2-Aminoindole hydrochloride supplier

Name
2-Aminoindole hydrochloride
EINECS
CAS No. 36946-70-0
Article Data7
CAS DataBase
Density 1.268±0.06 g/cm3(Predicted)
Solubility
Melting Point 215-220 ºC dec.
Formula C8H8 N2
Boiling Point 372.4°C at 760 mmHg
Molecular Weight 132.165
Flash Point 179°C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Aminoindole
PSA 41.81000
LogP 3.13330

Synthetic route

: 1131148-08-7
(1H-indol-1-yl)(pyridin-2-yl)methanone

: 36946-70-0
indoleamine

Conditions

Conditions	Yield
Stage #1: (1H-indol-1-yl)(pyridin-2-yl)methanone With tert.-butylnitrite; copper diacetate In 1,4-dioxane at 70℃; for 16h; Stage #2: With hydrazine hydrate; FeCl3/C In 1,4-dioxane; ethanol at 70℃;	93%

: 193686-70-3
2-nitroindole

: 36946-70-0
indoleamine

Conditions

Conditions	Yield
With sodium tetrahydroborate In water at 60℃; for 0.25h; Sonication;	88%

: 610-66-2
2-nitro-benzeneacetonitrile

: 36946-70-0
indoleamine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 30℃; for 3h;	52%

: 101258-96-2
2-methyl-2-pyrrolidin-1-yl-propan-1-ol

: 27667-51-2
5-Hydroxy-2-methyl-1H-indole-3-carboxylic acid benzyl ester

: 133-59-5
Toluene-2-sulfonyl chloride

A: 36946-70-0
indoleamine

B: 459449-48-0
2-Methyl-5-(2-methyl-2-pyrrolidin-1-yl-propoxy)-1H-indole-3-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With potassium carbonate; triethylamine; trifluoroacetic acid In acetonitrile	A n/a B 5%

...Expand

: 2973-50-4
2-aminophenylacetonitrile

: 141-52-6
sodium ethanolate

hydrogen: hydrogen

: 36946-70-0
indoleamine

...Expand

: 861571-31-5
(2-formylamino-phenyl)-acetonitrile

potassium carbonate: potassium carbonate

: 36946-70-0
indoleamine

: 36946-70-0
indoleamine

: 326-06-7
1-Phenyl-4,4,4-trifluorobutane-1,3-dione

: 869465-09-8
2-phenyl-4-(trifluoromethyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 1h; Heating;	89%
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	89%

: 36946-70-0
indoleamine

: 356-40-1
sodium 5,5,6,6,6-pentafluoro-2,4-hexanedione

: 1190370-62-7
2-methyl 4-(perfluoroethyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	87%

: 36946-70-0
indoleamine

: 1522-22-1
1,1,1,5,5,5-hexafluoroacetylacetone

: 869465-16-7
2,4-bis(trifluoromethyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	86%

: 36946-70-0
indoleamine

: 2062-21-7
1-Chlor-1,1-difluor-3-benzoyl-aceton

: 869465-10-1
4-(chlorodifluoromethyl)-2-phenyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	85%

: 36946-70-0
indoleamine

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 1018966-60-3
2-methyl-4-(trifluoromethyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 1h; Heating;	84%
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	84%

: 36946-70-0
indoleamine

: 41739-23-5
1,1-difluoro-1-phenyl-1,3-butanedione

: 1018966-65-8
4-(difluoromethyl)-2-methyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	81%

: 36946-70-0
indoleamine

: α-(2,2,2-trifluoroacetyl)-δ-valerolactone

: 1190370-42-3
3-(3-hydroxypropyl)-4-(trifluoromethyl)-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	74%

: 36946-70-0
indoleamine

: 24756-05-6
3-[(2-chlorophenyl)hydrazono]pentane-2,4-dione

: 3-(2-chlorophenyldiazenyl)-2,4-dimethyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	68%

: 36946-70-0
indoleamine

: 653-37-2
perfluorobenzaldehyde

A: 1190370-41-2
1,2,3,4-tetrafluoro-6H-indolo[2,3-b]quinoline

B: C15H10F5N3

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide Inert atmosphere; Reflux; regiospecific reaction;	A 67% B n/a

...Expand

: 36946-70-0
indoleamine

: 318-46-7
2-(2,2,2-trifluoroacetyl)-3,4-dihydro-2H-naphthalen-1-one

: 869465-12-3
7-(trifluoromethyl)-6,12-dihydro-5H-12,13-diazaindeno[1,2-b]phenanthrene

Conditions

Conditions	Yield
With acetic acid for 2h; Inert atmosphere; Reflux; regiospecific reaction;	64%

: 36946-70-0
indoleamine

: 22161-81-5
S-ketoprofen

: 1239447-49-4
2-(3-benzoylphenyl)-N-(1H-indol-2-yl)propanamide

Conditions

Conditions	Yield
Stage #1: S-ketoprofen With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: indoleamine In N,N-dimethyl-formamide at 20℃; for 2h;	62%

: 36946-70-0
indoleamine

: 100-52-7
benzaldehyde

: 56807-26-2
2,4-diphenyl-5H-pyrimido[5,4-b]indole

Conditions

Conditions	Yield
With ammonium iodide; oxygen; sodium hydrogencarbonate; dimethyl sulfoxide In chlorobenzene at 140℃; for 16h; Molecular sieve; Inert atmosphere;	57%

: 36946-70-0
indoleamine

: 24756-09-0
3-(2-(4-bromophenyl)hydrazineylidene) pentane-2,4-dione

: 3-(4-bromophenyldiazenyl)-2,4-dimethyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	51%

: 36946-70-0
indoleamine

: 3490-72-0
pentane-2,3,4-trione 3-[(3-nitro-phenyl)-hydrazone]

: 2,4-dimethyl-3-(3-nitrophenyldiazenyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	50%

: 3-[(2-bromo-phenyl)-hydrazono]-pentane-2,4-dione

: 36946-70-0
indoleamine

: 3-(2-bromophenyldiazenyl)-2,4-dimethyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	49%

: 36946-70-0
indoleamine

: 41095-26-5
4-ethyl 4-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)benzoate

: ethyl 4-(2,4-dimethyl-9H-pyrido[2,3-b]indol-3-yldiazenyl)benzoate

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	48%

: 3-[(2-iodo-phenyl)-hydrazono]-pentane-2,4-dione

: 36946-70-0
indoleamine

: 3-(2-iodophenyldiazenyl)-2,4-dimethyl-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	45%

: 36946-70-0
indoleamine

: 98-88-4
benzoyl chloride

A: 92264-37-4
2-(benzoylamino)indole

B: 1-benzoyl-2-benzamidoindole

Conditions

Conditions	Yield
With pyridine; dmap for 1h; Ambient temperature;	A 35% B 14%

...Expand

: 36946-70-0
indoleamine

: 1612153-85-1
C12H12O3

: 1612154-11-6
C20H16N2O

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; water; silver trifluoromethanesulfonate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 120℃; Michael Addition; Microwave irradiation;	34%

: 36946-70-0
indoleamine

: 1416983-93-1
1-(3-hydroperoxyprop-1-ynyl)-4-methoxybenzene

A: 1175675-37-2
2-(4-methoxyphenyl)-9H-pyrido[2,3-b]indole

B: 1612154-12-7
C18H14N2O

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; water; silver trifluoromethanesulfonate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 120℃; Michael Addition; Microwave irradiation;	A 30% B 28%

...Expand

: 36946-70-0
indoleamine

: 57397-70-3
ethyl 3-(ethoxymethylene)-2,4-dioxovalerate

: 77740-29-5
ethyl 3-acetyl-9H-pyrimido<2,3-b>indole-4-carboxylate

Conditions

Conditions	Yield
In ethanol for 2h;	28%

: 36946-70-0
indoleamine

: 1416984-00-3
C9H7BrO2

A: 1612154-09-2
C17H11BrN2

B: 1612154-13-8
C17H11BrN2

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; water; silver trifluoromethanesulfonate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 120℃; Michael Addition; Microwave irradiation;	A 26% B 23%

...Expand

: 36946-70-0
indoleamine

: 52942-64-0
diethyl(ethoxymethylene)oxalacetate

: 77740-30-8
diethyl 9H-pyrimido<2,3-b>indole-3,4-dicarboxylate

Conditions

Conditions	Yield
In ethanol for 2h;	25%

: 36946-70-0
indoleamine

: 1612153-84-0
C16H14O3

A: 1612154-10-5
C24H18N2O

B: 1612154-14-9
C24H18N2O

Conditions

Conditions	Yield
With (triphenylphosphine)gold(I) chloride; water; silver trifluoromethanesulfonate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 120℃; Michael Addition; Microwave irradiation;	A 24% B 25%

...Expand

: 36946-70-0
indoleamine

: 24756-03-4
3-[(2-methylphenyl)hydrazono]pentane-2,4-dione

: 2,4-dimethyl-3-(2-methylphenyldiazenyl)-9H-pyrido[2,3-b]indole

Conditions

Conditions	Yield
With pyridine at 20℃; for 72h;	19%

: 36946-70-0
indoleamine

: 78094-38-9, 138231-82-0
(5α,17α)-17-hydroxy-2-(hydroxymethylene)pregn-20-yn-3-one

: 138091-32-4
C30H34N2O

Conditions

Conditions	Yield
In ethanol Heating;	18%

: 36946-70-0
indoleamine

: 78094-38-9, 138231-82-0
(5α,17α)-17-hydroxy-2-(hydroxymethylene)pregn-20-yn-3-one

: 138091-31-3
C30H34N2O

Conditions

Conditions	Yield
In ethanol Heating;	18%

2-Aminoindole hydrochloride Chemical Properties

Molecular Structure of 2-Aminoindole hydrochloride (CAS NO.36946-70-0):

Molecular Formula: C₈H₉ClN₂
Molecular Weight: 168.6235
Systematic Name: 1H-Indol-2-amine hydrochloride (1:1)
Synonyms of 2-Aminoindole hydrochloride (CAS NO.36946-70-0): 1H-Indol-2-amine hcl
CAS NO: 36946-70-0
Product Categories: Nitrogen cyclic compounds ; Indole Derivatives
Melting point: 215-220°C
Flash Point: 179 °C
Enthalpy of Vaporization: 63.17 kJ/mol
Boiling Point: 372.4 °C at 760 mmHg
Vapour Pressure: 6.6E-06 mmHg at 25°C

Product Name

2-Aminoindole hydrochloride

Synthetic route

2-Aminoindole hydrochloride Chemical Properties

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