2-Pyridylacetonitrile supplier

Name
2-Pyridylacetonitrile
EINECS 220-364-6
CAS No. 2739-97-1
Article Data36
CAS DataBase
Density 1.085 g/cm³
Solubility Miscible with water.
Melting Point 23-25 °C
Formula C₇H₆N₂
Boiling Point 232.1 °C at 760 mmHg
Molecular Weight 118.138
Flash Point 93.9 °C
Transport Information UN 3276 6.1/PG 3
Appearance COLORLESS YELLOW TO ORANGE TO BROWN LIQUID
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (2-Pyridinyl)acetonitrile;(Pyridyl-2-yl)acetonitrile;2-(2-Pyridyl)acetonitrile;2-(Cyanomethyl)pyridine;
PSA 36.68000
LogP 1.14768

Synthetic route

: 117504-08-2
α-phenylsulfonylpyridine-2-acetonitrile

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With zinc In ethanol; acetic acid for 1h; Ambient temperature;	94%

: 372-48-5
2-fluoropyridine

: 75-05-8
acetonitrile

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With potassium hexamethylsilazane In toluene at 0 - 20℃;	87%

: 773837-37-9
sodium cyanide

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
In dimethyl sulfoxide for 2.5h; Heating;	84%
In dimethyl sulfoxide at 40℃; for 2.5h;	84%

: 5451-39-8
2-(pyridine-2-yl)acetamide

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With (dimethoxy)methylsilane; copper diacetate; 1,2-bis-(dicyclohexylphosphino)ethane In tetrahydrofuran at 20℃; for 12h; Sealed tube;	81%
With 1,2-dichloro-ethane; sodium chloride; trichlorophosphate

: 109-04-6
2-bromo-pyridine

: 75-05-8
acetonitrile

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Stage #1: acetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.75h; Metallation; Stage #2: 2-bromo-pyridine In tetrahydrofuran; hexane at -78 - 20℃; for 2.5h; Alkylation;	69%

: 109-04-6
2-bromo-pyridine

: 928664-98-6
4-isoxazoleboronic acid pinacol ester

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; water In dimethyl sulfoxide at 130℃; for 16h; Domino Suzuki coupling and fragmentation reaction; Inert atmosphere;	65%

: 694-59-7
pyridine N-oxide

A: 110-86-1
pyridine

B: 142-08-5
2-Pyridone

C: 2739-97-1
pyridine-2-acetonitrile

D: 366-18-7
[2,2]bipyridinyl

E: 109-97-7
pyrrole

Conditions

Conditions	Yield
at 750 - 850℃; under 0.001 - 0.01 Torr; Product distribution; Mechanism;	A 31% B 4% C 6% D 7% E n/a

...Expand

: 109-09-1
2-chloropyridine

: 75-05-8
acetonitrile

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran; toluene at 0 - 20℃;	15%

: 151-50-8
potassium cyanide

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With ethanol; potassium iodide

: 109-04-6
2-bromo-pyridine

: 75-05-8
acetonitrile

A: 504-29-0
2-aminopyridine

B: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With ammonia In diethyl ether for 0.25h; Irradiation;	A 16 % Chromat. B 75 % Chromat.

...Expand

: 2706-56-1
2-(aminoethyl)pyridine

A: 2739-97-1
pyridine-2-acetonitrile

B: N-chloro-2-(pyridin-2-yl)ethanimine

C: N,N-dichloro-2-(pyridin-2-yl)ethanamine

Conditions

Conditions	Yield
With TEA; trichloroisocyanuric acid In dichloromethane at 15℃; for 1h;

...Expand

: {HNC5H4CH2C(NH)Co(CN)4}(1-)

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With alkali hydroxide In not given from react. of acidic soln. with alkali hydroxide;;
With alkali hydroxide In not given from react. of acidic soln. with alkali hydroxide;;

: 55401-97-3
2-(Bromomethyl)pyridine

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: water 2: neat (no solvent) 3: perchloric acid 4: alkali hydroxide / not given View Scheme

: {C5H5NCH2Co(CN)5}(2-)

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: perchloric acid 2: alkali hydroxide / not given View Scheme

: 3K(1+)*{C5H4NCH2Co(CN)5}(3-)*H2O=K3{C5H4NCH2Co(CN)5}*H2O

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: neat (no solvent) 2: perchloric acid 3: alkali hydroxide / not given View Scheme

: 110-86-1
pyridine

: 75-05-8
acetonitrile

A: 2739-97-1
pyridine-2-acetonitrile

B: 6443-85-2
3-pyridinylacetonitrile

Conditions

Conditions	Yield
With water for 1h; Irradiation; Overall yield = 1.1 %;

...Expand

: 54765-14-9
2‐(pyridin‐2‐yl)acetaldehyde

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonia / water / 20 °C / Green chemistry 2: iodine / water / 20 °C / Green chemistry 3: ammonia / water / 20 °C / Green chemistry View Scheme

: 1221640-05-6
C7H8N2

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iodine / water / 20 °C / Green chemistry 2: ammonia / water / 20 °C / Green chemistry View Scheme

: C7H7IN2

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With ammonia In water at 20℃; Green chemistry;

: (E)-3-(dimethylamino)-2-(pyridin-2-yl)acrylonitrile

A: 2739-97-1
pyridine-2-acetonitrile

B: 493038-87-2
1H-3-amino-4-(pyridine-2-yl)-pyrazole

Conditions

Conditions	Yield
With hydrazine hydrate; acetic acid for 12h;

: 586-98-1
2-Hydroxymethylpyridine

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / 3 h / 60 °C 2: dimethyl sulfoxide / 2.5 h / Heating View Scheme

: 139585-70-9
2-bromo-5-cyanopyridine

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 2 h / 20 °C 1.2: 3 h / 120 °C 2.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux View Scheme

: tert-butyl 2-cyano-2-(5-cyanopyridin-2-yl)acetate

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 6h; Reflux;	1.2 g

: 773837-37-9
sodium cyanide

: 31106-82-8
2-(bromomethyl)pyridine hydrobromide

: 2739-97-1
pyridine-2-acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-(bromomethyl)pyridine hydrobromide With sodium hydrogencarbonate In water Stage #2: sodium cyanide In ethanol at 75℃; for 24h;

: 2739-97-1
pyridine-2-acetonitrile

: 39102-29-9
N-hydroxy-2-(2-pyridinyl)ethanimidamide

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium In methanol	100%
With hydroxylamine hydrochloride; sodium In methanol	100%
With hydroxylamine hydrochloride; triethylamine In methanol at 20℃;

: 2739-97-1
pyridine-2-acetonitrile

: 115-22-0
3-Hydroxy-3-methyl-2-butanone

: 2-imino-3-(2'-pyridyl)-4,5,5-trimethyl-2,5-dihydrofuran

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 0.133333h; Microwave irradiation;	100%
With sodium ethanolate; sodium In ethanol; dichloromethane

: 2739-97-1
pyridine-2-acetonitrile

: 111-24-0
1,5-dibromo-pentane

: 1-(pyridin-2-yl)cyclohexanecarbonitrile

Conditions

Conditions	Yield
With sodium hydride In diethyl ether; dimethyl sulfoxide; mineral oil at 15 - 20℃; for 25h; Inert atmosphere;	100%
Stage #1: pyridine-2-acetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h; Stage #2: 1,5-dibromo-pentane In tetrahydrofuran at -78 - 20℃; for 10h;	88%
With sodium hydride In diethyl ether; dimethyl sulfoxide; mineral oil at 15 - 20℃; for 25h; Inert atmosphere;	74%
In water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol	72%

: 110-52-1
1,4-dibromo-butane

: 2739-97-1
pyridine-2-acetonitrile

: 400727-04-0
1-(pyridin-2-yl)cyclopentanecarbonitrile

Conditions

Conditions	Yield
With sodium hydride In diethyl ether; dimethyl sulfoxide; mineral oil at 15 - 20℃; for 25h; Inert atmosphere;	100%
Stage #1: pyridine-2-acetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h; Stage #2: 1,4-dibromo-butane In tetrahydrofuran at -78 - 20℃; for 10h;	96%
Stage #1: pyridine-2-acetonitrile With sodium hydride In N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 1,4-dibromo-butane In N,N-dimethyl-formamide at 20℃; for 2h;	86.2%
With sodium hydride In diethyl ether; dimethyl sulfoxide at 0 - 20℃; for 4.5h;	82%

: 2739-97-1
pyridine-2-acetonitrile

: 50-00-0
formaldehyd

: 62-53-3
aniline

: 3-anilino-2-(pyridin-2-yl)propionitrile

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 70 - 72℃; for 5h; Solvent; Reagent/catalyst; Temperature; Mannich Aminomethylation;	99.1%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 125008-68-6
methyl (Z)-2-benzoylamino-3-dimethylaminopropenoate

: 154411-16-2
3-benzoylamino-1-cyano-4H-pyrido[1,2-a]pyridin-4-one

Conditions

Conditions	Yield
With acetic acid for 4h; Heating;	99%

: 2739-97-1
pyridine-2-acetonitrile

: 3171-45-7
4,5-dimethyl-1,2-phenylenediamine

: 141763-05-5
5,6-Dimethyl-2-pyridin-2-ylmethyl-1H-benzoimidazole

Conditions

Conditions	Yield
With PPA; Polyphosphoric acid (PPA) at 170 - 180℃; for 5h;	99%

: 2739-97-1
pyridine-2-acetonitrile

: 1820-80-0
3-aminopyrazole

: [(1H-pyrazol-3-yl)-hydrazono]-pyridin-2-yl-acetonitrile

Conditions

Conditions	Yield
Stage #1: 3-aminopyrazole With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: pyridine-2-acetonitrile With sodium acetate In water at 0 - 5℃; for 0.5h;	99%

: 2739-97-1
pyridine-2-acetonitrile

: 124-38-9
carbon dioxide

: 766-49-4
(2-fluorophenyl)acetylene

: 2-(2-fluorophenyl)-4-oxo-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: carbon dioxide; (2-fluorophenyl)acetylene With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	99%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 71-36-3
butan-1-ol

: 6340-34-7
2-(pyridin-2-yl)hexanenitrile

Conditions

Conditions	Yield
With C30H29BrMnNO2P2; caesium carbonate In toluene at 135℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry; chemoselective reaction;	99%

: 2739-97-1
pyridine-2-acetonitrile

: 90-02-8
salicylaldehyde

: 837-97-8
3-(pyridine-2-yl)-2H-chromen-2-one

Conditions

Conditions	Yield
With sodium hydroxide In water at 90℃; for 3h; pH 12.4;	98%
With sodium hydroxide; water at 90℃; for 3.5h;	92%
With piperidine Inert atmosphere;	71%
Multi-step reaction with 2 steps 1: piperidine / ethanol / 20 h / 20 °C / Cooling with ice 2: hydrogenchloride; water / ethanol / 10 h / Reflux View Scheme

: 2739-97-1
pyridine-2-acetonitrile

: 124-38-9
carbon dioxide

: 873-31-4
2-chlorophenylacetylene

: 2-(2-chlorophenyl)-4-oxo-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 2-chlorophenylacetylene With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	98%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 124-38-9
carbon dioxide

: 768-70-7
1-ethynyl-3-methoxybenzene

: 2-(3-methoxyphenyl)-4-oxo-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 1-ethynyl-3-methoxybenzene With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	98%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 110-62-3
pentanal

: 83917-92-4, 83918-35-8
(E)-2-Pyridin-2-yl-hept-2-enenitrile

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 3h; Heating;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 118-74-1
hexachlorobenzene

: 133560-79-9
1,2,3,4-tetrachloro-10-cyanopyrido<1,2-a>indole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 78-84-2
isobutyraldehyde

: 22346-07-2
4-methyl-2-(2-pirydyl)-2-pentenenitrile

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene for 3h; Heating;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 6994-25-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 3-[N'-(cyano-pyridin-2-yl-methylene)-hydrazino]-1H-pyrazole-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 3-amino-4-pyrazolecarboxylic acid ethyl ester With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: pyridine-2-acetonitrile With sodium acetate In water at 0 - 5℃;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 2-bromo-2-(pyridin-2-yl)acetonitrile

Conditions

Conditions	Yield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) at 20℃; for 6h; Inert atmosphere; Irradiation;	97%
With N-Bromosuccinimide In tetrachloromethane	18.6 g (94%)
With N-Bromosuccinimide In tetrachloromethane	18.6 g (94%)
With N-Bromosuccinimide In tetrachloromethane	18.6 g (94%)

: 2739-97-1
pyridine-2-acetonitrile

: 124-38-9
carbon dioxide

: 536-74-3
phenylacetylene

: 4-oxo-2-phenyl-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: carbon dioxide; phenylacetylene With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Catalytic behavior; Solvent; Reagent/catalyst; Inert atmosphere;	97%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 693-13-0
diisopropyl-carbodiimide

: C14H20N4

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at 60℃; under 760.051 Torr; for 6h; Inert atmosphere; Sealed tube;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 108-86-1
bromobenzene

: 5005-36-7
phenyl-pyridin-2-yl-acetonitrile

Conditions

Conditions	Yield
With potassium tert-butylate; palladium diacetate; nixantphos In 1,4-dioxane at 60℃; for 10h; Inert atmosphere; Sealed tube;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 2924-09-6
5-bromo-2-fluoroaniline

: C13H10FN3

Conditions

Conditions	Yield
With potassium tert-butylate; palladium diacetate; nixantphos In 1,4-dioxane at 60℃; for 10h; Inert atmosphere; Sealed tube;	97%

: 2739-97-1
pyridine-2-acetonitrile

: 219739-90-9
Methyl (Z)-2-<(benzyloxycarbonyl)amino>-3-dimethylaminopropenoate

: 223717-80-4
3-(benzyloxycarbonyl)amino-1-cyano-4H-pyrido[1,2-a]pyridin-4-one

Conditions

Conditions	Yield
In acetic acid for 2h; Heating;	96%
With acetic acid for 4h; Reflux;	87%

: 2739-97-1
pyridine-2-acetonitrile

: 363-72-4
Pentafluorobenzene

: 2-(pyridin-2-yl)-2-(2,3,5,6-tetrafluorophenyl)acetonitrile

Conditions

Conditions	Yield
With lithium tert-butoxide In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; regioselective reaction;	96%

: 2739-97-1
pyridine-2-acetonitrile

: 3360-41-6
4-phenyl-butan-1-ol

: C17H18N2

Conditions

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate In toluene at 135℃; for 4h; Inert atmosphere;	96%

: 2739-97-1
pyridine-2-acetonitrile

: diphenyl(vinyl)sulfonium trifluoromethanesulfonate

: 1-(pyridin-2-yl)cyclopropanecarbonitrile

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 21℃; for 12h;	96%

: 2739-97-1
pyridine-2-acetonitrile

: 124-38-9
carbon dioxide

: 766-97-2
4-n-methylphenylacetylene

: 4-oxo-2-(p-tolyl)-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: carbon dioxide; 4-n-methylphenylacetylene With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	96%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 6746-94-7
Cyclopropylacetylene

: 124-38-9
carbon dioxide

: 2-cyclopropyl-4-oxo-4H-quinolizine-1-carbonitrile

Conditions

Conditions	Yield
Stage #1: Cyclopropylacetylene; carbon dioxide With ethyl bromide; caesium carbonate; silver(l) oxide In N,N-dimethyl-formamide at 50℃; for 12h; Schlenk technique; Stage #2: pyridine-2-acetonitrile In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere;	96%

...Expand

: 2739-97-1
pyridine-2-acetonitrile

: 98041-44-2
2-iodophenyl isothiocyanate

: (Z)-2-(benzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-yl)acetonitrile

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide at 20℃; Temperature; Inert atmosphere;	96%

: 2739-97-1
pyridine-2-acetonitrile

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 104-88-1
4-chlorobenzaldehyde

: 3-(tert-butylamino)-2-(4-chlorophenyl)indolizine-1-carbonitrile

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium chloride In neat (no solvent) at 20℃; for 0.666667h; Catalytic behavior; Solvent; Temperature; Time;	96%

...Expand

2-Pyridylacetonitrile Specification

The 2-Pyridylacetonitrile, with the CAS registry number 2739-97-1 and EINECS registry number 220-364-6, has the systematic name of pyridin-2-ylacetonitrile. It belongs to the following product categories: Miscellaneous; Pyridines; Pyridine; C7 and C8; Heterocyclic Building Blocks. And the molecular formula of this chemical is C₇H₆N₂.

The physical properties of 2-Pyridylacetonitrile are as following: (1)ACD/LogP: -0.04; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.05; (4)ACD/LogD (pH 7.4): -0.04; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 22.45; (8)ACD/KOC (pH 7.4): 22.57; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 36.68 Å²; (13)Index of Refraction: 1.533; (14)Molar Refractivity: 33.8 cm³; (15)Molar Volume: 108.8 cm³; (16)Polarizability: 13.4×10^-24cm³; (17)Surface Tension: 47.8 dyne/cm; (18)Density: 1.085 g/cm³; (19)Flash Point: 93.9 °C; (20)Enthalpy of Vaporization: 46.87 kJ/mol; (21)Boiling Point: 232.1 °C at 760 mmHg; (22)Vapour Pressure: 0.0602 mmHg at 25°C.

Uses of 2-Pyridylacetonitrile: It can react with ethoxymethylene-malonic acid diethyl ester to produce 1-cyano-4-oxo-4H-quinolizin-3-carboxylic acid ethyl ester. This reaction will need reagent sodium ethoxide, and the solvent ethanol. The reaction time is 45 minutes with temperature of 25°C, and the yield is about 55%

2-Pyridylacetonitrile can react with ethoxymethylene-malonic acid diethyl ester to produce 1-cyano-4-oxo-4H-quinolizin-3-carboxylic acid ethyl ester

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: N#CCc1ncccc1
(2)InChI: InChI=1/C7H6N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4H2
(3)InChIKey: UKVQBONVSSLJBB-UHFFFAOYAP

Product Name

2-Pyridylacetonitrile

Synthetic route

2-Pyridylacetonitrile Specification

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