2-Chloro-4-hydroxybenzaldehyde supplier

Name
2-Chloro-4-hydroxybenzaldehyde
EINECS
CAS No. 56962-11-9
Article Data14
CAS DataBase
Density 1.404 g/cm³
Solubility
Melting Point 145-147 °C(lit.)
Formula C₇H₅ClO₂
Boiling Point 272.492 °C at 760 mmHg
Molecular Weight 156.569
Flash Point 118.599 °C
Transport Information
Appearance
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms o-Chloro-p-hydroxybenzaldehyde;
PSA 37.30000
LogP 1.85810

Synthetic route

: 3336-16-1
2-chloro-4-hydroxybenzonitrile

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-hydroxybenzonitrile With diisobutylaluminium hydride In tetrahydrofuran; hexane at -78 - 20℃; for 19h; Stage #2: With hydrogenchloride In tetrahydrofuran; hexane; water at 0℃;	84%
With diisobutylaluminium hydride In tetrahydrofuran; hexane at -78 - 20℃; for 3h;
Stage #1: 2-chloro-4-hydroxybenzonitrile With diisobutylaluminium hydride In hexane; chloroform at -50℃; for 1.5h; Stage #2: With hydrogenchloride In methanol; water

: 108-43-0
3-monochlorophenol

: 67-66-3
chloroform

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 3-monochlorophenol; chloroform With calcium hydroxide; water; sodium carbonate for 4.33333h; Heating / reflux; Stage #2: With hydrogenchloride In chloroform; water	16%
With water; sodium carbonate; calcium hydroxide for 4.33333h; Inert atmosphere; Reflux;	15.3%
With sodium carbonate; calcium hydroxide In water for 3h; Reflux; Inert atmosphere;	15.3%

: 108-43-0
3-monochlorophenol

: 74-90-8
hydrogen cyanide

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; aluminium trichloride; benzene at 30℃; Durch Erhitzen des Reaktionsproduktes mit verd. Salzsaeure;

: 121-86-8
2-chloro-4-nitrotoluene

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide; sulfur Diazotieren des Reaktionsproduktes und nachfolgendes Kochen mit 40prozentiger Schwefelsaeure;

: 874-42-0
2,4-dichlorobenzaldeyhde

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate at 220℃; unter Druck;

: 108-43-0
3-monochlorophenol

: 76-03-9
trichloroacetic acid

A: 2420-26-0
4-chlorosalicylaldehyde

B: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With potassium hydroxide; water

...Expand

: 108-43-0
3-monochlorophenol

: 67-66-3
chloroform

A: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

B 4-chloro-2-oxy-benzaldehyde: 4-chloro-2-oxy-benzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide Mengenverhaeltnis zwischen den Produkten;
With extinguished lime; sodium carbonate; calcium carbonate

...Expand

: 108-43-0
3-monochlorophenol

: 75-25-2
Bromoform

A: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

B 4-chloro-2-oxy-benzaldehyde: 4-chloro-2-oxy-benzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide Mengenverhaeltnis zwischen den Produkten;

...Expand

: 108-43-0
3-monochlorophenol

: 76-03-9
trichloroacetic acid

aqueous KOH: aqueous KOH

A: 2420-26-0
4-chlorosalicylaldehyde

B: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

...Expand

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 131543-46-9
Glyoxal

: 3-chloro-4-(1H-imidazol-2-yl)phenol

Conditions

Conditions	Yield
With ammonium hydroxide In methanol; water at 0 - 20℃; for 28h; Inert atmosphere;	100%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 2-(2-chloro-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Conditions

Conditions	Yield
With iodine In ethanol for 4h; Inert atmosphere; Reflux;	100%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 550377-89-4
4-{[tert-butyl(dimethyl)silyl]oxy}-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	99%
With 1H-imidazole; dmap In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	75%
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 65h;	39%

: 5162-44-7
1-bromo-4-butene

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1196879-38-5
4-(but-3-enyloxy)-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere;	98%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 114416-77-2
4-acetoxy-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With pyridine; acetic anhydride In dichloromethane	96%

: 2295-31-0
2,4-thiazolidinedion

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: (5-(2-chloro-4-hydroxybenzylidene)thiazolidine-2,4-dione)

Conditions

Conditions	Yield
With piperidine; acetic acid In toluene at 80℃; Dean-Stark;	95%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1374961-75-7
C13H14BrNO

: 1374961-77-9
2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	94%

: 946426-89-7
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1268246-55-4
2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]benzaldehyde

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;	94%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 75-03-6
ethyl iodide

: 4-ethoxy-2-chloro-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2.5h;	93%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 5759-64-8
6-(Butylamino)-3-methyluracil

: 84459-40-5
10-Butyl-8-hydroxy-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 5h; Heating;	92%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1268245-50-6
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

: 1268246-55-4
2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	90%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 111-25-1
1-bromo-hexane

: 2-chloro-4-n-hexyloxybenzaldehyde

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In butanone for 5h; Reflux;	89%

: 15832-09-4
6-methoxy-3-coumaranone

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: C16H11ClO4

Conditions

Conditions	Yield
With hydrogenchloride In water; acetic acid at 20℃; for 2h;	88.9%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 100-39-0
benzyl bromide

: 117490-57-0
4-(benzyloxy)-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 72h; Product distribution / selectivity;	87%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 72h; Product distribution / selectivity;	87%
With potassium carbonate In acetone for 2h; Heating;	80%
With caesium carbonate In acetonitrile at 20℃; for 2h;	59%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 4442-79-9
cyclohexylethan-1-ol

: 1234323-04-6
2-chloro-4-(2-cyclohexylethoxy)benzaldehyde

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu Displacement;	87%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 627-30-5
1-chloro-3-hydroxypropane

: 2-chloro-4-(3-hydroxypropoxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 5 - 70℃; for 16h; Inert atmosphere;	86.6%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 75-36-5
acetyl chloride

: 114416-77-2
4-acetoxy-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h;	86%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 2-oxa-6-azaspiro[3.3]heptane 0.5 oxalic acid salt

: 1254035-91-0
3-chloro-4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenol

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In dichloromethane	85%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 174-78-7
2-oxa-6-azaspiro[3.3]heptane

: 1254035-91-0
3-chloro-4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenol

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-hydroxybenzaldehyde; 2-oxa-6-azaspiro[3.3]heptane In dichloromethane for 0.333333h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃;	85%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 5759-63-7
6-methylamino-3-methyluracil

: 75427-52-0
3,10-Dimethyl-8-hydroxy-2,4(3H,10H)-pyrimido<4,5-b>chinolindion

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 5h; Heating;	83%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 2969-81-5
4-bromoethylbutanoate

: ethyl 4-[3-chloro-4-formylphenoxy]butanoate

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-hydroxybenzaldehyde With potassium carbonate; potassium iodide In 1-methyl-pyrrolidin-2-one at 20℃; for 0.5h; Inert atmosphere; Stage #2: Ethyl 4-bromobutyrate In 1-methyl-pyrrolidin-2-one at 60℃; for 7h; Inert atmosphere;	82%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 957774-27-5
5-bromo-2-chloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With pyridinium hydrobromide perbromide In methanol at 0℃; for 4h; Inert atmosphere;	81.27%
With pyridinium hydrobromide perbromide In methanol at 0℃; for 5h;	73%
With pyridinium tribromide In methanol at 0℃; for 4h;
With Pyridine hydrobromide In dichloromethane at 0℃; for 5h;

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 140690-56-8
2,4-bis(trifluoromethyl)benzyl bromide

: 1264753-63-0
4-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2-chlorobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3.5h;	81%

: 7037-30-1
3-(1-methylpiperidine-4-yl)propane-1-ol

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 848847-25-6
2-chloro-4-[3-(1-methyl-piperidin-4-yl)-propoxy]-benzaldehyde

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 16h;	80%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 7269-15-0
6-anilinouracil

: 84459-38-1
8-Hydroxy-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 5h; Heating;	79%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 278597-30-1
[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methanol

: 278597-32-3
3-(2,6-dichlorophenyl)-4-(3'-chloro-4'-formylphenoxy)-methyl-5-isopropyl-isoxazole

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 4h; Mitsunobu Displacement; Inert atmosphere;	78%
With di-isopropyl azodicarboxylate; thiamine diphosphate In dichloromethane at 20℃; for 4h; Mitsunobu reaction;	63%
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 4h; Mitsunobu reaction;	63%
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃;

: 87-41-2
2-benzofuran-1(3H)-one

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: N'-(2-chloro-4-hydroxybenzylidene)-2-(hydroxymethyl)benzohydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 78℃; for 8h; Green chemistry;	78%

: 898253-47-9
4-(bromomethyl)-3-(2,6-dichlorophenyl)-5-isopropyl-isoxazole

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 278597-32-3
3-(2,6-dichlorophenyl)-4-(3'-chloro-4'-formylphenoxy)-methyl-5-isopropyl-isoxazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	77%

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 1374961-76-8
C15H18BrNO

: 1374961-79-1
2-chloro-4-{[3-(2,6-dimethylphenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	77%

2-Chloro-4-hydroxybenzaldehyde Chemical Properties

The Molecular formula of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9): C₇H₅ClO₂
The Molecular Weight of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9): 156.57
The Molecular Structure of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9):

Melting point: 145-147 ^°C(lit.)
Boiling Point: 272.5 °C at 760 mmHg
Flash Point: 118.6 °C
Index of Refraction: 1.632
Molar Refractivity: 39.78 cm³
Molar Volume: 111.4 cm³
Polarizability: 15.77 10^-24 cm³
Surface Tension: 54.7 dyne/cm
Density: 1.404 g/cm³
Enthalpy of Vaporization: 53.13 kJ/mol
Vapour Pressure: 0.00363 mmHg at 25°C
Synonyms: Benzaldehyde, 2-chloro-4-hydroxy-;2-CHLORO-4-HYDROXYBENZALDEHYDE;TIMTEC-BB SBB004014;

2-Chloro-4-hydroxybenzaldehyde Safety Profile

The Hazard Codes of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9):

Xi
The Risk Statements information of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-Chloro-4-hydroxybenzaldehyde(56962-11-9):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3

Product Name

2-Chloro-4-hydroxybenzaldehyde

Synthetic route

2-Chloro-4-hydroxybenzaldehyde Chemical Properties

2-Chloro-4-hydroxybenzaldehyde Safety Profile

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