• Name

  2-ACETAMIDO-5-NITROTHIAZOLE

• EINECS
• CAS No. 140-40-9
• Article Data12
• CAS DataBase
• Density 1.598g/cm³
• Solubility
• Melting Point 263°C (dec.)
• Formula C5H5 N3 O3 S
• Boiling Point 303.8°Cat760mmHg
• Molecular Weight 187.179
• Flash Point 137.5°C
• Transport Information
• Appearance
• Safety Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
• Risk Codes 22
• Molecular Structure
• Hazard Symbols
• Synonyms Thiazole,2-acetamido-5-nitro- (6CI,7CI); 2-(Acetylamino)-5-nitrothiazole;2-Acetamido-5-nitrothiazole; 5-Nitro-2-acetamidothiazole; Acetyl enheptin;Acinitrazol; Acinitrazole; Ametoterina; Aminitrozol; Aminitrozole; CL 5279;Cyzine Premix; Enheptin A; Gynofon; Lavoflagin;N-(5-Nitro-2-thiazolyl)acetamide; NSC 31539; NSC 45914; Nitazol; Nitazole;Nithiamide; Pleocide; Trichlorad; Trichocid; Trichoman; Trichorad; Trichoral;Tricogen; Tricolaval; Tricoral; Tricosteril; Trikolaval; Tritheon
• PSA 116.05000
• LogP 1.60590

Synthetic route

121-66-4

2-amino-5-nitro-1,3-thiazole

108-24-7

acetic anhydride

140-40-9

Nitazole

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	91%

2719-23-5

2-acetamidothiazole

625-58-1

ethyl nitrate

140-40-9

Nitazole

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate

2719-23-5

2-acetamidothiazole

140-40-9

Nitazole

Conditions

Conditions	Yield
With sulfuric acid; nitric acid
With nitric acid; acetic anhydride
With ammonium nitrate; sulfuric acid at 20 - 30℃; for 2.5h; Yield given;

121-66-4

2-amino-5-nitro-1,3-thiazole

140-40-9

Nitazole

Conditions

Conditions	Yield
With acetic anhydride
With pyridine
With sulfuric acid

7336-54-1

2-acetamido-5-bromothiazole

140-40-9

Nitazole

Conditions

Conditions	Yield
With nitric acid; acetic anhydride; acetic acid

108-24-7

acetic anhydride

57530-25-3

thiazol-2-ylamine; nitrate

140-40-9

Nitazole

Conditions

Conditions	Yield
(i) Na2CO3, CCl4, (ii) H2SO4; Multistep reaction;

140-40-9

Nitazole

121-66-4

2-amino-5-nitro-1,3-thiazole

Conditions

Conditions	Yield
With hydrogenchloride

140-40-9

Nitazole

5875-25-2

2-bromo-propionic acid amide

23599-21-5

2-(2-acetylimino-5-nitro-thiazol-3-yl)-propionamide

Conditions

Conditions	Yield
With sodium hydride; N,N-dimethyl-formamide

140-40-9

Nitazole

5326-97-6

2-Bromo-N-(n-octyl)acetamide

38922-42-8

2-(2-acetylimino-5-nitro-thiazol-3-yl)-N-octyl-acetamide

Conditions

Conditions	Yield
With sodium hydride; N,N-dimethyl-formamide

140-40-9

Nitazole

105-36-2

ethyl bromoacetate

A

38922-43-9

N-acetyl-N-(5-nitro-thiazol-2-yl)-glycine ethyl ester

B

23599-22-6

(2-acetylimino-5-nitro-thiazol-3-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydride; N,N-dimethyl-formamide

...Expand

140-40-9

Nitazole

5332-06-9

4-bromobutanenitrile

A

39020-59-2

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide

B

38922-53-1

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyronitrile

Conditions

Conditions	Yield
With sodium hydride; N,N-dimethyl-formamide

...Expand

140-40-9

Nitazole

39020-59-2

N-(3-cyano-propyl)-N-(5-nitro-thiazol-2-yl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaH, DMF 2: aq. HCl View Scheme

140-40-9

Nitazole

38922-63-3

4-[acetyl-(5-nitro-thiazol-2-yl)-amino]-butyramide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaH, DMF 2: aq. HCl View Scheme
Multi-step reaction with 3 steps 1: NaH, DMF 2: aq. HCl 3: aq. HCl View Scheme

140-40-9

Nitazole

38922-54-2

4-(2-acetylimino-5-nitro-thiazol-3-yl)-butyramide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaH, DMF 2: aq. HCl View Scheme

2-ACETYLAMINO-5-NITROTHIAZOLE Chemical Properties

The MF of 2-ACETYLAMINO-5-NITROTHIAZOLE(140-40-9): C₅H₅N₃O₃S
The MW of 2-ACETYLAMINO-5-NITROTHIAZOLE(140-40-9): 187.18
EINECS: 205-414-7
Melting point: 263 °C (dec.)
Water Solubility: 1610 mg/L 25 °C
Other names: acinitrazole; N-(5-nitrothiazol-2-yl)acetamide; 2-Acetamido-5-nitrothiazole
The Structure of 2-ACETYLAMINO-5-NITROTHIAZOLE(140-40-9):

2-ACETYLAMINO-5-NITROTHIAZOLE Toxicity Data With Reference

2-ACETYLAMINO-5-NITROTHIAZOLE Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
Hazard Codes: Xn
Risk Statements: 22: Harmful if swallowed 
Safety Statements: 22-36/37
22:  Do not breathe dust 
36/37:  Wear suitable protective clothing and gloves 
RTECS: XJ1570000