2-Amino-5-Chloropyridine supplier

Name
2-Amino-5-chloropyridine
EINECS 214-020-4
CAS No. 1072-98-6
Article Data39
CAS DataBase
Density 1.326 g/cm³
Solubility 1 g/L (20 °C) in water
Melting Point 134-138 °C
Formula C₅H₅ClN₂
Boiling Point 257.8 °C at 760 mmHg
Molecular Weight 128.561
Flash Point 94.7 °C
Transport Information
Appearance beige to beige-brown crystalline powder
Safety 22-24/25-37/39-26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms AI3-52448;2-Pyridinamine, 5-chloro-;5-Chloro-2-pyridylamine;
PSA 38.91000
LogP 1.89840

Synthetic route

: 504-29-0
2-aminopyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With N-chloro-N-fluoro-benzenesulfonamide; 1,3-dimethylimidazolium chloride In dichloromethane at 25℃; for 1.5h; Reagent/catalyst; Concentration; Solvent; Temperature;	99%
With bromine; chlorine In acetonitrile for 2h; Solvent; UV-irradiation;	99.4%
With N-ethylpyridinium chloride aluminum trichloride; chlorine In acetonitrile for 0.833333h; Solvent; Reagent/catalyst; Microwave irradiation;	99.4%

: 74405-03-1
2,2-dimethyl-3-(5-chloropyrid-2-yl)-4-4H-1,3-benzoxazine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With hydrogenchloride for 8h; Heating;	95%

: 171774-38-2
N-(3-bromo-5-chloropyridin-2-yl)pyridin-1-ium-1-aminide

A: 1072-98-6
5-chloro-2-pyridylamine

B: 3-chloro-dipyrido[1,2-b;3',2'-d]pyrazole

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In acetonitrile; benzene at 80℃; for 24h;	A 90% B 2%
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile; benzene at 80℃; for 24h; Product distribution; Further Variations:; Reagents;	A 5% B 56%

: 19596-07-7
pent-4-ynenitrile

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With iron(III) chloride; chlorine; sodium hydroxide In chloroform; water at 40 - 45℃; for 5h; Solvent; Inert atmosphere;	89.1%

: C10H7ClIN3

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With triethylammonium formate; platinum on activated charcoal In acetonitrile for 4h; Heating;	87%

: 1480-65-5
2-fluoro-5-chloropyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;	84%

: 52092-47-4
5-chloro-2-nitropyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With sulfuric acid; hydrogen In ethanol at 25℃; Electrochemical reaction;	82%
With boron dimethyl-trifluoro sulphide In dichloromethane at 60℃; for 0.5h; Sealed tube;	72%
With hydrogenchloride; sodium hydrogensulfide
With hydrogenchloride; tin(ll) chloride
With ammonium hydroxide; iron(II) sulfate

: 172617-53-7
pyridinium N-(5'-chloropyridin-2'-yl)aminide

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With zinc In acetic acid for 29h; Ambient temperature;	79%

: propanal (5-chloropyridin-2-yl)hydrazone

A: 1072-98-6
5-chloro-2-pyridylamine

B: 1256803-09-4
5-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 72% B 6%

: 504-29-0
2-aminopyridine

A: 1072-98-6
5-chloro-2-pyridylamine

B: 39620-04-7
2-amino-3-chloropyridine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hypochlorite at 10 - 25℃; for 6h; Overall yield = 5.82 g;	A 71.6% B n/a

: 1-benzylpiperidin-4-one (5-chloropyridin-2-yl)hydrazone

A: 1072-98-6
5-chloro-2-pyridylamine

B: 6-benzyl-3-chloro-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid for 14h; Fischer Indole Synthesis; Inert atmosphere; Heating;	A 30% B 49%

: phenylethanal (5-chloropyridin-2-yl)hydrazone

A: 1072-98-6
5-chloro-2-pyridylamine

B: 5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 40% B 28%

: 1-methylpiperidin-4-one (5-chloropyridin-2-yl)hydrazone

A: 1072-98-6
5-chloro-2-pyridylamine

B: 1394062-37-3
3-chloro-6-methyl-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid for 14h; Fischer Indole Synthesis; Inert atmosphere; Heating;	A 29% B 36%

: butanal (5-chloropyridin-2-yl)hydrazone

A: 1072-98-6
5-chloro-2-pyridylamine

B: 5-chloro-3-ethyl-1H-pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid at 160 - 180℃; for 0.0833333h; Fischer Indole Synthesis;	A 36% B 25%

: 504-29-0
2-aminopyridine

A: 1072-98-6
5-chloro-2-pyridylamine

B: 4214-74-8
3,5-dichloropyridin-2-amine

Conditions

Conditions	Yield
With chloroform; chlorine
With chlorine; acetic acid
With chloroform; chlorine; acetic acid

: 504-29-0
2-aminopyridine

: 64-17-5
ethanol

: 7782-50-5
chlorine

: 1072-98-6
5-chloro-2-pyridylamine

...Expand

: 504-29-0
2-aminopyridine

: 67-66-3
chloroform

: 7782-50-5
chlorine

: 1072-98-6
5-chloro-2-pyridylamine

...Expand

: 504-29-0
2-aminopyridine

: 7782-50-5
chlorine

: 64-19-7
acetic acid

: 1072-98-6
5-chloro-2-pyridylamine

...Expand

diazotized 2.5-diamino-pyridine: diazotized 2.5-diamino-pyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With copper(l) chloride

: 6-amino-pyridine-3-diazonium ; chloride

copper (I)-chloride: copper (I)-chloride

: 1072-98-6
5-chloro-2-pyridylamine

: 1851-22-5
3-chloropyridine-N-oxide

A: 1072-98-6
5-chloro-2-pyridylamine

B potassium nitrite: potassium nitrite

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 68 percent / CHCl3 / 4 h / Heating 2: 95 percent / conc. HCl / 8 h / Heating View Scheme

: 15128-82-2
3-hydroxy-2-nitropyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water 5: FeSO4; aqueous NH3 View Scheme
Multi-step reaction with 5 steps 1: acetic acid; acetic acid anhydride; nitric acid 2: phosphorus (V)-chloride / 130 °C 3: methanol; N2H4 4: silver acetate; water 5: FeSO4; aqueous NH3 View Scheme

: 99848-04-1
(3-chloro-6-nitro-[2]pyridyl)-hydrazine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: silver acetate; water 2: FeSO4; aqueous NH3 View Scheme

: 15128-91-3
3-hydroxy-2,6-dinitropyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: phosphorus (V)-chloride / 130 °C 2: methanol; N2H4 3: silver acetate; water 4: FeSO4; aqueous NH3 View Scheme

: 101079-67-8
3-chloro-2,6-dinitro-pyridine

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol; N2H4 2: silver acetate; water 3: FeSO4; aqueous NH3 View Scheme

: 504-29-0
2-aminopyridine

concentrated sodium hydroxide: concentrated sodium hydroxide

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
With hydrogenchloride; chlorine In water; Petroleum ether

: 5-chloro-N-formyl-N-(3-oxobutyl)-2-pyridylamine

A: 1072-98-6
5-chloro-2-pyridylamine

B: 78-94-4
methyl vinyl ketone

Conditions

Conditions	Yield
With ammonium acetate

: N'-(5-chloropyridin-2-yl)-N,N-dimethylformimidamide

: 1072-98-6
5-chloro-2-pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water / 0.92 h / 140 °C / Microwave irradiation; Inert atmosphere; Sealed tube 2: ammonium acetate View Scheme

: 1072-98-6
5-chloro-2-pyridylamine

: 3282-30-2
pivaloyl chloride

: 86847-83-8
N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 1.08333h;	99%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1h;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 4743-17-3
5-Chloroisatoic anhydride

: (2-amino-5-chlorophenyl)-N-(5-chloro(2-pyridyl))carboxamide

Conditions

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	100%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	99%
With potassium hexamethylsilazane In tetrahydrofuran; toluene	99%

: 1072-98-6
5-chloro-2-pyridylamine

: 3740-52-1
2-(2-nitrophenyl)acetic acid

: 349124-95-4
N-(5-chloropyridin-2-yl)-2-(2-nitrophenyl)acetamide

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%

: 1072-98-6
5-chloro-2-pyridylamine

: 4743-17-3
5-Chloroisatoic anhydride

: 229343-30-0
2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 0.5h; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃;	100%
Stage #1: 5-chloro-2-pyridylamine With potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; for 0.5h; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃;	99%
Stage #1: 5-chloro-2-pyridylamine With dmap; potassium hexamethylsilazane In tetrahydrofuran; toluene at -78℃; Inert atmosphere; Stage #2: 5-Chloroisatoic anhydride In tetrahydrofuran; toluene at -78 - 20℃; for 10h; Inert atmosphere;

: 1072-98-6
5-chloro-2-pyridylamine

: 921-03-9
1,1,3-trichloroacetone

: 6-chloro-2-(dichloromethyl)-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrochloride

Conditions

Conditions	Yield
In tetrahydrofuran at 20 - 70℃; for 16.5h;	100%

: 1072-98-6
5-chloro-2-pyridylamine

: 852370-52-6
2-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-pyrido[3,4-d][1,3]oxazin-4-one

: 852370-53-7
3-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-4-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine; allylmagnesium bromide In tetrahydrofuran; diethyl ether at 0℃; for 0.0833333h; Stage #2: 2-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-pyrido[3,4-d][1,3]oxazin-4-one In tetrahydrofuran; diethyl ether at 0 - 20℃;	99%

: 1072-98-6
5-chloro-2-pyridylamine

: 4744-50-7
2,3-pyrazinedicarboxylic anhydride

: 43200-83-5
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	99%
In tetrahydrofuran at 20℃; for 1h;	99%
In dichloromethane at 5 - 20℃; for 3.5h; Product distribution / selectivity;
Stage #1: 5-chloro-2-pyridylamine; 2,3-pyrazinedicarboxylic anhydride In toluene at 20 - 52℃; for 2.5h; Stage #2: With hydrogenchloride In water at 10 - 15℃; for 1h;

: tetrakis-pivaloyloxymethyl ester of vinylidene-1,1-bisphosphonate

: 1072-98-6
5-chloro-2-pyridylamine

: tetrakispivaloyloxymethyl 2-(5-chloropyridine-2-ylamino)ethylidene-1,1-bisphosphonate

Conditions

Conditions	Yield
In chloroform at 20℃; for 1h;	99%

: 1072-98-6
5-chloro-2-pyridylamine

: 721-04-0
2-phenoxy-1-phenylethanone

: 6-chloro-3-phenoxy-2-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	99%

: 1072-98-6
5-chloro-2-pyridylamine

: 721-04-0
2-phenoxy-1-phenylethanone

: 3-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-6-bromoimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	99%

: 1072-98-6
5-chloro-2-pyridylamine

: 1885-14-9
phenyl chloroformate

: 95651-20-0
phenyl 5-chloropyridin-2-ylcarbamate

Conditions

Conditions	Yield
With pyridine In dichloromethane for 2h; Cooling with ice;	98%
With pyridine at 20℃;

: 1072-98-6
5-chloro-2-pyridylamine

: 98416-35-4
N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide

: 1435914-39-8
N-{2,2-dichloro-1-[(5-chloro-2-pyridinyl)amino]-2-phenylethyl}-4-chlorobenzenesulfonamide

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃; for 4h;	98%

: 1072-98-6
5-chloro-2-pyridylamine

: 630-18-2
tert-butyl isocyanide

: 100-52-7
benzaldehyde

: N-tert-butyl-6-chloro-2-phenylimidazo[1,2-a]pyridin-3-amine

Conditions

Conditions	Yield
With praseodymium(III) chloride In ethanol at 60℃; for 1h; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere;	98%

...Expand

: 1072-98-6
5-chloro-2-pyridylamine

: 163105-89-3
2-methoxy-pyridine-5-boronic acid

: 5-(6-methoxypyridin-3-yl)pyridin-2-amine

Conditions

Conditions	Yield
With potassium acetate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In water; butan-1-ol at 100℃; Suzuki-Miyaura cross-coupling;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 15865-57-3
2-nitro-3-methoxybenzoyl chloride

: 229342-58-9
N-(5-chloro-2-pyridinyl)-2-nitro-3-methoxyphenylcarboxamide

Conditions

Conditions	Yield
With pyridine; dmap at 20℃;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 1227600-76-1
2-bromo-1-[3-nitro-4-(trifluoromethyl)phenyl]ethanone

: 1383624-94-9
6-chloro-2-[3-nitro-4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
In acetonitrile at 100℃; for 18h;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 98416-35-4
N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide

: 1435914-48-9
N-(6-chloro-2-phenylimidazo[1,2-a]pyridine-3-yl)-4-chlorobenzenesulfonamide

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-pyridylamine; N-(2-benzene-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide In 1,4-dioxane at 20℃; for 4h; Stage #2: With sodium hydroxide at 20℃; for 5h;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 105-45-3
acetoacetic acid methyl ester

: 64500-18-1
7-chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
With bismuth(III) chloride at 100℃; for 3h; Green chemistry;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 19514-02-4
alpha-(3-methylphenoxy)acetophenone

: 6-chloro-2-phenyl-3-(m-tolyloxy)imidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	97%

: 1072-98-6
5-chloro-2-pyridylamine

: 74503-07-4
allyl oxalyl chloride

: 2-[(5-chloro-2-pyridyl)amino]-2-oxoacetic acid allyl ester hydrochloride

Conditions

Conditions	Yield
In acetonitrile at 30 - 50℃;	96.5%

: 1072-98-6
5-chloro-2-pyridylamine

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 280773-16-2
5-methoxy-2-nitro-N-(5-chloro-pyridine-2-yl)benzamide

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 1h; Solvent; Temperature;	96.2%
With pyridine; trichlorophosphate In acetonitrile at 0 - 30℃; for 1h; Inert atmosphere;	94%
With pyridine; trichlorophosphate In acetonitrile at 19 - 28℃; for 1h;	88.2%

: 1072-98-6
5-chloro-2-pyridylamine

: 104-88-1
4-chlorobenzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 79202-10-1
diethyl

Conditions

Conditions	Yield
at 80 - 100℃;	96%

...Expand

: 1072-98-6
5-chloro-2-pyridylamine

: 98-59-9
p-toluenesulfonyl chloride

: 54818-84-7
N-[5-Chloro-1H-pyridin-(2Z)-ylidene]-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With pyridine at 80 - 90℃;	96%

: 1072-98-6
5-chloro-2-pyridylamine

: 264881-99-4
methyl 2-(4-bromophenyl)-2-diazoacetate

: 1394824-05-5
methyl 2-(4-bromophenyl)-2-((5-chloropyridin-2-yl)amino)acetate

Conditions

Conditions	Yield
at 102℃; for 12h; Inert atmosphere;	96%

: 1072-98-6
5-chloro-2-pyridylamine

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 36404-88-3
2-chloro-3-carbaldehydepyridine

: N-tert-butyl-6-chloro-2-(2-chloropyridin-3-yl)imidazo[1,2-a]pyridin-3-amine

Conditions

Conditions	Yield
With iodine In ethanol at 70℃; for 0.5h; Solvent; Temperature;	96%

...Expand

: 1072-98-6
5-chloro-2-pyridylamine

: 2,2-dimethoxy-2-phenylethyl 4-methylbenzenesulfonate

: 168837-18-1
6-chloro-2-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) In acetonitrile at 120℃; for 24h;	96%

: 1072-98-6
5-chloro-2-pyridylamine

: C16H16O2

: 6-chloro-3-(4-ethylphenoxy)-2-phenylimidazo[1,2-a]pyridine

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	96%

: 1072-98-6
5-chloro-2-pyridylamine

: 122-01-0
4-chloro-benzoyl chloride

: 4-chloro-N-(5-chloropyridin-2-yl)benzamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h; Cooling;	96%

: 1072-98-6
5-chloro-2-pyridylamine

: 74205-82-6
1-(hydroxymethyl)-1,2,4-triazole

: (5-chloro-pyridin-2-yl)-[1,2,4]triazol-1-ylmethyl-amine

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	95.87%

2-Amino-5-Chloropyridine Specification

The IUPAC name of 2-Amino-5-Chloropyridine is 5-chloropyridin-2-amine. With the CAS registry number 1072-98-6, it is also named as 2-Pyridinamine, 5-chloro-. The product's categories are Nitrogen Cyclic Compounds; Amines; Bromides; Pyridines; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines Derivates; Chloropyridines; Halopyridines; Heterocyclic Building Blocks. It is beige to beige-brown crystalline powder which is stable under normal temperature and pressure. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.69; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.68; (5)ACD/BCF (pH 5.5): 9.76; (6)ACD/BCF (pH 7.4): 11.2; (7)ACD/KOC (pH 5.5): 170.92; (8)ACD/KOC (pH 7.4): 196.14; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.607; (13)Molar Refractivity: 33.47 cm³; (14)Molar Volume: 96.8 cm³; (15)Polarizability: 13.27×10^-24 cm³; (16)Surface Tension: 54.3 dyne/cm; (17)Enthalpy of Vaporization: 49.54 kJ/mol; (18)Vapour Pressure: 0.0142 mmHg at 25°C; (19)Tautomer Count: 2; (20)Exact Mass: 128.014126; (21)MonoIsotopic Mass: 128.014126; (22)Topological Polar Surface Area: 38.9; (23)Heavy Atom Count: 8; (24)Complexity: 76.8.

Preparation of 2-Amino-5-Chloropyridine: It can be obtained by 2,2-dimethyl-3-(5-chloropyrid-2-yl)-4-4H-1,3-benzoxazine. This reaction needs reagent conc. HCl by heating. The reaction time is 8 hours. The yield is 95%.

Uses of 2-Amino-5-Chloropyridine: It is used to produce herbicide and drug Zopiclone. It also can be used in organic synthesis. For example: it can react with hexane-2,5-dione to get N-(5-chloro-2-pyridyl)-2,5-dimethylpyrrole. This reaction must react at temperature of 100 °C for 3 hours. The yield is 32%.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. So people should not breathe dust and avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:c1cc(ncc1Cl)N
2. InChI:InChI=1/C5H5ClN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
3. InChIKey:MAXBVGJEFDMHNV-UHFFFAOYAS

Product Name

2-Amino-5-chloropyridine

Synthetic route

2-Amino-5-Chloropyridine Specification

Related Products

Hot Products