2-Hydroxyphenylacetic acid

Molecule structure of 2-Hydroxyphenylacetic acid (CAS NO.614-75-5):

IUPAC Name: 2-(2-Hydroxyphenyl)acetic acid 
Molecular Weight: 152.14732 g/mol
Molecular Formula: C₈H₈O₃ 
Density: 1.321 g/cm³ 
Melting Point: 145-147 °C(lit.)
Boiling Point: 321.8 °C at 760 mmHg 
Flash Point: 162.6 °C
Index of Refraction: 1.59
Molar Refractivity: 38.9 cm³
Molar Volume: 115.1 cm³
Polarizability: 15.42×10^-24 cm³
Surface Tension: 60.4 dyne/cm 
Enthalpy of Vaporization: 59.5 kJ/mol
Vapour Pressure: 0.00012 mmHg at 25 °C 
Water Solubility: 1.32E+05 mg/L
XLogP3: 0.9
H-Bond Donor: 2
H-Bond Acceptor: 3
Rotatable Bond Count: 2
Tautomer Count: 3
Exact Mass: 152.047344
MonoIsotopic Mass: 152.047344
Topological Polar Surface Area: 57.5
Heavy Atom Count: 11
Complexity: 144
Canonical SMILES: C1=CC=C(C(=C1)CC(=O)O)O
InChI: InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11)
InChIKey: CCVYRRGZDBSHFU-UHFFFAOYSA-N
EINECS: 210-393-2
Product Categories: FINE Chemical & INTERMEDIATES; Aromatic Phenylacetic Acids and Derivatives; Aromatics; C8; Carbonyl Compounds; Carboxylic Acids

 2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is used as an important intermediate in pharmaceutical synthesis.

 2-Chloro acetic acid reacts with 8-hydroxyquinoline copper (Ⅱ) at the presence of sodium hydroxide, reaction temperature 170 °C, pressure of 650 ~ 700kPa, can get the product.

Hazard Codes: Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10-23
Hazard Note: Irritant
HS Code: 29182990 

 2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is also named as (2-Hydroxyphenyl)acetic acid ; 2-Hydroxybenzeneacetic acid ; 2-Hydroxyphenylacetate ; 2-Hydroxyphenylacetic acid ; Hydroxyphenylacetic acid ; NSC 62000 ; o-Hydroxy phenylacetic acid ; o-Hydroxyphenylacetic acid . 2-Hydroxyphenylacetic acid (CAS NO.614-75-5) is off-white solid. It insoluble in water, soluble in benzene, toluene and other organic solvents.