Product Name

  • Name

    2-Amino-2-ethyl-1,3-propanediol

  • EINECS 204-101-2
  • CAS No. 115-70-8
  • Article Data14
  • CAS DataBase
  • Density 1.085 g/cm3
  • Solubility soluble in water
  • Melting Point 35-37 °C
  • Formula C5H13NO2
  • Boiling Point 273.386 °C at 760 mmHg
  • Molecular Weight 119.164
  • Flash Point 115.595 °C
  • Transport Information
  • Appearance clear yellow viscous liquid
  • Safety 37/39-26
  • Risk Codes 41-36/37/38
  • Molecular Structure Molecular Structure of 115-70-8 (2-Amino-2-ethyl-1,3-propanediol)
  • Hazard Symbols IrritantXi
  • Synonyms (1,1-Bis-(hydroxymethyl)propyl)amine;2-Amino-2-ethylpropanediol;2-Ethyl-2-amino-1,3-propanediol;2-Ethyl-2-aminopropanediol;
  • PSA 66.48000
  • LogP -0.22120

Synthetic route

2-nitro-2-ethyl-1,3-propanediol
597-09-1

2-nitro-2-ethyl-1,3-propanediol

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
With methanol; nickel at 50℃; under 51485.6 Torr; Hydrogenation;
With ethanol; nickel at 20℃; under 36775.4 - 102971 Torr; Hydrogenation;
With phosphoric acid; iron at 100℃;
With sulfuric acid; iron at 100℃;
With propylamine; hydrogen; molybdenum promoted RANEY type nickel catalyst In methanol at 35℃; under 36961.4 Torr; Product distribution / selectivity; Autoclave; Industry scale;
5-amino-5-ethyl-1.3-dioxane

5-amino-5-ethyl-1.3-dioxane

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
With mineral acid
cyclic acetal of 2-amino-2-ethyl-propanediol-(1.3)

cyclic acetal of 2-amino-2-ethyl-propanediol-(1.3)

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
With mineral acid
methanol
67-56-1

methanol

2-nitro-2-ethyl-1,3-propanediol
597-09-1

2-nitro-2-ethyl-1,3-propanediol

Raney nickel

Raney nickel

A

2-aminobutanol
96-20-8, 13054-87-0

2-aminobutanol

B

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
Hydrogenation;
...Expand
C13H25NO4
1033408-72-8

C13H25NO4

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 20℃; Inert atmosphere;
diethyl 2-acetylamino-2-ethylmalonate
32819-24-2

diethyl 2-acetylamino-2-ethylmalonate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / Reflux; Inert atmosphere
View Scheme
2-acetamido-2-ethyl-1,3-propanediol
39116-23-9

2-acetamido-2-ethyl-1,3-propanediol

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Conditions
ConditionsYield
With hydrogenchloride; water In methanol Reflux; Inert atmosphere;
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

N-(1,1-bis-hydroxymethyl-propyl)-2,2,2-trifluoro-acetamide

N-(1,1-bis-hydroxymethyl-propyl)-2,2,2-trifluoro-acetamide

Conditions
ConditionsYield
100%
acetic acid
64-19-7

acetic acid

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-ammonio-2-ethylpropane-1,3-diol acetate

2-ammonio-2-ethylpropane-1,3-diol acetate

Conditions
ConditionsYield
In chloroform for 0.75h; Ambient temperature;99%
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

6-ethyl-3,3,9,9-tetraisopropyl-2,10-dimethyl-4,8-dioxa-3,9-disilaundecan-6-amine

6-ethyl-3,3,9,9-tetraisopropyl-2,10-dimethyl-4,8-dioxa-3,9-disilaundecan-6-amine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 36h; Inert atmosphere;98%
With triethylamine In dichloromethane at 0 - 20℃; for 36h; Inert atmosphere;95%
With triethylamine In dichloromethane
With triethylamine In dichloromethane at 20℃;
N-(Benzyloxycarbonyloxy)succinimide
13139-17-8

N-(Benzyloxycarbonyloxy)succinimide

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

(1,1-bis-(hydroxymethyl)propyl)carbamic acid benzyl ester
1346041-88-0

(1,1-bis-(hydroxymethyl)propyl)carbamic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;97%
3-methoxy-2-hydroxybenzaldehyde
148-53-8

3-methoxy-2-hydroxybenzaldehyde

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-{[1-(2-hydroxy-3-methoxyphenyl)methylidene]amino}-2-ethylpropane-1,3-diol
68322-96-3

2-{[1-(2-hydroxy-3-methoxyphenyl)methylidene]amino}-2-ethylpropane-1,3-diol

Conditions
ConditionsYield
In methanol at 20℃; for 0.333333h;93%
In methanol Reflux;81.7%
With triethylamine In methanol for 1h; Reflux;
2,2'-dithiodibenzoic acid dichloride
19602-82-5

2,2'-dithiodibenzoic acid dichloride

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2,2'-dithiobisbenzamide>
81419-25-2

2,2'-dithiobisbenzamide>

Conditions
ConditionsYield
In tetrahydrofuran for 2h; Ambient temperature;90%
salicylaldehyde
90-02-8

salicylaldehyde

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-ethyl-2-((2-hydroxybenzylideneamino)propane-1,3-diol)

2-ethyl-2-((2-hydroxybenzylideneamino)propane-1,3-diol)

Conditions
ConditionsYield
In methanol at 45℃; for 1h;90%
In methanol at 50 - 60℃;87%
In methanol at 85℃; for 8h; Reflux;85%
In methanol for 1h; Heating;
In methanol for 4h; Reflux;
1,4-dioxane-2,6-dione
4480-83-5

1,4-dioxane-2,6-dione

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

polymer; monomer(s): diglycolic anhydride; 2-amino-2-ethyl-1,3-propanediol

polymer; monomer(s): diglycolic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
at 110℃; for 18h;90%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carbaldehyde
189763-05-1

4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carbaldehyde

2-[(1,1-bis-hydroxymethyl-propylamino)-methyl]-naphtho[2,3-b]furan-4,9-dione

2-[(1,1-bis-hydroxymethyl-propylamino)-methyl]-naphtho[2,3-b]furan-4,9-dione

Conditions
ConditionsYield
Stage #1: 2-ethyl-2-amino-propane-1,3-diol; 2-formyl-4,9-dihydronaphtho[2,3-b]-furan-4,9-dione With magnesium sulfate In dichloromethane for 24h; Condensation;
Stage #2: With sodium cyanoborohydride; acetic acid In methanol for 0.5h; pH=6 - 7; Reduction;		89%
4-biphenyl isocyanate
92-95-5

4-biphenyl isocyanate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

1-biphenyl-4-yl-3-(1,1-bis(hydroxymethyl)propyl)urea
1346041-33-5

1-biphenyl-4-yl-3-(1,1-bis(hydroxymethyl)propyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 15h; Inert atmosphere;89%
4-Nitrophenyl isocyanate
100-28-7

4-Nitrophenyl isocyanate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

1-(1,1-bis(hydroxymethyl)propyl)-3-(4-nitrophenyl)urea
1346040-78-5

1-(1,1-bis(hydroxymethyl)propyl)-3-(4-nitrophenyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 14h; Inert atmosphere;89%
succinic acid anhydride
108-30-5

succinic acid anhydride

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

polymer; monomer(s): succinic anhydride; 2-amino-2-ethyl-1,3-propanediol

polymer; monomer(s): succinic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
at 130℃; for 45h;88%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

1,2-cis-cyclohexanedicarboxylic anhydride
13149-00-3

1,2-cis-cyclohexanedicarboxylic anhydride

polymer; monomer(s): cis-1,2-cyclohexanedicarboxylic anhydride; 2-amino-2-ethyl-1,3-propanediol

polymer; monomer(s): cis-1,2-cyclohexanedicarboxylic anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
at 125℃; for 29h;88%
isophorone diisocyanate
4098-71-9

isophorone diisocyanate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

hyperbranched poly(urea-urethane) copolymer, polycondensation, degree of branching 56.5 percent, Mw 21970; monomer(s): isophorone diisocyanate; 2-amino-2-ethyl-1,3-propanediol

hyperbranched poly(urea-urethane) copolymer, polycondensation, degree of branching 56.5 percent, Mw 21970; monomer(s): isophorone diisocyanate; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 60℃; for 150h;85%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

di(4-isocyanatophenyl)methane
101-68-8

di(4-isocyanatophenyl)methane

hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 44.4 percent, Mw 25450; monomer(s): 4,4\-methylenebis(phenyl isocyanate); 2-amino-2-ethyl-1,3-propanediol

hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 44.4 percent, Mw 25450; monomer(s): 4,4\-methylenebis(phenyl isocyanate); 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 60℃; for 60h;85%
glutaric anhydride,
108-55-4

glutaric anhydride,

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

polymer; monomer(s): glutaric anhydride; 2-amino-2-ethyl-1,3-propanediol

polymer; monomer(s): glutaric anhydride; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
at 120℃; for 45h;85%
p-Tolylisocyanate
622-58-2

p-Tolylisocyanate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

1-(1,1-bis(hydroxymethyl)propyl)-3-p-tolyl-urea
1346041-12-0

1-(1,1-bis(hydroxymethyl)propyl)-3-p-tolyl-urea

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 13h; Inert atmosphere;85%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-((tert-butoxycarbonyl)amino)-2-ethyl-1,3-propanediol
391678-52-7

2-((tert-butoxycarbonyl)amino)-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 20h;84%
With N-ethyl-N,N-diisopropylamine In methanol at 0 - 20℃; for 16.6667h;
With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 16.6667h; Ice-cooling;
phenyl isocyanate
103-71-9

phenyl isocyanate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

1-(1,1-bis(hydroxymethyl)propyl)-3-phenylurea
1357098-09-9

1-(1,1-bis(hydroxymethyl)propyl)-3-phenylurea

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere;84%
C18H14N2O2

C18H14N2O2

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

C22H23N3O3

C22H23N3O3

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; dimethyl sulfoxide Reflux; Inert atmosphere;84%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

5-chlorosalicyclaldehyde
635-93-8

5-chlorosalicyclaldehyde

2-(5-chloro-2-hydroxybenzylideneamino)-2-ethylpropane-1,3-diol

2-(5-chloro-2-hydroxybenzylideneamino)-2-ethylpropane-1,3-diol

Conditions
ConditionsYield
In methanol for 1h; Reflux;83%
In methanol for 1h; Heating;
In methanol for 4h; Reflux;
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2,6-dimethylphenylisocyanate
28556-81-2

2,6-dimethylphenylisocyanate

1-(2-ethyl-1,3-dihydroxypropan-2-yl)-3-(2,6-dimethylphenyl)urea
1346041-50-6

1-(2-ethyl-1,3-dihydroxypropan-2-yl)-3-(2,6-dimethylphenyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;83%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2,4-Toluene diisocyanate
584-84-9

2,4-Toluene diisocyanate

hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 43.8 percent, Mw 19450; monomer(s): toluene-2,4-diisocyanate; 2-amino-2-ethyl-1,3-propanediol

hyperbranced poly(urea-urethane) copolymer, polycondensation, degree of branching 43.8 percent, Mw 19450; monomer(s): toluene-2,4-diisocyanate; 2-amino-2-ethyl-1,3-propanediol

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 60℃; for 60h;81%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

Diethyl carbonate
105-58-8

Diethyl carbonate

4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone
162632-59-9

4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

Conditions
ConditionsYield
With sodium methylate at 109.85℃; for 24h;80%
With sodium methylate In ethyl acetate80%
With sodium methylate In ethyl acetate80%
bis(acetylacetonato)dioxomolybdenum(VI)

bis(acetylacetonato)dioxomolybdenum(VI)

salicylaldehyde
90-02-8

salicylaldehyde

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

MoO2(2+)*C6H4(O)CHNC(C2H5)(CH2O)CH2OH(2-)*CH3OH=MoO2(C6H4(O)CHNC(C2H5)(CH2O)CH2OH)(CH3OH)
168099-60-3

MoO2(2+)*C6H4(O)CHNC(C2H5)(CH2O)CH2OH(2-)*CH3OH=MoO2(C6H4(O)CHNC(C2H5)(CH2O)CH2OH)(CH3OH)

Conditions
ConditionsYield
With MeOH In methanol equimolar amts.; refluxing aldehyde with amine for 1 h, cooling, addn. of Mo-compd. (stirring), refluxing for 2 h; cooling, pptn. on slow evapn. in air (several d); elem. anal.;80%
...Expand
C24H16N2O2
1452783-09-3

C24H16N2O2

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

C28H25N3O3
1452783-13-9

C28H25N3O3

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; dimethyl sulfoxide Inert atmosphere; Schlenk technique; Reflux;80%
ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-methyl-N-(1,3-dihydroxy-2-ethylpropan-2-yl)benzamide

2-methyl-N-(1,3-dihydroxy-2-ethylpropan-2-yl)benzamide

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 0 - 20℃;80%
2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-hydroxynaphthalene-1-carbaldehyde
708-06-5

2-hydroxynaphthalene-1-carbaldehyde

2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol
1415911-94-2

2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol

Conditions
ConditionsYield
In methanol for 4h; Reflux;78%
In methanol at 50 - 60℃;
In methanol for 1h; Reflux;
ethyl 1-imidazolecarboxylate
19213-72-0

ethyl 1-imidazolecarboxylate

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone
162632-59-9

4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran for 15h; Reflux;78%
2-hydroxy-5-methylbenzaldehyde
613-84-3

2-hydroxy-5-methylbenzaldehyde

2-ethyl-2-amino-propane-1,3-diol
115-70-8

2-ethyl-2-amino-propane-1,3-diol

2-ethyl-2-{[1-(2-hydroxy-5-methylphenyl)methylidene]amino}propane-1,3-diol

2-ethyl-2-{[1-(2-hydroxy-5-methylphenyl)methylidene]amino}propane-1,3-diol

Conditions
ConditionsYield
In methanol for 0.5h; Reflux;78%

2-Amino-2-ethyl-1,3-propanediol Specification

The 1,3-Propanediol,2-amino-2-ethyl-, with the CAS registry number 115-70-8, is also known as 2-Amino-1,3-dihydroxy-2-ethylpropane. It belongs to the product categories of Industrial/Fine Chemicals; API Intermediates. Its EINECS registry number is 204-101-2. This chemical's molecular formula is C5H13NO2 and molecular weight is 119.16. What's more, both its IUPAC name and systematic name are the same which is called 2-Amino-2-ethylpropane-1,3-diol. It should be stored in a cool, dry and well-ventilated place.

Physical properties about 1,3-Propanediol,2-amino-2-ethyl- are: (1)ACD/LogP: -1.239; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.33; (4)ACD/LogD (pH 7.4): -3.81; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 3 ; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 66.48 Å2; (13)Index of Refraction: 1.491; (14)Molar Refractivity: 31.784 cm3; (15)Molar Volume: 109.807 cm3; (16)Polarizability: 12.6×10-24cm3; (17)Surface Tension: 47.761 dyne/cm; (18)Density: 1.085 g/cm3; (19)Flash Point: 115.595 °C; (20)Enthalpy of Vaporization: 59.41 kJ/mol; (21)Boiling Point: 273.386 °C at 760 mmHg; (22)Vapour Pressure: 0.00100 mmHg at 25 °C.

Uses of 1,3-Propanediol,2-amino-2-ethyl-: it is used to produce other chemicals. For example, it can react with acetic acid to get 2-ammonio-2-ethylpropane-1,3-diol acetate. This reaction needs solvent CHCl3 at ambient temperature. The reaction time is 45 min. The yield is 99 %.

1,3-Propanediol,2-amino-2-ethyl- can react with acetic acid to get 2-ammonio-2-ethylpropane-1,3-diol acetate.

When you are dealing with this chemical, you should be very careful. This chemical may cause inflammation to the skin, eyes and respiratory system or other mucous membranes. Therefore, you should wear suitable gloves and eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: OCC(N)(CC)CO
(2) InChI: InChI=1S/C5H13NO2/c1-2-5(6,3-7)4-8/h7-8H,2-4,6H2,1H3
(3) InChIKey: IOAOAKDONABGPZ-UHFFFAOYSA-N

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