Conditions | Yield |
---|---|
With propionic acid In water; toluene at 2 - 70℃; Product distribution / selectivity; Inert atmosphere; | 95% |
With acetic acid In water; toluene at 2 - 22℃; under 39.754 Torr; Product distribution / selectivity; Inert atmosphere; |
trans-Crotonaldehyde
methylthiol
A
3-(methylthio)butyraldehyde
B
1,3-bis-methylsulfanyl-but-1-ene
Conditions | Yield |
---|---|
With hydrogenchloride; tetrachloromethane |
Conditions | Yield |
---|---|
With ascaridole | |
With piperidine | |
With hydrogenchloride In tetrachloromethane |
pyrrolidine
3-(methylthio)butyraldehyde
3-(methylthio)-1-(pyrrolidin-1-yl)-1-butene
Conditions | Yield |
---|---|
With potassium carbonate at -5℃; for 0.166667h; | 96% |
With potassium carbonate at 4 - 20℃; Inert atmosphere; | |
In toluene at 3 - 26℃; under 18.0018 Torr; Product distribution / selectivity; |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Stage #1: methyl 4-{1-[(tert-butoxycarbonyl)amino]prop-2-yn-1-yl}benzoate; 3-(methylthio)butyraldehyde With bis(norbornadiene)rhodium(l)tetrafluoroborate; 1,1-dicyclohexyl-N-(dicyclohexylphosphino)-N-methylphosphinamine In acetone at 20℃; for 4h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In acetone; acetonitrile at 20℃; for 4h; Inert atmosphere; | 75% |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
With triphenyl phosphite; bromine; triethylamine In dichloromethane at -78 - 20℃; Schlenk technique; Inert atmosphere; | 41% |
methyl (2E)-3-methoxy-2-propenoate
3-(methylthio)butyraldehyde
4-methoxy-5-(2-methyl-sulfanyl-propyl)-5H-furan-2-one
Conditions | Yield |
---|---|
Stage #1: methyl (2E)-3-methoxy-2-propenoate With lithium diisopropyl amide In tetrahydrofuran at -100 - -95℃; for 0.1h; Stage #2: 3-(methylthio)butyraldehyde In tetrahydrofuran at -100 - -78℃; for 1.53333h; | 30% |
formaldehyd
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Stage #1: formaldehyd With sodium hydroxide In acetonitrile at 60℃; for 0.333333h; Cannizzaro Reaction; Stage #2: 3-(methylthio)butyraldehyde In acetonitrile for 1h; Reflux; | 28% |
3-(methylthio)butyraldehyde
sodium cyanide
5-(2-methylsulfanyl-propyl)-imidazolidine-2,4-dione
Conditions | Yield |
---|---|
With ammonium carbonate |
pyrrolidine
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
With potassium carbonate at 10 - 20℃; | |
With potassium carbonate at 4 - 20℃; | |
With potassium carbonate at 4 - 20℃; |
3-(methylthio)butyraldehyde
dimethyl amine
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; for 1.5h; |
3-(methylthio)butyraldehyde
4-methyl-D,L-methionine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4>2CO3 2: Hydrolysis View Scheme |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 4>2CO3 2: Hydrolysis 3: H2O2 View Scheme |
3-(methylthio)butyraldehyde
2-amino-4-(imino-methyl-oxo-λ6-sulfanyl)-valeric acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4>2CO3 2: Hydrolysis 3: H2O2 4: HN3 View Scheme |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4>2CO3 2: Hydrolysis 3: H2O2 4: H2O2 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis(norbornadiene)rhodium(l)tetrafluoroborate; 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-ethane / 1 h / 65 °C / Inert atmosphere 2: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
With bis(norbornadiene)rhodium(l)tetrafluoroborate; 1,2-bis-(diphenylphosphino)ethane In 1,2-dichloro-ethane at 65℃; for 1h; Inert atmosphere; |
3-(methylthio)butyraldehyde
1-triphenylphosphoranylidene-2-propanone
(E)-6-methylsulfanylhept-3-en-2-one
Conditions | Yield |
---|---|
In dichloromethane for 7h; Reflux; | 5.409 g |
In dichloromethane for 7h; Reflux; | 5.409 g |
3-(methylthio)butyraldehyde
ethyl 2-(2-methylsulfanylpropyl)-4,6-dioxocyclohexanecarboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: dichloromethane / 7 h / Reflux 2.1: sodium / ethanol / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice 2.2: 20 °C / Inert atmosphere; Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: dichloromethane / 7 h / Reflux 2.1: sodium; ethanol / 1.33 h / 20 °C / Cooling with ice; Inert atmosphere 2.2: 4 h / 20 °C / Cooling with ice View Scheme |
3-(methylthio)butyraldehyde
5-(2-methylsulfanylpropyl)cyclohexane-1,3-dione
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dichloromethane / 7 h / Reflux 2.1: sodium / ethanol / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice 2.2: 20 °C / Inert atmosphere; Cooling with ice 3.1: hydrogenchloride / water / 6 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: dichloromethane / 7 h / Reflux 2.1: sodium; ethanol / 1.33 h / 20 °C / Cooling with ice; Inert atmosphere 2.2: 4 h / 20 °C / Cooling with ice 3.1: hydrogenchloride / water / 6 h / Heating View Scheme |
3-(methylthio)butyraldehyde
sulfoxaflor
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / toluene / 5 h / 10 - 20 °C / Inert atmosphere 2: acetonitrile / 15 - 20 °C / Inert atmosphere 3: ammonium acetate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere 4: [bis(acetoxy)iodo]benzene / acetonitrile / 2.17 h / 10 - 30 °C 5: sodium permanganate / water; dichloromethane / 1.92 h / 13 - 20 °C View Scheme |
3-(methylthio)butyraldehyde
1,1,1-trifluoro-6-(methylthio)-5-(pyrrolidine-1-ylmethylene)hept-3-en-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / toluene / 5 h / 10 - 20 °C / Inert atmosphere 2: acetonitrile / 15 - 20 °C / Inert atmosphere View Scheme |
3-(methylthio)butyraldehyde
(1-{6-[trifluoromethyl]pyridin-3-yl}ethyl)-(methyl)-λ4-sulfanylidenecyanamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / toluene / 5 h / 10 - 20 °C / Inert atmosphere 2: acetonitrile / 15 - 20 °C / Inert atmosphere 3: ammonium acetate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere 4: [bis(acetoxy)iodo]benzene / acetonitrile / 2.17 h / 10 - 30 °C View Scheme |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / toluene / 5 h / 10 - 20 °C / Inert atmosphere 2: acetonitrile / 15 - 20 °C / Inert atmosphere 3: ammonium acetate / acetonitrile / 0.5 h / 80 °C / Inert atmosphere View Scheme |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: formic acid / water; methanol / 20 h / 20 °C / Inert atmosphere 2: C46H34I4O6; potassium fluoride / o-xylene / 24 h / 25 °C / Inert atmosphere View Scheme |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: formic acid / water; methanol / 20 h / 20 °C / Inert atmosphere 2: Tetraethylene glycol; potassium fluoride / o-xylene / 24 h / 25 °C / Inert atmosphere View Scheme |
3-(methylthio)butyraldehyde
tert-Butyl N-hydroxycarbamate
sodium benzenesulfonate
Conditions | Yield |
---|---|
With formic acid In methanol; water at 20℃; for 20h; Inert atmosphere; |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
With phenylsilane; dibutyltin chloride In tetrahydrofuran at 20℃; for 16h; |
3-(methylthio)butyraldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triphenyl phosphite; bromine; triethylamine / dichloromethane / -78 - 20 °C / Schlenk technique; Inert atmosphere 2: copper(I) bromide dimethylsulfide complex; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium tert-butoxide / tetrahydrofuran; dimethyl sulfoxide / 0 - 20 °C / Schlenk technique; Inert atmosphere View Scheme |
Molecular Structure of 3-(Methylthio)butanal (CAS NO.16630-52-7):
IUPAC Name: 3-Methylsulfanylbutanal
Canonical SMILES: CC(CC=O)SC
InChI: InChI=1S/C5H10OS/c1-5(7-2)3-4-6/h4-5H,3H2,1-2H3
InChIKey: NCBDFIPMWRKPDU-UHFFFAOYSA-N
Molecular Formula: C5H10OS
Molar mass: 118.1973 g/mol
EINECS: 240-678-7
Density: 0.963 g/cm3
vapor density: 4.1 (vs air)
Sensitive: Air Sensitive
Flash Point: 62.2 °C
Index of Refraction: 1.455
Boiling Point: 174 °C at 760 mmHg
Vapour Pressure: 1.23 mmHg at 25 °C
Appearance: Colorless to pale yellow liquid
Product Categories: sulfide Flavor; Alphabetical Listings; Flavors and Fragrances; M-N
3-(Methylthio)butanal (CAS NO.16630-52-7) is used for the production of seasonings.
With piperidine or copper acetate as catalyst, 3-(Methylthio)butanal(16630-52-7) can be formed from methyl mercaptan reacting in the crotonaldehyde which has been in pre-cooling to -20 ℃ .
Safety Information of 3-(Methylthio)butanal (CAS NO.16630-52-7):
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 1989
WGK Germany: 3
3-(Methylthio)butanal (CAS NO.16630-52-7), its Synonyms are 3-(Methylthio)butyraldehyde ; Butanal, 3-(methylthio)- ; Butyraldehyde, 3-(methylthio)- ; beta-(Methylthio)butyraldehyde .
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