2,5-Furandimethanol supplier

Name
2,5-Furandimethanol
EINECS 217-544-1
CAS No. 1883-75-6
Article Data153
CAS DataBase
Density 1.283 g/cm³
Solubility
Melting Point 74-77 °C
Formula C₆H₈O₃
Boiling Point 275.4 °C at 760 mmHg
Molecular Weight 128.128
Flash Point 120.3 °C
Transport Information
Appearance Off-white to pale yellow solid
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2,5-Bis(hydroxymethyl)furan;2,5-Di(hydroxymethyl)furan;5-(Hydroxymethyl)furfuryl alcohol;FaRez 6305;NSC40737;NSC 524614;
PSA 53.60000
LogP 0.26420

Synthetic route

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With hydrogen; 3mol% Pt/C In ethanol at 20℃; under 3750.38 Torr; for 48h; Product distribution / selectivity;	100%
With methanol; magnesium oxide at 160℃; under 750.075 Torr; for 3h; Meerwein-Ponndorf-Verley Reduction; Autoclave; Inert atmosphere; chemoselective reaction;	100%
With sodium tetrahydroborate In water	100%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 6338-41-6
5-hydroxymethyl-furan-2-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 5-hydroxymethyl-2-furfuraldehyde With potassium hydroxide Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water for 0.0833333h; Reagent/catalyst; Time; Green chemistry;	A 99% B 99%
With sodium dithionite; sodium hydroxide In water Cannizzaro Reaction;	A 96% B 94%
With sodium hydroxide In water; isopropyl alcohol at 20℃; for 16h; Solvent; Cannizzaro Reaction; Microwave irradiation;	A 30% B 31 %Chromat.

: 69924-30-7
5-hydroxymethyl-tetrahydrofuran-2-carbaldehyde

A: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With hydrogen In 1,4-dioxane at 60℃; under 45004.5 Torr; for 6h; Catalytic behavior; Reagent/catalyst; Overall yield = 100 %;	A 96.2% B 3.6%

: 823-82-5
2,5-diformylfurane

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol Cooling;	94%
Stage #1: 2,5-diformylfurane With phenylsilane; caesium carbonate In 2-methyltetrahydrofuran at 25℃; for 1h; Green chemistry; Stage #2: With ethanol In 2-methyltetrahydrofuran at 80℃; for 2h; Green chemistry; chemoselective reaction;	87%
With trans-Ru(mer-2-(4-phenyl-1H-1,2,3-triazol-1-yl)-N-(pyridin-2-ylmethyl)ethan-1-amine)(PPh3)Cl2; potassium tert-butylate; hydrogen In tetrahydrofuran at 80℃; under 7500.75 Torr; Autoclave; Sealed tube;	52%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 620-02-0
5-Methylfurfural

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With hydrogen; 20Cu/Al2O3 In methanol at 130℃; under 22502.3 Torr; for 1h; Catalytic behavior; Solvent;	A 6.62% B 93.01%
With water; hydrogen at 160℃; under 30003 Torr; for 4h; Autoclave;
With hydrogen In ethanol at 100℃; under 37503.8 Torr; for 6h; Autoclave;

: 10551-58-3
5-acetoxymethyl-2-furaldehyde

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 0.5h;	92%
Stage #1: 5-acetoxymethyl-2-furaldehyde With sodium tetrahydroborate In ethanol at 0 - 20℃; for 48h; Stage #2: With hydrogenchloride In ethanol at 0℃; pH=4;	91%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 67-63-0
isopropyl alcohol

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 2,5-bis[(1-methylethoxy)methyl]furan

Conditions

Conditions	Yield
With ZnO-ZrO2/USY(Si/Al-7) at 180℃; for 2.5h; Reagent/catalyst; Autoclave;	A 6.6% B 91.4%
With ZrO2/Beta1401 at 150℃; for 2.5h; Reagent/catalyst; Autoclave;	A 22.8% B 16.4%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 1356930-86-3
5-hydroxymethylfuran-2-carboxylic acid sodium

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 20℃; for 19h; Reagent/catalyst; Solvent; Temperature; Concentration; Cannizzaro Reaction; Green chemistry;	A 90% B 85%

: (5-(1,3-dioxan-2-yl)furan-2-yl)methanol

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With NiRe0.5/TiO2; hydrogen; sodium carbonate In water at 40℃; under 37503.8 Torr; for 4h; pH=10.4; Reagent/catalyst; pH-value; Autoclave; Glovebox;	89%
Multi-step reaction with 2 steps 1: sodium carbonate; Ni/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / pH 10.4 / Autoclave; Glovebox 2: Ni/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / Autoclave; Glovebox View Scheme
Multi-step reaction with 2 steps 1: NiRe0.5/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / pH 7 / Autoclave; Glovebox 2: Ni/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / Autoclave; Glovebox View Scheme

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-17-5
ethanol

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 99181-63-2
2,5-furandimethanol diethyl ether

Conditions

Conditions	Yield
With BaO-ZrO2/SBA-15 at 150℃; for 4h; Reagent/catalyst; Time; Temperature; Autoclave;	A 88.6% B 5.2%

...Expand

: 10551-58-3
5-acetoxymethyl-2-furaldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 6338-41-6
5-hydroxymethyl-furan-2-carboxylic acid

Conditions

Conditions	Yield
With water; sodium hydroxide at 0℃; Cannizzaro Reaction;	A 86% B 76%

: (5-(1,3-dioxan-2-yl)furan-2-yl)methanol

A: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With NiRe2/TiO2; hydrogen; sodium carbonate In water at 40℃; under 37503.8 Torr; for 4h; pH=10.2; Reagent/catalyst; Autoclave; Glovebox;	A 6.9% B 86%
Multi-step reaction with 2 steps 1: NiRe0.5/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / pH 7 / Autoclave; Glovebox 2: NiRe0.5/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / Autoclave; Glovebox View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate; Ni/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / pH 10.4 / Autoclave; Glovebox 2: NiRe0.5/TiO2; hydrogen / water / 4 h / 40 °C / 37503.8 Torr / Autoclave; Glovebox View Scheme

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-17-5
ethanol

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 195962-50-6
5-(hydroxymethyl)-furfural diethyl acetal

Conditions

Conditions	Yield
With ZrO(OH)2 In ethanol at 109.84℃; for 2h; Time; Inert atmosphere;	A 85.3% B 11.4%
With hydrogen at 60℃; under 10343.2 Torr; for 5h; Autoclave;	A 82% B 8%
With hafnium-beta zeolite In water at 119.84℃; under 5933.09 Torr; for 4h;	A 13% B 6%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 2144-40-3
cis-2,5-bis(hydroxymethyl)tetrahydrofuran

: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
trans-2,5-bis(hydroxymethyl)tetrahydrofuran

Conditions

Conditions	Yield
With hydrogen In ethanol at 120℃; under 52505.3 Torr; for 3h; Reagent/catalyst; Autoclave;	A 85% B n/a C n/a
With palladium/alumina; hydrogen In ethanol at 120℃; under 52505.3 Torr; for 3h; Reagent/catalyst; Autoclave;	A 1% B n/a C n/a

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 3857-25-8
2-hydroxymethyl-5-methylfuran

Conditions

Conditions	Yield
With Cu(66)-ZnO; hydrogen In butan-1-ol at 100℃; under 11251.1 Torr; for 4h; Reagent/catalyst;	A 85% B 6%
With hydrogen In water at 35℃; under 6000.6 Torr; for 0.166667h; Solvent; Autoclave;
With hydrogen In 1,4-dioxane at 220℃; under 22502.3 Torr; for 5h; Autoclave;	A 81 %Chromat. B 10 %Chromat.
With hydrogen In isopropyl alcohol at 110℃; under 7500.75 Torr; for 24h; Reagent/catalyst; Autoclave; chemoselective reaction;	A 86 %Chromat. B 10 %Chromat.

: 67-56-1
methanol

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 18801-76-8
2,5-furandimethanol dimethyl ether

Conditions

Conditions	Yield
With BaO-ZrO2/SBA-15 at 100℃; for 2.5h; Autoclave;	A 78.7% B 9.6%
With MgO-ZrO2/SBA-15 at 100℃; for 2.5h; Autoclave;	A 64.6% B 17.6%

...Expand

: (5-(1,3-dioxan-2-yl)furan-2-yl)methanol

A: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

B: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

C: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With NiRe0.5/TiO2; hydrogen In water at 40℃; under 37503.8 Torr; for 4h; pH=7; Autoclave; Glovebox;	A 5% B 8.5% C 78.7%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With hydrogen In methanol at 100℃; under 61506.2 Torr; for 16h; Reagent/catalyst; Autoclave; Sealed tube;	A 78% B 17%
With Ni0.53Al0.47O1.10H0.39; hydrogen In water at 79.84℃; under 15001.5 Torr; for 6h; Kinetics; Temperature; Autoclave; Inert atmosphere;	A 71% B 25%
With hydrogen In water at 40℃; under 60006 Torr; for 1h; Reagent/catalyst; Autoclave;	A 34.7% B n/a

: 823-82-5
2,5-diformylfurane

A: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With nickel(II) oxide; isopropyl alcohol In neat (no solvent) at 150℃; for 4h; Sealed tube;	A 16.7% B 76.9%
With isopropyl alcohol at 180℃; for 4h;	A 23.2% B 70.6%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 625-86-5
2,5-dimethylfuran

B: 620-02-0
5-Methylfurfural

C: 1883-75-6
2,5-bis-(hydroxymethyl)furan

D: C7H10O

E: 121709-55-5
2,2′-(1,2-ethanediyl)bis [5-methylfuran]

Conditions

Conditions	Yield
With hydrogen In tetrahydrofuran at 130℃; under 7500.75 Torr; for 24h; Pressure; Temperature; Reagent/catalyst; Time; Autoclave; High pressure;	A 76% B n/a C n/a D n/a E n/a

...Expand

: (5-Hydroxymethyl-furan-2-yl)-acetaldehyde

A: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With ruthenium-carbon composite; hydrogen; 1-butyl-3-methylimidazolium chloride In water at 50℃; under 37503.8 Torr; for 6h; Reagent/catalyst; Pressure; Temperature;	A 74.3% B 20.1%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 65313-46-4
1-hydroxyl-2,5-hexanedione

C: 110-13-4
2,5-hexanedione

Conditions

Conditions	Yield
With hydrogen In water at 139.84℃; under 30003 Torr; for 2h; Reagent/catalyst; Autoclave;	A 8% B 67% C 6%
With palladium on activated carbon; water; hydrogen; acetic acid at 89.84℃; under 30003 Torr; for 1h; Autoclave;	A n/a B 57% C n/a
With platinum on activated charcoal; hydrogen In water at 139.84℃; under 30003 Torr; for 2h; Reagent/catalyst; Autoclave;	A 44% B 10% C 7%
With water In aq. buffer at 20℃; pH=2; Reagent/catalyst; Electrochemical reaction;	A 6.32 mmol B 1.98 mmol C 1.3 mmol

...Expand

: 64-18-6
formic acid

: 10489-79-9
α-D-fructofuranose

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With Co-MNC (cobalt supported azacarbon catalyst) In 1,4-dioxane; water at 130℃; under 3750.38 - 7500.75 Torr; for 12h; Temperature; Reagent/catalyst; High pressure; Inert atmosphere;	65%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-17-5
ethanol

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 113983-97-4
(5-(ethoxymethyl)furan-2-yl)methanol

C: 99181-63-2
2,5-furandimethanol diethyl ether

Conditions

Conditions	Yield
With ZrO(OH)2 In ethanol at 189.84℃; for 2h; Time; Inert atmosphere;	A 63.8% B 24.7% C n/a

...Expand

: 67-56-1
methanol

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 1883-75-6
2,5-bis-(hydroxymethyl)furan

B: 934-93-0
(5-(methoxymethyl)furan-2-yl)methanol

C: 18801-76-8
2,5-furandimethanol dimethyl ether

Conditions

Conditions	Yield
With hydrogen at 120℃; under 15001.5 Torr; Temperature; Autoclave;	A 8.4% B 28.4% C 62.3%

...Expand

: 98-00-0
(2-furyl)methyl alcohol

: 50-00-0
formaldehyd

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
Stage #1: (2-furyl)methyl alcohol With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 0.5h; Inert atmosphere; Stage #2: formaldehyd In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Inert atmosphere;	58%
Stage #1: (2-furyl)methyl alcohol With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; Stage #2: formaldehyd In tetrahydrofuran; hexane at -78 - 20℃;
With Fe2O3-CoO2-CuO2/ZrO2 supported catalyst In water at 35℃; for 60h; Green chemistry;

: 4282-32-0
furan-2,5-dicarboxylic acid dimethyl ester

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With C15H29MnNO3P2(1+)*Br(1-); potassium tert-butylate; hydrogen In 1,4-dioxane at 120℃; under 22502.3 Torr; for 48h; Inert atmosphere; Autoclave;	58%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 64-18-6
formic acid

A: 1003-38-9
2,5-dimethyltetrahydrofuran

B: 625-86-5
2,5-dimethylfuran

C: 1883-75-6
2,5-bis-(hydroxymethyl)furan

D: 102390-86-3
5-(2-furaldehyde)methyl formate

E: 1253934-87-0
2-(formyloxy)methyl-5-(hydroxymethyl)furan

F: 110-13-4
2,5-hexanedione

Conditions

Conditions	Yield
With gold nanoparticles anchored on tetragonal-phase zirconia In toluene at 140℃; under 760.051 Torr; for 0.5h; Solvent; Inert atmosphere;	A n/a B 58% C n/a D 8 %Chromat. E n/a F n/a

...Expand

: (5-(1,3-dioxan-2-yl)furan-2-yl)methanol

A: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With Ni/TiO2; hydrogen; sodium carbonate In water at 40℃; under 37503.8 Torr; for 4h; pH=10.4; Reagent/catalyst; pH-value; Autoclave; Glovebox;	A 56% B 34.1%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 18162-48-6
tert-butyldimethylsilyl chloride

: 349648-88-0
2,5-[(di-tert-butyldimethylsiloxy)methyl]furan

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 16h;	100%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 104-80-3, 1122-89-0, 2144-40-3, 81370-88-9, 81370-89-0
tetrahydrofuran-2,5-dimethanol

Conditions

Conditions	Yield
With hydrogen In isopropyl alcohol at 40℃; for 3h; Green chemistry;	100%
With hydrogen In water; isopropyl alcohol at 110℃; under 36201.3 Torr; for 3h;	97%
With palladium on activated carbon; hydrogen In ethanol at 80 - 130℃; under 30003 - 75007.5 Torr; for 12h; Temperature; Pressure; Autoclave;	95%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 823-82-5
2,5-diformylfurane

Conditions

Conditions	Yield
With Ru/Al2O3; oxygen In toluene at 80℃; for 24h; Solvent; Reagent/catalyst;	99%
With pyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; iodine; sodium hydrogencarbonate In dichloromethane; water at 20 - 25℃; for 1h;	98%
With dipyridinium dichromate In dichloromethane for 24h;	60%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 3238-40-2
furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In water at 90℃; for 10h; Catalytic behavior;	99%
With C24H33IrN4O3; water; sodium carbonate for 18h; Reflux;	88%
With recombinant 5-hydroxymethylfurfural oxidase In aq. phosphate buffer at 25℃; for 15h; pH=7; Enzymatic reaction;	4.4%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 142-62-1
hexanoic acid

A: hexanoic acid 1,1’-[2,5-furandiylbis(methylene)] ester

B: [5-(hydroxymethyl)furan-2-yl]methyl hexanoate

Conditions

Conditions	Yield
With lipase B from Candida antarctica immobilized on macroporous acrylic resin In 2-methyltetrahydrofuran at 35℃; for 11h; Catalytic behavior; Time; Temperature; Reagent/catalyst; Molecular sieve; Sealed tube; Enzymatic reaction;	A 99% B n/a

...Expand

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 124-07-2
Octanoic acid

A: octanoic acid 1,1’-[2,5-furandiylbis(methylene)] ester

B: [5-(hydroxymethyl)furan-2-yl]methyl octanoate

Conditions

Conditions	Yield
With lipase B from Candida antarctica immobilized on macroporous acrylic resin In 2-methyltetrahydrofuran at 35℃; for 24h; Molecular sieve; Sealed tube; Enzymatic reaction;	A 99% B n/a

...Expand

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 108-24-7
acetic anhydride

: 5076-10-8
2,5-bis(hydroxymethyl)furan diacetate

Conditions

Conditions	Yield
With pyridine at 24℃; for 6h;	98%
With pyridine In acetonitrile at 20℃; for 3h; Inert atmosphere;	92%
With pyridine In 2-methyltetrahydrofuran at 24℃; for 24h; Autoclave;	86%

: 143-07-7
lauric acid

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: C30H52O5

Conditions

Conditions	Yield
With 6CHO3(1-)*2Sb(3+) at 200℃; for 11h; Inert atmosphere;	98%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 625-86-5
2,5-dimethylfuran

Conditions

Conditions	Yield
With tetradecane; hydrogen In ethanol at 200℃; under 22502.3 Torr; for 15h; Reagent/catalyst; Temperature; Pressure;	97.6%
With formic acid; sulfuric acid; palladium on carbon In tetrahydrofuran for 15h; Reflux;
With formic acid; sulfuric acid; palladium on activated charcoal In tetrahydrofuran for 15h; Reflux;

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 3050-69-9
vinyl caproate

: hexanoic acid 1,1’-[2,5-furandiylbis(methylene)] ester

Conditions

Conditions	Yield
With lipase B from Candida antarctica immobilized on macroporous acrylic resin In 2-methyltetrahydrofuran at 35℃; for 0.5h; Molecular sieve; Sealed tube; Enzymatic reaction;	97%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 120040-07-5
6-hydroxy-6-(hydroxymethyl)-2H-pyran-3(6H)-one

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 30℃; for 0.5h; Temperature; Reagent/catalyst; Molecular sieve;	95.2%
With oxygen; 5,15,10,20-tetraphenylporphyrin; triphenylphosphine 1.) acetone, irradiation, -70 deg C, 2 h, 2.) -70 deg C, 10 min; Yield given. Multistep reaction;
With 3,3-dimethyldioxirane In acetone Ambient temperature;
With choline chloride; 3-chloro-benzenecarboperoxoic acid for 1h; Achmatowicz Reaction; Milling;

: 67-56-1
methanol

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 18801-76-8
2,5-furandimethanol dimethyl ether

Conditions

Conditions	Yield
With 2% Sn-ZSM-5 at 120℃; for 6h; Autoclave;	95.13%
With dual acidic Glu-TsOH-Ti catalyst at 70℃; for 8h;	89%
With Hβ (Si/Al=25) at 120℃; under 15001.5 Torr; for 1h; Inert atmosphere; Autoclave;	80.5%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 334-48-5
1-decanoic acid

: 2,5-furandimethanol didecyl ester

Conditions

Conditions	Yield
With sulfonic acid ionic resin at 100℃; Reagent/catalyst; Temperature;	95.04%
With tin(IV) oxide In toluene for 8h; Reflux;

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 1119-51-3
bromopentene

: 2,5-bis(pent-4-enyloxymethyl)furan

Conditions

Conditions	Yield
With potassium hydroxide; Aliquat 336 In water at 85℃; for 24h; Williamson reaction;	95%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 106-89-8
epichlorohydrin

: 1269765-69-6
2,5-bis((oxiran-2-ylmethoxy)-methyl)furan

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water at 0 - 20℃; Temperature; Reagent/catalyst; Solvent;	95%
With tetrabutylammomium bromide; sodium hydroxide at 50℃; for 2h; Inert atmosphere;	85%
Stage #1: 2,5-bis-(hydroxymethyl)furan; epichlorohydrin With tetra(n-butyl)ammonium hydrogensulfate at 60℃; for 4h; Inert atmosphere; Stage #2: With sodium hydroxide In water at 50℃; for 2h;	60%
Stage #1: 2,5-bis-(hydroxymethyl)furan; epichlorohydrin at 80℃; under 206.271 Torr; for 0.5h; Dean-Stark; Stage #2: With sodium hydroxide In water for 3.58333h;	79.6 %Chromat.

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 143-15-7
1-dodecylbromide

: 2,5-bis((dodecyloxy)methyl)furan

Conditions

Conditions	Yield
With potassium hydroxide; Aliquat 336 at 180℃; for 0.166667h; Irradiation;	94%
Stage #1: 2,5-bis-(hydroxymethyl)furan With potassium tert-butylate In dimethyl sulfoxide at -10℃; for 0.5h; Stage #2: 1-dodecylbromide In dimethyl sulfoxide at -10 - 20℃; Inert atmosphere;	39%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 74-88-4
methyl iodide

: 18801-76-8
2,5-furandimethanol dimethyl ether

Conditions

Conditions	Yield
Stage #1: 2,5-bis-(hydroxymethyl)furan With sodium hydride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 14h;	94%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 107-92-6
butyric acid

A: [5-(hydroxymethyl)furan-2-yl]methyl butyrate

B: butanoic acid 1,1’-[2,5-furandiylbis(methylene)] ester

Conditions

Conditions	Yield
With lipase B from Candida antarctica immobilized on macroporous acrylic resin In 2-methyltetrahydrofuran at 35℃; for 24h; Molecular sieve; Sealed tube; Enzymatic reaction;	A n/a B 94%

...Expand

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 112-82-3
hexadecanyl bromide

: 2,5-Bis-hexadecyloxymethyl-furan

Conditions

Conditions	Yield
With potassium hydroxide; Aliquat 336 at 85℃; for 5h;	93%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 71-36-3
butan-1-ol

: 101099-24-5
2,5-furandimethanol dibutyl ether

Conditions

Conditions	Yield
With dual acidic Glu-TsOH-Ti catalyst at 120℃; for 8h;	93%
With Amberlyst 15 at 48.04℃; Kinetics; Temperature;
With Amberyst-15 at 60℃; for 10h; Temperature;	74 %Chromat.
With Fe2O3-CoO2-CuO2/ZrO2 supported catalyst at 40℃; for 56h; Reagent/catalyst; Green chemistry;

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

A: 13529-17-4
5-Formyl-2-furancarboxylic acid

B: 3238-40-2
furan-2,5-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; sodium hydrogencarbonate In water at 90℃; for 10h; Catalytic behavior; Reagent/catalyst;	A 6% B 93%
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 0.5 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 0.5 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 4 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction 2: recombinant 5-hydroxymethylfurfural oxidase / aq. phosphate buffer / 1 h / 25 °C / pH 7 / Enzymatic reaction View Scheme
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor In aq. phosphate buffer at 25℃; for 24h; pH=6;

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 917-61-3
sodium isocyanate

: furan-2,5-diylbis(methylene) dicarbamate

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 25 - 41℃; for 0.25h;	93%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 64-17-5
ethanol

: 99181-63-2
2,5-furandimethanol diethyl ether

Conditions

Conditions	Yield
With dual acidic Glu-TsOH-Ti catalyst at 80℃; for 8h;	92%
With 2% Sn-ZSM-5 at 130℃; for 4h; Autoclave;	92.1%
With toluene-4-sulfonic acid at 60℃; for 3h;	81%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

: 100-39-0
benzyl bromide

: 174153-23-2
2,5-Bis-benzyloxymethyl-furan

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 67℃; for 2.5h; Etherification;	92%
With potassium hydroxide; Aliquat 336 at 105℃; for 0.0833333h; Irradiation;	74%

2,5-Furandimethanol Chemical Properties

Molecule structure of 2,5-Furandimethanol (CAS NO.1883-75-6):

IUPAC Name: [5-(Hydroxymethyl)furan-2-yl]methanol
Molecular Weight: 128.12592 g/mol
Molecular Formula: C₆H₈O₃
Density: 1.283 g/cm³
Melting Point: 74-77 °C
Boiling Point: 275.4 °C at 760 mmHg
Flash Point: 120.3 °C
Index of Refraction: 1.542
Molar Refractivity: 31.45 cm³
Molar Volume: 99.8 cm³
Polarizability: 12.46×10^-24 cm³
Surface Tension: 52.1 dyne/cm
Enthalpy of Vaporization: 54.27 kJ/mol
Vapour Pressure: 0.00248 mmHg at 25 °C
XLogP3-AA: -0.7
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Exact Mass: 128.047344
MonoIsotopic Mass: 128.047344
Topological Polar Surface Area: 53.6
Heavy Atom Count: 9
Complexity: 74.4
Canonical SMILES: C1=C(OC(=C1)CO)CO
InChI: InChI=1S/C6H8O3/c7-3-5-1-2-6(4-8)9-5/h1-2,7-8H,3-4H2
InChIKey: DSLRVRBSNLHVBH-UHFFFAOYSA-N
EINECS: 217-544-1
Product Categories: Detergents;Mutagenesis Research Chemicals

2,5-Furandimethanol Specification

2,5-Furandimethanol (CAS NO.1883-75-6) is also named as 2,5-Bis(hydroxymethyl)furan ; NSC 40737 ; NSC 524614 ; 2,5-Furandimethanol ; Furan-2,5-diyldimethanol . 2,5-Furandimethanol (CAS NO.1883-75-6) is off-white to pale yellow solid.

Product Name

2,5-Furandimethanol

Synthetic route

2,5-Furandimethanol Chemical Properties

2,5-Furandimethanol Specification

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