2-Chloro-4-nitropyridine supplier

Name
2-Chloro-4-nitropyridine
EINECS -0
CAS No. 23056-36-2
Article Data5
CAS DataBase
Density 1.489 g/cm³
Solubility
Melting Point 52-56 °C
Formula C₅H₃ClN₂O₂
Boiling Point 258.4 °C at 760 mmHg
Molecular Weight 158.544
Flash Point 110.1 °C
Transport Information
Appearance Light yellow powder
Safety 26-36
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 2-Chlor-4-nitropyridin;pyridine, 2-chloro-4-nitro-;
PSA 58.71000
LogP 2.16640

Synthetic route

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

: 23056-36-2
2-chloro-4-nitropyridine

Conditions

Conditions	Yield
With phosphorus trichloride In dichloromethaneu for 4h; Reflux;	88%
With phosphorus trichloride In chloroform at 20℃; Heating / reflux;	78%
With ethyl acetate; phosphorus trichloride

: 1124-33-0
4-nitraminopyridine N-oxide

POCl3/PCl5: POCl3/PCl5

: 23056-36-2
2-chloro-4-nitropyridine

Conditions

Conditions	Yield
	60%

: 109-09-1
2-chloropyridine

: 23056-36-2
2-chloro-4-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: peroxyacetic acid; acetic acid 2: concentrated sulfuric acid; nitric acid 3: phosphorus (III)-chloride; ethyl acetate View Scheme

: 2402-95-1
2-chloropyridine-N-oxide

: 23056-36-2
2-chloro-4-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated sulfuric acid; nitric acid 2: phosphorus (III)-chloride; ethyl acetate View Scheme

: 23056-36-2
2-chloro-4-nitropyridine

: 109-86-4
2-methoxy-ethanol

: 1067914-32-2
2-chloro-4-(2-methoxyethoxy)pyridine

Conditions

Conditions	Yield
With potassium tert-butylate at 0 - 20℃; for 16.5h;	100%
With sodium hydride In tetrahydrofuran at 0 - 25℃; for 10h;	98%
With potassium tert-butylate at 0 - 20℃; for 2h;	97%

: 23056-36-2
2-chloro-4-nitropyridine

: 670-95-1
4-Phenylimidazole

: 1244039-73-3
C14H10ClN3

Conditions

Conditions	Yield
Stage #1: 4-Phenylimidazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h; Stage #2: 2-chloro-4-nitropyridine In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.166667h;	100%

: 23056-36-2
2-chloro-4-nitropyridine

: 7417-21-2
2-(3,4-dimethoxyphenyl)ethyl alcohol

: 1185999-53-4
2-chloro-4-(2-(3,4-dimethoxyphenyl)ethoxy)pyridine

Conditions

Conditions	Yield
With sodium hydride In paraffin oil (nujol); N,N-dimethyl-formamide at 0 - 20℃; for 1h;	100%

: 23056-36-2
2-chloro-4-nitropyridine

: 14704-41-7
3,5-bis(trifluoromethyl)pyrazole

: 5-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-2-nitropyridine

Conditions

Conditions	Yield
In N-methyl-acetamide; hexane; ethyl acetate	99%

: 23056-36-2
2-chloro-4-nitropyridine

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: C7H6N2O3

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-nitropyridine; tributyl(1-ethoxyvinyl)stannane With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 85℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; Solvent; Temperature; Reagent/catalyst;	99%

: 23056-36-2
2-chloro-4-nitropyridine

: 14432-12-3
4-Amino-2-chloropyridine

Conditions

Conditions	Yield
With titanium for 0.25h;	98%
With zinc borohydride pyridine complex In tetrahydrofuran for 2h; Heating;	96%
With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; chemoselective reaction;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 31846-36-3
7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 942077-61-4
7-[(2-chloropyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-nitropyridine; 7-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid With caesium carbonate In N,N-dimethyl-formamide at 50℃; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; pH=1.5;	97%

: 110-89-4
piperidine

: 23056-36-2
2-chloro-4-nitropyridine

: 4-nitro-2-(piperidin-1-yl)pyridine

Conditions

Conditions	Yield
With lithium trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 80℃; for 12h;	97%

: 123-75-1
pyrrolidine

: 23056-36-2
2-chloro-4-nitropyridine

: 914397-51-6
4-nitro-2-(pyrrolidin-1-yl)pyridine

Conditions

Conditions	Yield
With lithium trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 80℃; for 12h;	96%
In tetrahydrofuran at 80℃;	24%

: 23056-36-2
2-chloro-4-nitropyridine

: 622-08-2
2-Benzyloxyethanol

: 1029803-69-7
4-(2-benzyloxyethoxy)-2-chloropyridine

Conditions

Conditions	Yield
Stage #1: 2-Benzyloxyethanol With sodium hydride In tetrahydrofuran at 20℃; for 0.25h; Stage #2: 2-chloro-4-nitropyridine In tetrahydrofuran at 20℃;	96%

: 23056-36-2
2-chloro-4-nitropyridine

: 111-70-6
n-heptan1ol

: 1069098-66-3
2-chloro-4-(heptyloxy)pyridine

Conditions

Conditions	Yield
Stage #1: n-heptan1ol With sodium hydride In tetrahydrofuran; mineral oil at 50℃; for 4h; Inert atmosphere; Stage #2: 2-chloro-4-nitropyridine In tetrahydrofuran; mineral oil at 20℃; for 24h; Inert atmosphere;	96%

: 23056-36-2
2-chloro-4-nitropyridine

: 34851-41-7
tetrabutyl ammonium methoxide

: 17228-69-2
2-chloro-4-methoxy-pyridine

Conditions

Conditions	Yield
In tetrahydrofuran; methanol at 23℃; for 2h;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 109-85-3
2-methoxyethylamine

: 891856-57-8
2-(2-methoxyethyl)amino-4-aminopyridine

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-nitropyridine; 2-methoxyethylamine In ethanol for 1h; Heating / reflux; Stage #2: With hydrogen; palladium 10% on activated carbon In ethanol under 2585.81 Torr; for 2h;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 109-86-4
2-methoxy-ethanol

: 936112-80-0
2-(2-methoxyethoxy)-4-aminopyridine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-ethanol With sodium hydride at 20℃; for 0.5h; Stage #2: 2-chloro-4-nitropyridine at 20℃; for 0.333333h; Stage #3: With hydrogen; palladium 10% on activated carbon In methanol under 2585.81 Torr; for 2h;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 1351997-30-2
((1S,4S)-4-hydroxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-carbamic acid tert-butyl ester

: 1443243-09-1
[(1S,4S)-4-(2-chloro-pyridin-4-yloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere;	95%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 6295-87-0
N-aminopyridin-1-ium iodide

: (2-chloropyridin-4-yl)(pyridin-1-ium-1-yl)amide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 23℃; for 10h;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 105-53-3
diethyl malonate

: 13508-96-8
2-methyl-4-nitro-pyridine

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium at 90 - 120℃; for 1.75h; Stage #2: 2-chloro-4-nitropyridine In toluene at 20 - 110℃; for 16.5h;	95%
Stage #1: diethyl malonate With sodium at 90 - 120℃; for 1.75h; Stage #2: 2-chloro-4-nitropyridine In toluene at 20 - 110℃; for 16.5h; Stage #3: With hydrogenchloride; water for 3.5h; Reflux;	95%

: 23056-36-2
2-chloro-4-nitropyridine

: 141-52-6
sodium ethanolate

: 52311-50-9
2-chloro-4-ethoxy-pyridine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 25℃; for 12h;	92%
In tetrahydrofuran at 0 - 25℃; for 12h; Large scale;	92.4%
In tetrahydrofuran at 0 - 25℃; for 12h;	92.4%
In tetrahydrofuran at 25℃; for 10h;	57%
In tetrahydrofuran at 0 - 25℃; for 12h;

: 23056-36-2
2-chloro-4-nitropyridine

: 111-92-2
dibutylamine

: N,N-dibutyl-4-nitropyridin-2-amine

Conditions

Conditions	Yield
With lithium trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 80℃; for 12h;	92%

: 23056-36-2
2-chloro-4-nitropyridine

: 75-89-8
2,2,2-trifluoroethanol

: 2-chloro-4-(2,2,2-trifluoroethoxy)pyridine

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 60℃; Sealed tube;	91%

: 23056-36-2
2-chloro-4-nitropyridine

: 108-95-2
phenol

: 334010-49-0
2-chloro-4-(phenoxy)pyridine

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	90%
With sodium hydride In 1,4-dioxane at 100℃; for 12h;	52%
With sodium hydride In 1,4-dioxane Heating;	52%

: 23056-36-2
2-chloro-4-nitropyridine

: 945988-41-0
methyl 3-(2-chloropyridin-4-yloxy)benzoate

Conditions

Conditions	Yield
Stage #1: methyl 3-hydroxybenzoate With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Stage #2: 2-chloro-4-nitropyridine In N,N-dimethyl-formamide at 0 - 20℃;	90%

: 1121-25-1
2-methyl-3-pyridinol

: 23056-36-2
2-chloro-4-nitropyridine

: 1043022-76-9
2-chloro-4-(2-methylpyridin-3-yl)oxy-pyridine

Conditions

Conditions	Yield
Stage #1: 2-methyl-3-pyridinol With sodium hydride In N,N-dimethyl-formamide for 1h; Stage #2: 2-chloro-4-nitropyridine In N,N-dimethyl-formamide at 20℃;	90%

: 110-85-0
piperazine

: 23056-36-2
2-chloro-4-nitropyridine

: 79-03-8
propionyl chloride

: 947249-82-3
1-[4-(5-amino-pyridin-2-yl)-piperazin-1-yl]-propan-1-one

Conditions

Conditions	Yield
Stage #1: piperazine; 2-chloro-4-nitropyridine In ethanol for 1h; Heating / reflux; Stage #2: propionyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h; Stage #3: With hydrogen; palladium 10% on activated carbon In ethanol under 2585.81 Torr; for 2h;	90%

...Expand

: 23056-36-2
2-chloro-4-nitropyridine

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

Conditions

Conditions	Yield
Stage #1: 2-chloro-4-nitropyridine With urea hydrogen peroxide adduct; trifluoroacetic acid In dichloromethane at 0 - 20℃; for 72h; Stage #2: With sodium dithionite In dichloromethane; water for 0.25h; Stage #3: With hydrogenchloride In dichloromethane; water	90%
With urea hydrogen peroxide adduct; trifluoroacetic anhydride In dichloromethane at 0 - 20℃; for 4.5h;	84%

: 23056-36-2
2-chloro-4-nitropyridine

: 109-89-7
diethylamine

: 18614-49-8
N,N-diethyl-4-nitropyridin-2-amine

Conditions

Conditions	Yield
With lithium trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 80℃; for 12h;	90%

: 23056-36-2
2-chloro-4-nitropyridine

: 7318-33-4
cinnamaldehyde tosylhydrazone

: 4-nitro-2-(3-phenyl-1H-pyrazol-1-yl)pyridine

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 60℃; regioselective reaction;	90%

: 23056-36-2
2-chloro-4-nitropyridine

: 1011797-06-0
N-[3-(5-amino-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-2-methyl-phenyl]-4-tert-butyl-benzamide

: 4-tert-butyl-N-{2-methyl-3-[1-methyl-5-(4-nitro-pyridin-2-ylamino)-6-oxo-1,6-dihydro-pyridin-2-yl]-phenyl}-benzamide

Conditions

Conditions	Yield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 95℃; for 16.25h;	85%

: 23056-36-2
2-chloro-4-nitropyridine

: 6258-60-2
p-methoxybenzylmercaptan

: 945988-82-9
4-(4-methoxybenzylthio)-2-chloropyridine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	85%

2-Chloro-4-nitropyridine Chemical Properties

Molecular Structure of 2-Chloro-4-nitropyridine (CAS NO.23056-36-2):

Molecular formula: C₅H₃ClN₂O₂.
Molecular Weight: 158.54
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 58.71 Å²
Index of Refraction: 1.587
Molar Refractivity: 35.78 cm³
Molar Volume: 106.4 cm³
Surface Tension: 57.2 dyne/cm
Density: 1.489 g/cm³
Flash Point: 110.1 °C
Enthalpy of Vaporization: 47.6 kJ/mol
Boiling Point: 258.4 °C at 760 mmHg
Vapour Pressure: 0.0222 mmHg at 25°C
Melting point: 52-56 °C
Product Categories: Pyridine; Pyridines; Pyridine Derivertives; C5Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks

2-Chloro-4-nitropyridine Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
HazardClass: Irritant
PackingGroup: III

2-Chloro-4-nitropyridine Specification

2-Chloro-4-nitropyridine , with CAS number of 23056-36-2, can be called pyridine, 2-chloro-4-nitro- ; 2-Chlor-4-nitropyridin . It is a light yellow powder, 2-Chloro-4-nitropyridine (CAS NO.23056-36-2) is used as intermediates in fields of medicine, materials of chemical industry and so on.

Product Name

2-Chloro-4-nitropyridine

Synthetic route

2-Chloro-4-nitropyridine Chemical Properties

2-Chloro-4-nitropyridine Safety Profile

2-Chloro-4-nitropyridine Specification

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