Product Name

  • Name

    (3,3,3-TRIFLUOROPROPYL)TRIMETHOXYSILANE

  • EINECS 207-059-3
  • CAS No. 429-60-7
  • Article Data4
  • CAS DataBase
  • Density 1.098 g/cm3
  • Solubility
  • Melting Point
  • Formula C6H13F3O3Si
  • Boiling Point 124.406 °C at 760 mmHg
  • Molecular Weight 218.248
  • Flash Point 29.04 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance Colorless clear liquid
  • Safety 26-36
  • Risk Codes 10-36/37/38
  • Molecular Structure Molecular Structure of 429-60-7 ((3,3,3-TRIFLUOROPROPYL)TRIMETHOXYSILANE)
  • Hazard Symbols IrritantXi, FlammableF
  • Synonyms (3,3,3-Trifluoropropyl)trimethoxysilane;1,1,1-Trifluoro-3-(trimethoxysilyl)propane;AP Silane 75;AY 43-013;FAS 3;FAS3 (silane);KBM 7103;LS 1090;Q 3-9030;T 2847;TSL 8262;Trimethoxy(3,3,3-trifluoropropyl)silane;XC 95-418;Z 6333;
  • PSA 27.69000
  • LogP 1.81690

Synthetic route

methanol
67-56-1

methanol

3,3,3-trifluoropropyltrichlorosilane
592-09-6

3,3,3-trifluoropropyltrichlorosilane

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

tetramethylorthosilicate
681-84-5

tetramethylorthosilicate

3,3,3-trifluoropropyl magnesium chloride
461-21-2

3,3,3-trifluoropropyl magnesium chloride

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

trimethoxysilane
2487-90-3

trimethoxysilane

perfluoropropylene
116-15-4

perfluoropropylene

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

Conditions
ConditionsYield
With caesium carbonate; triethylamine; [Rh{(Z)-CF=CF(CF3)}(PEt3)3] In hexane at 20℃; for 20h;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

1,3,5,7,9,11,14-heptakis-(3,3,3-trifluoro-propyl)-3,7,14-tris-trimethylsilanyloxy-2,4,6,8,10,12,13,15,16-nonaoxa-1,3,5,7,9,11,14-heptasila-tricyclo[7.3.3.15,11]hexadecane

1,3,5,7,9,11,14-heptakis-(3,3,3-trifluoro-propyl)-3,7,14-tris-trimethylsilanyloxy-2,4,6,8,10,12,13,15,16-nonaoxa-1,3,5,7,9,11,14-heptasila-tricyclo[7.3.3.15,11]hexadecane

Conditions
ConditionsYield
Stage #1: 3,3,3-trifluoropropyltrimethoxysilane With sodium hydroxide In tetrahydrofuran; water for 5h; Heating;
Stage #2: chloro-trimethyl-silane With triethylamine In tetrahydrofuran at 20℃; for 3h;		100%
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water Inert atmosphere;100%
With sodium hydroxide; water In tetrahydrofuran for 5h; Heating / reflux;
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 24h;
1,2,3,4-tetrahydroisoquinoline
91-21-4

1,2,3,4-tetrahydroisoquinoline

3,3,3-Trifluoropropyl(1,2,3,4-tetrahydroisoquinolinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(1,2,3,4-tetrahydroisoquinolinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

3,3,3-trifluoropropyl(1,2,3,4-tetrahydroisoquinolinyl)dimethoxysilane

3,3,3-trifluoropropyl(1,2,3,4-tetrahydroisoquinolinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran99%
...Expand
1,2,3,4-tetrahydroisoquinoline
635-46-1

1,2,3,4-tetrahydroisoquinoline

3,3,3-Trifluoropropyl(1,2,3,4-tetrahydroquinolinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(1,2,3,4-tetrahydroquinolinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

3,3,3-trifluoropropyl(1,2,3,4-tetrahydroquinolinyl)dimethoxysilane

3,3,3-trifluoropropyl(1,2,3,4-tetrahydroquinolinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran99%
...Expand
3,3,3-Trifluoropropyl(bis(2-ethylhexyl)aminodimethoxysilane - A

3,3,3-Trifluoropropyl(bis(2-ethylhexyl)aminodimethoxysilane - A

2-ethyl-N-(2-ethylhexyl)-1-hexanamine
106-20-7

2-ethyl-N-(2-ethylhexyl)-1-hexanamine

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

(3,3,3-trifluoropropyl)(bis(2-ethylhexyl)amino)dimethoxysilane
227768-97-0

(3,3,3-trifluoropropyl)(bis(2-ethylhexyl)amino)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran98%
...Expand
3,3,3-Trifluoropropyl(2-trimethylsilylpyrrolidinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(2-trimethylsilylpyrrolidinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

2-(Trimethylsilyl)pyrrolidine
174363-70-3

2-(Trimethylsilyl)pyrrolidine

(3,3,3-trifluoropropyl)(2-trimethylsilylpyrrolidino)dimethoxysilane

(3,3,3-trifluoropropyl)(2-trimethylsilylpyrrolidino)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran91%
...Expand
3,3,3-Trifluoropropyl(2-trimethylsilylpiperidinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(2-trimethylsilylpiperidinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

2-(trimethylsilyl)piperidine
174363-71-4

2-(trimethylsilyl)piperidine

(3,3,3-trifluoropropyl)(2-trimethylsilylpiperidino)dimethoxysilane

(3,3,3-trifluoropropyl)(2-trimethylsilylpiperidino)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran85%
...Expand
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

tetrabutyl ammonium fluoride
429-41-4

tetrabutyl ammonium fluoride

tetra-n-butylammonium octa(3,3,3-trifluoropropyl)octasilsesquioxane fluoride
1358980-93-4

tetra-n-butylammonium octa(3,3,3-trifluoropropyl)octasilsesquioxane fluoride

Conditions
ConditionsYield
In tetrahydrofuran; water; toluene for 16h; Reflux;81%
2-(3-methylphenyl)piperidine

2-(3-methylphenyl)piperidine

3,3,3-Trifluoropropyl(2-(3-methylphenyl)piperidinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(2-(3-methylphenyl)piperidinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

3,3,3-trifluoropropyl(2-(3-methylphenyl)piperidinyl)dimethoxysilane

3,3,3-trifluoropropyl(2-(3-methylphenyl)piperidinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran80.4%
...Expand
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

C3H4F7Si(1-)*H3N*H(1+)

C3H4F7Si(1-)*H3N*H(1+)

Conditions
ConditionsYield
With ammonium hydrogen difluoride In water at 20℃;75%
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

(acetoxyethyl)trichlorosilane
18204-80-3

(acetoxyethyl)trichlorosilane

(2-acetoxyethyl)hepta(3,3,3-trifluoropropyl)-T8-silsesquioxane

(2-acetoxyethyl)hepta(3,3,3-trifluoropropyl)-T8-silsesquioxane

Conditions
ConditionsYield
Stage #1: 3,3,3-trifluoropropyltrimethoxysilane With sodium hydroxide In tetrahydrofuran; water for 5h; Heating;
Stage #2: (acetoxyethyl)trichlorosilane With triethylamine In tetrahydrofuran at 20℃; for 4h;		66%
2-(3-methylphenyl)pyrrolidine

2-(3-methylphenyl)pyrrolidine

3,3,3-Trifluoropropyl(2-(3-methylphenyl)pyrrolidinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(2-(3-methylphenyl)pyrrolidinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

3,3,3-trifluoropropyl(2-(3-methylphenyl)pyrrolidinyl)dimethoxysilane

3,3,3-trifluoropropyl(2-(3-methylphenyl)pyrrolidinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran62.2%
...Expand
3,3,3-Trifluoropropyl(cis-2,6-dimethylpiperidinyl)dimethoxysilane - A

3,3,3-Trifluoropropyl(cis-2,6-dimethylpiperidinyl)dimethoxysilane - A

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

(2R,6S)-2,6-dimethylpiperidine
766-17-6, 1218906-26-3

(2R,6S)-2,6-dimethylpiperidine

3,3,3-trifluoropropyl(cis-2,6-dimethylpiperidinyl)dimethoxysilane

3,3,3-trifluoropropyl(cis-2,6-dimethylpiperidinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran48%
...Expand
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

3,3,3-trifluoropropyl magnesium chloride
461-21-2

3,3,3-trifluoropropyl magnesium chloride

dimethoxy-bis-(3,3,3-trifluoro-propyl)-silane
563-02-0

dimethoxy-bis-(3,3,3-trifluoro-propyl)-silane

1-[N,N-bis(2-hydroxyethyl)amino]-2-propanol
6712-98-7

1-[N,N-bis(2-hydroxyethyl)amino]-2-propanol

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

3-methyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane
63453-66-7

3-methyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

Conditions
ConditionsYield
With sodium ethanolate In ethanol
triisopropanolamine
122-20-3

triisopropanolamine

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

3,7,10-trimethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane
63453-67-8

3,7,10-trimethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

triethanolamine
102-71-6

triethanolamine

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

1-(3,3,3-Trifluoropropyl)silatrane
63071-88-5

1-(3,3,3-Trifluoropropyl)silatrane

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

3-[bis(2-hydroxyethyl)amino]1,1,1-trifluoro-2-propanol
404-07-9

3-[bis(2-hydroxyethyl)amino]1,1,1-trifluoro-2-propanol

3-trifluoromethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane
63453-69-0

3-trifluoromethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

N,N-bis(2-hydroxypropyl)-N-(hydroxyethyl)amine
10353-86-3

N,N-bis(2-hydroxypropyl)-N-(hydroxyethyl)amine

3,7-dimethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane
63495-22-7

3,7-dimethyl-1-(3,3,3-trifluoro-propyl)-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3,3,3-trifluoropropyl-4-methylbenzene sulphonate
2342-67-8

3,3,3-trifluoropropyl-4-methylbenzene sulphonate

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid Yield given. Multistep reaction;
Methyltrimethoxysilan
1185-55-3

Methyltrimethoxysilan

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

2,4,6,8-tetrakis-[2-(trimethoxy-silanyl)-ethyl]-2,4,6,8-tetramethyl-[1,3,5,7,2,4,6,8]tetroxatetrasilocane
93236-49-8

2,4,6,8-tetrakis-[2-(trimethoxy-silanyl)-ethyl]-2,4,6,8-tetramethyl-[1,3,5,7,2,4,6,8]tetroxatetrasilocane

Reaxys ID: 11387454

Reaxys ID: 11387454

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at -78 - 70℃; for 24h;
...Expand
sodium hydroxide
1310-73-2

sodium hydroxide

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

water
7732-18-5

water

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 5h; Heating / reflux;
In tetrahydrofuran at 20℃; for 5h; Heating / reflux;
...Expand
sodium hydroxide
1310-73-2

sodium hydroxide

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

hepta(3,3,3-trifluoropropyl)tricycloheptasiloxane trisodium silanolate

Conditions
ConditionsYield
With water In tetrahydrofuran at 20℃; Heating / reflux;
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

2-ethylpiperidine
1484-80-6, 78738-37-1

2-ethylpiperidine

(3,3,3-trifluoro-n-propyl)(2-ethylpiperidinyl)dimethoxysilane

(3,3,3-trifluoro-n-propyl)(2-ethylpiperidinyl)dimethoxysilane

Conditions
ConditionsYield
In tetrahydrofuran
...Expand
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

C22H30F21O11Si7(3-)*3Na(1+)

C22H30F21O11Si7(3-)*3Na(1+)

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran for 5h; Reflux;
3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

benzene-1,2-diol
120-80-9

benzene-1,2-diol

diisopropylamine
108-18-9

diisopropylamine

diisopropylammonium bis(catecholato)(3,3,3-trifluoropropyl)silicate

diisopropylammonium bis(catecholato)(3,3,3-trifluoropropyl)silicate

Conditions
ConditionsYield
Stage #1: benzene-1,2-diol; diisopropylamine In tetrahydrofuran at 20℃; for 0.25h; Inert atmosphere; Sealed tube;
Stage #2: 3,3,3-trifluoropropyltrimethoxysilane In tetrahydrofuran at 75℃; for 16h; Inert atmosphere; Sealed tube;
Inert atmosphere; Autoclave; Reflux;
...Expand
18-crown-6 ether
17455-13-9

18-crown-6 ether

3,3,3-trifluoropropyltrimethoxysilane
429-60-7

3,3,3-trifluoropropyltrimethoxysilane

benzene-1,2-diol
120-80-9

benzene-1,2-diol

C15H12F3O4Si(1-)*C12H24KO6(1+)

C15H12F3O4Si(1-)*C12H24KO6(1+)

Conditions
ConditionsYield
With potassium methanolate In methanol at 20℃; for 3h; Schlenk technique; Inert atmosphere;
...Expand

3,3,3-Trifluoropropyltrimethoxysilane Specification

The 3,3,3-Trifluoropropyltrimethoxysilane, with the cas registry number of 429-60-7, is also known as Silane, trimethoxy(3,3,3-trifluoropropyl)- and 3-(Trimethoxysilyl)-1,1,1-trifluoropropane. It belongs to the product categories of Organics; Fluoro Silanes. Its EINECS number is 207-059-3. This chemical's molecular formula is C6H13F3O3Si and formula weight is 218.25. What's more, both its IUPAC name and systematic name are the same which is called Trimethoxy(3,3,3-trifluoropropyl)silane. This chemical is colorless clear liquid.

Physical properties about this chemical are: (1)ACD/LogP: 1.32; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.32; (4)ACD/LogD (pH 7.4): 1.32; (5)ACD/BCF (pH 5.5): 5.91; (6)ACD/BCF (pH 7.4): 5.91; (7)ACD/KOC (pH 5.5): 124.13; (8)ACD/KOC (pH 7.4): 124.13; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 27.69 Å2; (13)Index of Refraction: 1.363; (14)Molar Refractivity: 44.25 cm3; (15)Molar Volume: 198.7 cm3; (16)Surface Tension: 18.5 dyne/cm; (17)Density: 1.097 g/cm3; (18)Flash Point: 29 °C; (19)Enthalpy of Vaporization: 34.73 kJ/mol; (20)Boiling Point: 124.4 °C at 760 mmHg; (21)Vapour Pressure: 15.4 mmHg at 25°C; (22)Sensitive: Moisture Sensitive.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes and may catch fire in contact with air. It only needs brief contact with an ignition source and has a very low flash point or evolve highly flammable gases in contact with water. Secondly, it irritates to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact this chemical, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CO[Si](CCC(F)(F)F)(OC)OC;
(2)InChI: InChI=1S/C6H13F3O3Si/c1-10-13(11-2,12-3)5-4-6(7,8)9/h4-5H2,1-3H3;
(3)InChIKey: JLGNHOJUQFHYEZ-UHFFFAOYSA-N.

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