2-Amino-4-(methylsulfonyl)phenol supplier

Name
2-Amino-4-(methylsulfonyl)phenol
EINECS 202-654-4
CAS No. 98-30-6
Article Data7
CAS DataBase
Density 1.419 g/cm³
Solubility
Melting Point 156.0 to 160.0 °C
Formula C7H9 N O3 S
Boiling Point 436.3 °C at 760 mmHg
Molecular Weight 187.219
Flash Point 217.6 °C
Transport Information
Appearance LIGHT GREAY COLOUR DRY POWDER
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Amino-4-(methylsulfonyl)phenol;4-Methylsulfonyl-2-aminophenol
PSA 88.77000
LogP 2.03990

Synthetic route

: 20945-70-4
2-methoxy-5-(methylsulfonyl)aniline

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

Conditions

Conditions	Yield
Stage #1: 2-methoxy-5-(methylsulfonyl)aniline With boron tribromide In dichloromethane; chloroform at 0℃; for 0.333333h; Stage #2: With water; sodium hydrogencarbonate pH=7;	15%
With boron tribromide In dichloromethane for 5h; Reflux;
With boron tribromide

2-nitro-4-methanesulfonyl-phenol: 2-nitro-4-methanesulfonyl-phenol

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

Conditions

Conditions	Yield
With sodium hydroxide; nickel at 130℃; under 36775.4 Torr; Hydrogenation;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 1427468-96-9
N-(tert-butyl)-2-(tert-butylimino)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3-amine

Conditions

Conditions	Yield
With palladium dichloride In 1,4-dioxane at 50℃; for 8h;	89%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 1427468-76-5
N-(tert-butyl)-5-(methylsulfonyl)benzo[d]oxazol-2-amine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 50℃; for 8h;	88%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 85-44-9
phthalic anhydride

: 2-[2-hydroxy-5-(methylsulfonyl)phenyl]-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
With acetic acid at 120℃; for 18h;	80%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 98-86-2
acetophenone

: 2-benzyl-5-(methylsulfonyl)benzoxazole

Conditions

Conditions	Yield
With N-methylcyclohexylamine; sulfur at 80℃; for 16h; Inert atmosphere; Sealed tube;	80%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 100-52-7
benzaldehyde

: 5-(methylsulfonyl)-2-phenylbenzoxazole

Conditions

Conditions	Yield
With sulfur; sodium sulfide pentahydrate; dimethyl sulfoxide at 70℃; for 16h; Inert atmosphere;	80%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 150-60-7
dibenzyl disulphide

: 5-(methylsulfonyl)-2-phenylbenzoxazole

Conditions

Conditions	Yield
With N-methylcyclohexylamine; sulfur; dimethyl sulfoxide at 100℃; for 16h; Inert atmosphere;	74%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 98-86-2
acetophenone

: (5-(methylsulfonyl)benzoxazol-2-yl)(phenyl)methanone

Conditions

Conditions	Yield
With 4-methyl-morpholine; sulfur; dimethyl sulfoxide at 110℃; for 16h; Inert atmosphere;	74%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 936-99-2
3-tert-butylcyclohexanone

: (5aS*,11aS*,15S*)-15-(tert-butyl)-2,8-bis(methylsulfonyl)-6,12-dihydro-5a,11a-butanobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine

Conditions

Conditions	Yield
With sulfur; acetic acid; dimethyl sulfoxide at 80℃; for 16h; Inert atmosphere; stereoselective reaction;	72%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 950772-15-3
1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinone

: 1134197-45-7
2-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-(methylsulfonyl)phenol

Conditions

Conditions	Yield
Stage #1: 1-hydroxy-2-amino-4-methylsulphonyl-benzene; 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinone With polymer supported cyanoborohydride; acetic acid In tetrahydrofuran at 100℃; for 0.5h; Microwave; Stage #2: With ammonia In methanol; dichloromethane	67%
With acetic acid In dichloromethane at 100℃; Microwave irradiation;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 140-89-6
potassium ethyl xanthogenate

: 93614-45-0
5-(methylsulfonyl)benzoxazole-2-thione

Conditions

Conditions	Yield
With pyridine for 3h; Heating;	57%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 107-02-8
acrolein

: 1417737-57-5
5-(methylsulfonyl)quinolin-8-ol

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In water for 2h; Skraup, Doebner-Miller Synthesis; Reflux;	57%
With hydrogenchloride In water at 100℃; for 1h; Skraup Quinoline Synthesis; Inert atmosphere;	52%

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 950772-26-6
1-[trans-1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinone

: 1134197-77-5
2-({1-[trans-1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinyl}amino)-4-(methylsulfonyl)phenol

Conditions

Conditions	Yield
Stage #1: 1-hydroxy-2-amino-4-methylsulphonyl-benzene; 1-[trans-1-methyl-4-(propyloxy)cyclohexyl]-4-piperidinone With polymer supported cyanoborohydride; acetic acid In tetrahydrofuran at 100℃; for 1.5h; Microwave; Stage #2: With ammonia In methanol; dichloromethane	35%
With acetic acid In dichloromethane at 100℃; Microwave irradiation;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 598-21-0
2-Bromoacetyl bromide

: 459190-08-0
6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform; water at 0 - 20℃;	33%
With caesium carbonate In N,N-dimethyl-formamide

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 74-11-3
para-chlorobenzoic acid

: 2-(4-chlorophenyl)-5-(methylsulfonyl)benzo[d]oxazole

Conditions

Conditions	Yield
With polyphosphoric acid Heating;	21%

: 75-44-5
phosgene

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 13920-98-4
5-methanesulfonyl-3H-benzooxazol-2-one

Conditions

Conditions	Yield
With alkaline solution

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 101861-04-5
2-amino-4-methanesulfonyl-6-nitrophenol

Conditions

Conditions	Yield
With sulfuric acid; water; nitric acid

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 854450-37-6
2-hydroxy-5-methanesulfonyl-benzenediazonium-betaine

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 52238-17-2
4,4'-stilbenedicarbonyl dichloride

: C30H26N2O8S2

Conditions

Conditions	Yield
Heating;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 13234-52-1
1,4-naphthalenedicarboxylic acid dichloride

: 40349-94-8
Naphthalene-1,4-dicarboxylic acid bis-[(2-hydroxy-5-methanesulfonyl-phenyl)-amide]

Conditions

Conditions	Yield
Heating;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 177268-37-0
2-Chloro-5-methanesulfonyl-benzooxazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 57 percent / pyridine / 3 h / Heating 2: 100 percent / thionyl chloride, DMF / 0.5 h / 65 - 70 °C View Scheme

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 1027247-39-7
(5-Methanesulfonyl-benzooxazol-2-yl)-prop-2-ynyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 57 percent / pyridine / 3 h / Heating 2: 100 percent / thionyl chloride, DMF / 0.5 h / 65 - 70 °C 3: 21 percent / triethylamine / acetonitrile / 0.5 h / 65 - 70 °C View Scheme

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 6-Methanesulfonyl-2H-9-oxa-1,4a-diaza-fluorene

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 57 percent / pyridine / 3 h / Heating 2: 100 percent / thionyl chloride, DMF / 0.5 h / 65 - 70 °C 3: 21 percent / triethylamine / acetonitrile / 0.5 h / 65 - 70 °C 4: silver tetrafluoroborate / CD3CN / 40 °C View Scheme

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 1-(2-hydroxy-5-methanesulfonyl-phenylazo)-3-methanesulfonyl-cyclopenta-2,4-dienecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: water / bei der Einwirkung von Sonnenlicht View Scheme

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 3-methanesulfonyl-1-(5-methanesulfonyl-2-methoxy-phenylazo)-cyclopenta-2,4-dienecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: water / bei der Einwirkung von Sonnenlicht 3: aq. NaOH solution View Scheme

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 1134198-09-6
1-{trans-4-[(cyclopropylmethyl)oxy]-1-methylcyclohexyl}-4-piperidinone

: 1134198-10-9
2-[(1-{trans-1-methyl-4-[(cyclopropylmethyl)oxy]cyclohexyl}-4-piperidinyl)amino]-4-(methylsulfonyl)phenol

Conditions

Conditions	Yield
With acetic acid In tetrahydrofuran at 100℃; for 1.5h; Microwave;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 1134198-16-5
1-{trans-1-methyl-4-[(1-methylethyl)oxy]cyclohexyl}-4-piperidinone

: 1134198-17-6
2-[(1-{trans-1-methyl-4-[(1-methylethyl)oxy]cyclohexyl}-4-piperidinyl)amino]-4-(methylsulfonyl)phenol

Conditions

Conditions	Yield
With acetic acid In tetrahydrofuran at 100℃; for 1h; Microwave;

: 98-30-6
1-hydroxy-2-amino-4-methylsulphonyl-benzene

: 93-09-4
naphthalene-2-carboxylate

: 1118624-27-3
5-(methylsulfonyl)-2-(naphthalen-2'-yl)benzo[d]oxazole

Conditions

Conditions	Yield
With polyphosphoric acid at 110 - 120℃; for 16h;	1.157 g

2-Amino-4-(methylsulfonyl)phenol Chemical Properties

Molecular Structure:

Molecular Formula: C₇H₉NO₃S
Molecular Weight: 187.2163
IUPAC Name: 2-Amino-4-methylsulfonylphenol
Synonyms of Phenol,2-amino-4-(methylsulfonyl)- (CAS NO.98-30-6): 2-Amino-4-(methylsulfonyl)phenol ; CCRIS 5961 ; EINECS 202-654-4 ; 2-Amino-4-(methylsulphonyl)phenol
CAS NO: 98-30-6
Index of Refraction: 1.603
Molar Refractivity: 45.343 cm³
Molar Volume: 131.921 cm³
Surface Tension: 59.57 dyne/cm
Density: 1.419 g/cm³
Flash Point: 217.648 °C
Enthalpy of Vaporization: 71.942 kJ/mol
Boiling Point: 436.27 °C at 760 mmHg

Product Name

2-Amino-4-(methylsulfonyl)phenol

Synthetic route

2-Amino-4-(methylsulfonyl)phenol Chemical Properties

Related Products

Hot Products