2-Methyl-4,6-dinitrophenol supplier

Name
2-Methyl-4,6-dinitrophenol
EINECS 208-601-1
CAS No. 534-52-1
Article Data74
CAS DataBase
Density 1.55 g/cm³
Solubility slightly soluble
Melting Point 83-85 ºC
Formula C7H6 N2 O5
Boiling Point 332.4 °C at 760 mmHg
Molecular Weight 198.135
Flash Point 149.2 °C
Transport Information UN 1598
Appearance straw yellow to yellow crystal
Safety Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardiac and gastrointestinal changes. Mutation data reported. An eye and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and 3,5-DINITRO-o-CRESOL; 3,5-DINITRO-p-CRESOL; 2,6-DINITRO-p-CRESOL; 4,6-DINITRO-m-CRESOL; 4,6-DINITRO-o-CRESOL AMMONIUM SALT; 4,6-DINITRO-o-CRESOL BARIUM DERIVATIVE; 4,6-DINITRO-o-CRESOL DIETHYLAMINE SALT; 4,6-DINITRO-o-CRESOL METHYLAMINE (1:1); 4,6-DINITRO-o-CRESOL MORPHOLINE (1:1); 4,6-DINITRO-o-CRESOL SODIUM SALT.
Analytical Methods:

For occupational chemical analysis use NIOSH: Dinitro-o-cresol S166.
Risk Codes R26/27/28;R38;R40;R41;R43;R44;R50/53
Molecular Structure
Hazard Symbols
Synonyms o-Cresol,4,6-dinitro- (8CI);2,4-Dinitro-6-methylphenol;2-Methyl-4,6-dinitrophenol;3,5-Dinitro-2-hydroxytoluene;4,6-Dinitro-2-methylphenol;4,6-Dinitro-o-cresol;6-Methyl-2,4-dinitrophenol;Antinonin;Antinonnin;Arborol;DNOC;Degrassan;Dekrysil;Detal;Dillex;Dinitro;Dinitrocresol;Dinitrodendtroxal;Dinitrol;Dinoc;Dinurania;Ditrosol;Effusan;Effusan 3436;Elgetol;Elgetol 30;Elipol;Extrar;Flavin-Sandoz;Hedolit;Hedolite;K III;KIV;Kreozan;Krezotol 50;Lipan;NSC 2082;Neudorff DN 50;Nitrofan;Prokarbol;Rafex;Rafex 35;Raphatox;Sandolin;Sandolin A;Selinon;Sinox;Winterwash;
PSA 111.87000
LogP 2.56340

Synthetic route

: 95-48-7
ortho-cresol

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With (NH4)2Ce(NO3)6 on pillared bentonite In methanol at 25℃; for 48h;	100%
With thionyl chloride; bismuth subnitrate In dichloromethane at 20℃; for 2h;	83%
With cupric nitrate trihydrate supported on K 10 montmorillonite clay; nitric acid; acetic anhydride In tetrachloromethane for 1h; Ambient temperature;	80%

: 95-48-7
ortho-cresol

A: 13073-29-5
2-methyl-6-nitrophenol

B: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With zirconyl nitrate In acetone at 20℃; for 0.45h;	A 43% B 52%
With bismuth(III) nitrate In acetone at 20℃; for 0.0666667h;	A 35% B 45%

: 95-48-7
ortho-cresol

A: 99-53-6
2-methyl-4-nitrophenol

B: 13073-29-5
2-methyl-6-nitrophenol

C: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With Montmorillonite KSF; nitric acid; hafnium oxychloride In tetrahydrofuran at 20℃; for 16h;	A 36% B 46% C 4%
With Yb-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;	A 45% B 39% C 9%
With Eu-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;	A 42% B 40% C 9%
With Montmorillonite KSF; nitric acid; bismuth(III) nitrate In tetrahydrofuran at 20℃; for 16h;	A 26% B 24% C 22%
With sulfuric acid; calcium(II) nitrate In water at 2℃; for 5h; Product distribution; other substituted phenols; other nitrating agent, var. temp.;

...Expand

: 81484-48-2
2-Methyl-4-cyclopropyl-6-nitrophenol

A: 534-52-1
2-methyl-4,6-dinitrophenol

B: 95970-37-9
5,6-Dinitro-2-methyl-4-cyclopropylphenol

C: 96020-52-9
3-Nitrooxy-1-(3-methyl-4-hydroxy-5-nitrophenyl)-1-propanol

D: 95970-36-8
3,4,6-Trinitro-2-hydroxy-2-methyl-4-cyclopropyl-5-cyclohexen-1-one

Conditions

Conditions	Yield
With dinitrogen tetraoxide In dichloromethane at -10℃; for 3h; Product distribution;	A 30% B 18% C 10% D 17%

...Expand

: 64-17-5
ethanol

: 90084-63-2
2-hydroxy-toluene-3,5-disulfonyl chloride

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
anschliessen Behandeln mit 2n-Salpetersaeure;

: 98-27-1
2-Methyl-4-t-butylphenol

A: 20294-44-4
5-Nitro-6-hydroxy-1-methyl-3-tert.-butyl-benzol

B: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid; benzene

: 98-27-1
2-Methyl-4-t-butylphenol

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid; acetic acid at -20℃;
With nitric acid; benzene unter Kuehlung;

: 578-58-5
2-methylmethoxybenzene

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With sulfuric acid; acetic acid; sodium nitrite at 0℃;
Multi-step reaction with 2 steps 1: glacial acetic acid; nitrosylsulfuric acid / -15 - -10 °C 2: diluted nitric acid / 40 °C View Scheme
Multi-step reaction with 2 steps 1: nitric acid 2: NaOH-solution View Scheme

: 611-23-4
2-nitrosotoluene

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid; cis-nitrous acid Erwaermen der erhaltenen Diazoniumsalz-Loesung auf 35-50grad;

: 20294-44-4
5-Nitro-6-hydroxy-1-methyl-3-tert.-butyl-benzol

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid

: 29027-13-2
2-methyl-4,6-dinitroanisole

: furan-2,3,5(4H)-trione pyridine (1:1)

: 534-52-1
2-methyl-4,6-dinitrophenol

: 29027-13-2
2-methyl-4,6-dinitroanisole

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With sodium hydroxide

: 499-76-3
4-hydroxy-3-methylbenzoic acid

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid

: 83-40-9
3-methylsalicylic acid

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitrogen oxides; sulfuric acid; water

: 6971-38-6
p-nitroso-o-cresol

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With diethyl ether; dinitrogen tetraoxide
With nitric acid
With nitric acid at 40℃;

: 98-33-9
2-aminotoluene-5-sulfonic acid

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
Diazotization.Erhitzen der Diazoniumverbindung mit verd. Salpetersaeure;
With nitrogen oxides; water

: 609-74-5
1-methyl-2,3,5-trinitrobenzene

: 127-09-3
sodium acetate

: 534-52-1
2-methyl-4,6-dinitrophenol

: 609-74-5
1-methyl-2,3,5-trinitrobenzene

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With sodium acetate

: 609-22-3
2,4-dibromo-6-methylphenol

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With ethanol; nitric acid

: 125708-82-9
1-methoxy-2-methyl-4-nitrosobenzene

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid at 40℃;

: 15499-39-5, 22785-71-3
2-bromo-6-methyl-[1,4]benzoquinone-4-oxime

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid

: 7134-04-5
6-hydroxy-toluene-3-sulfonic acid

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitric acid
With nitric acid

: 90084-63-2
2-hydroxy-toluene-3,5-disulfonyl chloride

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With ethanol nachf. Erhitzen mit Salpetersaeure;

: 78497-67-3
2,4-dinitro-6-methylphenyl p-toluenesulfonate

: 139-02-6
sodium phenoxide

A: 534-52-1
2-methyl-4,6-dinitrophenol

B: 640-60-8
toluene-4-sulfonic acid phenyl ester

...Expand

: 68189-38-8
2-amino-1-methylbenzene-3,5-disulfonic acid

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With nitrogen oxides; water

: 60-29-7
diethyl ether

: 1002-16-0
amyl nitrate

: 95-48-7
ortho-cresol

: 534-52-1
2-methyl-4,6-dinitrophenol

...Expand

: 95-48-7
ortho-cresol

: 110-46-3
isopentyl nitrite

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With diethyl ether

: 95-53-4
o-toluidine

A: 13073-29-5
2-methyl-6-nitrophenol

B: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite

: 99-52-5
2-methyl-4-nitro-benzenamine

: 534-52-1
2-methyl-4,6-dinitrophenol

Conditions

Conditions	Yield
Diazotization.Eintragen der Diazoniumnitratloesung in Salpetersaeure;

: 18461-55-7
2-methyl-4,6-dinitrophenyl acetate

A: 534-52-1
2-methyl-4,6-dinitrophenol

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With buffer solution; pilocarpine hydrochloride In water; acetonitrile at 24.9℃; Rate constant; other catalysts, var. pH-values;
With water at 24℃; Kinetics;

: 534-52-1
2-methyl-4,6-dinitrophenol

: 15872-73-8
4.6-diamino-o-cresol

Conditions

Conditions	Yield
With hydrogen; Raney nickel In methanol at 20℃; under 3750.38 Torr; for 4h;	98%
With hydrogen In methanol at 50℃; under 1500.15 Torr; for 0.25h; Inert atmosphere;	75%
With hydrogenchloride; tin

: 534-52-1
2-methyl-4,6-dinitrophenol

: 98-59-9
p-toluenesulfonyl chloride

: 78497-67-3
2,4-dinitro-6-methylphenyl p-toluenesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	80%
With sodium carbonate

: 534-52-1
2-methyl-4,6-dinitrophenol

: 108-24-7
acetic anhydride

: 18461-55-7
2-methyl-4,6-dinitrophenyl acetate

Conditions

Conditions	Yield
	68%
With sulfuric acid

: 534-52-1
2-methyl-4,6-dinitrophenol

: 151-50-8
potassium cyanide

: 3-hydroxy-2-hydroxyamino-4-methyl-6-nitro-benzonitrile; potassium salt

Conditions

Conditions	Yield
With ethanol
With water

: 534-52-1
2-methyl-4,6-dinitrophenol

: 7477-94-3
2-methyl-4,6-dinitroaniline

Conditions

Conditions	Yield
With ammonia at 175 - 185℃;
Multi-step reaction with 2 steps 1: K2CO3; acetone 2: water; methanol; ammonia View Scheme

: 534-52-1
2-methyl-4,6-dinitrophenol

: 4102-92-5
benzoic acid-(2-methyl-4,6-dinitro-phenyl ester)

: 534-52-1
2-methyl-4,6-dinitrophenol

: 6265-03-8
2-amino-6-methyl-4-nitro-phenol

Conditions

Conditions	Yield
With ammonium sulfide

2-Methyl-4,6-dinitrophenol Chemical Properties

Molecular Formula:C₇H₆N₂O₅
Molecular Weight:198.15
EINECS:208-601-1
Density:1.55 g/cm³
Melting Point:83-85°C
Boiling Point:332.4 °C at 760 mmHg
Flash Point:149.2 °C
Storage temp.:0-6°C
Solubility:slightly soluble
Appearance:straw yellow to yellow crystal
DINITRO-o-CRESOL's Synonyms: 3,5-DINITRO-2-HYDROXYTOLUENE;4,6-DINITRO-2-METHYLPHENOL;4,6-DINITRO-O-CRESOL;4,6-DNOC;TRIFANEX;TRIFOCIDE;TRIFOCIDE(R);TRIFRINA

2-Methyl-4,6-dinitrophenol Toxicity Data With Reference

1.	skn-rbt 105 mg/9D-I MLD	JIHTAB Journal of Industrial Hygiene and Toxicology. 30 (1948),10.
2.	eye-rbt 20 mg/24H MOD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,678.
3.	mma-sat 1 µmol/plate	AIDZAC Aichi Ika Daigaku Igakkai Zasshi. Journal of the Aichi Medical Univ. Assoc. 10 (1982),305.
4.	sln-dmg-orl 250 µmol/L	ARTODN Archives of Toxicology.Suppl. 4(1980),59.
5.	orl-man TDLo:7500 µg/kg/7D:CNS	CMEP** Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1.
6.	ihl-hmn TCLo:1 mg/m3:BRN,CVS,GIT	HYSAAV Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 30 (1965),197.
7.	unr-man LDLo:29 mg/kg	85DCAI Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
8.	orl-rat LD50:10 mg/kg	85ARAE Agricultural Chemicals, Books I, II, III, and IV. 3 (1976),54.
9.	skn-rat LD50:200 mg/kg	WRPCA2 World Review of Pest Control. 9 (1970),119.
10.	ipr-rat LDLo:28 mg/kg

2-Methyl-4,6-dinitrophenol Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Community Right-To-Know List. EPA Extremely Hazardous Substances List.

2-Methyl-4,6-dinitrophenol Safety Profile

Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardiac and gastrointestinal changes. Mutation data reported. An eye and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and 3,5-DINITRO-o-CRESOL; 3,5-DINITRO-p-CRESOL; 2,6-DINITRO-p-CRESOL; 4,6-DINITRO-m-CRESOL; 4,6-DINITRO-o-CRESOL AMMONIUM SALT; 4,6-DINITRO-o-CRESOL BARIUM DERIVATIVE; 4,6-DINITRO-o-CRESOL DIETHYLAMINE SALT; 4,6-DINITRO-o-CRESOL METHYLAMINE (1:1); 4,6-DINITRO-o-CRESOL MORPHOLINE (1:1); 4,6-DINITRO-o-CRESOL SODIUM SALT.

DINITRO-o-CRESOL's Safety Information
Hazard Codes T+,N,T,F
Risk Statements 26/27/28-38-41-43-44-50/53-68-40-39/23/24/25-23/24/25-11-52/53
Safety Statements 36/37-45-60-61-16-7
RIDADR UN 1598 6.1/PG 2
WGK Germany 2
RTECS GO9625000
HazardClass 6.1(a)
PackingGroup II

2-Methyl-4,6-dinitrophenol Standards and Recommendations

OSHA PEL: TWA 0.2 mg/m³ (skin)
ACGIH TLV: TWA 0.2 mg/m³ (skin)
DFG MAK: 0.2 mg/m³
NIOSH REL: (Dinitro-o-Cresol) TWA 0.2 mg/m³
DOT Classification: 6.1; Label: Poison

2-Methyl-4,6-dinitrophenol Analytical Methods

For occupational chemical analysis use NIOSH: Dinitro-o-cresol S166.

Product Name

2-Methyl-4,6-dinitrophenol

Synthetic route

2-Methyl-4,6-dinitrophenol Chemical Properties

2-Methyl-4,6-dinitrophenol Toxicity Data With Reference

2-Methyl-4,6-dinitrophenol Consensus Reports

2-Methyl-4,6-dinitrophenol Safety Profile

2-Methyl-4,6-dinitrophenol Standards and Recommendations

2-Methyl-4,6-dinitrophenol Analytical Methods

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