2-Amino-4-Methylbenzoic Acid supplier

Name
2-Amino-4-methylbenzoic acid
EINECS 218-976-3
CAS No. 2305-36-4
Article Data26
CAS DataBase
Density 1.254 g/cm³
Solubility
Melting Point 174-177 ºC
Formula C8H9 N O2
Boiling Point 329.8 °C at 760 mmHg
Molecular Weight 151.165
Flash Point 153.3 °C
Transport Information
Appearance white crystalline powder
Safety S26;S37/39
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols
Synonyms p-Toluicacid, 2-amino- (6CI,7CI,8CI); 2-Amino-4-methylbenzoic acid; 2-Amino-p-toluicacid; 4-Methylanthranilic acid; NSC 39155
PSA 63.32000
LogP 1.85660

Synthetic route

: 27329-27-7
4-methyl-2-nitrobenzoic acid

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr;	100%
With platinum (IV) oxide; hydrogen In methanol for 3h;	98%
With palladium on activated carbon; hydrogen In ethyl acetate at 20℃; for 14h; Saturated gas;	95%
With hydrogenchloride; tin
With iron(III) chloride; hydrazine hydrate; sodium hydroxide In water at 70℃; for 1h; Temperature;

: 7697-27-0
2-bromo-4-methylbenzoic acid

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate In 1-methyl-pyrrolidin-2-one at 110℃; for 12h;	87%

: 89-58-7
mononitro-p-xylene

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With selenium; nitrobenzene; sodium hydroxide In methanol; water; dimethyl sulfoxide at 90℃; for 5h; Inert atmosphere;	70%

: 53078-85-6
2-bromo-5-methylaniline

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With tert.-butyl lithium In hydrogenchloride; diethyl ether; water; pentane	59%

: 1128-47-8
6-methylindoline-2,3-dione

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide

: 33900-96-8
7-methyl-3-m-tolyl-1H-quinazoline-2,4-dione

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 39549-79-6
2-amino-4-methylbenzamide

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 26830-96-6
5-methyl-2-cyanoaniline

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 67-56-1
methanol

: 1128-47-8
6-methylindoline-2,3-dione

A: 18595-17-0
methyl 4-methylanthranilate

B: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;

...Expand

: 1128-47-8
6-methylindoline-2,3-dione

: 7722-84-1
dihydrogen peroxide

: furan-2,3,5(4H)-trione pyridine (1:1)

: 2305-36-4
4-methylanthranilic acid

...Expand

: 63480-11-5
7-methyl-2H-3,1-benzoxazin-2,4(1H)-dione

acid: acid

A: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

B: 2305-36-4
4-methylanthranilic acid

...Expand

: 63480-11-5
7-methyl-2H-3,1-benzoxazin-2,4(1H)-dione

alkaline solution: alkaline solution

A: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

B: 2305-36-4
4-methylanthranilic acid

...Expand

: 7647-01-0
hydrogenchloride

: 27329-27-7
4-methyl-2-nitrobenzoic acid

tin: tin

: 2305-36-4
4-methylanthranilic acid

...Expand

: 85167-56-2
4,4'-dimethyl-2,2'-triazenediyl-di-benzonitrile

alkaline solution: alkaline solution

: 2305-36-4
4-methylanthranilic acid

: 26830-95-5
4-methyl-2-nitrobenzonitrile

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated hydrochloric acid / im Druckrohr 2: tin; hydrochloric acid View Scheme

: 81115-52-8
2-acetylamino-4-methylbenzoic acid

: 62-53-3
aniline

A: 103-84-4
Acetanilid

B: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
In toluene at 20 - 110℃; for 10h;	A 0.12 g B 0.1 g

...Expand

: 18595-17-0
methyl 4-methylanthranilate

: 2305-36-4
4-methylanthranilic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; ethanol; water at 50℃; for 3h; Inert atmosphere;

: 186581-53-3, 908094-01-9
diazomethane

: 2305-36-4
4-methylanthranilic acid

: 18595-17-0
methyl 4-methylanthranilate

Conditions

Conditions	Yield
In diethyl ether for 1h; Inert atmosphere;	100%

: 57-13-6
urea

: 2305-36-4
4-methylanthranilic acid

: 62484-15-5
7-methyl-quinazoline-2,4(1H,3H)-dione

Conditions

Conditions	Yield
at 160℃; for 10h;	99%
at 180℃; for 2h;	85%
Stage #1: urea; 4-methylanthranilic acid at 160℃; for 6h; Stage #2: With water at 100℃; for 0.0833333h;	41%

: triphosgene

: 2305-36-4
4-methylanthranilic acid

: 63480-11-5
7-methyl-2H-3,1-benzoxazin-2,4(1H)-dione

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate at 20℃; for 0.25h;	99%

: 103-72-0
phenyl isothiocyanate

: 2305-36-4
4-methylanthranilic acid

: 7-methyl-3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 3h; Reflux;	97%

: 32315-10-9
bis(trichloromethyl) carbonate

: 2305-36-4
4-methylanthranilic acid

: 63480-11-5
7-methyl-2H-3,1-benzoxazin-2,4(1H)-dione

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 5h; Inert atmosphere; Large scale;	93%
In tetrahydrofuran at 20℃;
In tetrahydrofuran at -5℃; for 5h;
Stage #1: 4-methylanthranilic acid In 1,4-dioxane Reflux; Stage #2: bis(trichloromethyl) carbonate In 1,4-dioxane Reflux;

: 6061-04-7
1,1-dichloro-2-nitro ethylene

: 2305-36-4
4-methylanthranilic acid

: 4-methyl-2-(2-nitroacetamido)benzoic acid

Conditions

Conditions	Yield
In water at 50℃; for 5h; Green chemistry;	92%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 2305-36-4
4-methylanthranilic acid

: 1309763-88-9
C13H16N2O

Conditions

Conditions	Yield
at 150℃; for 2h; Neat (no solvent);	90%

: 874-60-2
4-methyl-benzoyl chloride

: 2305-36-4
4-methylanthranilic acid

: 2-benzoylamino-4-methyl-benzoic acid

Conditions

Conditions	Yield
With triethylamine at 20℃;	90%

: 16502-01-5
tetrahydrobetacarboline

: 2305-36-4
4-methylanthranilic acid

: (2-amino-4-methylphenyl)(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)methanone

Conditions

Conditions	Yield
With triethylamine; HATU	90%

: 67-56-1
methanol

: 2305-36-4
4-methylanthranilic acid

: 18595-17-0
methyl 4-methylanthranilate

Conditions

Conditions	Yield
With thionyl chloride	89%
With sulfuric acid for 48h; Reflux;	84%
Stage #1: methanol; 4-methylanthranilic acid With sulfuric acid at 0℃; for 16h; Reflux; Stage #2: With sodium hydrogencarbonate In water	82%

: 104-88-1
4-chlorobenzaldehyde

: 100-46-9
benzylamine

: 2305-36-4
4-methylanthranilic acid

: 3-benzyl-2-(4-chlorophenyl)-7-methylquinazolin-4(3H)-one

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone In ethyl acetate at 20℃; for 5h;	89%

...Expand

: 2305-36-4
4-methylanthranilic acid

: 81335-87-7
(2-amino-4-methylphenyl)methanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 2h;	87%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 45℃;	70%
With sulfuric acid at 25℃; durch elektrolytische Reduktion an einer Bleikathode;

: 79-04-9
chloroacetyl chloride

: 2305-36-4
4-methylanthranilic acid

: 65077-83-0
2-(2-chloroacetamido)-4-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-methylanthranilic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: chloroacetyl chloride at 0 - 20℃;	87%
In benzene for 0.5h; Heating;
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;

: 2305-36-4
4-methylanthranilic acid

: 329-01-1
1-isocyanato-3-trifluoromethyl-benzene

: 4-methyl-2-[3-(3-trifluoromethyl-phenyl)-ureido]-benzoic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	87%

: 931-53-3
Cyclohexyl isocyanide

: 2305-36-4
4-methylanthranilic acid

: 1309763-87-8
C15H18N2O

Conditions

Conditions	Yield
at 150℃; for 2h; Neat (no solvent);	87%

: 14542-93-9
1,1,3,3-tetramethylbutane isonitrile

: 2305-36-4
4-methylanthranilic acid

: 1309763-89-0
C17H24N2O

Conditions

Conditions	Yield
at 150℃; for 2h; Neat (no solvent);	86%

: 2305-36-4
4-methylanthranilic acid

: Bis-(2-carboxy-5-methyl-phenyl)-diselenid

Conditions

Conditions	Yield
Stage #1: 4-methylanthranilic acid With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: With sodium diselenide In water at 50℃; for 2.5h;	86%

: 2305-36-4
4-methylanthranilic acid

: 18595-17-0
methyl 4-methylanthranilate

Conditions

Conditions	Yield
In methanol	85.7%

: 2-bromo-1-chloro-3-iodobenzene

: 2305-36-4
4-methylanthranilic acid

: C14H11BrClNO2

Conditions

Conditions	Yield
With potassium acetate; copper diacetate; copper at 140℃; Inert atmosphere;	85%
With potassium acetate; copper diacetate; copper at 140℃; Inert atmosphere;	82.2%

: C11H15BrClNO

: 2305-36-4
4-methylanthranilic acid

: C19H23ClN2O3

Conditions

Conditions	Yield
With potassium acetate; copper diacetate; copper In water at 20 - 140℃; Inert atmosphere;	84.8%

: 590-28-3
potassium cyanate

: 2305-36-4
4-methylanthranilic acid

: 62484-15-5
7-methyl-quinazoline-2,4(1H,3H)-dione

Conditions

Conditions	Yield
Stage #1: potassium cyanate; 4-methylanthranilic acid With acetic acid In water at 20℃; for 0.5h; Stage #2: With sodium hydroxide In water at 50℃;	83%

: 17356-08-0
thiourea

: 2305-36-4
4-methylanthranilic acid

: 1463501-49-6
C9H8N2OS

Conditions

Conditions	Yield
at 40℃; for 2.5h; Inert atmosphere; Ionic liquid;	83%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 2305-36-4
4-methylanthranilic acid

: 75844-40-5
7-methyl-quinazolin-4(3H)-one

Conditions

Conditions	Yield
at 140℃;	82%
at 150℃; for 1h; Temperature; Microwave irradiation;	63%
at 120 - 130℃;

: 98-88-4
benzoyl chloride

: 2305-36-4
4-methylanthranilic acid

: 7-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 3h; Inert atmosphere;	82%
With pyridine

: 1221280-89-2
6-[(R)-5-(3-amino-propyl)-2-oxo-oxazolidin-3-yl]-4H-benzo[1,4]thiazin-3-one

: 2305-36-4
4-methylanthranilic acid

: 2-amino-4-methyl-N-{3-[(R)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-yl]-propyl}-benzamide

Conditions

Conditions	Yield
	82%

: bis-silyl-1,3-dienediolate

: 100-52-7
benzaldehyde

: 2305-36-4
4-methylanthranilic acid

: C21H21NO4

Conditions

Conditions	Yield
Stage #1: bis-silyl-1,3-dienediolate; benzaldehyde; 4-methylanthranilic acid With water; samarium(III) trifluoromethanesulfonate In dichloromethane; tert-butyl alcohol at -20℃; Inert atmosphere; Stage #2: With 2,4-dinitrobenzenesulfonic acid In dichloromethane; tert-butyl alcohol at -20℃; Inert atmosphere; diastereoselective reaction;	80%

...Expand

: 51674-77-2
4-chloropyrido<3,2-d>pyrimidine

: 2305-36-4
4-methylanthranilic acid

: 1304513-65-2
C14H12N4O

Conditions

Conditions	Yield
With hydrogenchloride; water In isopropyl alcohol at 140℃; for 1h; Microwave irradiation;	79%

: 917-54-4
methyllithium

: 2305-36-4
4-methylanthranilic acid

: 122710-21-8
2’-amino-4’-methylacetophenone

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; monoethylene glycol diethyl ether at 0℃; for 2h; Inert atmosphere;	79%

2-Amino-4-Methylbenzoic Acid Chemical Properties

Molecular Formula: C₈H₉NO₂
Molar mass:151.16256 g/mol
Structure of 2-Amino-4-methylbenzoic acid(2305-36-4):

Synonyms of2-Amino-4-methylbenzoic acid(2305-36-4):Benzoic acid, 2-amino-4-methyl-;4-METHYLANTHRANILIC ACID;Benzoic acid, 2-amino-4-methyl- (9CI)
Melting point:174-177 ^oC
Density:1.254 g/cm³
Flash Point:153.3 °C
Boiling Point: 329.8 °C at 760 mmHg

2-Amino-4-Methylbenzoic Acid Safety Profile

Hazard Codes:Xi

Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37: Wear suitable gloves
39: Wear eye/face protection

2-Amino-4-Methylbenzoic Acid Specification

Product Categories of 2-Amino-4-methylbenzoic acid(2305-36-4):CARBOXYLICACID;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Carboxylic Acids;Phenyls & Phenyl-Het;Benzoic acid;Phenyls & Phenyl-Het;API intermediates

Product Name

2-Amino-4-methylbenzoic acid

Synthetic route

2-Amino-4-Methylbenzoic Acid Chemical Properties

2-Amino-4-Methylbenzoic Acid Safety Profile

2-Amino-4-Methylbenzoic Acid Specification

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