2-Fluoro-6-formylpyridine supplier

Name
2-Fluoro-6-formylpyridine
EINECS
CAS No. 208110-81-0
Article Data8
CAS DataBase
Density 1.27 g/cm³
Solubility
Melting Point
Formula C₆H₄FNO
Boiling Point 192.378 °C at 760 mmHg
Molecular Weight 125.102
Flash Point 70.148 °C
Transport Information
Appearance
Safety 16-26-36
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi, F
Synonyms 6-Fluoro-2-pyridinecarboxaldehyde;6-Fluoropyridine-2-carbaldehyde;
PSA 29.96000
LogP 1.03320

Synthetic route

: 455-71-0
methyl 6-fluoropyridine-2-carboxylate

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
With diisobutylaluminium hydride In dichloromethane at -55℃; for 3h; Inert atmosphere;	84%

: 64197-03-1
6-fluoropyridine-2-carbonyl chloride

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
With Pd-BaSO4; hydrogen Rosenmund reduction;	68%

: 1243694-61-2
2-fluoro-6-(dibromomethyl)pyridine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
With silver nitrate In water; acetonitrile at 20℃; for 3h;	60%

: 407-22-7
2-fluoro-6-methylpyridine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
With sodium periodate; tert-Butoxybis(dimethylamino)methane 1.) 140 deg C, 24 h, 2.) H2O, 25 deg C, p = 80 mbar; Yield given; Multistep reaction;
With sodium periodate; n-butyllithium; diisopropylamine In tetrahydrofuran; water
Multi-step reaction with 3 steps 1: potassium permanganate / water / Reflux 2: thionyl chloride 3: Pd-BaSO4; hydrogen View Scheme
With sodium periodate; n-butyllithium; diisopropylamine In tetrahydrofuran; water
Stage #1: 2-fluoro-6-methylpyridine With n-butyllithium; diisopropylamine; N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -78 - 0℃; for 1.75h; Stage #2: With sodium periodate In tetrahydrofuran; hexanes; water at 0 - 20℃; for 25h;

: 407-22-7
2-fluoro-6-methylpyridine

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
With sodium periodate In tetrahydrofuran
With sodium periodate In water

: 1824-81-3
2-Amino-6-methylpyridine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrafluoroboric acid; sodium nitrite / water 2: potassium permanganate / water / Reflux 3: thionyl chloride 4: Pd-BaSO4; hydrogen View Scheme

: 402-69-7
6-fluoropyridine-2-carboxylic acid

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride 2: Pd-BaSO4; hydrogen View Scheme

: 2459-07-6
methyl pyridine-2-carboxylate

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: silver(II) fluoride / acetonitrile / 20 °C / Inert atmosphere; Autoclave 2: diisobutylaluminium hydride / dichloromethane / 3 h / -55 °C / Inert atmosphere View Scheme

: 99-98-9
4-amino-N,N-dimethylaniline

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 4-(((6-fluoropyridin-2-yl)methylene)amino)-N,N-dimethylaniline

Conditions

Conditions	Yield
With sodium sulfate In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Schlenk technique;	100%

: 579-66-8
2,6-diethylaniline

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: C16H17FN2

Conditions

Conditions	Yield
In ethanol at 80℃; for 12h; Inert atmosphere;	97%

: 24544-04-5
2,6-diisopropylbenzenamine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: C18H21FN2

Conditions

Conditions	Yield
In ethanol at 80℃; for 12h; Inert atmosphere;	96%

: 643-28-7
2-isopropylaniline

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: C15H15FN2

Conditions

Conditions	Yield
In ethanol at 80℃; for 12h; Inert atmosphere;	90%

: 109-77-3
malononitrile

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 1284237-48-4
C9H6FN3

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; piperdinium acetate In toluene at 105℃; for 3h; Inert atmosphere;	86%

: 107-21-1
ethylene glycol

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 208111-44-8
2-(1,3-dioxolan-2-yl)-6-fluoropyridin

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 18h; Heating;	80%

: 645-36-3
2,2-diethoxy-ethanamine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: (2,2-diethoxyethyl)((6-fluoropyridin-2-yl)methyl)amine

Conditions

Conditions	Yield
Stage #1: 2,2-diethoxy-ethanamine; 2-Fluoropyridine-6-carboxaldehyde With acetic acid In tetrahydrofuran at 20℃; for 0.416667h; Stage #2: With sodium tris(acetoxy)borohydride at 20℃; for 1.16667h;	74%

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 1319649-66-5
2-fluoropyridine-6-aldoxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium hydroxide In water for 0.333333h; Reflux;	71%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: C16H22FN3O2

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 18h;	53%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: (E)-tert-butyl 4-(((6-fluoropyridin-2-yl)methylene)amino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃;	53%

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 1610379-38-8
2-(6-fluoropyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; sodium hydrogensulfite In N,N-dimethyl acetamide at 120℃; for 20h;	49%

: 7144-05-0
4-Aminomethylpiperidine

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 208109-29-9
(3,4-Dichloro-phenyl)-(4-{[(6-fluoro-pyridine-2-ylmethyl)-amino]methyl}-piperidine-1-yl)-methanone

Conditions

Conditions	Yield
With Potassium borohydride; triethylamine In tetrahydrofuran; methanol; water; benzene	40%

...Expand

: 7144-05-0
4-Aminomethylpiperidine

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 1025812-07-0
[1-(6-Fluoro-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine

Conditions

Conditions	Yield
In toluene for 2h; Heating;

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-76-6
6-(methylthio)pyridine-2-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C 3: 45 percent / HCO2H / H2O / 65 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-77-7
6-(methylsulfinyl)pyridine-2-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C 3: 67 percent / NaIO4 / methanol; H2O / 18 h / Ambient temperature 4: 60 percent / HCO2H / H2O / 65 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-66-4
2-(1H-pyrazol-1-yl)pyridine-6-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / PTSAH2O / benzene / 18 h / Heating 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 80 deg C, 3 h 3: 79 percent / CuSO45H2O, formic acid / H2O / 5 h / 65 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-79-9
6-n-butoxypyridine-2-carboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 90 percent / Na / 18 h / 100 °C 3: HCO2H / H2O / 65 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-74-4
2-(1,3-dioxolan-2-yl)-6-(methylthio)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-75-5
6-(methylsulfinyl)-2-(1,3-dioxolan-2-yl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C 3: 67 percent / NaIO4 / methanol; H2O / 18 h / Ambient temperature View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-64-2
6-pyrazolo-2-(1,3-dioxolan-2-yl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 80 deg C, 3 h View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: 217657-78-8
6-n-butoxy-2-(1,3-dioxolan-2-yl)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 90 percent / Na / 18 h / 100 °C View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: [1-(6-Methylsulfanyl-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C 3: 45 percent / HCO2H / H2O / 65 °C 4: toluene / 2 h / Heating View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: [1-(6-Methanesulfinyl-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 73 percent / dimethylformamide / 18 h / 100 °C 3: 67 percent / NaIO4 / methanol; H2O / 18 h / Ambient temperature 4: 60 percent / HCO2H / H2O / 65 °C 5: toluene / 2 h / Heating View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: [2-(4-methoxy-phenyl)-ethyl]-(6-pyrazol-1-yl-pyridin-2-ylmethyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / PTSAH2O / benzene / 18 h / Heating 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 80 deg C, 3 h 3: 79 percent / CuSO45H2O, formic acid / H2O / 5 h / 65 °C 4: NaBH(OAc)3 / 1,2-dichloro-ethane / 24 h / Ambient temperature View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: Piperidin-4-ylmethyl-[1-(6-pyrazol-1-yl-pyridin-2-yl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / PTSAH2O / benzene / 18 h / Heating 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 80 deg C, 3 h 3: 79 percent / CuSO45H2O, formic acid / H2O / 5 h / 65 °C 4: toluene / 2 h / Heating View Scheme

: 208110-81-0
2-Fluoropyridine-6-carboxaldehyde

: [1-(6-Butoxy-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / PTSA*H2O / benzene / 18 h / Heating 2: 90 percent / Na / 18 h / 100 °C 3: HCO2H / H2O / 65 °C 4: toluene / 2 h / Heating View Scheme

2-Fluoro-6-formylpyridine Chemical Properties

The molecular formula of 2-Fluoro-6-formylpyridine(208110-81-0) is C₆H₄FNO and its formula weight is 125.1.
The chemical synonyms of 2-Fluoro-6-formylpyridine(208110-81-0) are 2-FLUORO-6-FORMYLPYRIDINE;CHEMPACIFIC 38134;6-Fluoropyridine-2-carboxalehyde;6-FLUORO-PYRIDINE-2-CARBALDEHYDE;6-Fluoropyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde,6-fluoro-(9CI);6-Fluoropicolinaldehyde;6-FLUOROPICOLINALDEHYDE,98.5%
The molecular structure of 2-Fluoro-6-formylpyridine(208110-81-0):

2-Fluoro-6-formylpyridine Safety Profile

Hazard Codes Xi,F
Risk Statements 10-36/37/38
Safety Statements 16-26-36

Product Name

2-Fluoro-6-formylpyridine

Synthetic route

2-Fluoro-6-formylpyridine Chemical Properties

2-Fluoro-6-formylpyridine Safety Profile

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