• Name

  2,5-Furandicarboxylic acid

• EINECS 221-800-8
• CAS No. 3238-40-2
• Article Data288
• CAS DataBase
• Density 1.604 g/cm³
• Solubility 1g/L(18 oC)
• Melting Point >310°C (dec.)
• Formula C₆H₄O₅
• Boiling Point 419.2 °C at 760 mmHg
• Molecular Weight 156.095
• Flash Point 207.3 °C
• Transport Information
• Appearance White powder
• Safety 26-36/37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Dehydromucicacid;Furane-a,a'-dicarboxylic acid;NSC 40740;
• PSA 87.74000
• LogP 0.67600

Synthetic route

67-47-0

5-hydroxymethyl-2-furfuraldehyde

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With Mg-Al hydrotalcite; oxygen In water at 140℃; under 750.075 Torr; for 38h; Autoclave;	100%
With sodium carbonate at 80 - 120℃; under 30003 Torr; for 4h; Temperature; Reagent/catalyst;	100%
With oxygen at 80℃; under 750.075 Torr; for 30h; Catalytic behavior; Time;	100%

823-82-5

2,5-diformylfurane

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With immobilized lipase B from Candida antarctica; dihydrogen peroxide In ethyl acetate; tert-butyl alcohol at 40℃; for 24h; Enzymatic reaction;	100%
With oxygen In aq. phosphate buffer; acetonitrile at 37℃; pH=7; pH-value; Concentration; Reagent/catalyst; Temperature; Enzymatic reaction;	99%
With NADH oxidase and vanillin dehydrogenase 2 co-expressed in Escherichia coli cells In aq. phosphate buffer at 30℃; for 12h; pH=7; Microbiological reaction;	96%

13529-17-4

5-Formyl-2-furancarboxylic acid

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With NADH oxidase and vanillin dehydrogenase 2 co-expressed in Escherichia coli cells In aq. phosphate buffer at 30℃; for 12h; pH=7; Microbiological reaction;	99%
With platinum; oxygen; sodium hydrogencarbonate In water at 100℃; under 760.051 Torr; Kinetics; Reagent/catalyst;	95.1%
With sodium hypochlorite In N,N-dimethyl-formamide at 25℃; for 24h; Reagent/catalyst;	95%

1883-75-6

2,5-bis-(hydroxymethyl)furan

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In water at 90℃; for 10h; Catalytic behavior;	99%
With C24H33IrN4O3; water; sodium carbonate for 18h; Reflux;	88%
With recombinant 5-hydroxymethylfurfural oxidase In aq. phosphate buffer at 25℃; for 15h; pH=7; Enzymatic reaction;	4.4%

13341-77-0

2-acetyl-5-furancarboxylic acid

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With cesium hydroxide; sodium hypoiodite In 1,4-dioxane; water at 100℃; pH=7; Solvent; Temperature; Reagent/catalyst;	99%
With oxygen; cobalt(II) acetate; manganese(II) acetate; acetic acid; sodium bromide at 240℃; for 6h; Temperature;	98%
With ammonium hydroxide; iodine; potassium iodide In water; dimethyl sulfoxide at 120℃; pH=7; Reagent/catalyst; Temperature;	90%

88-14-2

2-furanoic acid

124-38-9

carbon dioxide

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With Pd/G In 1,2-dimethoxyethane at 70℃; under 7500.75 Torr; for 10h; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube; Green chemistry;	98%
With Pd/4A molecular sieve catalyst In 1,2-dimethoxyethane at 70 - 100℃; under 75.0075 Torr; for 1.66667h; Solvent; Reagent/catalyst; Temperature; Pressure; Molecular sieve; Large scale;	98.8%
Stage #1: 2-furanoic acid With potassium carbonate; caesium carbonate In water Green chemistry; Stage #2: carbon dioxide at 260 - 285℃; under 6000.6 Torr; for 24h; Flow reactor; Green chemistry; Stage #3: With hydrogenchloride In water pH=2; Reagent/catalyst; Pressure; Temperature; Green chemistry;	89%

110-00-9

furan

124-38-9

carbon dioxide

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With Pd/G at 100℃; under 7500.75 Torr; for 10h; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube; Green chemistry;	98.6%
With 4Å molecular sieve impregnated with palladium at 100℃; for 1.66667h; Reagent/catalyst; Temperature; Flow reactor; Large scale;	98.6%

585-70-6

5-bromo-furan-2-carboxylic acid

201230-82-2

carbon monoxide

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With disodium hydrogenphosphate; palladium(II) trifluoroacetate In water at 90℃; under 760.051 Torr; for 10h; Reagent/catalyst; Solvent; Temperature;	97%
With potassium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride In water; N,N-dimethyl-formamide at 90℃; for 12h; Reagent/catalyst; Autoclave;	91%

1703-52-2

2-ethyl-5-methylfuran

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 60℃; for 3h; Reagent/catalyst; Temperature; Solvent;	95.3%

1623-88-7

5-chloromethylfurfural

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With nickel(III) oxide; sodium hypochlorite In water at 20℃; under 760.051 Torr; for 0.5h; Reagent/catalyst;	95.23%
With nitric acid In water at 80℃; for 24h;	59%
Multi-step reaction with 2 steps 1: acetonitrile / 0.17 h / 20 °C 2: sodium hydrogencarbonate; oxygen; water; 10 wt% platinum on carbon / 2 h / 70 °C View Scheme

611-13-2

2-furoic acid methyl ester

108-24-7

acetic anhydride

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-furoic acid methyl ester; acetic anhydride With aluminium(III) chloride hexahydrate In dichloromethane at 0 - 20℃; for 4h; Stage #2: With sodium hypochlorite; water; sodium hydroxide at 0℃; for 2h;	95%

1917-64-2

5-(methoxymethyl)-2-furaldehyde

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With nickel(III) oxide; sodium hypochlorite In water at 20℃; under 760.051 Torr; for 0.5h; Reagent/catalyst;	94.56%

611-13-2

2-furoic acid methyl ester

75-36-5

acetyl chloride

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-furoic acid methyl ester; acetyl chloride With iron(III) chloride In dichloromethane at 0 - 20℃; for 4h; Stage #2: With sodium hypochlorite; water; sodium hydroxide at 0℃; for 2h; Solvent; Reagent/catalyst;	94%

5-(1,3-dioxan-2-yl)-2-furancarboxylic acid

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; sodium carbonate In water at 139.84℃; under 3750.38 Torr; for 15h; Kinetics; Autoclave;	94%

67-47-0

5-hydroxymethyl-2-furfuraldehyde

80937-33-3

oxygen

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With CoFe Prussian Blue Analogue film/Ni foam In water for 2.66667h; Electrochemical reaction;	94%

1883-75-6

2,5-bis-(hydroxymethyl)furan

A

13529-17-4

5-Formyl-2-furancarboxylic acid

B

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In water at 90℃; for 10h; Catalytic behavior; Reagent/catalyst;	A 6% B 93%
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 0.5 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 0.5 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor In aq. phosphate buffer at 25℃; for 24h; pH=6;

609-38-1

furan-2-carboxylic acid amide

506-96-7

Acetyl bromide

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: furan-2-carboxylic acid amide; Acetyl bromide With trifluoroacetic acid In benzene at -2 - 0℃; for 8h; Stage #2: With water; sodium methylate; chlorine at 40℃; for 3.5h;	93%

25466-26-6

α-ketoglutarate

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With aluminium(III) triflate; acetic acid at 120℃; under 15001.5 Torr; for 3h; Concentration;	93%

67-47-0

5-hydroxymethyl-2-furfuraldehyde

A

13529-17-4

5-Formyl-2-furancarboxylic acid

B

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen In water at 99.84℃; under 3750.38 Torr; for 12h; Reagent/catalyst;	A n/a B 92%
With 50% Fe-CeO2-500 °C; oxygen; potassium carbonate In methanol at 150℃; under 7600.51 Torr; for 10h; Temperature; Time; Reagent/catalyst; Autoclave; Overall yield = 98.2%;	A 89.6% B 5.5%
With oxygen; sodium hydrogencarbonate In water at 100℃; under 30003 Torr; for 6h; Kinetics; Reagent/catalyst; Autoclave;	A 8% B 84%

4-deoxy-5-dehydroglucaric acid dipotassium salt

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In water at 60℃; for 4h; Concentration; Temperature; Reagent/catalyst;	91%
With hydrogen bromide; acetic acid In water at 60℃; for 4h; Reagent/catalyst; Temperature; Solvent;
With hydrogen bromide; acetic acid In water at 60℃; for 4h; Reagent/catalyst; Solvent; Temperature;

C14H20O5

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 100℃; for 12h;	91%

10551-58-3

5-acetoxymethyl-2-furaldehyde

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; acetic acid; peracetic acid; manganese(II) acetate; cobalt(II) diacetate tetrahydrate at 130℃; under 7483.15 Torr; for 2h; Product distribution / selectivity; Autoclave;	90.2%
With oxygen; acetic acid; peracetic acid; manganese(II) acetate; cobalt(II) diacetate tetrahydrate at 130℃; under 7483.15 Torr; for 2h; Product distribution / selectivity; Autoclave;	90.2%
With manganese; oxygen; cobalt; acetic acid at 130℃; under 7483.15 Torr; Concentration;	90.2%

98-01-1

furfural

124-38-9

carbon dioxide

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen at 100℃; under 6750.68 Torr; for 16h; Reagent/catalyst; Temperature; Pressure; Autoclave;	90.1%

67-47-0

5-hydroxymethyl-2-furfuraldehyde

A

823-82-5

2,5-diformylfurane

B

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With methylammonium lead bromide In acetonitrile at 15℃; for 10h; Irradiation;	A 90% B n/a
With oxygen at 110℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	A 86.2% B 11.7%
With oxygen In N,N-dimethyl-formamide at 120℃; under 750.075 Torr; for 4h; Solvent; Time; Pressure; Reagent/catalyst; Autoclave; Green chemistry;	A 82.1% B 11.5%

67-47-0

5-hydroxymethyl-2-furfuraldehyde

A

6338-41-6

5-hydroxymethyl-furan-2-carboxylic acid

B

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen In water at 90℃; under 750.075 Torr; for 8h; Reagent/catalyst;	A 8% B 90%
With sodium hydroxide In water at 30℃; under 7500.75 Torr; for 4h;	A 89% B 5%
With oxygen In water at 29.84℃; for 7h;	A 87% B 7%

2-dichloroacetyl-5-furancarboxylic acid

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With sodium hypobromide; water; potassium carbonate In N,N-dimethyl acetamide at 140℃; pH=7;	90%

98-01-1

furfural

79-37-8

oxalyl dichloride

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: furfural; oxalyl dichloride With hydrogenchloride In water; ethyl acetate at -20 - -4℃; for 10h; Stage #2: With sodium hypochlorite; water; potassium hydrogencarbonate at 100℃; for 4h;	90%

39131-44-7

5-bromomethyl-furan-2-carbaldehyde

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With nickel(III) oxide; sodium hypochlorite In water at 20℃; under 760.051 Torr; for 0.5h; Reagent/catalyst;	89.14%

1917-65-3

5-(ethoxymethyl)furfural

3238-40-2

furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; acetic acid; peracetic acid; manganese(II) acetate; cobalt(II) diacetate tetrahydrate at 130℃; under 7483.15 Torr; for 2h; Product distribution / selectivity; Autoclave;	89%
With oxygen; acetic acid; peracetic acid; manganese(II) acetate; cobalt(II) diacetate tetrahydrate at 130℃; under 7483.15 Torr; for 2h; Product distribution / selectivity; Autoclave;	89%
With manganese; oxygen; cobalt; acetic acid at 130℃; under 7483.15 Torr; Temperature; Concentration;	88.8%

3238-40-2

furan-2,5-dicarboxylic acid

C6H8O5*2H3N

Conditions

Conditions	Yield
Stage #1: furan-2,5-dicarboxylic acid With palladium on activated charcoal; hydrogen; acetic acid at 60℃; for 69h; Stage #2: With ammonia In water at 20℃; for 0.5h;	100%

3238-40-2

furan-2,5-dicarboxylic acid

112-30-1

1-Decanol

didecyl 2,5-furandicarboxylate

Conditions

Conditions	Yield
With sulfuric acid at 120℃; under 375.038 Torr; for 8h; Temperature; Reagent/catalyst;	99.5%
With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate at 140℃; for 10h;

67-56-1

methanol

3238-40-2

furan-2,5-dicarboxylic acid

4282-32-0

furan-2,5-dicarboxylic acid dimethyl ester

Conditions

Conditions	Yield
With sulfuric acid for 3h; Reflux;	99%
With aluminum(III) sulphate octadecahydrate at 150℃; for 0.416667h; Sealed tube; Microwave irradiation;	98.5%
With gallium(III) triflate at 175℃; for 2h; Reagent/catalyst; Sealed tube; Inert atmosphere;	95%

3238-40-2

furan-2,5-dicarboxylic acid

71-36-3

butan-1-ol

107821-25-0

2,5-furandicarboxylic acid di-n-butyl ester

Conditions

Conditions	Yield
Silarox 30/350 at 250℃; under 7500.75 Torr; for 3h; Product distribution / selectivity;	99%
silica-alumina at 250℃; under 7500.75 Torr; for 3h; Product distribution / selectivity;	99%
With sulfuric acid In toluene Dean-Stark;	80%

3238-40-2

furan-2,5-dicarboxylic acid

616-38-6

carbonic acid dimethyl ester

4282-32-0

furan-2,5-dicarboxylic acid dimethyl ester

Conditions

Conditions	Yield
With tetramethylammonium bromide; lithium carbonate In N,N-dimethyl-formamide at 150℃; for 10.5h; Temperature; Reagent/catalyst; Solvent;	98.62%
With magnesium doped aluminia; tetrabutylammomium bromide In N,N-dimethyl-formamide at 150℃; for 6h; Temperature; Reagent/catalyst;	66.68%

186581-53-3, 908094-01-9

diazomethane

3238-40-2

furan-2,5-dicarboxylic acid

4282-32-0

furan-2,5-dicarboxylic acid dimethyl ester

Conditions

Conditions	Yield
In diethyl ether at -78℃;	98%

3238-40-2

furan-2,5-dicarboxylic acid

64-17-5

ethanol

53662-83-2

diethyl furan-2,5-dicarboxylate

Conditions

Conditions	Yield
With sulfuric acid In water at 78℃; for 67h; Dean-Stark;	98%
With sulfuric acid for 18h; Reflux; Inert atmosphere;	98%
Silarox 30/350 at 220℃; under 11251.1 Torr; for 4h; Product distribution / selectivity;	97%

3238-40-2

furan-2,5-dicarboxylic acid

823-82-5

2,5-diformylfurane

Conditions

Conditions	Yield
With zinc(II) chloride In dichloromethane; dimethyl sulfoxide for 0.383333h;	98%

3238-40-2

furan-2,5-dicarboxylic acid

20812-90-2, 51092-72-9, 51092-73-0

aluminium monohydroxide diacetate

C6H2O5(2-)*Al(3+)*HO(1-)

Conditions

Conditions	Yield
In water for 24h; Reflux;	93%
In water at 100℃; for 96h;

3238-40-2

furan-2,5-dicarboxylic acid

scandium (III) chloride hexahydrate

7732-18-5

water

2Sc(3+)*2H2O*3C6H2O5(2-)

Conditions

Conditions	Yield
at 120℃; for 24h; Sealed tube; High pressure;	93%

...Expand

2,5-Furandicarboxylic acid Chemical Properties

2,5-Furandicarboxylic acid Safety Profile

2,5-Furandicarboxylic acid Specification