2-Benzothiazolamine supplier

Name
2-Benzothiazolamine
EINECS 205-268-4
CAS No. 136-95-8
Article Data180
CAS DataBase
Density 1.383 g/cm³
Solubility <0.1 g/100 mL at 19℃
Melting Point 126-129 °C(lit.)
Formula C₇H₆N₂S
Boiling Point 307.5 °C at 760 mmHg
Molecular Weight 150.204
Flash Point 139.8 °C
Transport Information UN 2811 6.1/PG 3
Appearance Odorless gray to white powder
Safety 26
Risk Codes 22-36
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzothiazoline,2-imino- (4CI);1,3-Benzothiazol-2-ylamine;2-Aminobenzo[d]thiazole;2-Iminobenzothiazoline;ABT;Benzo[d]thiazol-2-amine;NSC 4670;SKA 1;
PSA 67.15000
LogP 2.45970

Synthetic route

: 108-94-1
cyclohexanone

: 17356-08-0
thiourea

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With dihydrogen peroxide; iodine; toluene-4-sulfonic acid In acetonitrile at 75℃; for 24h;	100%
With iodine; oxygen; toluene-4-sulfonic acid In dimethyl sulfoxide at 75℃; under 760.051 Torr; for 24h; Solvent; Reagent/catalyst;	84%

: 615-20-3
2-chlorobenzo[d][1,3]thiazole

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With 2-(di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl; C58H78NO4PPdS; ammonia; sodium t-butanolate In 1,4-dioxane at 20℃; Inert atmosphere;	96%
With 5 wt% ruthenium/carbon; formamide; lithium tert-butoxide at 80℃; for 8h;	84%
With ammonia at 150 - 160℃;

: 103-85-5
monophenylthiourea

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With thionyl chloride at 50 - 55℃; for 4h;	95.6%
With bromine; acetic acid at 0 - 20℃; for 12h;	80%
Stage #1: monophenylthiourea With bromine In chloroform at 0 - 5℃; Reflux; Stage #2: With ammonia In water	75%

: 108-86-1
bromobenzene

: 2-iodophenylisothiourea

A: 136-95-8
2-amino-benzthiazole

B: 1843-21-6
N-phenyl-2-benzothiazolamine

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(II) acetate monohydrate; caesium carbonate In dimethyl sulfoxide Heating;	A 95% B n/a
With 1,10-Phenanthroline; cobalt(II) sulfate monohydrate; caesium carbonate In dimethyl sulfoxide at 100℃; for 20h;

...Expand

: 103-85-5
phenyl-carbamimidothioic acid

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
In isopropyl alcohol at 45℃; for 1.33333h; Temperature;	93%

: 23505-64-8
2-nitrobenzothiazole

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With triethylamine In water at 80℃; for 6h; Inert atmosphere; Green chemistry; chemoselective reaction;	92%

: 333-20-0
potassium thioacyanate

: 62-53-3
aniline

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃; for 10h;	91%
Stage #1: potassium thioacyanate; aniline With acetic acid at 5℃; for 0.5h; Stage #2: With bromine; acetic acid at 0 - 20℃;	91%
With sodium iodide dichloride at 70℃; for 3h;	87%

: 1147550-11-5
ammonium thiocyanate

: 62-53-3
aniline

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride In acetonitrile at 20℃; for 10h; Catalytic behavior; Mechanism; Reagent/catalyst; Solvent; Irradiation;	90%
With bromine; acetic acid at 10℃;	88.5%
With bromine; acetic acid at 0 - 20℃;	74%

: 615-43-0
2-iodophenylamine

: 17356-08-0
thiourea

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
bis(triethylphosphine)nickel(II) chloride; sodium cyanoborohydride In N,N-dimethyl-formamide at 60℃; for 20h;	87%
bis(triethylphosphine)nickel(II) chloride; sodium cyanoborohydride In N,N-dimethyl-formamide at 60℃; for 20h; Product distribution; other temp., other reaction time;	87%

: 2516-40-7
2-bromo-1,3-benzothiazole

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With ammonium hydroxide; potassium phosphate; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-2-methylpropan-1-one; copper(I) bromide In dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere; Sealed tube;	81%
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;	73%
Stage #1: 2-bromo-1,3-benzothiazole With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.1h; Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; hexane; toluene at -30℃; for 2h; Inert atmosphere;	26%

: ammonium thiocyanate

: 62-53-3
aniline

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
Stage #1: ammonium thiocyanate; aniline With acetic acid at 0℃; Stage #2: With bromine at -3 - 0℃;	75%
With bromine; acetic acid at 0 - 20℃;	74%
Stage #1: ammonium thiocyanate; aniline With acetic acid at 10℃; Stage #2: With bromine at 10 - 20℃; for 4h;	72%

: 137-07-5
2-amino-benzenethiol

: 104619-51-4
di(1H-imidazol-1-yl)methanimine

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h;	71%

: 137-07-5
2-amino-benzenethiol

: 623-49-4
ethyl cyanoformate

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With lithium bromide In 1,4-dioxane at 100 - 105℃; for 1h;	68%

: 95-16-9
1,3-Benzothiazole

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride at 100℃; for 3h;	63%
Stage #1: 1,3-Benzothiazole With lithium di-tert-butyl(2,2,6,6-tetramethylpiperidino)zincate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Schlenk technique; Stage #2: With N-benzyloxyamine; copper(l) cyanide In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique; regioselective reaction;	56%
Stage #1: 1,3-Benzothiazole With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -30℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;	26%

: potassium sulphocyanide

: 62-53-3
aniline

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With bromine In acetic acid at 30℃; for 10h;	60%

: copper(l) cyanide

: 1141-88-4
2-Aminophenyl disulfide

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; oxygen In acetonitrile at 60℃; for 1h;	57%

: 2-iodophenylisothiourea

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With 1,10-Phenanthroline; iodobenzene; cobalt(II) sulfate monohydrate; caesium carbonate In dimethyl sulfoxide at 70℃; for 20h; Reagent/catalyst;	55%
With 1,10-Phenanthroline; copper(II) acetate monohydrate; caesium carbonate; chlorobenzene In dimethyl sulfoxide Heating;

: 39582-59-7
benzothiazol-2-yl-lithium

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With 1-azidostyrene In tetrahydrofuran for 2h; from -78 deg.C to room temp.;	53%

: 136343-79-8
N-(2-chlorophenyl)thiazol-2-amine

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With sodium hydroxide In water; tert-butyl alcohol for 29h; Irradiation;	47%

: 420-04-2
CYANAMID

: 137-07-5
2-amino-benzenethiol

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With zinc(II) acetate dihydrate In neat (no solvent) at 120℃; under 7600.51 Torr; for 18h; Autoclave; Inert atmosphere; Green chemistry;	45%

: (E)-N-(1,3-benzothiazol-2-yl)-3-(thiophen-2-yl)acrylamide

A: 136-95-8
2-amino-benzthiazole

B: 1124-65-8, 15690-25-2, 51019-83-1
3-(2-thienyl)-2-propenoic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Reflux;	A 43% B 32%

: N-Cyclohexyl-2-phenylbenzo[d]imidazo[2,1-b]thiazol-3-amine

A: 136-95-8
2-amino-benzthiazole

B: 724-92-5
N-cicloesil-α-ossofenilacetamide

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 20℃; for 1h; Schlenk technique; chemoselective reaction;	A n/a B 35%

: 2987-49-7
2-(methylsulfonyl)aniline

: 17356-08-0
thiourea

A: 136-95-8
2-amino-benzthiazole

B: C7H9N3S*H(1+)

Conditions

Conditions	Yield
In water; tert-butyl alcohol at 20 - 25℃; for 6h; Irradiation; DRL-400 mercury lamp (400 W);	A 34% B n/a

...Expand

: copper(l) cyanide

: 3982-42-1
N,N'-(disulfanediylbis(2,1-phenylene))bis(4-methylbenzenesulfonamide)

A: 136-95-8
2-amino-benzthiazole

B: C21H18N2O4S3

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine In acetonitrile at 60℃;	A n/a B 23%

...Expand

: 149-30-4
2-thioxo-3H-1,3-benzothiazole

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With ammonium hydroxide; ammonium bisulfite at 150℃;

: 2769-30-4
2-nitrophenyl thiocyanate

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;
With sulfuric acid bei der elektrolytischen Reduktion;
With hydrogenchloride; tin(ll) chloride
With ammonium hydroxide; iron(II) sulfate

: 40229-47-8
(5-amino-[1,2,4]dithiazol-3-ylidene)-phenyl-amine

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With hydrogenchloride at 165℃; im Rohr;

: 17356-08-0
thiourea

: 137-07-5
2-amino-benzenethiol

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
at 150℃;

: 645-48-7
1-phenyl-3-thiosemicarbazide

: 136-95-8
2-amino-benzthiazole

Conditions

Conditions	Yield
With hydrogenchloride at 125 - 130℃; im Rohr;

: 136-95-8
2-amino-benzthiazole

: 74-88-4
methyl iodide

: 2-amino-3-methylbenzo[d]thiazol-3-ium iodide

Conditions

Conditions	Yield
In acetonitrile at 45℃; for 12h;	100%
In acetonitrile at 45℃; for 12h;	100%
In N,N-dimethyl-formamide at 80℃; for 24h;	90%
In tetrahydrofuran at 20℃;

: 136-95-8
2-amino-benzthiazole

: 591-50-4
iodobenzene

: 1201683-08-0
N-(2-(phenylthio)phenyl)cyanamide

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline Alkaline conditions;	100%
With copper(l) iodide; potassium tert-butylate In dimethyl sulfoxide at 80℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere;	90%
With copper(ll) sulfate pentahydrate; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 4h;

: 136-95-8
2-amino-benzthiazole

: 1711-06-4
3-Methylbenzoyl chloride

: 200726-48-3
N-(benzo[d]thiazol-2-yl)-3-methylbenzamide

Conditions

Conditions	Yield
With pyridine at 60℃; for 16h; Inert atmosphere; Sealed tube;	100%
With pyridine at 60℃; for 16h;	90%

: 136-95-8
2-amino-benzthiazole

: 7677-24-9
trimethylsilyl cyanide

: 59379-02-1
tert-butyl 3-formylpyrrolidine-1-carboxylate

: tert-butyl 3-((benzo[d]thiazol-2-ylamino)(cyano)methyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-amino-benzthiazole; tert-butyl 3-formylpyrrolidine-1-carboxylate With sodium sulfate In methanol at 20℃; for 24h; Stage #2: With acetic acid In methanol at 20℃; for 24h; Stage #3: trimethylsilyl cyanide With lithium perchlorate In tetrahydrofuran; phenol at 0 - 20℃; for 21h; Reflux;	100%

...Expand

: 136-95-8
2-amino-benzthiazole

: 909262-73-3
4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid

: N-(1,3-benzothiazol-2-yl)-4-hydroxy-1-(4-methylbenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	100%

: 136-95-8
2-amino-benzthiazole

: 1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1-(benzenesulfonyl)-N-(1,3-benzothiazol-2-yl)-4-hydroxypyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	100%

: 136-95-8
2-amino-benzthiazole

: 88867-96-3
1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

: N-(1,3-benzothiazol-2-yl)-1-(4-nitrobenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.98%

: 136-95-8
2-amino-benzthiazole

: 51077-01-1, 110771-95-4
L-N-tosyl-proline

: N-(1,3-benzothiazol-2-yl)-1-(4-methylbenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.98%

: 136-95-8
2-amino-benzthiazole

: 4-hydroxy-1-(4-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid

: N-(1,3-benzothiazol-2-yl)-4-hydroxy-1-(4-nitrobenzenesulfonyl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.96%

: 136-95-8
2-amino-benzthiazole

: C19H20N2O7S

: N-(1,3-benzothiazol-2-yl)-3-methyl-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]pentanamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.87%

: 136-95-8
2-amino-benzthiazole

: 88425-46-1
N-benzenesulfonyl-L-proline

: 1-(benzenesulfonyl)-N-(1,3-benzothiazol-2-yl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.82%

: 136-95-8
2-amino-benzthiazole

: 3-(1H-indol-2-yl)-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]propanoic acid

: N-(1,3-benzothiazol-2-yl)-3-(1H-indol-2-yl)-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]propanamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	99.33%

: 136-95-8
2-amino-benzthiazole

: 79-04-9
chloroacetyl chloride

: 3028-02-2
N-benzothiazol-2-yl-2-chloroacetamide

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane at 20℃; for 1h;	99%
With potassium carbonate In chloroform for 10h; Reflux;	96%
Stage #1: 2-amino-benzthiazole With pyridine In benzene at 0 - 5℃; for 0.5h; Stage #2: chloroacetyl chloride In benzene for 2h;	95%

: 136-95-8
2-amino-benzthiazole

: 104-88-1
4-chlorobenzaldehyde

: 135-19-3
β-naphthol

: 1-((benzo[d]thiazol-2-ylamino)(4-chloro-phenyl)methyl)naphthalen-2-ol

Conditions

Conditions	Yield
With C5H14N2BiCl5(2-)2H(1+) In neat (no solvent) at 100℃; for 0.116667h;	99%
With 1. 2-pyrrolidon-1-ium hydrogen sulfate at 80℃; for 0.1h; Catalytic behavior; Reagent/catalyst; Time; Temperature; Concentration; Green chemistry;	96%
With C12H28O3PS(1+)*Cl4Fe(1-) In neat (no solvent) at 45℃; for 0.05h; Ionic liquid; Green chemistry;	96%

...Expand

: 136-95-8
2-amino-benzthiazole

: 591-50-4
iodobenzene

: 1843-21-6
N-phenyl-2-benzothiazolamine

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(II) acetate monohydrate; caesium carbonate In dimethyl sulfoxide at 90℃; for 14h;	99%
With copper(l) iodide; potassium tert-butylate In 1,4-dioxane at 110℃; for 24h; Sealed tube;	91%
With Pd(tris[2-(diphenylphosphino)ethyl]phosphine tetrasulfide)(dibenzylideneacetone); caesium carbonate In isopropyl alcohol at 80℃; for 4h; Ullmann Condensation;	83%

: 136-95-8
2-amino-benzthiazole

: 873-76-7
para-Chlorobenzyl alcohol

: N‐(4‐chlorobenzyl)benzo[d]thiazol‐2‐amine

Conditions

Conditions	Yield
With [N,S-(2-(2-(diphenylphosphino)benzylidene)-N-ethylthiosemicarbazone)RuH(CO)(PPh3)2]; potassium hydroxide In toluene at 100℃; for 12h; Reagent/catalyst;	99%
With cesium hydroxide; palladium diacetate In toluene at 150℃; for 12h;	98%
With C41H36AsClN3OPRuS; potassium hydroxide In toluene at 100℃; for 12h;	98%

: 136-95-8
2-amino-benzthiazole

: 100-51-6
benzyl alcohol

: 21816-82-0
N-benzyl-2-aminobenzo[d]thiazole

Conditions

Conditions	Yield
With C39H34CuN3P2S; potassium hydroxide In toluene at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; regioselective reaction;	99%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide at 150℃; for 12h; Inert atmosphere; regioselective reaction;	97%
With [N,S-(2-(2-(diphenylphosphino)benzylidene)-N-ethylthiosemicarbazone)RuH(CO)(PPh3)2]; potassium hydroxide In toluene at 100℃; for 12h; Reagent/catalyst;	97%

: 136-95-8
2-amino-benzthiazole

: 19514-02-4
alpha-(3-methylphenoxy)acetophenone

: 2- phenyl-3-(m-tolyloxy)benzo[d]imidazo[2,1-b]thiazole

Conditions

Conditions	Yield
With iodine In 1,2-dichloro-ethane at 100℃; for 0.5h;	99%

: 136-95-8
2-amino-benzthiazole

: 1679-64-7
Monomethyl terephthalate

: methyl 4-(benzo[d]thiazol-2-ylcarbamoyl)benzoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Sealed tube;	99%

: 136-95-8
2-amino-benzthiazole

: 98-09-9
benzenesulfonyl chloride

: 13068-60-5
N-(benzo[d]thiazol-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With pyridine for 1h; Heating;	98.9%
With pyridine at 0℃; for 2h; Inert atmosphere;	87%
In pyridine	52%
With pyridine

: 136-95-8
2-amino-benzthiazole

: 3-methyl-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]butanoic acid

: N-(1,3-benzothiazol-2-yl)-3-methyl-2-[N-(4-nitrobenzenesulfonyl)-1-phenylformamido]butanamide

Conditions

Conditions	Yield
With boric acid In toluene for 6h; Dean-Stark; Reflux; Green chemistry;	98.66%

: 136-95-8
2-amino-benzthiazole

: 141-97-9
ethyl acetoacetate

: 89-98-5
2-chloro-benzaldehyde

: 2-methyl-4-(2-chlorophenyl)-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With Fe3O4(at)nano-cellulose/TiCl In neat (no solvent) at 70℃; for 0.666667h; Green chemistry;	98.5%
With nano-TiCl2/cellulose at 70℃; for 1h;	97%
With agar In ethanol; water for 1.08333h; Reflux; Green chemistry;	93%

...Expand

: 136-95-8
2-amino-benzthiazole

: 141-97-9
ethyl acetoacetate

: 104-88-1
4-chlorobenzaldehyde

: 1360614-10-3
ethyl 4-(4-chlorophenyl)-2-methyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With Fe3O4(at)nano-cellulose/TiCl In neat (no solvent) at 70℃; for 0.666667h; Green chemistry;	98.5%
With nano-TiCl2/cellulose at 70℃; for 1h;	97%
With Cu(II) supported on nano-cellulose with Fe3O4 core In neat (no solvent) at 80℃; for 0.5h; Green chemistry;	95%

...Expand

: 136-95-8
2-amino-benzthiazole

: 98-88-4
benzoyl chloride

: 5005-14-1
N-(benzo[d]thiazol-2-yl)benzamide

Conditions

Conditions	Yield
With pyridine for 12h;	98%
In pyridine	87%
In pyridine for 2h; Ambient temperature;	80%

: 136-95-8
2-amino-benzthiazole

: 110-13-4
2,5-hexanedione

: 28142-87-2
1-(benzothiazol-2-yl)-2,5-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
montmorillonite K-10 at 90℃; for 0.1h; modified Paal-Knorr synthesis; microwave heating;	98%
With benzene
With toluene

: 136-95-8
2-amino-benzthiazole

: 24424-99-5
di-tert-butyl dicarbonate

: 2-(tert-butoxycarbonylamino)benzo[d]thiazole

Conditions

Conditions	Yield
With sulfonic acid-functionalized ordered nanoporous Na+-montmorillonite In acetonitrile at 20℃; for 0.166667h; Neat (no solvent);	98%
With guanidine hydrochloride In ethanol at 35 - 40℃; for 5.5h;	95%
With glycerol at 20℃; for 0.583333h; Green chemistry; chemoselective reaction;	93%

: 136-95-8
2-amino-benzthiazole

: 141-97-9
ethyl acetoacetate

: 555-16-8
4-nitrobenzaldehdye

: ethyl 2-methyl-4-(4-nitrophenyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate

Conditions

Conditions	Yield
With Fe3O4(at)nano-cellulose/TiCl In neat (no solvent) at 70℃; for 0.666667h; Catalytic behavior; Solvent; Reagent/catalyst; Temperature; Green chemistry;	98%
With nano-cellulose/BF3/Fe3O4 In neat (no solvent) at 100℃; for 0.75h; Green chemistry;	98%
With nano-kaolin/Ti4+/Fe3O4 In neat (no solvent) at 100℃; for 0.5h;	98%

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: 136-95-8
2-amino-benzthiazole

: 141-97-9
ethyl acetoacetate

: 100-52-7
benzaldehyde

: ethyl 2-methyl-4-(phenyl)-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylate

Conditions

Conditions	Yield
With Copper(II) supported graphene quantum dots modified NiFe2O4 nanoparticles In water at 20℃; for 0.666667h; Green chemistry;	98%
With nano-TiCl2/cellulose at 70℃; for 1h;	97%
With magnesium oxide In acetonitrile for 0.0833333h; Reflux;	95%

...Expand

: 136-95-8
2-amino-benzthiazole

: 141-97-9
ethyl acetoacetate

: 123-11-5
4-methoxy-benzaldehyde

: ethyl 2-methyl-4-(4-methoxyphenyl)-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylate

Conditions

Conditions	Yield
With Copper(II) supported graphene quantum dots modified NiFe2O4 nanoparticles In water at 20℃; for 0.583333h; Green chemistry;	98%
With magnesium oxide In acetonitrile for 0.166667h; Reflux;	93%
With aminosulfonic acid In ethanol for 0.916667h; Reflux;	90%

...Expand

2-Benzothiazolamine Chemical Properties

The Molecular formula of 2-Benzothiazolamine (136-95-8): C₇H₆N₂S
The Molecular Weight of 2-Benzothiazolamine (136-95-8): 150.2 g/mol
Molecular Structure:
EINECS: 205-268-4
Melting point: 126-129 °C(lit.)
Boiling Point: 307.5 °C at 760 mmHg
Flash Point: 139.8 °C
Index of Refraction: 1.763
Molar Refractivity: 44.8 cm³
Molar Volume: 108.5 cm³
Polarizability: 17.76 10^-24 cm³
Surface Tension: 70.2 dyne/cm
Density: 1.383 g/cm3
Enthalpy of Vaporization: 54.81 kJ/mol
Vapour Pressure: 0.000723 mmHg at 25°C
Water Solubility: <0.1 g/100 mL at 19 ^oC
Merck: 14,424
BRN: 116315
IUPAC Name: 1,3-benzothiazol-2-amine
Synonyms: 2(3H)-Benzothiazolimine;2-Iminobenzothiazoline;USAF EK-3941;USAF xr-27;2-amino-benzothiazol;2-Aminobenzthiazole;o-Aminobenzothiazole;u-Aminoben-zothiazole;

2-Benzothiazolamine Uses

2-Benzothiazolamine (136-95-8) is used as a medicine, dyes intermediates.

2-Benzothiazolamine Toxicity Data With Reference

1.	mma-sat 2500 µg/plate	FCTOD7 Food and Chemical Toxicology. 23 (1985),695.
2.	orl-mus LD50:>1 g/kg	FSTEAI Farmaco (Pavia); Scienza e Tecnica. 45 (1990),223.
3.	ipr-mus LD50:200 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
4.	ivn-mus LD50:126 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 105 (1952),486.

2-Benzothiazolamine Consensus Reports

Reported in EPA TSCA Inventory.

2-Benzothiazolamine Safety Profile

Low toxicity by ingestion. Poison by intraperitoneal and intravenous routes. Mutation data reported. Dangerous; when heated to decomposition it emits highly toxic fumes of NO_x and SO_x.
The Hazard Codes of 2-Benzothiazolamine (136-95-8): Xn,Xi
Hazard Note: Irritant
HS Code: 29342080
The Risk Statements information of 2-Benzothiazolamine (136-95-8):
22: Harmful if swallowed
36: Irritating to the eyes
The Safety Statements information of 2-Benzothiazolamine (136-95-8):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 2
RTECS: DL1050000
Hazard Note: Irritant
HS Code: 29342080
Hazardous Substances Data: 136-95-8(Hazardous Substances Data)

Product Name

2-Benzothiazolamine

Synthetic route

2-Benzothiazolamine Chemical Properties

2-Benzothiazolamine Uses

2-Benzothiazolamine Toxicity Data With Reference

2-Benzothiazolamine Consensus Reports

2-Benzothiazolamine Safety Profile

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