2,7-Dihydroxy-9-fluorenone supplier

Name
2,7-Dihydroxy-9-fluorenone
EINECS
CAS No. 42523-29-5
Article Data15
CAS DataBase
Density 1.497 g/cm³
Solubility
Melting Point 338 °C
Formula C₁₃H₈O₃
Boiling Point 444.5 °C at 760 mmHg
Molecular Weight 212.205
Flash Point 236.7 °C
Transport Information
Appearance Brown red powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2,7-Dihydroxy-9H-fluoren-9-one;2,7-Dihydroxyfluoren-9-one;RMI 15152;9H-Fluoren-9-one,2,7-dihydroxy-;
PSA 57.53000
LogP 2.30920

Synthetic route

: 53133-99-6
9-oxo-9H-fluorene-2,7-diyl diacetate

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With potassium hydroxide for 2h; Heating;	97.6%

: 765944-63-6
4,4'-dihydroxy-biphenyl-2-carboxylic acid methyl ester

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With zinc(II) chloride at 110 - 120℃; for 2h;	95%
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 78 °C 2: thionyl chloride / 79 °C View Scheme

: 53197-57-2
4,4'-dihydroxy-[1,1'-biphenyl]-2-carboxylic acid

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With zinc(II) chloride at 210℃; Neat (no solvent);	90%
With zinc(II) chloride
With zinc(II) chloride at 200℃;
With thionyl chloride at 79℃; Friedel-Crafts acylation;
Multi-step reaction with 2 steps 1: sulfuric acid / methanol / 2 h / Reflux 2: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

: 42523-28-4
2,7-dimethoxy-9H-fluorenon-9-one

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid In water for 12h; Reflux;	87%
With hydrogen bromide In acetic acid

: 202865-84-7
4-bromo-3-iodo-phenol

: 100-83-4
meta-hydroxybenzaldehyde

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With palladium diacetate; potassium hydrogencarbonate; DL-Pro-NHMe In tert-Amyl alcohol at 120℃; for 24h; Inert atmosphere;	74%

: 89450-82-8
2,7-dihydroxy-9-oxo-fluorene-1-carboxylic acid

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With calcium oxide melting;

: Fluorenon-Tetrazonium Tetrafluoroborat

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With sulfuric acid

diazotized 2.7-diamino-fluorenone: diazotized 2.7-diamino-fluorenone

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C 3: thionyl chloride / 79 °C View Scheme

: 154607-00-8
methyl 2-bromo-5-hydroxybenzoate

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C 3: thionyl chloride / 79 °C View Scheme

: 84185-72-8
3-(p-anisyl)-6-hydroxyphthalic anhydride

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / AlCl3 / benzene / Heating 2: CaO / melting View Scheme

: 84185-84-2
4-Hydroxy-4'-methoxy-biphenyl-2,3-dicarboxylic acid

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 66 percent 2: 87 percent / AlCl3 / benzene / Heating 3: CaO / melting View Scheme

: 31551-45-8
2,7-dinitro-9-fluorenone

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) SnCl2, HCl, AcOH, (ii) NaOH 2: aq. HBF4, NaNO2 3: aq. H2SO4 View Scheme

: 2915-84-6
2,7-diaminofluoren-9-one

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. HBF4, NaNO2 2: aq. H2SO4 View Scheme

: 696-62-8
para-iodoanisole

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Cu, (ii) aq. NaOH, MeOH 2: polyphosphoric acid 3: aq. HBr / acetic acid View Scheme
Multi-step reaction with 2 steps 1: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: anthranilic acid; palladium diacetate; silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Cu, (ii) aq. NaOH, MeOH 2: polyphosphoric acid 3: aq. HBr / acetic acid View Scheme

: 42523-25-1
4,4'-dimethoxy-[1,1'-biphenyl]-2-carboxylic acid

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: polyphosphoric acid 2: aq. HBr / acetic acid View Scheme

: 86-73-7
9H-fluorene

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Stage #1: 9H-fluorene With aluminum (III) chloride; acetic anhydride Stage #2: With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid In chloroform Further stages;
Multi-step reaction with 4 steps 1.1: sulfuric acid / 100 °C 1.2: 100 °C 2.1: potassium permanganate / water / Heating 3.1: sodium hydroxide 4.1: zinc(II) chloride / 210 °C / Neat (no solvent) View Scheme
Multi-step reaction with 5 steps 1.1: sulfuric acid / water / 2 h / 110 - 115 °C 1.2: 0.5 h / 20 °C 2.1: potassium permanganate / water / 2 h / 20 - 30 °C 3.1: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 4.1: sulfuric acid / methanol / 2 h / Reflux 5.1: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

: 13354-15-9
9H-fluorene-2,7-disulfonic acid dipotassium salt

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium permanganate / water / Heating 2: sodium hydroxide 3: zinc(II) chloride / 210 °C / Neat (no solvent) View Scheme
Multi-step reaction with 4 steps 1: potassium permanganate / water / 2 h / 20 - 30 °C 2: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 3: sulfuric acid / methanol / 2 h / Reflux 4: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

: 9-oxo-9H-fluorene-2,7-disulfonic acid dipotassium salt

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydroxide; sodium hydroxide / 1 h / 270 - 300 °C 2: sulfuric acid / methanol / 2 h / Reflux 3: zinc(II) chloride / 2 h / 110 - 120 °C View Scheme

: 591-31-1
3-methoxy-benzaldehyde

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: anthranilic acid; palladium diacetate; silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: 1,1,1,3',3',3'-hexafluoro-propanol / 8 h / 110 °C / Inert atmosphere 2: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 3: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

: C20H16N2O3Pd

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: silver trifluoroacetate; acetic acid; 1,1,1,3',3',3'-hexafluoro-propanol / 36 h / 120 °C / Sealed tube 2: acetic acid; hydrogen bromide / water / 12 h / Reflux View Scheme

: 14348-75-5
2,7-dibromofluorene-9-one

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; copper(II) acetylacetonate In water; dimethyl sulfoxide at 120℃; for 4h;	865 mg

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 100-39-0
benzyl bromide

: 2,7-bis-benzoyloxy-fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux;	96%

: 111-83-1
1-bromo-octane

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 2,7-dioctyloxyfluoren-9-one

Conditions

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 1.5h; Stage #2: 1-bromo-octane In N,N-dimethyl-formamide at 120℃; for 24h;	95%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 1h; Stage #2: 1-bromo-octane In N,N-dimethyl-formamide at 110℃; for 24h;	3.92 g

: 96-49-1
[1,3]-dioxolan-2-one

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 129375-33-3
2,7-bis(2-hydroxyethoxy)-9H-fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate at 100 - 120℃;	93%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 62-53-3
aniline

: 657862-72-1
9,9-bis(4-aminophenyl)-2,7-dihydroxyfluorenone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 150℃; for 10h; Inert atmosphere;	92.3%
With methanesulfonic acid at 150℃; for 10h;	86%
With aniline hydrochloride at 180℃; for 1h;	73.6%
With methanesulfonic acid at 150℃; for 10h;
With methanesulfonic acid at 150℃; for 14h;

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 350-46-9
4-Fluoronitrobenzene

: 1332524-31-8
2,7-bis(4-nitrophenoxy)-9-fluorenone

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Inert atmosphere;	92.2%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 90℃; for 3h; Inert atmosphere;	92.2%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 84487-73-0
3,6-Dichloro-2,7-dihydroxyfluoren-9-one

Conditions

Conditions	Yield
With sulfuryl dichloride In acetic acid at 42 - 45℃; regioselective reaction;	90%
With sulfuryl dichloride; acetic acid at 42 - 45℃; for 0.666667h; Inert atmosphere;	90.2%
With sulfuryl dichloride In acetic acid at 45℃; for 0.5h;	82%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 75-03-6
ethyl iodide

: 303735-64-0
2,7-diethoxy-fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	90%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 74-88-4
methyl iodide

: 42523-28-4
2,7-dimethoxy-9H-fluorenon-9-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4h; Heating;	90%
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 6h;	80%
With sodium hydroxide In dimethyl sulfoxide for 3h;	65%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 107-06-2
1,2-dichloro-ethane

: 28686-75-1
2,7-bis(2-chloroethoxy)fluoren-9-one

Conditions

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 75℃; for 24h;	87%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 108-95-2
phenol

: 2,7-dihydroxy-9,9-bis(4-hydroxyphenyl)fluorene

Conditions

Conditions	Yield
With 3-mercaptopropionic acid at 90 - 120℃; Green chemistry;	85.6%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride

: 27591-97-5
2,7-bis(2-[diethylamino]ethoxy)-9-fluorenone

Conditions

Conditions	Yield
With potassium hydroxide In water; toluene for 8h; Reflux;	85%
With potassium hydroxide In water; toluene for 24h; Reflux;	72%
With potassium hydroxide In toluene
With potassium hydroxide; trimethylbenzylammonium bromide In toluene
With potassium hydroxide In water; toluene for 24h; Reflux;

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 107-08-4
1-iodo-propane

: 2,7-dipropoxyfluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	85%

: 109-65-9
1-bromo-butane

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 2,7-dibutoxyl-9H-fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 20h; Inert atmosphere;	84%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 96-32-2
bromoacetic acid methyl ester

: 123305-05-5
2,7-bis(methoxycarbonylmethoxy)fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Heating;	83%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 109-70-6
1,3-chlorobromopropane

: 2,7-bis(3-chloropropoxy)fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	83%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 540-63-6
ethane-1,2-dithiol

: 129395-16-0
2,7-dihydroxyfluoren-9-(1,3-dithiolane)

Conditions

Conditions	Yield
With aluminium trichloride In 1,4-dioxane at 50℃; for 2.5h;	82%

: 18991-98-5
n-butyl bromoacetate

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 123278-11-5
(7-Butoxycarbonylmethoxy-9-oxo-9H-fluoren-2-yloxy)-acetic acid butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Heating;	80%

: 5197-66-0
2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 844638-09-1
2,7-bis(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)-9H-fluoren-9-one

Conditions

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	80%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: 2-(2-(2-(2-chloroethoxy)ethoxy)ethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	80%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 35h;	80%

: 5197-67-1
14-chloro-3,6,9,12-tetraoxatetradecanol

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 1062593-11-6
2,7-bis(15-hydroxy-1,4,7,10,13-pentaoxapentadecyl)-9H-fluoren-9-one

Conditions

Conditions	Yield
With potassium hydroxide; sodium iodide In ethanol for 50h; Heating;	80%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 100-63-0
phenylhydrazine

: 84487-74-1
2,7-Dihydroxy-9-fluorenone phenylhydrazone

Conditions

Conditions	Yield
In ethanol for 4h;	79%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 119-26-6
(2,4-dinitro-phenyl)-hydrazine

: 9-[(2,4-dinitro-phenyl)-hydrazono]-9H-fluorene-2,7-diol

Conditions

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 0.5h;	78%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 628-89-7
2-(2-Chloroethoxy)ethanol

: 299167-98-9
2,7-bis[2-(2-hydroxyethoxy)ethoxy]-9H-fluoren-9-one

Conditions

Conditions	Yield
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: 2-(2-Chloroethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	78%
Stage #1: 2,7-dihydroxy-9H-fluoren-9-one With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 1h; Stage #2: 2-(2-Chloroethoxy)ethanol In N,N-dimethyl-formamide at 80℃; for 35h;	78%
With potassium carbonate In N,N-dimethyl-formamide at 80 - 85℃; for 30h;	78%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 80℃; for 35h;	78%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 107-07-3
2-chloro-ethanol

: 129375-33-3
2,7-bis(2-hydroxyethoxy)-9H-fluoren-9-one

Conditions

Conditions	Yield
With sodium hydroxide In water at 30 - 70℃; for 4h;	78%
With sodium hydroxide In dimethyl sulfoxide at 70℃;	55%

: 111-24-0
1,5-dibromo-pentane

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 2,7-bis(5-bromopentoxy)fluoren-9-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;	78%

: 18908-66-2
2-ethylhexyl bromide

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: C29H40O

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h;	78%

: 42523-29-5
2,7-dihydroxy-9H-fluoren-9-one

: 84487-72-9
3,6-Dibromo-2,7-dihydroxyfluoren-9-one

Conditions

Conditions	Yield
With 1,4-dioxane dibromide at 60 - 65℃; for 0.666667h;	77%

2,7-Dihydroxy-9-fluorenone Chemical Properties

Structure of 2,7-Dihydroxy-9-fluorenone (CAS NO.42523-29-5):

Empirical Formula: C₁₃H₈O₃
Molecular Weight: 212.2008
Index of Refraction: 1.749
Molar Refractivity: 57.68 cm³
Molar Volume: 141.6 cm³
Polarizability: 22.86×10^-24cm³
Surface Tension: 77.2 dyne/cm
Density: 1.497 g/cm³
Flash Point: 236.7 °C
Enthalpy of Vaporization: 72.93 kJ/mol
Boiling Point: 444.5 °C at 760 mmHg
Vapour Pressure: 1.63E-08 mmHg at 25°C
Product Categories: Fluorene Derivatives;Fluorenes, Flurenones
Synonyms of 2,7-Dihydroxy-9-fluorenone (CAS NO.42523-29-5): 9H-fluoren-9-one, 2,7-dihydroxy- ; 2,7-Dihydroxy-9-fluorenone .

Product Name

2,7-Dihydroxy-9-fluorenone

Synthetic route

2,7-Dihydroxy-9-fluorenone Chemical Properties

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