2,6-Diethyl-4-methylaniline supplier

Name
2,6-Diethyl-4-methylaniline
EINECS 246-307-5
CAS No. 24544-08-9
Article Data6
CAS DataBase
Density 0.94 g/cm³
Solubility 570mg/L at 20℃
Melting Point
Formula C₁₁H₁₇N
Boiling Point 259.058 °C at 760 mmHg
Molecular Weight 163.263
Flash Point 111.736 °C
Transport Information
Appearance Colourless to yellowish liquid
Safety 26-36/37/39
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols
Synonyms p-Toluidine,2,6-diethyl- (8CI);2,6-Diethyl-4-methylaniline;2,6-Diethyl-p-toluidine;4-Methyl-2,6-diethylaniline;NSC 203033;
PSA 26.02000
LogP 3.28320

Synthetic route

: 64-17-5
ethanol

: 540-23-8
p-toluidine hydrochloride

: 24544-08-9
2,6-diethyl-4-methylaniline

Conditions

Conditions	Yield
at 300℃;

: 106-49-0
p-toluidine

: 7429-90-5
aluminium

: 24544-08-9
2,6-diethyl-4-methylaniline

Conditions

Conditions	Yield
aluminium trichloride In water

: 24544-08-9
2,6-diethyl-4-methylaniline

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1526920-89-7
C22H34N2O3

Conditions

Conditions	Yield
Stage #1: (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 0.5h; Stage #2: 2,6-diethyl-4-methylaniline In dichloromethane at 0 - 20℃; for 24h;	99%

: 24544-08-9
2,6-diethyl-4-methylaniline

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: 2,6-diethyl-4-methylaniline With hydrogen bromide at 10℃; for 0.5h; Stage #2: With sodium nitrite at -5 - 0℃; for 2.5h; Stage #3: With ferrous(II) sulfate heptahydrate; hydrogen bromide; sodium bromide In water at 65 - 75℃; for 0.5h; Reagent/catalyst;	95%
Stage #1: 2,6-diethyl-4-methylaniline With hydrogen bromide In water at 80℃; for 1.5h; Stage #2: With sodium nitrite In water at -10 - -5℃; for 2h; Stage #3: With ferrous(II) sulfate heptahydrate; hydrogen bromide In water at 80℃; for 2h;	94.66%
Stage #1: 2,6-diethyl-4-methylaniline With hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: With copper(I) bromide at 5 - 60℃; for 4h;	89.2%

: 24544-08-9
2,6-diethyl-4-methylaniline

: 105-53-3
diethyl malonate

: 328932-70-3
2-(2,6-diethyl-4-methylphenyl)malonic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2,6-diethyl-4-methylaniline With copper(l) iodide; isopentyl nitrite In tetrahydrofuran at 5 - 10℃; for 2h; Stage #2: diethyl malonate With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃; for 2.5h; Reagent/catalyst;	92%

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2-chloro-1,3-diethyl-5-methylbenzene

Conditions

Conditions	Yield
Stage #1: 2,6-diethyl-4-methylaniline With hydrogenchloride In 1,2-dichloro-benzene at 45 - 70℃; Stage #2: With hydrogenchloride; isopentyl nitrite In 1,2-dichloro-benzene at 45 - 50℃; for 2h;	90%
Stage #1: 2,6-diethyl-4-methylaniline With hydrogenchloride In water at 50℃; Sandmeyer Reaction; Stage #2: With sodium nitrite In water at -10 - -5℃; for 1h; Sandmeyer Reaction; Stage #3: With hydrogenchloride; iron(III) chloride In water at -10 - 65℃; for 1.5h; Product distribution / selectivity; Sandmeyer Reaction;

: cobalt(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 96413-30-8
α,α′-dioxo-2,3:5,6-bis(hexamethylene)pyridine

: C39H51Cl2CoN3

Conditions

Conditions	Yield
With acetic acid for 12h; Reflux;	90%
With acetic anhydride at 130℃; for 12h;	90%

...Expand

: 24544-08-9
2,6-diethyl-4-methylaniline

: C11H16NO3S(1-)*Na(1+)

: 77545-45-0
3’,6’-dichlorospiro[3H-2,1-benzoxathiol-3,9’-[9H]xanthene]-1,1-dioxide

: C41H41N2O7S2(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: C11H16NO3S(1-)*Na(1+); 3’,6’-dichlorospiro[3H-2,1-benzoxathiol-3,9’-[9H]xanthene]-1,1-dioxide With 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium bromide In ethylene glycol at 120℃; for 2h; Stage #2: 2,6-diethyl-4-methylaniline In ethylene glycol at 180℃; for 18h; Reagent/catalyst;	88%

...Expand

: iron(II) chloride tetrahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 96413-30-8
α,α′-dioxo-2,3:5,6-bis(hexamethylene)pyridine

: [2,3:5,6-{C5H10C(N-4-Me-2,6-Et2C6H2)}2C5HN]FeCl2

Conditions

Conditions	Yield
With acetic anhydride at 130℃; for 12h;	87%
In acetic acid for 12h; Inert atmosphere; Schlenk technique; Reflux;	75%

...Expand

: 1433897-26-7
6-(2,4,6-triisopropylphenyl)-2-pyridinecarboxaldehyde

: 24544-08-9
2,6-diethyl-4-methylaniline

: (E)-N-(2,6-diethyl-4-methylphenyl)-1-(6-(2,4,6-triisopropylphenyl)pyridin-2-yl)methanimine

Conditions

Conditions	Yield
With formic acid In methanol at 60℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	87%

: 75-35-4
1,1-Dichloroethylene

: 24544-08-9
2,6-diethyl-4-methylaniline

: C13H17Cl3

Conditions

Conditions	Yield
With tert.-butylnitrite; copper dichloride In acetonitrile at 10 - 20℃; for 16h; Reagent/catalyst;	85.1%

: 24544-08-9
2,6-diethyl-4-methylaniline

: 77545-45-0
3’,6’-dichlorospiro[3H-2,1-benzoxathiol-3,9’-[9H]xanthene]-1,1-dioxide

: 3,5-diisopropyl sulfanilic acid sodium salt

: C42H43N2O7S2(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: 3’,6’-dichlorospiro[3H-2,1-benzoxathiol-3,9’-[9H]xanthene]-1,1-dioxide; 3,5-diisopropyl sulfanilic acid sodium salt With 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium bromide In ethylene glycol at 120℃; for 2h; Stage #2: 2,6-diethyl-4-methylaniline In ethylene glycol at 180℃; for 18h;	85%

...Expand

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2,6-diethyl-4-methyliodobenzene

Conditions

Conditions	Yield
Stage #1: 2,6-diethyl-4-methylaniline With hydrogenchloride In water at 80 - 90℃; Stage #2: With sodium nitrite In water at -10 - 0℃; Stage #3: With hydrogenchloride; sodium iodide In water at 80 - 90℃; for 16h;	83%
Stage #1: 2,6-diethyl-4-methylaniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With potassium iodide In water at 5 - 20℃; Reagent/catalyst;

: 81-64-1
1,4-dihydroxy-9,10-anthracenedione

: 24544-08-9
2,6-diethyl-4-methylaniline

: 32724-62-2
C.I. Solvent Blue 97

Conditions

Conditions	Yield
With LACTIC ACID; Trimethyl borate; 2,3-dihydro-1,4-dihydroxyanthraquinone at 115 - 145℃; for 11.5h;	82%

: 86-57-7
1-Nitronaphthalene

: 24544-08-9
2,6-diethyl-4-methylaniline

: C21H23N

Conditions

Conditions	Yield
With potassium phosphate tribasic trihydrate; 2-(2,6-diethyl-4-methylphenyl)-5-(2,4,6-triisopropylphenyl)imidazo[1,5-a]pyridin-2-ium chloride; palladium(II) acetylacetonate In 1,4-dioxane at 130℃; for 24h; Sealed tube; Inert atmosphere;	80%
With bis(acetylacetonato)palladium(II); potassium phosphate tribasic trihydrate; 2-(2,6-diethyl-4-methylphenyl)-5-(2,4,6-triisopropylphenyl)imidazo[1,5-a]pyridin-2-ium chloride In 1,4-dioxane at 130℃; for 24h; Inert atmosphere;	80%

: 2-acetyl-cycloheptapyridine

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2-(1-(2,6-diethyl-4-methylphenylimino)ethyl)cycloheptapyridine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 6h; Inert atmosphere; Schlenk technique; Reflux;	78%

: nickel(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2-(hydroxymethyl)-6,7-dihydroquinolin-8(5H)-one

: C21H26Cl2N2NiO

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 8h; Reflux;	78%

...Expand

: cobalt(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 1,2,3,7,8,9,10-heptahydrocyclohepta[b]-quinoline-4,6-dione

: N4,N6-bis(2,6-diethyl-4-methylphenyl)-2,3,7,8,9,10-hexahydro-1H-cycloheptaquinoline-4,6-diimine cobalt dichloride

Conditions

Conditions	Yield
In acetic acid for 12h; Inert atmosphere; Schlenk technique; Reflux;	77%
With acetic acid at 130℃; for 12h; Inert atmosphere;	77%

...Expand

: iron(II) chloride tetrahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 1,2,3,7,8,9,10-heptahydrocyclohepta[b]-quinoline-4,6-dione

: N4,N6-bis(2,6-diethyl-4-methylphenyl)-2,3,7,8,9,10-hexahydro-1H-cycloheptaquinoline-4,6-diimine ferric dichloride

Conditions

Conditions	Yield
With acetic acid at 130℃; for 12h; Inert atmosphere;	74%

...Expand

: 49568-10-7
4-oxo-1,2,3,4-tetrahydroacridine

: nickel(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 4-(2,6-diethyl-4-methylphenylimino)-1,2,3-trihydroacridylnickel(II) dichloride

Conditions

Conditions	Yield
In acetic acid for 3h; Reflux;	72.9%

...Expand

: nickel(II) chloride hexahydrate

: 1369217-33-3
2-isopropyl-5,6,7-trihydroquinolin-8-one

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2,6-diethyl-4-methyl-N-(2-isopropyl-5,6,7-trihydroquinolin-8-ylidene)phenylaminonickel(II) dichloride

Conditions

Conditions	Yield
In acetic acid under N2, Schlenk technique; quinoline deriv., amine, NiCl2*6H2O and acetic acid placed in round bottom flask; stirred at reflux for 5 h; acid removed under reduced pressure; residue dissolved in MeOH; pptd. with Et2O; filtered, washed with Et2O, dried under vac.; elem. anal.;	72%

...Expand

: nickel(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 129337-86-6
2-chloro-5,6,7,8-tetrahydroquinolin-8-one

: 1263563-92-3
[2,6-diethyl-4-methyl-N-(2-chloro-5,6,7-trihydroquinolin-8-ylidene)phenylamino]nickel(II) dichloride

Conditions

Conditions	Yield
In acetic acid (N2); quinolinone, aniline and NiCl2*6H2O were refluxed in AcOH for 3 h; evapd. in vac., dissolved in MeOH, filtered, precipitated with Et2O, filtered, washed with Et2O, dried in vac., elem. anal.;	71%

...Expand

: 49568-10-7
4-oxo-1,2,3,4-tetrahydroacridine

: iron(II) chloride tetrahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: C24H26Cl2FeN2

Conditions

Conditions	Yield
With acetic acid for 3h; Inert atmosphere; Reflux;	70.3%
With acetic acid for 3h; Inert atmosphere; Reflux;	70.3%

...Expand

: nickel(II) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2-propyl-2,3-dihydroacridine-4-one

: 4-(2,6-diethyl-4-methylphenylimino)-2-propyl-1,3-dihydroacridine nickel dichloride

Conditions

Conditions	Yield
With acetic acid for 5h; Reflux;	70%

...Expand

: chromium(III) chloride hexahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 96413-29-5
α,α’-dioxo-2,3 : 5,6-bis(pentamethylene)pyridine

: C37H47Cl3CrN3

Conditions

Conditions	Yield
In acetic acid for 3h; Reflux; Inert atmosphere; Schlenk technique;	70%

...Expand

: 1396115-05-1
2-((2,6-dibenzhydryl-4-chlorophenyl)imino)acenaphthylen-1-one

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2,6-dibenzhydryl-N-(2-(2,6-diethyl-4-methylphenylimino)acenaphthylenylidne)-4-chlorobenzenamine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃;	69%

: 24544-08-9
2,6-diethyl-4-methylaniline

: 2-benzoyl-5,6,7,8-tetrahydro cyclohepta[b]pyridin-9-one

: iron(II) chloride

: C39H45Cl2FeN3

Conditions

Conditions	Yield
With acetic acid for 6h; Inert atmosphere; Reflux;	68.4%

...Expand

: 1011-47-8
1-quinolin-2-yl-ethanone

: 24544-08-9
2,6-diethyl-4-methylaniline

: 1319733-82-8
2,6-diethyl-4-methyl-N-(1-(quinolin-2-yl)ethylidene) benzenamine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux;	68%

: iron(II) chloride tetrahydrate

: 24544-08-9
2,6-diethyl-4-methylaniline

: 96413-29-5
α,α’-dioxo-2,3 : 5,6-bis(pentamethylene)pyridine

: C37H47Cl2FeN3

Conditions

Conditions	Yield
With acetic acid In acetic acid at 120℃; for 4h; Inert atmosphere;	67.5%

...Expand

2,6-Diethyl-4-methylaniline Specification

The Benzenamine,2,6-diethyl-4-methyl-, with CAS registry number 24544-08-9, belongs to the following product categories: (1)Intermediates of Dyes and Pigments; (2)O-alkylated Anilines; (3)Aniline Derivatives. It has the systematic name of 2,6-diethyl-4-methylaniline. This chemical is a kind of colourless to yellowish liquid. What's more, its EINECS is 246-307-5.

Physical properties of Benzenamine,2,6-diethyl-4-methyl-: (1)ACD/LogP: 3.38; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.33; (4)ACD/LogD (pH 7.4): 3.38; (5)ACD/BCF (pH 5.5): 195.35; (6)ACD/BCF (pH 7.4): 217.55; (7)ACD/KOC (pH 5.5): 1471.97; (8)ACD/KOC (pH 7.4): 1639.26; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.539; (14)Molar Refractivity: 54.41 cm³; (15)Molar Volume: 173.6 cm³; (16)Polarizability: 21.57×10^-24cm³; (17)Surface Tension: 35.5 dyne/cm; (18)Enthalpy of Vaporization: 49.67 kJ/mol; (19)Vapour Pressure: 0.0132 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The Benzenamine,2,6-diethyl-4-methyl- irritates to eyes, respiratory system and skin. This chemical is also harmful by inhalation, in contact with skin and if swallowed. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Nc1c(cc(cc1CC)C)CC
(2)InChI: InChI=1/C11H17N/c1-4-9-6-8(3)7-10(5-2)11(9)12/h6-7H,4-5,12H2,1-3H3
(3)InChIKey: OIXUMNZGNCAOKY-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C11H17N/c1-4-9-6-8(3)7-10(5-2)11(9)12/h6-7H,4-5,12H2,1-3H3
(5)Std. InChIKey: OIXUMNZGNCAOKY-UHFFFAOYSA-N

Product Name

2,6-Diethyl-4-methylaniline

Synthetic route

2,6-Diethyl-4-methylaniline Specification

Related Products

Hot Products