2-Chloro-4,6-diphenyl-1,3,5-triazine supplier

Name
2-chloro-4,6-diphenyl-1,3,5-triazine
EINECS
CAS No. 3842-55-5
Article Data102
CAS DataBase
Density 1.265 g/cm³
Solubility
Melting Point 138-140℃
Formula C₁₅H₁₀ClN₃
Boiling Point 485.1 °C at 760 mmHg
Molecular Weight 267.717
Flash Point 279.2 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms s-Triazine,2-chloro-4,6-diphenyl- (6CI,7CI,8CI);2-Chloro-4,6-bisphenyl-1,3,5-triazine;2-Chloro-4,6-diphenyl-1,3,5-triazine;2-Chloro-4,6-diphenyl-s-triazine;6-Chloro-2,4-diphenyl-s-triazine;NSC 231670;
PSA 38.67000
LogP 3.85900

Synthetic route

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 98-80-6
phenylboronic acid

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With bis(tricyclohexylphosphine)nickel(II) dichloride; potassium carbonate In tetrahydrofuran at 70℃; for 12h; Reagent/catalyst; Solvent; Temperature; Friedel-Crafts Alkylation; Green chemistry;	94.1%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 8h; Inert atmosphere; Reflux;	71%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene for 8h; Inert atmosphere; Reflux;	71%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 71-43-2
benzene

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With aluminum (III) chloride In 5,5-dimethyl-1,3-cyclohexadiene at 70℃; for 4h; Time; Temperature;	92%
With hydrogenchloride; aluminum (III) chloride In water; chlorobenzene at 20℃; for 25h; Temperature; Reagent/catalyst; Cooling with ice;	84%
With aluminum (III) chloride In ethyl acetate; chlorobenzene at 18 - 22℃; for 4h;

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 100-58-3
phenylmagnesium bromide

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;	89%
In tetrahydrofuran at 0 - 20℃; for 12h;	80%
In tetrahydrofuran; diethyl ether at 0 - 20℃; for 13h;	80.5%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With potassium phosphate; palladium diacetate In water; N,N-dimethyl-formamide at 130℃; for 10h; Inert atmosphere;	85.2%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃;	64%

: 1700-02-3
2,4-dichloro-6-phenyl-1,3,5-triazine

: 98-80-6
phenylboronic acid

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 10h; Inert atmosphere;	75.4%
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In water; toluene for 10h; Inert atmosphere; Reflux;	75%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 10h; Inert atmosphere;	67.3%

: 1917-44-8
4,6-diphenyl-1H-[1,3,5]triazin-2-one

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With N,N-diethylaniline; trichlorophosphate at 140℃; for 6h; Sealed tube;	74%
With thionyl chloride; phosphorus pentachloride; 1,2-dichloro-benzene at 140℃;

: 108-86-1
bromobenzene

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran for 4h; Inert atmosphere; Reflux; Stage #2: 1,3,5-trichloro-2,4,6-triazine In tetrahydrofuran for 5h; Inert atmosphere;	73.5%
Stage #1: bromobenzene With iodine; magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: 1,3,5-trichloro-2,4,6-triazine In tetrahydrofuran for 7h; Reflux; Inert atmosphere;	73.5%
Stage #1: bromobenzene With magnesium In tetrahydrofuran at 40 - 50℃; Stage #2: 1,3,5-trichloro-2,4,6-triazine In tetrahydrofuran at -5 - 5℃;	72.8%

: 1700-02-3
2,4-dichloro-6-phenyl-1,3,5-triazine

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide In tetrahydrofuran; water Reflux;	66%

: 3764-01-0
2,4,6-trichloropyrimidine

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 90℃;	65%

: 3764-01-0
2,4,6-trichloropyrimidine

: 100-58-3
phenylmagnesium bromide

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 50℃; for 10h;	61%

: 93-98-1
N-phenyl benzoyl amide

: 17513-09-6
N′-cyanobenzamidine

A: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

B: 30369-20-1
(4,6-Diphenyl-1,3,5-triazin-2-yl)phenylamine

Conditions

Conditions	Yield
With phosphorus pentachloride CH3CN, 1h, reflux; Yield given. Multistep reaction;	A 48% B n/a
With phosphorus pentachloride CH3CN, 1h, reflux; Yield given. Multistep reaction;	A n/a B 25%

...Expand

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: phenylmagnesium bromide

A: 1700-02-3
2,4-dichloro-6-phenyl-1,3,5-triazine

B: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: phenylmagnesium bromide

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 95390-15-1
5-nitroso-2,4-diphenyl-imidazole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With chloroform; phosphorus pentachloride

: 17513-09-6
N′-cyanobenzamidine

: 4-(Chloro-phenyl-methylene)-morpholin-4-ium; chloride

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
In toluene for 1h; Heating; Yield given;

: 17513-09-6
N′-cyanobenzamidine

: 611-74-5
N,N-dimethylbenzamide

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With trichlorophosphate 1.) 5 min, 100 deg C, 2.) CH3CN, 30 min, reflux; Yield given. Multistep reaction;

: 67-66-3
chloroform

: 95390-15-1
5-nitroso-2,4-diphenyl-imidazole

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

...Expand

6-oxy-2.4-diphenyl-1.3.5-triazine: 6-oxy-2.4-diphenyl-1.3.5-triazine

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With trichlorophosphate

: 108-86-1
bromobenzene

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

iodine-activated magnesium: iodine-activated magnesium

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; water; toluene
With hydrogenchloride In tetrahydrofuran; water; chlorobenzene; toluene

...Expand

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / Reflux 2: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / Reflux View Scheme

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 100-59-4
phenylmagnesium chloride

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 15h;	42.8 g

: 98-80-6
phenylboronic acid

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 10 h / 80 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 10 h / 80 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 10 h / 80 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 10 h / 80 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / toluene / 10 h / Inert atmosphere; Reflux 2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / toluene; water / 10 h / Inert atmosphere; Reflux View Scheme

: 108-80-5
isocyanuric acid

: 71-43-2
benzene

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
Stage #1: isocyanuric acid; benzene With 1-butyl-3-methylimidazolium Tetrafluoroborate In 1,2-dichloro-benzene at 5℃; for 2h; Stage #2: With hydrogenchloride In 1,2-dichloro-benzene at 5 - 15℃; for 12h; Reagent/catalyst;

: 108-86-1
bromobenzene

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pd catalyst / tetrahydrofuran / 5 h / 80 °C / Inert atmosphere 2: potassium phosphate; palladium diacetate / water; N,N-dimethyl-formamide / 10 h / 130 °C / Inert atmosphere View Scheme

: 833486-94-5
4-amino-3-nitrophenylboronic acid pinacol ester

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C21H15N5O2

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 12h; Reflux;	100%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 5,8-dihydro-indolo[2,3-C]carbazole

: C48H30N8

Conditions

Conditions	Yield
Stage #1: 5,8-dihydro-indolo[2,3-C]carbazole With sodium hydride In N,N-dimethyl-formamide for 1h; Inert atmosphere; Stage #2: 2-chloro-4,6-diphenyl-1,3,5-triazine In N,N-dimethyl acetamide Inert atmosphere;	100%
With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide In water Reflux; Inert atmosphere;

: 1592-95-6
3-bromo-9H-carbazole

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 1266389-17-6
3-bromo-9-(4,6-diphenyl-[1,3,5]triazin-2-yl)-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;	98%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; Inert atmosphere;	93.2%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h; Inert atmosphere;	90%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 5467-74-3
4-Bromophenylboronic acid

: 23449-08-3
2-(4-bromobenzenyl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 12h; Inert atmosphere;	96%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water; toluene for 12h; Reflux;	96.5%
With tetrakis(triphenylphosphine) palladium(0); tetrabutyl-ammonium chloride; potassium carbonate In ethanol; water; toluene at 78℃; for 10h; Inert atmosphere;	82%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C42H37BO2

: C51H35N3

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran at 80℃; for 20h; Inert atmosphere;	96%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 73852-17-2
2,6-dichlorophenylboronic acid

: 2-(2,6-dichlorophenyl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water for 12h; Reflux; Inert atmosphere;	96%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 2-chloro-4,6-bis(phenyl-D5)-1,3,5-triazine

Conditions

Conditions	Yield
With platinum(IV) oxide; water-d2 at 250℃; for 14h;	96%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 1765-93-1
4-fluoroboronic acid

: 2-di(4-fluorophenyl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at -20℃; Suzuki Coupling; Reflux;	95.3%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 10h; Inert atmosphere; Reflux;	93%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran for 10h; Inert atmosphere; Reflux;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 100622-34-2
anthracene-9-boronic acid

: 2-(9-anthryl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 90℃; for 12h;	95%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; toluene at 110℃; for 12h; Inert atmosphere;	95.17%
Stage #1: 2-chloro-4,6-diphenyl-1,3,5-triazine; anthracene-9-boronic acid With tetrakis(triphenylphosphine) palladium(0) In ethanol; toluene for 0.5h; Inert atmosphere; Stage #2: With sodium carbonate In ethanol; toluene at 80℃; for 12h; Inert atmosphere;	70%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C33H31BO3

: C42H29N3O

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 8h; Inert atmosphere;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 89598-96-9
(3-bromophenyl)boronic acid

: 864377-31-1
2-(3-bromo-phenyl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 12h; Inert atmosphere;	95%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 12h; Inert atmosphere;	95%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 12h; Inert atmosphere;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 1257247-97-4
7-bromo-12,12-dimethyl-10,12-dihydro-10-azaindeno[2,1-b]fluorene

: 1257247-98-5
2-bromo-5- (4,6-diphenyl-1,3,5-triazin-2-yl)-7,7-dimethyl-5,7-dihydroindeno[2,1-b]carbazole

Conditions

Conditions	Yield
Stage #1: 7-bromo-12,12-dimethyl-10,12-dihydro-10-azaindeno[2,1-b]fluorene With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 2-chloro-4,6-diphenyl-1,3,5-triazine In N,N-dimethyl-formamide; mineral oil at 20℃; for 12h;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C24H15N

: C39H24N4

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 15h; Inert atmosphere;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C25H18N2

: C40H27N5

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In toluene for 3h; Reflux;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 2,2'-(4-fluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

: 6,6'-(4-fluoro-1,3-phenylene)bis(2,4-diphenyl-1,3,5-triazine)

Conditions

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 100℃; for 16h; Suzuki Coupling; Inert atmosphere;	95%
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 100℃; for 16h; Inert atmosphere;

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C29H20N2

: C44H29N5

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In toluene at 100℃; for 3h;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 2-(6-(9,9-dimethyl-9H-xanthen-3-yl)dibenzo[b,d]furan-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: C42H29N3O2

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 120℃; for 3h;	95%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 143418-49-9
3,4,5-trifluorophenylboronic acid

: 2, 4-diphenyl-6-(3,4,5-trifluorophenyl)-1,3,5-triazine

Conditions

Conditions	Yield
Stage #1: 2-chloro-4,6-diphenyl-1,3,5-triazine; 3,4,5-trifluorophenylboronic acid With potassium carbonate In tetrahydrofuran; water at 20℃; Inert atmosphere; Stage #2: With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water for 12h; Reflux;	94%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 106℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	77%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; trifluoroacetic acid
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C33H30BNO3

: C42H28N4O

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 4.5h; Inert atmosphere; Heating;	94%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 144432-85-9
3-chloro-4-fluorophenylboronic acid

: 2-(3-chloro-4-fluorophenyl)-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With palladium diacetate; sodium carbonate; tris-(o-tolyl)phosphine In tetrahydrofuran; water for 2h; Inert atmosphere; Reflux;	94%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene Reflux;	82%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 3-bromo-9H-carbazole sodium salt

: 1266389-17-6
3-bromo-9-(4,6-diphenyl-[1,3,5]triazin-2-yl)-9H-carbazole

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	94%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 1346669-46-2
3-(dibenzo[b,d]furan-4-yl)-9H-carbazole

: 1346669-12-2
3-(dibenzo[b,d]furan-4-yl)-9-(4,6-diphenyl-1,3,5-triazin-2-yl)-9H-carbazole

Conditions

Conditions	Yield
Stage #1: 3-(dibenzo[b,d]furan-4-yl)-9H-carbazole With sodium hydride In N,N-dimethyl-formamide for 0.25h; Inert atmosphere; Stage #2: 2-chloro-4,6-diphenyl-1,3,5-triazine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	93.5%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C28H17NO

: C43H26N4O

Conditions

Conditions	Yield
Stage #1: C28H17NO With sodium hydride In N,N-dimethyl-formamide for 0.25h; Inert atmosphere; Stage #2: 2-chloro-4,6-diphenyl-1,3,5-triazine In N,N-dimethyl-formamide for 2h;	93.5%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: 124-41-4
sodium methylate

: 108718-58-7
2-methoxy-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
In methanol for 0.5h; Ambient temperature;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C18H11NO2

: C33H20N4O2

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C26H16N2

: C41H25N5

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C30H20N2

: C45H29N5

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C24H16N2

: C39H25N5

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	93%

: 3842-55-5
2-chloro-4,6-diphenyl-1,3,5-triazine

: C24H16N2

: C39H25N5

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	93%

2-Chloro-4,6-diphenyl-1,3,5-triazine Specification

1.Introduction of 2-Chloro-4,6-diphenyl-1,3,5-triazine

The 2-Chloro-4,6-diphenyl-1,3,5-triazine, with the CAS registry number 3842-55-5, is also known as 1,3,5-Triazine, 2-chloro-4,6-diphenyl-. This chemical's molecular formula is C₁₅H₁₀ClN₃ and formula weight is 267.71. What's more, both its IUPAC name and systematic name are the same which is called 2-Chloro-4,6-diphenyl-1,3,5-triazine.

2.Physical properties about this chemical

(1)ACD/LogP: 4.36; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.36; (4)ACD/LogD (pH 7.4): 4.36; (5)ACD/BCF (pH 5.5): 1213.32; (6)ACD/BCF (pH 7.4): 1213.32; (7)ACD/KOC (pH 5.5): 5611.87; (8)ACD/KOC (pH 7.4): 5611.88; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 38.67 Å²; (13)Index of Refraction: 1.622; (14)Molar Refractivity: 74.6 cm³; (15)Molar Volume: 211.6 cm³; (16)Surface Tension: 53.4 dyne/cm; (17)Density: 1.265 g/cm³; (18)Flash Point: 279.2 °C; (19)Enthalpy of Vaporization: 72.19 kJ/mol; (20)Boiling Point: 485.1 °C at 760 mmHg; (21)Vapour Pressure: 4.3E-09 mmHg at 25°C.

3.Structure descriptors of 2-Chloro-4,6-diphenyl-1,3,5-triazine

(1)Canonical SMILES: C1=CC=C(C=C1)C2=NC(=NC(=N2)Cl)C3=CC=CC=C3
(2)InChI: InChI=1S/C15H10ClN3/c16-15-18-13(11-7-3-1-4-8-11)17-14(19-15)12-9-5-2-6-10-12/h1-10H
(3)InChIKey: DDGPPAMADXTGTN-UHFFFAOYSA-N

4. Preparation of 2-Chloro-4,6-diphenyl-1,3,5-triazine

2-Chloro-4,6-diphenyl-1,3,5-triazine can be prepared by N-Phenyl-benzamide and N-Cyano-benzamidine. This reaction will need reagent PCl₅. The reaction time is 1 hour. The yield is about 48%.

5.Uses of 2-Chloro-4,6-diphenyl-1,3,5-triazine

2-Chloro-4,6-diphenyl-1,3,5-triazine can be used to produce 2-Ethoxy-4,6-diphenyl-[1,3,5]triazine at the ambient temperature. This reaction will need reagent sodium methanolate and solvent ethanol with reaction time of 7 days. The yield is about 36.1%.

Product Name

2-chloro-4,6-diphenyl-1,3,5-triazine

Synthetic route

2-Chloro-4,6-diphenyl-1,3,5-triazine Specification

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