2-Amino-5-methylthiazole supplier

Name
2-Amino-5-methylthiazole
EINECS 423-800-5
CAS No. 7305-71-7
Article Data23
CAS DataBase
Density 1.258 g/cm³
Solubility
Melting Point 93-98 °C(lit.)
Formula C₄H₆N₂S
Boiling Point 232.5 °C at 760 mmHg
Molecular Weight 114.171
Flash Point 94.4 °C
Transport Information UN 2811
Appearance white to light yellow crystal powder
Safety 60-61-29-26-37/39
Risk Codes 22-48/22-50/53-36/37/38
Molecular Structure
Hazard Symbols Xn, N, Xi
Synonyms 2-Thiazolamine, 5-methyl-;5-methylthiophen-2-amine;5-methyl-1,3-thiazol-2-amine;Thiazole, 2-amino-5-methyl-;2-Amino-5-inethylthiazole;
PSA 67.15000
LogP 1.61490

Synthetic route

: 35511-15-0
methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

: 71125-38-7
meloxicam

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With montmorillonite MK10 impregnated with ZnCl2 In o-xylene for 24h; Reagent/catalyst; Reflux; Green chemistry;	90%

potassium thioacyanate: potassium thioacyanate

: 78-95-5
chloroacetone

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With ammonium acetate on neutral alumina; silica gel In benzene at 80℃; for 6h;	83%

: 137768-73-1
1-isothiocyanatopropa-1,2-diene

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With ammonia	59%
With ammonium hydroxide In tetrahydrofuran at 20℃; for 72h;	59%

: 137768-73-1
1-isothiocyanatopropa-1,2-diene

A: 7305-71-7
5-methyl-2-thiazol-2-amine

B: 137768-80-0
(5,5'-dimethyl-[2,3'-bithiazolyl]-2'-ylidene)-(5-methylthiazol-2-yl)-amine

C: 137768-81-1
5,5'-dimethyl-2'-imino-[2,3'-bithiazolyl]

Conditions

Conditions	Yield
With ammonium hydroxide In tetrahydrofuran at 20℃;	A 11% B 50% C n/a

...Expand

: 71-23-8
propan-1-ol

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With chlorine at 8 - 10℃; Behandeln des Reaktionsprodukts mit Thioharnstoff;

: 123-38-6
propionaldehyde

: 17356-08-0
thiourea

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With sulfuryl dichloride
With chloroform; bromine
With chloroform; iodine

: 683-50-1
2-chloropropanal

: 17356-08-0
thiourea

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 19967-57-8
bromo-2 propanal

: 17356-08-0
thiourea

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
Reaktion des Hydrats;

: 17356-08-0
thiourea

: 3400-55-3
2-bromopropionaldehyde diethyl acetal

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With hydrogenchloride

: 17356-08-0
thiourea

2-bromo-propionaldehyde-hydrate: 2-bromo-propionaldehyde-hydrate

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 921203-76-1
phenyl N-2-(5-methylthiazolyl)carbamate

A: 7305-71-7
5-methyl-2-thiazol-2-amine

B: 108-95-2
phenol

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 25℃; Kinetics;

: 123-38-6
propionaldehyde

: 7305-71-7
5-methyl-2-thiazol-2-amine

Conditions

Conditions	Yield
With sulfuryl dichloride; thiourea In ethanol; chloroform
With sulfuryl dichloride; thiourea In ethanol; chloroform

: 2-(5-methylthiazol-2-yliminomethyl)phenol

A: 7305-71-7
5-methyl-2-thiazol-2-amine

B: 90-02-8
salicylaldehyde

Conditions

Conditions	Yield
With aluminium(III) chloride hexahydrate; water In methanol at 20℃; for 2h;

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 4-(((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)methyl)benzoic acid

: 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylamino)methyl)-N-(5-methylthiazol-2-yl)benzamide

Conditions

Conditions	Yield
Stage #1: 4-(((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)methyl)benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Stage #2: 5-methyl-2-thiazol-2-amine In N,N-dimethyl-formamide at 20℃;	98.61%
Stage #1: 4-(((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)methyl)benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Stage #2: 5-methyl-2-thiazol-2-amine In N,N-dimethyl-formamide at 20℃;	98.61%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 148673-71-6
6-chloropyrazine-2-carboxylic acid chloride

: 6-chloro-pyrazine-2-carboxylic acid (5-methyl-thiazol-2-yl)-amide

Conditions

Conditions	Yield
With pyridine In acetone at 20℃; for 0.5h;	98%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 879131-25-6
6-chloro-5-tert-butylpyrazine-2-carboxylic acid chloride

: 5-tert-butyl-6-chloro-pyrazine-2-carboxylic acid (5-methyl-thiazol-2-yl)-amide

Conditions

Conditions	Yield
With pyridine In acetone at 20℃; for 0.5h;	98%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 24683-26-9
ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

: 71125-38-7
meloxicam

Conditions

Conditions	Yield
In o-xylene for 24h; Product distribution / selectivity; Heating / reflux;	95%
In xylene at 139 - 140℃; for 32 - 37h; Product distribution / selectivity; Heating / reflux; Molecular sieve;	92.48%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1609119-40-5
5-((4,6-dichloropyrimidin-2-yl)oxy)-4-fluoro-2-methyl-1H-indole

: 1609119-46-1
N-(6-chloro-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidin-4-yl)-5-methylthiazol-2-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; sodium iodide In N,N-dimethyl-formamide at 70℃;	95%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 1-(E)-[(5-methylthiazol-2-ylimino)methyl]naphthalen-2-ol

Conditions

Conditions	Yield
In methanol for 6h; Reflux;	95%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 372-09-8
cyanoacetic acid

: 2-cyano-N-(5-methylthiazol-2-yl)acetamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;	95%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 30216-57-0
1,3-thiazole-2-carbonyl chloride

: 475637-27-5
N-(2-methylthiazole-5-yl)-thiazole-2-carboxamide

Conditions

Conditions	Yield
With triethylamine; lithium chloride In 1-methyl-pyrrolidin-2-one at 20℃; for 72h;	94%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 610-14-0
2-nitrobenzyl chloride

: N-(5-methylthiazol-2-yl)-2-nitrobenzamide

Conditions

Conditions	Yield
In dichloromethane at 0℃; Inert atmosphere;	94%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 75-36-5
acetyl chloride

: 61996-32-5
N-(5-methylthiazol-2-yl)acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 2h;	94%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃;

: 59944-65-9
4-methyl-[1,2,3]thiadiazole-5-carbonyl chloride

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 4-methyl-N-(5'-methyl-1,3-thiazol-2'-yl)-1,2,3-thiadiazole-5-carboxamide

Conditions

Conditions	Yield
In toluene at 100 - 105℃; for 4h; Solvent; Temperature; Reflux;	94%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 104-88-1
4-chlorobenzaldehyde

: 7-(4-chlorophenyl)-10-methyl-6H,7H-chromeno[4,3-d]thiazolo[3,2-a]pyrimidin-6-one

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; 4-chlorobenzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.5h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst; Reflux; Green chemistry;	94%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 34036-07-2
3,4 difluorobenzaldehyde

: C20H12F2N2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; 3,4 difluorobenzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.583333h; Reflux; Green chemistry;	94%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: N2,N6-bis(5-methylthiazol-2-yl)pyridine-2,6-dicarboxamide

Conditions

Conditions	Yield
Stage #1: 5-methyl-2-thiazol-2-amine; Pyridine-2,6-dicarboxylic acid With pyridine at 120℃; for 0.5h; Stage #2: With triphenyl phosphite at 100 - 120℃; for 6h;	94%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 33342-65-3
2-chloro-5-methyl-thiazole

Conditions

Conditions	Yield
With t-butyl thionitrite; copper dichloride In acetonitrile at 25℃; for 2.66667h; Inert atmosphere;	93%
With t-butyl thionitrite; copper dichloride In acetonitrile at 25℃; for 2.66667h; Time; Inert atmosphere;	93%
With 2-methylchlorobenzene; copper(l) chloride In hexane at 6 - 65℃; for 15h; Temperature;	81%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 434-75-3
2-chloro-6-fluorobenzoic acid

: 6-fluoro-2-methyl-5H-[1,3]-thiazolo[2,3-b]quinazolin-5-one

Conditions

Conditions	Yield
With copper; potassium carbonate In N,N-dimethyl-formamide at 25℃; for 0.25h; sonication;	93%
With copper Ullmann condensation; Sonication;

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 4-(3-chloro-4-cyanophenoxy)butanoic acid

: 4-(3-chloro-4-cyanophenoxy)-N-(5-methylthiazol-2-yl)butanamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 45℃; for 16h;	93%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 121-90-4
m-nitrobenzoic acid chloride

: N-(5-methylthiazol-2-yl)-3-nitrobenzamide

Conditions

Conditions	Yield
In dichloromethane at 0℃; Inert atmosphere;	92%

: 7305-71-7
5-methyl-2-thiazol-2-amine

1-halo-2,4-dinitrobenzene: 1-halo-2,4-dinitrobenzene

: C10H8N4O4S

Conditions

Conditions	Yield
With tributyl-amine In N,N-dimethyl-formamide at 100℃; for 12h; Flow reactor;	92%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 100-52-7
benzaldehyde

: C20H14N2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; benzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.5h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 89-98-5
2-chloro-benzaldehyde

: C20H13ClN2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; 2-chloro-benzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.583333h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 587-04-2
3-Chlorobenzaldehyde

: C20H13ClN2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; m-Chlorobenzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.5h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 3132-99-8
m-bromobenzoic aldehyde

: C20H13BrN2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; m-bromobenzoic aldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.633333h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 104-87-0
4-methyl-benzaldehyde

: C21H16N2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; 4-methyl-benzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.5h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 459-57-4
4-fluorobenzaldehyde

: C20H13FN2O2S

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one; 4-fluorobenzaldehyde at 20℃; Knoevenagel Condensation; Green chemistry; Stage #2: 5-methyl-2-thiazol-2-amine for 0.75h; Reflux; Green chemistry;	92%

...Expand

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 4-(4-chloro-3-methylphenoxy)-2-methylbutanoic acid

: 4-(4-chloro-3-methylphenoxy)-2-methyl-N-(5-methylthiazol-2-yl)butanamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1,2-dichloro-ethane at 45℃; for 16h;	92%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 56914-82-0
3,4-dichloro-isothiazole-5-carbonyl chloride

: C8H5Cl2N3OS2

Conditions

Conditions	Yield
Stage #1: 5-methyl-2-thiazol-2-amine With triethylamine In dichloromethane for 0.166667h; Cooling with ice; Stage #2: 3,4-dichloro-isothiazole-5-carbonyl chloride In dichloromethane at 20℃; for 3h;	91.6%

: 108-30-5
succinic acid anhydride

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 888125-33-5
C8H10N2O3S

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 2h;	91.3%
In tetrahydrofuran at 65℃; for 3h;

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 85-44-9
phthalic anhydride

: 832091-87-9
2-(5-methyl-thiazol-2-yl)-isoindole-1,3-dione

Conditions

Conditions	Yield
With triethylamine In toluene at 200℃; for 2h; Sealed tube;	91%
In 1,4-dioxane at 110℃;	56%

: 7305-71-7
5-methyl-2-thiazol-2-amine

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 1258205-29-6
C7H5Cl2N5S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -5℃; Inert atmosphere;	91%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -5℃;	91%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -5℃;

2-Amino-5-methylthiazole Chemical Properties

IUPAC Name: 5-Methyl-1,3-thiazol-2-amine
Synonyms oF 2-Amino-5-methylthiazole (CAS NO.7305-71-7): 2-Thiazolamine, 5-methyl- ; 2-Amino-5-methylthiazole;akos bbs-00006638 ; 5-Methyl-2-thiazolamine ; 5-Methyl-thiazol-2-ylamine ; 5-Methyl-1,3-thiazol-2-amine ; Labotest-bb lt00080645 ; Buttpark 18\10-87 ;
CAS NO: 7305-71-7
Molecular Formula: C₄H₆N₂S
Molecular Weight: 114.1688
Index of Refraction: 1.618
Surface Tension: 55.9 dyne/cm
Density oF 2-Amino-5-methylthiazole (CAS NO.7305-71-7): 1.258 g/cm³
Flash Point: 94.4 °C
Enthalpy of Vaporization: 46.92 kJ/mol
Boiling Point: 232.5 °C at 760 mmHg
Vapour Pressure: 0.0588 mmHg at 25°C
Molecular Structure:

2-Amino-5-methylthiazole Safety Profile

Hazard Codes oF 2-Amino-5-methylthiazole (CAS NO.7305-71-7): Xn Harmful ,N Dangerous ,Xi Irritant
Risk Statements: 22-48/22-50/53-36/37/38
R24: Toxic in contact with skin. R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed. R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 60-61-29-26-37/39
S60: This material and its container must be disposed of as hazardous waste. S61: Avoid release to the environment. Refer to special instructions / safety data sheets. S29: Do not empty into drains. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39: Wear suitable gloves and eye/face protection.
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: 9
PackingGroup: III

Product Name

2-Amino-5-methylthiazole

Synthetic route

2-Amino-5-methylthiazole Chemical Properties

2-Amino-5-methylthiazole Safety Profile

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