2-Amino-5-diethylaminopentane supplier

Name
2-Amino-5-diethylaminopentane
EINECS 205-435-1
CAS No. 140-80-7
Density 0.817
Solubility
Melting Point 37.5°C (estimate)
Formula C9H22 N2
Boiling Point 200.5 °C at 760 mmHg
Molecular Weight 158.287
Flash Point 155 ºF
Transport Information UN 2946
Appearance Colorless clear liquid
Safety Poison by intravenous route. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes R34
Molecular Structure
Hazard Symbols
Synonyms 1-(Diethylamino)-4-aminopentane;1-Methyl-4-(diethylamino)butylamine;2-Amino-5-(diethylamino)pentane;2-Amino-5-diethylamino-n-pentane;4-(Diethylamino)-1-methylbutylamine;4-Amino-1-(diethylamino)pentane;5-(Diethylamino)-2-pentanamine;5-(Diethylamino)-2-pentylamine;N,N-Diethyl-1,4-pentanediamine;N1,N1-Diethyl-1,4-pentanediamine;N5,N5-Diethyl-2,5-pentanediamine;NSC 2606;Novoldiamine;d-(Diethylamino)-a-methylbutylamine;
PSA 29.26000
LogP 2.15590

Synthetic route

: 67459-50-1
(R)-(-)-4-amino-1-(diethylamino)pentane

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With nickel In toluene at 70℃; for 12h;	97.2%

: 5412-69-1
5-diethylaminopentan-2-ol

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With ammonia; nickel at 200℃; unter Druck;
With ammonia; nickel at 200℃; unter Druck;

: 39749-10-5
diethyl-(4-chloro-pentyl)-amine

A: 344325-82-2
N1,N1-diethyl-1-methyl-butanediyldiamine

B: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With potassium phthalide; xylene at 150 - 160℃; anschl. Erwaermen mit HCl;

: 105-14-6
5-diethylamino-2-pentanone

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With methanol; ammonia; nickel at 95 - 96℃; under 36775.4 Torr; Hydrogenation;
With ethanol; ammonia at 40℃;
Multi-step reaction with 2 steps 1: ethanol; Raney nickel; NH3 / Hydrogenation 2: methanol; nickel catalyst; hydrogen; NH3 / 14710.2 Torr View Scheme
With methanol; ammonia; nickel at 70 - 80℃; Hydrogenation.unter Druck;

: 105-14-6
5-diethylamino-2-pentanone

A: 101881-56-5
bis-(4-diethylamino-1-methyl-butyl)-amine

B: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With ethanol; ammonia at 20℃;
With ethanol; ammonia; nickel Hydrogenation;

: 5426-96-0
5-diethylamino-pentan-2-one oxime

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With ethanol; sodium

: 101881-56-5
bis-(4-diethylamino-1-methyl-butyl)-amine

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
With methanol; ammonia; hydrogen; nickel under 14710.2 Torr;

: 7647-01-0
hydrogenchloride

: 491-92-9
pamaquine

: 7732-18-5
water

NaNO2: NaNO2

A: 477601-28-8
6-methoxy-quinolin-8-ol

B: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
anschl. mit methanol. KOH;

...Expand

: 67-56-1
methanol

: 101881-56-5
bis-(4-diethylamino-1-methyl-butyl)-amine

: 7664-41-7
ammonia

hydrogen: hydrogen

nickel catalyst: nickel catalyst

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
under 14710.2 Torr;

...Expand

: 105-14-6
5-diethylamino-2-pentanone

: 7664-41-7
ammonia

nickel: nickel

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 105-14-6
5-diethylamino-2-pentanone

methanol.NH3: methanol.NH3

nickel: nickel

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 18997-67-6
(4-diethylamino-1-methyl-butyl)-dithiocarbamic acid

A: 140-80-7
5-diethylamino-2-pentylamine

B CS2: CS2

Conditions

Conditions	Yield
durch Saeuren;
durch Saeuren;

: 32314-21-9
2-(diethylamino)acetaldehyde

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alkaline solution 2: Raney nickel / Hydrogenation 3: ethanol; NH3 / 40 °C View Scheme

: 136571-69-2
5-diethylamino-pent-3-en-2-one

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney nickel / Hydrogenation 2: ethanol; NH3 / 40 °C View Scheme

: C9H22N2*C8H8O3

: 140-80-7
5-diethylamino-2-pentylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / pH 11 - 12 2: nickel / toluene / 12 h / 70 °C View Scheme

: 1150313-28-2
11-chloro-5-methyl-5H-indolo[2,3-b]quinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 1150313-32-8
N1,N1-diethyl-N4-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)pentane-1,4-diamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 135 - 155℃;	99%
Heating;	98%
at 80 - 120℃;	98%
at 135 - 155℃; Neat (no solvent);	77%

: 3-(1-hydroxyhexylidene)-5-(2-(methylthio)ethyl)-1-(3,5,5-trimethylhexanoyl)pyrrolidine-2,4-dione

: 140-80-7
5-diethylamino-2-pentylamine

: C31H57N3O3S

Conditions

Conditions	Yield
In toluene Reflux;	99%

: 1-benzoyl-3-(1-hydroxy-4-phenoxybutylidene)-5-isobutylpyrrolidine-2,4-dione

: 140-80-7
5-diethylamino-2-pentylamine

: C34H47N3O4

Conditions

Conditions	Yield
In toluene Reflux;	99%

: 607-69-2
2-chloro-4-hydroxy-quinazoline

: 140-80-7
5-diethylamino-2-pentylamine

: 76005-48-6
2-<<4-(diethylamino)-1-methylbutyl>amino>-4-quinazolinol

Conditions

Conditions	Yield
In ethanol for 14h; Heating;	97%

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: 140-80-7
5-diethylamino-2-pentylamine

: 106409-01-2
N,N'-bis(4-diethylamino-1-methylbutyl)perylene-3,4:9,10-tetracarboxylic acid bisimide

Conditions

Conditions	Yield
With 1H-imidazole at 160℃; for 16h;	97%

: 140-80-7
5-diethylamino-2-pentylamine

: 181189-00-4
8-amino-4,6-dichloroquinoline

: 181189-01-5
8-amino-6-chloro-4-(4-diethylamino-1-methylbutyl)aminoquinoline

Conditions

Conditions	Yield
at 180℃; for 16h;	96%

: 501947-42-8
1-[7-chloro-4-(dimethylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one

: 140-80-7
5-diethylamino-2-pentylamine

: 1-[7-chloro-4-(5-diethylaminopentan-2-ylamino)quinolin-3-yl]-2,2,2-trifluoroethan-1-one

Conditions

Conditions	Yield
In acetonitrile for 8h; Reflux;	95%

: 16714-25-3
2-azidobenzaldehyde

: 140-80-7
5-diethylamino-2-pentylamine

: C16H25N3

Conditions

Conditions	Yield
at 100℃; under 10343.2 Torr; Microwave irradiation;	95%

: 17199-29-0
(S)-Mandelic acid

: 140-80-7
5-diethylamino-2-pentylamine

: C9H22N2*C8H8O3

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃;	94.9%

: 611-71-2
(R)-Mandelic Acid

: 140-80-7
5-diethylamino-2-pentylamine

: C9H22N2*C8H8O3

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; for 3h;	94.9%
In isopropyl alcohol at 20℃; for 3h;	94.9%

: 86-98-6
4,7-dichloroquinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 54-05-7
Chloroquine

Conditions

Conditions	Yield
With diethylamine; phenol at 90 - 100℃; under 1140.08 Torr; Temperature; Reagent/catalyst; Pressure;	90.72%
With indium(III) chloride In acetonitrile at 120℃; for 1h; Microwave irradiation; regioselective reaction;	73%
1.) 100 deg C, 2 h, 2.) 150-160 deg C, 5 h;
at 135 - 140℃; for 24h;
With N-ethyl-N,N-diisopropylamine; sodium sulfite In isopropyl alcohol at 133 - 138℃; for 10h;	137.5 g

: 140-80-7
5-diethylamino-2-pentylamine

: 3964-04-3
4-bromoquinoline

: 1915-92-0
4-(4-diethylamino-1-methylbutylamino)-quinoline

Conditions

Conditions	Yield
With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate In 1,4-dioxane at 85℃; for 18h;	88%

: 140-80-7
5-diethylamino-2-pentylamine

: 109-94-4
formic acid ethyl ester

: N,N-diethyl-4-isocyanopentan-1-amine

Conditions

Conditions	Yield
Stage #1: 5-diethylamino-2-pentylamine; formic acid ethyl ester for 16h; Reflux; Stage #2: With bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine In dichloromethane at -40 - 0℃; for 2h;	88%

: 159763-36-7
3-hydroxy-2-methylene-3-(2-nitrophenyl)propanoic acid methyl ester

: 140-80-7
5-diethylamino-2-pentylamine

: methyl 2-[(4-diethylamino-1-methylbutyl)amino-methy]-3-hydroxy-3-(2-nitrophenyl)propanoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 48h;	87%

: 140-80-7
5-diethylamino-2-pentylamine

: 181189-02-6
4-chloro-2-methylquinoline-6-carboxylic acid

: 181189-03-7
4-(4-diethylamino-1-methylbutyl)amino-2-methylquinoline-6-carboxylic acid

Conditions

Conditions	Yield
at 150℃; for 5.5h;	86%

: 21617-12-9
4,8-dichloroquinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 32668-65-8
N4-(8-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine

Conditions

Conditions	Yield
1.) 100 deg C, 2 h, 2.) 140-150 deg C, 7 h;	85%
at 170℃;

: 1150313-29-3
1,11-dichloro-5-methyl-5H-indolo[2,3-b]quinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 1150313-33-9
N4-(1-chloro-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions

Conditions	Yield
at 135 - 155℃; Neat (no solvent);	85%

: 11-Chlor-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid

: 140-80-7
5-diethylamino-2-pentylamine

: (R,S)-11-(4-Diethylamino-2-pentyl)-amino-5,10-dimethyl-10H-indolo<3,2-b>chinolinium-chlorid-hydrochlorid

Conditions

Conditions	Yield
In ethanol at 70℃; for 4h;	84%

: 1416412-79-7
11-chloro-2-methoxychromeno[2,3-b]indole

: 140-80-7
5-diethylamino-2-pentylamine

: 1453096-24-6
C25H31N3O2

Conditions

Conditions	Yield
at 80℃;	84%

: 1603109-75-6
C25H35NO6

: 140-80-7
5-diethylamino-2-pentylamine

: 1603109-04-1
C34H55N3O5

Conditions

Conditions	Yield
In toluene Reflux;	84%

: 120075-53-8
5-(benzyloxy)-4-chloro-6-methoxyquinazoline

: 140-80-7
5-diethylamino-2-pentylamine

: 120075-68-5
N4-(5-Benzyloxy-6-methoxy-quinazolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions

Conditions	Yield
With triethylamine In ethanol for 24h; Ambient temperature;	83%

: 885461-50-7
7-chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine

: 140-80-7
5-diethylamino-2-pentylamine

: C16H25F3N6

Conditions

Conditions	Yield
In ethanol at 20℃; for 43h;	83%

: C23H19N5O3S

: 140-80-7
5-diethylamino-2-pentylamine

: (4″RS,2‴RS)-5-[3-(6-Amino-5-cyano-3-methyl-4-isopropyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]-N-[5-(diethylamino)pent-2-yl]thiophene-2-carboxamide

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 25℃; for 0.5h;	83%

: 91641-02-0
1-(β-carboxyethyl)-1,2,3,4-tetrahydroquinoline

: 140-80-7
5-diethylamino-2-pentylamine

: N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide

Conditions

Conditions	Yield
Stage #1: 1-(β-carboxyethyl)-1,2,3,4-tetrahydroquinoline With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 5-diethylamino-2-pentylamine In N,N-dimethyl-formamide at 20℃; for 1h;	82.5%

: 1150313-26-0
3,11-dichloro-6H-indolo[2,3-b]quinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 1150313-44-2
N4-(3-chloro-6H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethyl-pentane-1,4-diamine

Conditions

Conditions	Yield
at 20 - 155℃; for 13h;	82%

: 1356825-65-4
2-bromo-11-chloro-5-methyl-5H-indolo[2,3-b]quinoline

: 140-80-7
5-diethylamino-2-pentylamine

: 1393344-27-8
N4-(2-bromo-5-methyl-5H-indolo[2,3-b]quinolin-11-yl)-N1,N1-diethylpentane-1,4-diamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 135 - 155℃;	82%
Heating;	64%

: 1416412-74-2
2,11-dichlorochromeno[2,3-b]indole

: 140-80-7
5-diethylamino-2-pentylamine

: 1453096-22-4
C24H28ClN3O

Conditions

Conditions	Yield
at 80℃;	82%

: 1536007-04-1
C11H9Cl2N

: 140-80-7
5-diethylamino-2-pentylamine

: 1536007-16-5
N4-(7-chloro-2-ethylquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

Conditions

Conditions	Yield
With samarium(III) trifluoromethanesulfonate at 140℃; for 48h; Inert atmosphere;	82%

: 2‑(methanesulfonyl)‑4‑methyl‑6‑(4‑methylphenyl)pyrimidine

: 140-80-7
5-diethylamino-2-pentylamine

: N‑[5‑(diethylamino)pentan‑2‑yl]‑4‑methyl‑6‑(4‑methylphenyl)pyrimidin‑2‑amine

Conditions

Conditions	Yield
In tetrahydrofuran at 120℃; for 13h; Microwave irradiation;	81%

2-Amino-5-diethylaminopentane Chemical Properties

Molecular Formula: C₉H₂₂N₂
Molecular Weight: 158.28
EINECS: 205-435-1
Boiling point: 101 °C / 37mmHg
Density: 0.817 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.4429(lit.)
Flash point: 155 °F
Merck: 6723
N,N-Diethyl-4-Methyltetramethylene-Diamine's(140-80-7) Synonyms: 1-(Diethylamino)-4-aminopentane;1-Diethylamino-4-aminopentane;1-Methyl-4-(diethylamino)butylamine;1-Methyl-4-dietylaminobutylamine;4-(Diethylamino)-1-methylbutylamine;4-Pentanediamine,N’,N’-diethyl-1;5-(Diethylamino)-2-pentylamine;delta-(Diethylamino)-alpha-methylbutylamine
N,N-Diethyl-4-Methyltetramethylene-Diamine's(140-80-7) structural formula:

2-Amino-5-diethylaminopentane Toxicity Data With Reference

ivn-mus LD50:180 mg/kg

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#05228 .

2-Amino-5-diethylaminopentane Consensus Reports

Reported in EPA TSCA Inventory.

2-Amino-5-diethylaminopentane Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NO_x.

Safety Information for N,N-Diethyl-4-Methyltetramethylene-Diamine(140-80-7)
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 2946 6.1/PG 3
WGK Germany 1
RTECS XE1900000
HazardClass 8
PackingGroup III

2-Amino-5-diethylaminopentane Specification

Accidental Release Measures for N,N-Diethyl-4-Methyltetramethylene-Diamine(140-80-7)
【Small spills/leaks】Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard.

N,N-Diethyl-4-Methyltetramethylene-Diamine's(140-80-7) Stability and Reactivity
【Incompatibilities】Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.

Product Name

2-Amino-5-diethylaminopentane

Synthetic route

2-Amino-5-diethylaminopentane Chemical Properties

2-Amino-5-diethylaminopentane Toxicity Data With Reference

2-Amino-5-diethylaminopentane Consensus Reports

2-Amino-5-diethylaminopentane Safety Profile

2-Amino-5-diethylaminopentane Specification

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