2-Pyridineboronic acid supplier

Name
2-Pyridineboronic acid
EINECS
CAS No. 197958-29-5
Article Data7
CAS DataBase
Density 1.23 g/cm³
Solubility
Melting Point >300 °C
Formula C₅H₆BNO₂
Boiling Point 308.782 °C at 760 mmHg
Molecular Weight 122.919
Flash Point 140.547 °C
Transport Information
Appearance White to light yellow crystal powder
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Boronicacid, 2-pyridinyl- (9CI);(2-Pyridinyl)boronic acid;
PSA 53.35000
LogP -1.23860

Synthetic route

: 109-04-6
2-bromo-pyridine

: 5419-55-6
Triisopropyl borate

: 197958-29-5
pyridin-2-ylboronic acid

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine; Triisopropyl borate With n-butyllithium In tetrahydrofuran; hexane; toluene at -30℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; hexane; water; toluene at 20℃; for 1h; Inert atmosphere;	81%
Stage #1: 2-bromo-pyridine; Triisopropyl borate With n-butyllithium In tetrahydrofuran; hexane; toluene at -30 - 20℃; for 6h; Stage #2: With hydrogenchloride In tetrahydrofuran; hexane; toluene at 20℃; for 1h;	81%
With n-butyllithium In tetrahydrofuran; hexane; toluene at -30 - 20℃; for 6h; Inert atmosphere;	81%
Stage #1: 2-bromo-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Stage #2: Triisopropyl borate In diethyl ether; hexane at -78 - 20℃;	73%

: 109-04-6
2-bromo-pyridine

: 121-43-7
Trimethyl borate

: 197958-29-5
pyridin-2-ylboronic acid

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: Trimethyl borate In tetrahydrofuran; hexane for 2h;	77%
Stage #1: 2-bromo-pyridine With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	66.8%

: 109-04-6
2-bromo-pyridine

: 197958-29-5
pyridin-2-ylboronic acid

Conditions

Conditions	Yield
Stage #1: 2-bromo-pyridine With isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 2h; Stage #2: With tris(trimethylsilyl)borate In tetrahydrofuran at 0 - 20℃; for 24h; Stage #3: With hydrogenchloride at 0℃; pH=6 - 7;	70%

: C31H28N2O2

: 197958-29-5
pyridin-2-ylboronic acid

: C36H30BN3O2

Conditions

Conditions	Yield
In methanol; toluene for 15h; Inert atmosphere; Reflux;	99%

: 197958-29-5
pyridin-2-ylboronic acid

: 142-08-5
2-hydroxypyridin

Conditions

Conditions	Yield
With hydrazine hydrate; caesium carbonate In water at 80℃; for 12h;	96%

: potassium cyanide

: 197958-29-5
pyridin-2-ylboronic acid

: 33893-89-9
5-(2-pyridyl)-1H-tetrazole

Conditions

Conditions	Yield
With sodium azide; potassium carbonate In ethanol; water for 5h; Catalytic behavior; Reflux; Inert atmosphere; Green chemistry;	96%

: C29H20BBrN2

: 197958-29-5
pyridin-2-ylboronic acid

: C34H24BN3

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In toluene at 110℃; for 3h; Inert atmosphere;	95%

: 197958-29-5
pyridin-2-ylboronic acid

: 108-98-5
thiophenol

: 3111-54-4
2-phenylsulfanylpyridine

Conditions

Conditions	Yield
With copper slag In N,N-dimethyl-formamide at 100℃; for 0.166667h; Temperature; Wavelength; Microwave irradiation; Green chemistry;	94%

: 72754-04-2
3,7-dibromo-1,8-naphthyridine

: 197958-29-5
pyridin-2-ylboronic acid

: C13H8BrN3

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 8h; Inert atmosphere; Reflux;	93.7%

: 932372-99-1
2-bromo-5-iodophenol

: 197958-29-5
pyridin-2-ylboronic acid

: C11H8BrNO

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 90℃; for 5h; Inert atmosphere;	93%

: C31H18BrCl

: 197958-29-5
pyridin-2-ylboronic acid

: C36H22ClN

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; triphenylphosphine In toluene at 100℃; for 12h;	92.5%

: 6-bromo-N,N-diphenylanthracen-2-amine

: 197958-29-5
pyridin-2-ylboronic acid

: C30H21N3

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene at 80℃; Inert atmosphere;	92%

: 3138-86-1
2,3-bis(bromomethyl)quinoxaline

: 521-74-4
broxyquinoline

: 197958-29-5
pyridin-2-ylboronic acid

: 4,6-di(pyridin-2-yl)-8,15-dihydro-1H-quinolino[8′,1′:2,3,4][1,4]oxazocino[6,7-b]-quinoxalin-1-one

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In ethanol; water at 20℃; for 24h; Irradiation; Inert atmosphere;	92%

...Expand

: 51-17-2
benzoimidazole

: 197958-29-5
pyridin-2-ylboronic acid

: 25660-37-1
1-pyridin-2-yl-1H-benzoimidazole

Conditions

Conditions	Yield
With 2Na(1+)*CuC6H4(NCHC6H3OO3S)2(2-)=CuC6H4(NCHC6H3ONaO3S)2 In water at 100℃; for 6h;	90%

: 7-(2-chlorophenyl)-2-(3-methylbenzofuran-2-yl)-5,6,7,8-tetrahydro-4H-benzo[4,5]imidazo[1,2-b]pyrazole-3-carbonitrile

: 197958-29-5
pyridin-2-ylboronic acid

: 2-(3-methylbenzofuran-2-yl)-7-(2-(pyridin-2-yl)phenyl)-5,6,7,8-tetrahydro-4H-benzo[4 ,5]imidazo[1,2-b]pyrazole-3-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 60℃; for 0.5h; Inert atmosphere;	90%

: 5-bromo-4-cyclopentyl-1H-pyrrole-2-carboxylic acid (4-methylcyclohexyl)ester

: 197958-29-5
pyridin-2-ylboronic acid

: 4-methylcyclohexyl 4-cyclopentyl-5-(pyridin-2-yl)-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 1h; Microwave irradiation; Inert atmosphere;	90%

: 7-(5-bromo-2-fluorophenyl)-1-methyloctahydro-1H-pyrrolo[2,3-b]pyridine

: 197958-29-5
pyridin-2-ylboronic acid

: 7-(2-fluoro-5-(pyridin-2-yl)phenyl)-1-methyloctahydro-1H-pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate at 60℃; for 0.166667h; Inert atmosphere;	89%

: 197958-29-5
pyridin-2-ylboronic acid

: 108-90-7
chlorobenzene

: 1008-89-5
2-phenylpyridine

Conditions

Conditions	Yield
Stage #1: pyridin-2-ylboronic acid; chlorobenzene With potassium phosphate In para-xylene at 128℃; for 1.5h; Suzuki-Miyaura Coupling; Sealed tube; Inert atmosphere; Microwave irradiation; Stage #2: In ethanol; para-xylene; water at 130℃; for 24h; Sealed tube; Inert atmosphere;	89%

: 1384848-86-5
4-((4-bromo-5-(4-methoxyphenyl)-2H-1,2,3-triazol-2-yl)methyl)benzonitrile

: 197958-29-5
pyridin-2-ylboronic acid

: 710947-00-5
4-[4-(4-methoxy-phenyl)-5-pyridin-2-yl-[1,2,3]triazol-2-ylmethyl]-benzonitrile

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate monohydrate In water; acetonitrile at 85℃; Suzuki-Miyaura coupling; chemoselective reaction;	88%

: 197958-29-5
pyridin-2-ylboronic acid

: 873-76-7
para-Chlorobenzyl alcohol

: 98061-39-3
(4-(pyridine-2-yl)phenyl)methanol

Conditions

Conditions	Yield
With C38H37ClN4O2Pd; potassium carbonate In butan-1-ol at 100℃; for 36h; Inert atmosphere; Schlenk technique;	88%

: 201230-82-2
carbon monoxide

: 640-60-8
toluene-4-sulfonic acid phenyl ester

: 197958-29-5
pyridin-2-ylboronic acid

: 91-02-1
phenyl(pyridin-2-yl)methanone

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; 1,2-bis-(diphenylphosphino)ethane In N,N-dimethyl acetamide at 80℃; under 760.051 Torr; for 6h; Suzuki-Miyaura Coupling;	87%

...Expand

: C8H8BrNOS

: 197958-29-5
pyridin-2-ylboronic acid

: C13H12N2OS

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 80℃; Suzuki Coupling; Inert atmosphere;	87%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane at 80℃; Inert atmosphere;	87%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 80℃; Suzuki Coupling; Inert atmosphere;	87%

: 197958-29-5
pyridin-2-ylboronic acid

: 366-18-7
[2,2]bipyridinyl

Conditions

Conditions	Yield
With palladium diacetate at 20℃; for 0.5h;	87%
With potassium phosphate In 1,4-dioxane at 85℃; for 3h; Catalytic behavior; Suzuki Coupling; Green chemistry;	82%
With nano-CuO-grafted triazine-functionalized covalent organic framework In methanol at 60℃; Catalytic behavior;	59%

: C12H13ClN2O2Si

: 197958-29-5
pyridin-2-ylboronic acid

: C17H17N3O2Si

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 12h; Reflux; Inert atmosphere;	87%

: 585-79-5
3-Bromonitrobenzene

: 197958-29-5
pyridin-2-ylboronic acid

: 4253-79-6
2-(3-nitrophenyl)pyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide at 80 - 100℃; Inert atmosphere;	86%

: 17180-93-7
4-chloropyrimidine

: 197958-29-5
pyridin-2-ylboronic acid

: 52997-82-7
2-(pyrimidin-4-yl)pyridine

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In water at 60℃; for 8h; Suzuki coupling;	85%

: 201230-82-2
carbon monoxide

: 17763-67-6
Phenyl triflate

: 197958-29-5
pyridin-2-ylboronic acid

: 91-02-1
phenyl(pyridin-2-yl)methanone

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium(II) trifluoroacetate In tert-butyl methyl ether at 80℃; under 760.051 Torr; for 6h; Suzuki-Miyaura Coupling;	85%

...Expand

: ethyl 5-bromo-4-cyclopentyl-1H-pyrrole-2-carboxylate

: 197958-29-5
pyridin-2-ylboronic acid

: ethyl 4-cyclopentyl-5-(pyridin-2-yl)-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 1h; Microwave irradiation; Inert atmosphere;	85%

: 288-32-4
1H-imidazole

: 197958-29-5
pyridin-2-ylboronic acid

: 25700-14-5
2-(1H-imidazolyl)pyridine

Conditions

Conditions	Yield
With 2Na(1+)*CuC6H4(NCHC6H3OO3S)2(2-)=CuC6H4(NCHC6H3ONaO3S)2 In water at 100℃; for 6h;	83%

: 1456506-83-4
(S)-3-(4-(5-bromo-2-fluoropyridin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

: 197958-29-5
pyridin-2-ylboronic acid

: 1456505-78-4
(S)-3-(4-(6-fluoro-[3,3'-bipyridin]-5-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 100℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;	83%

: 197958-29-5
pyridin-2-ylboronic acid

: 504-29-0
2-aminopyridine

Conditions

Conditions	Yield
With N-Bromosuccinimide; N-methoxylamine hydrochloride; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃;	83%
With N-Bromosuccinimide; CYANAMID; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile at 20℃; for 1h; chemoselective reaction;	77%

: C16H9BrClN3

: 197958-29-5
pyridin-2-ylboronic acid

: C21H13ClN4

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 5h; Inert atmosphere; Reflux;	83%

: 1229012-68-3
2,9-dichloro-4,7-diphenyl-1,10-phenanthroline

: 197958-29-5
pyridin-2-ylboronic acid

: C34H22N4

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 12h; Inert atmosphere; Reflux;	83%

2-Pyridineboronic acid Chemical Properties

The molecular formula of 2-Pyridineboronic acid(197958-29-5) is C₅H₆BNO₂ and its formula weight is 122.9177.
The chemical synonyms of 2-Pyridineboronic acid(197958-29-5) are PYRIDIN-2-YLBORONIC ACID;PYRIDIN-2-YL-2-BORONIC ACID;PYRIDINE-2-BORONIC ACID;2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-PYRIDINEBORNIC ACID;2-PYRIDINEBORONIC ACID;2-PYRIDINYLBORONIC ACID;Boronic acid, 2-pyridinyl- (9CI)
The molecular structure of 2-Pyridineboronic acid(197958-29-5):

2-Pyridineboronic acid Safety Profile

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39
Hazard Note Irritant/Keep Cold under -20C

Product Name

2-Pyridineboronic acid

Synthetic route

2-Pyridineboronic acid Chemical Properties

2-Pyridineboronic acid Safety Profile

Related Products

Hot Products