2-Chloropropionyl chloride supplier

Name
2-Chloropropionyl chloride
EINECS 231-540-7
CAS No. 7623-09-8
Article Data40
CAS DataBase
Density 1.291 g/cm³
Solubility MAY DECOMPOSE
Melting Point -71 °C
Formula C₃H₄Cl₂O
Boiling Point 110.1 °C at 760 mmHg
Molecular Weight 126.97
Flash Point 41.8 °C
Transport Information UN 2920 8/PG 2
Appearance clear colorless to light yellow liquid
Safety 26-36/37/39-45-25-16
Risk Codes 10-35-37
Molecular Structure
Hazard Symbols C
Synonyms 2-Chloropropionyl chloride
PSA 17.07000
LogP 1.37910

Synthetic route

: 598-78-7
(R,S)-2-chloropropionic acid

: 7623-09-8
2-chloropropionyl chloride

Conditions

Conditions	Yield
With thionyl chloride In hexane for 3h; Heating;	95%
With pyridine; phosgene at 55℃; for 1h; Reagent/catalyst; Temperature;	95.4%
With thionyl chloride In N,N-dimethyl-formamide at 85℃; for 2h;	85%

: 849585-22-4
LACTIC ACID

: 7623-09-8
2-chloropropionyl chloride

Conditions

Conditions	Yield
With pyridine; thionyl chloride
With phosphorus pentachloride; water

: 79-03-8
propionyl chloride

: 7623-09-8
2-chloropropionyl chloride

Conditions

Conditions	Yield
With iodine; chlorine
With sulfuryl dichloride; iodine

: 79-03-8
propionyl chloride

A: 7623-09-8
2-chloropropionyl chloride

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With chlorine at 0 - 5℃; Irradiation.unter UV-Bestrahlung;
With sulfuryl dichloride; dibenzoyl peroxide
With sulfuryl dichloride; dibenzoyl peroxide

: 76-00-6
1,1,1-trichloropropan-2-ol

A: 7623-09-8
2-chloropropionyl chloride

B: 21400-25-9
1,1,2-trichloropropene

C: 78049-86-2
1,1,1-trichloroisopropyl α-chloropropionate

Conditions

Conditions	Yield
With phosphorus pentoxide Heating; Yield given. Yields of byproduct given;
With phosphorus pentoxide Product distribution; Heating;
With phosphorus pentoxide Heating; Yield given;

...Expand

: 7791-25-5
sulfuryl dichloride

: 7553-56-2
iodine

: 79-03-8
propionyl chloride

: 7623-09-8
2-chloropropionyl chloride

...Expand

: 7623-09-8
2-chloropropionyl chloride

: 13120-10-0
N,N'-diisopropyl selenourea

: 3-isopropyl-2-isopropylimino-5-methyl-1,3-selenazolidin-4-one

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0℃;	100%

: 7623-09-8
2-chloropropionyl chloride

: 1117-97-1
N,0-dimethylhydroxylamine

: 2-chloro-N-methoxy-N-methylpropionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 7623-09-8
2-chloropropionyl chloride

: 62618-75-1
6-(2-chloropropanoyl)-3,4-dihydroquinolin-2(1H)-one

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 50℃; for 2h; Friedel-Crafts reaction;	100%
Stage #1: 2-chloropropionyl chloride With carbon disulfide; aluminum (III) chloride for 0.25h; Inert atmosphere; Cooling with ice; Stage #2: 3,4-dihydro-2(1H)-quinolone for 2.75h; Reflux;	91%
aluminium trichloride In carbon disulfide
AlCl3 In CS2	27.7 g (91%)

: 7623-09-8
2-chloropropionyl chloride

: 3182-95-4
L-Phenylalaninol

: 1048970-96-2
C15H19Cl2NO3

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	100%

: 7623-09-8
2-chloropropionyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1181803-80-4
tert-butyl 4-(2-chloropropanoyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%

: 7623-09-8
2-chloropropionyl chloride

: 3-amino-4-[(methylsulfonyl)methyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide

: 3-[(2-chloropropanoyl)amino]-4-[(methylsulfonyl)methyl]-N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide

Conditions

Conditions	Yield
In toluene at 100℃; for 2h;	100%

: 7623-09-8
2-chloropropionyl chloride

: 10250-27-8
2-benzylamino-2-methyl-1-propanol

: N-benzyl-2-chloro-N-(1-hydroxy-2-methylpropan-2-yl)propanamide

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 0 - 20℃;	100%
With triethylamine In isopropyl alcohol at 0 - 20℃;
With triethylamine In isopropyl alcohol at 0 - 20℃;
With triethylamine In isopropyl alcohol at 0 - 20℃; for 0.5h;

: 7623-09-8
2-chloropropionyl chloride

: (2S)-2-(benzyl-amino)butane-1,4-diol

: N-benzyl-2-chloro-N-[(2S)-1,4-dihydroxybutan-2-yl]propanamide

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 0 - 20℃; for 0.5h;	100%
With triethylamine In isopropyl alcohol at 0 - 20℃;
With triethylamine In isopropyl alcohol at 0 - 20℃; for 0.5h;
With triethylamine In isopropyl alcohol at 0℃; Inert atmosphere;

: 7623-09-8
2-chloropropionyl chloride

: 117554-09-3
(2R)-2-(benzylamino)butane-1,4-diol

: N-benzyl-2-chloro-N-[(2R)-1,4-dihydroxybutan-2-yl]propanamide

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 0℃; for 0.166667h;	100%

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 7623-09-8
2-chloropropionyl chloride

: (rac)-methyl 4-chloro-2-(2-chloropropanamido)benzoate

Conditions

Conditions	Yield
Stage #1: 2-amino-4-chloro-benzoic acid methyl ester With potassium carbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2-chloropropionyl chloride In tetrahydrofuran at 0 - 20℃;	100%

: 7623-09-8
2-chloropropionyl chloride

: 62-53-3
aniline

: 21262-52-2
2-chloro-N-phenylpropanamide

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine; potassium carbonate In acetonitrile at 0 - 5℃; for 1h;	99%
In dichloromethane at 0 - 5℃;	95.5%
In acetone at 20℃; for 4h;	93.2%

: 7623-09-8
2-chloropropionyl chloride

: 106-49-0
p-toluidine

: 40781-30-4, 51063-63-9, 147372-41-6
2-chloro-N-(4-methyl-phenyl)propionamide

Conditions

Conditions	Yield
In toluene at 120℃; for 1h;	99%
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 25℃; for 5h; Reagent/catalyst; Solvent; Temperature; Flow reactor;	93%
With sodium carbonate In water; toluene at 20℃; for 2.5h;	89.9%

: 7623-09-8
2-chloropropionyl chloride

: 106-47-8
4-chloro-aniline

: 40781-33-7, 51063-58-2, 21262-05-5
2-chloro-N-(4-chloro-phenyl)propionamide

Conditions

Conditions	Yield
In toluene for 1h; Heating;	99%
In toluene at 120℃; for 1h;	98%
In N,N-dimethyl acetamide at 0 - 50℃; for 96h;	86%
In benzene Reflux;
With pyridine In chloroform at 20℃; for 12h;

: 7623-09-8
2-chloropropionyl chloride

: 106-40-1
4-bromo-aniline

: 21262-08-8
N-(4-bromophenyl)-2-chloropropanamide

Conditions

Conditions	Yield
In toluene at 120℃; for 1h;	99%
In toluene Heating;
With pyridine In chloroform at 20℃; for 12h;

: 7623-09-8
2-chloropropionyl chloride

: 3863-11-4
3,4-difluoroaniline

: 868771-20-4
2-chloro-N-(3,4-difluoro-phenyl)-propionamide

Conditions

Conditions	Yield
In toluene at 120℃; for 1h;	99%
In toluene Heating;

: 313369-40-3
tert-butyl 6-amino-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

: 7623-09-8
2-chloropropionyl chloride

: 313369-41-4
tert-butyl 6-[(3-chloropropanoyl)amino]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; dmap In benzene	99%

: 5466-88-6
3,4-dihydro-3-oxo-2H-1,4-benzoxazine

: 7623-09-8
2-chloropropionyl chloride

: 293741-63-6
6-(2-chloropropanoyl)-2H-1,4-benzoxazin-3(4H)-one

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 20℃; for 12h;	99%

: 7623-09-8
2-chloropropionyl chloride

: 91340-32-8
2-(benzylamino)-2-methyl-propan-1,3-diol

: N-benzyl-2-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)propanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	99%
With triethylamine In dichloromethane at 0℃; for 0.166667h;	99%
With triethylamine In dichloromethane at 0℃; Temperature;
With triethylamine In dichloromethane at 0 - 20℃; for 0.166667h; Time; Concentration;

: 7623-09-8
2-chloropropionyl chloride

: 3-[3-amino-4-(trifluoromethoxy)phenyl]-7-bromoquinazolin-4(3H)-one

: N-[5-(7-bromo-4-oxoquinazolin-3(4H)-yl)-2-(trifluoromethoxy)phenyl]-2-chloropropanamide

Conditions

Conditions	Yield
In toluene at 100℃; for 2h;	99%
In toluene at 100℃; for 2h;	99%

: 100-02-7
4-nitro-phenol

: 7623-09-8
2-chloropropionyl chloride

: 141479-87-0
4-nitrophenyl 2-chloropropanoate

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 0.5h;	98.5%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water for 0.5h;	38%
In pyridine; dichloromethane Ambient temperature;

: 7623-09-8
2-chloropropionyl chloride

: 371-40-4
4-fluoroaniline

: 21262-04-4
N-4'-fluorophenyl-2-chloropropanamide

Conditions

Conditions	Yield
In toluene at 120℃; for 1h;	98.5%
In toluene Heating;
With triethylamine In dichloromethane at 20℃; for 4h;
With triethylamine In dichloromethane at 0 - 20℃; for 4.33h; Inert atmosphere;

: 7623-09-8
2-chloropropionyl chloride

: 57675-96-4
3-amino-2-imino-3,4-dihydro-2H-1,3-benzothiazin-4-one

: 122604-30-2
2-(1-Chloroethyl)-1,2,4-triazolo<5,1-b><1,3>benzothiazin-9-one

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 2h; Heating;	98%

: 7623-09-8
2-chloropropionyl chloride

: 121-44-8
triethylamine

: N-triethyl-N-(2-propanoyl-N-triethylammonium chloride) ammonium chloride

Conditions

Conditions	Yield
In benzene for 1h; Heating;	98%

: 7623-09-8
2-chloropropionyl chloride

: 104-94-9
4-methoxy-aniline

: 40781-31-5, 51063-61-7, 21262-10-2
2-chloro-N-(4-methoxy-phenyl)propionamide

Conditions

Conditions	Yield
In toluene at 120℃; for 1h;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 4.33h; Inert atmosphere;	97%
In N,N-dimethyl acetamide at 0 - 50℃; for 96h;	81%

: 930786-49-5
C22H20BrClN2O3

: 7623-09-8
2-chloropropionyl chloride

: C25H23BrCl2N2O4

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃; for 1h;	98%

: 615-16-7
1,3-dihydro-2H-benzimidazol-2-one

: 7623-09-8
2-chloropropionyl chloride

: 5-(2-chloropropanoyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 5 - 25℃; for 19h; Friedel-Crafts Alkylation; Inert atmosphere; regioselective reaction;	98%

: 40033-95-2
Spiro-<2,3-dihydro-4H-1,3-benzoxazine-1,2'-cyclohexan>-4-one

: 7623-09-8
2-chloropropionyl chloride

: 3-(2-chloro-1-oxopropyl)spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one

Conditions

Conditions	Yield
With pyridine In toluene at 30 - 50℃; for 5h;	97.4%
With pyridine In chlorobenzene at 50℃; for 8h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	95%
With pyridine In chloroform at 50℃; for 8h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	95%
With propylamine In toluene at 10 - 75℃; Reagent/catalyst; Green chemistry;

2-Chloropropionyl chloride Specification

The 2-Chloropropionyl chloride, with the cas registry number 7623-09-8, is a kind of clear colorless to light yellow liquid, with the product categories including Acid Halides; Carbonyl Compounds; Organic Building Blocks. Then it is a kind of chemical which is incompatible with strong oxidizing agents,strong bases, amines,alcohols. As to its usage, it could be used as the intermediate in the pharmaceutic, dyes, pesticide and also as the crops protective agent. What's more, it could be prepared by the 1,2-dichloropropane.

The physical properties of this chemical are below: (1)ACD/LogP: 1.04; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.04; (4)ACD/LogD (pH 7.4): 1.04; (5)ACD/BCF (pH 5.5): 3.61; (6)ACD/BCF (pH 7.4): 3.61; (7)ACD/KOC (pH 5.5): 87.32; (8)ACD/KOC (pH 7.4): 87.32; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07; (13)Index of Refraction: 1.434; (14)Molar Refractivity: 25.63 cm³; (15)Molar Volume: 98.3 cm³; (16)Polarizability: 10.16 ×10^-24 cm³; (17)Surface Tension: 30.3 dyne/cm; (18)Density: 1.291 g/cm³; (19)Flash Point: 41.8 °C; (20)Enthalpy of Vaporization: 34.88 kJ/mol; (21)Boiling Point: 110.1 °C at 760 mmHg; (22)Vapour Pressure: 24.1 mmHg at 25°C; (23)Exact Mass: 125.96392; (24)MonoIsotopic Mass: 125.96392; (25)Topological Polar Surface Area: 17.1; (26)Heavy Atom Count: 6; (27)Formal Charge: 0; (28)Complexity: 61.8.

When you are using this chemical, you should be very cautious. For being a kind of corrosive chemical, it may destroy living tissue on contact. Then it is flammable which may causes severe burns. Besides, it is irritating to respiratory system.

Therefore, you should be better take the following advices to protect yourself. Wear suitable protective clothing, gloves and eye/face protection. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice, and if in case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). And you could keep away from sources of ignition - No smoking and then remember to avoid contacting with eyes.

Additionally, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CC(C(=O)Cl)Cl
(2)InChI: InChI=1S/C3H4Cl2O/c1-2(4)3(5)6/h2H,1H3
(3)InChIKey: JEQDSBVHLKBEIZ-UHFFFAOYSA-N

Product Name

2-Chloropropionyl chloride

Synthetic route

2-Chloropropionyl chloride Specification

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