2-Butylaminoethanol supplier

Name
2-(BUTYLAMINO)ETHANOL
EINECS 203-904-5
CAS No. 111-75-1
Article Data17
CAS DataBase
Density 0.875 g/cm³
Solubility 1000g/L at 20℃
Melting Point 28.94°C (estimate)
Formula C₆H₁₅NO
Boiling Point 199.1 °C at 760 mmHg
Molecular Weight 117.191
Flash Point 79.3 °C
Transport Information UN 2735 8/PG 2
Appearance
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols C
Synonyms 2-(Butylamino)ethanol;2-(N-Monobutylamino)ethanol;2-(n-Butylamino)ethanol;2-Hydroxyethyl(butyl)amine;Butyl(2-hydroxyethyl)amine;Butylethanolamine;MBM;N-Butyl-N-(2-hydroxyethyl)amine;N-Butylethanolamine;NSC 1098;Synergex;
PSA 32.26000
LogP 0.75930

Synthetic route

: 75-21-8
oxirane

: 109-73-9
N-butylamine

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
In ethanol; water at 30 - 40℃;	78%
With water

: 1630-71-3
2-isobutyl-3-butyloxazolidine

A: 123-51-3
i-Amyl alcohol

B: 111-75-1
2-butylamino-ethanol

C: 91322-90-6
1-butyl-3-isopropylpyrrole

Conditions

Conditions	Yield
With potassium hydroxide Reflux;	A n/a B n/a C 73%

...Expand

: 51370-34-4
4-Butyl-1-oxa-4-aza-spiro[4.5]decane

A: 51265-35-1
1-butyl-4,5,6,7-tetrahydro-1H-indole

B: 111-75-1
2-butylamino-ethanol

C: 108-93-0
cyclohexanol

Conditions

Conditions	Yield
With potassium hydroxide Heating; CH3ONa as reagent;	A 62% B n/a C n/a

...Expand

: 109-65-9
1-bromo-butane

: 141-43-5
ethanolamine

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
at 50 - 60℃;
at 50 - 60℃;

: 141-43-5
ethanolamine

: 123-72-8
butyraldehyde

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
With ethanol; platinum Hydrogenation;

: 109-73-9
N-butylamine

: 107-07-3
2-chloro-ethanol

: 111-75-1
2-butylamino-ethanol

: 1-Butyltriazoline

A: 1120-85-0
N-butylaziridine

B: 111-75-1
2-butylamino-ethanol

C: 75-07-0
acetaldehyde

D: 109-73-9
N-butylamine

Conditions

Conditions	Yield
With water at 25℃; Rate constant; Mechanism; pH 10.75 (lysine buffer); H/D isotope effect;

...Expand

: 64-17-5
ethanol

: 141-43-5
ethanolamine

: 123-72-8
butyraldehyde

platinum oxide: platinum oxide

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
Hydrogenation;

...Expand

N-<2-hydroxy-ethyl>-N-butyl-aniline: N-<2-hydroxy-ethyl>-N-butyl-aniline

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
With sodium nitrite und Zersetzung des Reaktionsprodukts mit konz.NaOH;
With sodium nitrite und Zersetzung des Reaktionsprodukts mit konz.NaOH;

: 102-79-4
n-butyldiethanolamine

: 7664-41-7
ammonia

hydrogen: hydrogen

Raney nickel: Raney nickel

A: 5610-49-1
N-butylpiperazine

B: 111-75-1
2-butylamino-ethanol

C: 30935-67-2
N-(2-aminoethyl)-N-butyl-1,2-ethanediamine

Conditions

Conditions	Yield
at 200℃; under 51485.6 Torr;

...Expand

: 141-43-5
ethanolamine

: 71-36-3
butan-1-ol

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
With mesoporous Cs-B-Zr mixed oxide In neat (no solvent) at 220℃; under 32253.2 Torr; for 0.5h; Autoclave; Inert atmosphere; Green chemistry;

: C6H13NO

: 111-75-1
2-butylamino-ethanol

Conditions

Conditions	Yield
With sodium tetrahydroborate

: 111-75-1
2-butylamino-ethanol

: 4897-84-1
Methyl 4-bromobutyrate

: methyl 4-(butyl(2-hydroxyethyl)amino)butanoate

Conditions

Conditions	Yield
Stage #1: 2-butylamino-ethanol With potassium carbonate In acetonitrile at 20℃; for 0.166667h; Stage #2: Methyl 4-bromobutyrate In acetonitrile Reflux;	100%

: 79-43-6
dichloro-acetic acid

: 111-75-1
2-butylamino-ethanol

: C6H15NO*C2H2Cl2O2

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	98%

: 111-75-1
2-butylamino-ethanol

: 69-72-7
salicylic acid

: 2-hydroxy-N-butylethanaminium salicylate

Conditions

Conditions	Yield
In methanol at 0 - 50℃;	97.59%

: 111-75-1
2-butylamino-ethanol

: 107291-76-9
4-Ethyl-4-hydroxyhex-2-ynenitrile

: 134965-81-4
2-[Butyl-(2,2-diethyl-5-imino-2,5-dihydro-furan-3-yl)-amino]-ethanol

Conditions

Conditions	Yield
In dichloromethane at 40℃; for 24h;	95%

: 75-15-0
carbon disulfide

: 111-75-1
2-butylamino-ethanol

: C7H14NOS2(1-)*K(1+)

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 0 - 20℃; for 5h; Inert atmosphere; Schlenk technique;	95%
With potassium hydroxide In ethanol at 0 - 20℃; for 5h; Schlenk technique; Inert atmosphere;	95%

: 617-86-7
triethylsilane

: 111-75-1
2-butylamino-ethanol

: 20467-03-2
1-triethylsilyloxy-2-(butylamino)ethane

Conditions

Conditions	Yield
With nickel at 130℃; for 2h;	93%
With sodium

: 7681-84-7
tetrahydrofuran-2-carbaldehyde

: 111-75-1
2-butylamino-ethanol

: 78749-73-2
2-(2'-tetrahydrofuryl)-3-butyl-1,3-oxazolidine

Conditions

Conditions	Yield
	92%

: 111-75-1
2-butylamino-ethanol

: 75-36-5
acetyl chloride

: 19520-95-7
1-acetoxy-2-(acetyl-butyl-amino)-ethane

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h; Acetylation;	92%

: 75-15-0
carbon disulfide

: 111-75-1
2-butylamino-ethanol

: 20667-12-3
silver(l) oxide

: C7H14NOS2(1-)*Ag(1+)

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 10h; Inert atmosphere; Schlenk technique;	89%

...Expand

: 111-75-1
2-butylamino-ethanol

: 57682-09-4
methyl 2-(4-benzoylphenoxy)acetate

: 1129771-59-0
C21H25NO4

Conditions

Conditions	Yield
With potassium hydroxide at 105℃; for 2h;	87%

: 111-75-1
2-butylamino-ethanol

: 201230-82-2
carbon monoxide

: 4-butyl-2,3-morpholinedione

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; oxygen In acetonitrile for 20h; Ambient temperature;	86%

: 67-66-3
chloroform

: 111-75-1
2-butylamino-ethanol

: 2-(N-butyl-N-formylamino)ethanol

Conditions

Conditions	Yield
With potassium fluoride on basic alumina In acetonitrile at 20℃; for 24h;	86%

: 111-75-1
2-butylamino-ethanol

: 74788-58-2
(1-Isothiocyanato-2-methyl-propyl)-benzene

: 74787-94-3
1-Butyl-1-(2-hydroxy-ethyl)-3-(2-methyl-1-phenyl-propyl)-thiourea

Conditions

Conditions	Yield
In chloroform for 1h; Heating;	85.7%

: 111-75-1
2-butylamino-ethanol

: 16004-15-2
1-bromomethyl-4-iodobenzene

: 106790-67-4
2-[Butyl-(4-iodo-benzyl)-amino]-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 4h;	85%

: 111-75-1
2-butylamino-ethanol

: 563-47-3
3-Chloro-2-methylpropene

: 2-[Butyl-(2-methyl-allyl)-amino]-ethanol

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water Heating;	83%

: 2243-35-8
2-acetoxyacetophenone

: 111-75-1
2-butylamino-ethanol

: 21532-12-7
4-butyl-2-phenyl-morpholine

Conditions

Conditions	Yield
With formic acid at 180℃; for 20h;	82%

: 111-75-1
2-butylamino-ethanol

: 1214385-51-9
5-bromo-6-oxo-1,6-dihydropyridine-2-carboxylic acid

: 1420476-85-2
7-bromo-2-butyl-3,4-dihydro-1H-pyrido[1,2-a]pyrazine-1,6(2H)-dione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane Reflux;	82%

: 111-75-1
2-butylamino-ethanol

: 105627-79-0
isoquinoline-5-sulfonyl chloride hydrochloride

: 116970-52-6
Isoquinoline-5-sulfonic acid butyl-(2-hydroxy-ethyl)-amide

Conditions

Conditions	Yield
With sodium hydrogencarbonate 1) H2O, 2) CHCl3, RT, 1 h;	79%

: 111-75-1
2-butylamino-ethanol

: 77545-45-0
3’,6’-dichlorospiro[3H-2,1-benzoxathiol-3,9’-[9H]xanthene]-1,1-dioxide

: C31H38N2O6S

Conditions

Conditions	Yield
In isopropyl alcohol at 80℃; for 8h;	78%

: 1135-24-6
3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 111-75-1
2-butylamino-ethanol

: 2‑(butylamino)ethanol ferulate

Conditions

Conditions	Yield
In water for 24h;	77.66%
In water for 24h; Reflux;

: 111-75-1
2-butylamino-ethanol

: 95-92-1
oxalic acid diethyl ester

: 4-butyl-2,3-morpholinedione

Conditions

Conditions	Yield
With potassium hydroxide 1) 110 deg C, 2 h; 2) 100 deg C, 2 h;	75%

: 111-75-1
2-butylamino-ethanol

: 1346549-28-7
C17H25N3O2

: 1346549-30-1
C23H40N4O3

Conditions

Conditions	Yield
In chloroform for 4h; Inert atmosphere;	75%

: 111-75-1
2-butylamino-ethanol

: 106-96-7
propargyl bromide

: 13105-74-3
N-Butyl-N-(2-hydroxyethyl)-propargylamin

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; toluene at 0 - 20℃;	75%

: 131543-46-9
Glyoxal

: 111-75-1
2-butylamino-ethanol

: 68182-84-3
N-butylmorpholine-2-one

Conditions

Conditions	Yield
In water for 1h; Heating;	73%

: 111-75-1
2-butylamino-ethanol

: 4-chloro-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidine

A: 2-[butyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethan-1-ol

B: butyl[2-[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yloxy]ethyl]amine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 130℃; for 6h;	A 71% B 24%

...Expand

: 111-75-1
2-butylamino-ethanol

: 107-05-1
3-chloroprop-1-ene

: 152563-34-3
2-(allyl-butyl-amino)-ethanol

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water Heating;	70%

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 111-75-1
2-butylamino-ethanol

: 677277-87-1
2-[butyl-(6-methoxy-3-nitro-pyridin-2-yl)amino]ethanol

Conditions

Conditions	Yield
In 1,4-dioxane; water for 2h; Heating / reflux;	70%

: 111-75-1
2-butylamino-ethanol

: 70-11-1
α-bromoacetophenone

: 126806-92-6
4-Butyl-2-phenyl-morpholin-2-ol; hydrochloride

Conditions

Conditions	Yield
In diethyl ether	68%

2-Butylaminoethanol Consensus Reports

Reported in EPA TSCA Inventory.

2-Butylaminoethanol Specification

The 2-Butylaminoethanol with CAS registry number of 111-75-1 is also known as 2-(N-Monobutylamino)ethanol. The IUPAC name and product name are the same. Its EINECS registry number is 203-904-5. In addition, the formula is C₆H₁₅NO and the molecular weight is 117.19.

Physical properties about 2-Butylaminoethanol are: (1)ACD/LogP: 0.63; (2)ACD/LogD (pH 5.5): -2.46; (3)ACD/LogD (pH 7.4): -1.85; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.435; (12)Molar Refractivity: 34.97 cm³; (13)Molar Volume: 133.8 cm³; (14)Surface Tension: 30.8 dyne/cm; (15)Density: 0.875 g/cm³; (16)Flash Point: 79.3 °C; (17)Enthalpy of Vaporization: 50.64 kJ/mol; (18)Boiling Point: 199.1 °C at 760 mmHg; (19)Vapour Pressure: 0.0875 mmHg at 25 °C.

Preparation of 2-Butylaminoethanol: it is prepared by reaction of oxirane with butylamine. The reaction needs solvent ethanol, H₂O at the temperature of 30-40 °C. The yield is about 78%.

2-Butylaminoethanol is prepared by reaction of oxirane with butylamine.

Uses of 2-Butylaminoethanol: it is used to produce 1-triethylsilyloxy-2-(butylamino)ethane by reaction with triethylsilane. The reaction occurs with reagent Ni at 130 °C for 2 hours. The yield is about 93%.

2-Butylaminoethanol is used to produce 1-triethylsilyloxy-2-(butylamino)ethane by reaction with triethylsilane.

When you are using this chemical, please be cautious about it. As a chemical, it is harmful if swallowed and may cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CCCCNCCO
2. InChI: InChI=1S/C6H15NO/c1-2-3-4-7-5-6-8/h7-8H,2-6H2,1H3
3. InChIKey: LJDSTRZHPWMDPG-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	7100mg/kg (7100mg/kg)	CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 8, Pg. 344, 1966.
rat	LD50	intraperitoneal	840mg/kg (840mg/kg)		Toxicology and Applied Pharmacology. Vol. 12, Pg. 486, 1968.
rat	LD50	oral	1150mg/kg (1150mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.

Product Name

2-(BUTYLAMINO)ETHANOL

Synthetic route

2-Butylaminoethanol Consensus Reports

2-Butylaminoethanol Specification

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