 149.1 cm³
Surface Tension: 36.1 dyne/cm
Enthalpy of Vaporization: 54.84 kJ/mol
Vapour Pressure: 0.00071 mmHg at 25 °C
Water Solubility: insoluble
Sensitive: air sensitive
XLogP3: 1.7
H-Bond Acceptor: 3
Rotatable Bond Count: 3
Exact Mass: 166.062994
MonoIsotopic Mass: 166.062994
Topological Polar Surface Area: 35.5
Heavy Atom Count: 12
Canonical SMILES: COC1=CC(=C(C=C1)C=O)OC
InChI: InChI=1S/C9H10O3/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-6H,1-2H3
InChIKey: LWRSYTXEQUUTKW-UHFFFAOYSA-N
EINECS: 210-342-4
Product Categories: Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Aromatics; Aldehydes; C9; Carbonyl Compounds

2,4-Dimethoxybenzaldehyde Uses

2,4-Dimethoxybenzaldehyde (CAS NO.613-45-6) is a component of hair dyes. It also can be used as pharmaceutical intermediate.

2,4-Dimethoxybenzaldehyde Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
HS Code: 29124900

2,4-Dimethoxybenzaldehyde Specification

2,4-Dimethoxybenzaldehyde (CAS NO.613-45-6) is also named as AI3-21269 ; NSC 27023 ; Benzaldehyde, 2,4-dimethoxy- . 2,4-Dimethoxybenzaldehyde (CAS NO.613-45-6) is white solid.

Product Name

2,4-Dimethoxybenzaldehyde

Synthetic route

2,4-Dimethoxybenzaldehyde Chemical Properties

2,4-Dimethoxybenzaldehyde Uses

2,4-Dimethoxybenzaldehyde Safety Profile

2,4-Dimethoxybenzaldehyde Specification

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