3,4-DIAMINOPYRIDINE supplier

Name
3,4-Diaminopyridine
EINECS 200-220-9
CAS No. 54-96-6
Article Data16
CAS DataBase
Density 1.251 g/cm³
Solubility water: 24 g/L (20 °C)
Melting Point 216-218 °C(lit.)
Formula C₅H₇N₃
Boiling Point 369.3 °C at 760 mmHg
Molecular Weight 109.131
Flash Point 204.9 °C
Transport Information UN 2811 6.1/PG 2
Appearance brownish to brown-grey crystalline powder
Safety 26-28-36/37/39-45-37/39-28A-36
Risk Codes 25-26-36/37/38
Molecular Structure
Hazard Symbols T+,T,Xi
Synonyms Pyridine, 3,4-diamino-;3,4-pyridinediamine;pyridine-3,4-diamine;3,4-DAP;Diamino-3,4 pyridine;1H-pyridine-3,4-diamine;5-22-11-00266 (Beilstein Handbook Reference);4,5-Diaminopyridine;3,4-Pyridinediamine (9CI);SC10;
PSA 64.93000
LogP 1.40840

Synthetic route

: 1681-37-4
4-amino-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 5250.42 Torr; for 20h; Hydrogenation;	98%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 10℃; under 760.051 Torr; for 24h;	97%
With palladium on activated charcoal; hydrogen In tetrahydrofuran; methanol at 20℃;	97%

: 33544-42-2
3-nitro-4-hydrazinopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 20 - 50℃; under 3102.9 Torr; for 2h;	94%

: 100306-70-5
4-(benzylamino)-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol at 80℃; under 3102.9 Torr; for 30h;	76%

: 504-24-5
4-aminopyridine

6-(2,6-dichlorophenyl)-2-methanesulfinyl(or sulfonyl)-8-methyl-8H-pyrido<2,3-d>pyrimidin-7-one: 6-(2,6-dichlorophenyl)-2-methanesulfinyl(or sulfonyl)-8-methyl-8H-pyrido<2,3-d>pyrimidin-7-one

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 97 percent / Et3N / acetonitrile / 1 h / 20 °C 2: 72 percent / N2O5 / nitromethane / 0.17 h / 0 °C 3: 96 percent / 2 M aq. HCl / 5 h / 70 °C 4: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 5221-42-1
4-acetylaminopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 72 percent / N2O5 / nitromethane / 0.17 h / 0 °C 2: 96 percent / 2 M aq. HCl / 5 h / 70 °C 3: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 79371-42-9
N-(3-nitropyridin-4-yl)acetamide

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / 2 M aq. HCl / 5 h / 70 °C 2: 98 percent / H2 / 5 percent Pd/C / methanol / 20 h / 20 °C / 5250.42 Torr View Scheme

: 626-64-2
pyridin-4-ol

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 90 percent / N2H4 / acetonitrile / 5 h / Heating 4: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 87 percent / CH3COONH4 / H2O / 7 h / Heating 4: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 4 steps 1: 70 percent / fuming HNO3, fuming H2SO4 / 1,2-dichloro-ethane / 7 h / 80 - 82 °C 2: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 3: 163 g / ethanol / 18 h / Heating 4: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 94602-04-7
4-ethoxy-3-nitropyridine hydrochloride

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / N2H4 / acetonitrile / 5 h / Heating 2: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 2 steps 1: 87 percent / CH3COONH4 / H2O / 7 h / Heating 2: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 2 steps 1: 163 g / ethanol / 18 h / Heating 2: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 5435-54-1
4-hydroxy-3-nitropyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 90 percent / N2H4 / acetonitrile / 5 h / Heating 3: 94 percent / H2 / Raney Ni / ethanol / 2 h / 20 - 50 °C / 3102.9 Torr View Scheme
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 87 percent / CH3COONH4 / H2O / 7 h / Heating 3: 85 percent / H2 / 5percent Pd/C / methanol / 1.5 h / 20 - 30 °C / 2585.7 Torr View Scheme
Multi-step reaction with 3 steps 1: PCl5 / 1) PCl5, 1,2-dichloroethane, reflux, 6 h , 2) reflux, 1 h 2: 163 g / ethanol / 18 h / Heating 3: 76 percent / H2 / 5percent Pd/C / ethanol / 30 h / 80 °C / 3102.9 Torr View Scheme

: 504-24-5
4-aminopyridine

: 54-96-6
3,4-diaminopyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 6.5 h / 10 - 65 °C 2: sodium sulfide / methanol; water / 0 - 65 °C View Scheme

: 54-96-6
3,4-diaminopyridine

: 131543-46-9
Glyoxal

: 254-86-4
pyrido[3,4-b]pyrazine

Conditions

Conditions	Yield
In ethanol; water at 110℃; for 1h; Inert atmosphere; Microwave irradiation;	100%
In ethanol for 12h; Reflux;	100%
In water for 12h; Reflux;	100%

: 54-96-6
3,4-diaminopyridine

: 24424-99-5
di-tert-butyl dicarbonate

: 183311-28-6
(3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In tetrahydrofuran	100%
Stage #1: 3,4-diaminopyridine; di-tert-butyl dicarbonate In dichloromethane at 20℃; Stage #2: With potassium carbonate In dichloromethane regioselective reaction;	78%
In dichloromethane at 20℃;	78%
In dichloromethane at 20℃;	75%
With sodium chloride; potassium carbonate In tetrahydrofuran; water; ethyl acetate	950 mg (53%)

: 54-96-6
3,4-diaminopyridine

: 7071-83-2
9-fluorenone-4-carbonyl chloride

: 915138-72-6
C19H11N3O

Conditions

Conditions	Yield
Stage #1: 3,4-diaminopyridine; 9-fluorenone-4-carbonyl chloride With triethylamine In dichloromethane for 4h; Stage #2: With hydrogenchloride; trifluoroacetic acid; trifluoroacetic anhydride at 109℃; for 0.333333h; Microwave irradiation;	100%

: 54-96-6
3,4-diaminopyridine

: C5H7N3*(x)H3O4P

Conditions

Conditions	Yield
With phosphoric acid In ethanol at 22 - 60.4℃; for 17.5333h; Temperature; Solvent;	99.7%

: 75-15-0
carbon disulfide

: 54-96-6
3,4-diaminopyridine

: 7239-81-8
1H-imidazo[4,5-c]pyridine-2(3H)-thione

Conditions

Conditions	Yield
In pyridine for 5h; Heating;	99%
With potassium hydroxide In water at 70℃;

: 54-96-6
3,4-diaminopyridine

: 83431-63-4
Dimethyl N-(4-chloro-2-benzothiazolyl)-dithiocarbonimidate

: 103588-29-0
(4-Chloro-benzothiazol-2-yl)-(1H-imidazo[4,5-c]pyridin-2-yl)-amine

Conditions

Conditions	Yield
In various solvent(s) Heating;	98%

: 54-96-6
3,4-diaminopyridine

: 201230-82-2
carbon monoxide

: 7397-68-4
1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one

Conditions

Conditions	Yield
With selenium In tetrahydrofuran at 100℃; under 22800.7 Torr; for 20h;	98%
With selenium 1.) THF, 31 kg/cm2, 100 degC, 20 h, 2.) 25 degC, 1 h;	96%

: 54-96-6
3,4-diaminopyridine

: 134-81-6
benzil

: 67899-59-6
2,3-diphenylpyrido<3,4-b>pyrazine

Conditions

Conditions	Yield
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 3h; Reflux;	98%
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	97%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	96%

: 54-96-6
3,4-diaminopyridine

: 4057-84-5
acetyllithocholic acid

: 3α-(O-acetyllithocholoyloxy)-23-(1H-imidazo(4,5-c)pyridin-2-yl)norcholane

Conditions

Conditions	Yield
With boric acid In xylene for 480h; Heating;	98%

: 54-96-6
3,4-diaminopyridine

: 76-05-1
trifluoroacetic acid

: 19918-36-6
2-Trifluoromethyl-3H-imidazo<4,5-c>pyridine

Conditions

Conditions	Yield
for 48h; Heating;	98%

: 54-96-6
3,4-diaminopyridine

: 3973-08-8
Thiazole-4-carboxylic acid

: 65911-26-4
4-(1H-imidazo[4,5-c]pyridin-2-yl)thiazole

Conditions

Conditions	Yield
With PPA at 180℃; for 2h;	98%

: 54-96-6
3,4-diaminopyridine

: 35251-84-4
1,4-dihydro-pyrido[3,4-b]pyrazine-2,3-dione

Conditions

Conditions	Yield
With oxalic acid In hydrogenchloride	98%

: 54-96-6
3,4-diaminopyridine

: 579-39-5
1,2-bis(4-fluorophenyl)ethane-1,2-dione

: 309970-10-3
2,3-bis(4-fluorophenyl)pyrido[3,4-b]pyrazine

Conditions

Conditions	Yield
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	98%
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 2h; Reflux;	97%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	95%
With ziconium(IV) oxychloride octahydrate In water at 100℃; for 2.5h; Green chemistry;	88%
With mesoporous silica SBA-15 functionalized with Cu(II)-DiAmSar complex In neat (no solvent) at 100℃; for 0.833333h;	78%

: 54-96-6
3,4-diaminopyridine

: 82-86-0
acenaphthene quinone

: 22724-35-2
acenaphtho[1,2-b]pyrido[3,4-e]pyrazine

Conditions

Conditions	Yield
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 2h; Reflux;	98%
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	96%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	96%
With ziconium(IV) oxychloride octahydrate In water at 100℃; for 2.5h; Green chemistry;	86%
With mesoporous silica SBA-15 functionalized with Cu(II)-DiAmSar complex In neat (no solvent) at 100℃; for 0.833333h;	80%

: 54-96-6
3,4-diaminopyridine

: 84-11-7
9,10-phenanthrenequinone

: 215-65-6
dibenzo[f,h]pyrido[3,4-b]quinoxaline

Conditions

Conditions	Yield
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 2h; Reflux;	98%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	97%
In ethanol for 6h; Reflux; Inert atmosphere;	95%
With ziconium(IV) oxychloride octahydrate In water at 100℃; for 2.5h; Green chemistry;	87%
With mesoporous silica SBA-15 functionalized with Cu(II)-DiAmSar complex In neat (no solvent) at 100℃; for 0.833333h;	80%

: 54-96-6
3,4-diaminopyridine

: 2533-69-9
methyl 2,2,2-trichloroacetimidate

: 1448536-56-8
N-(3-aminopyridin-4-yl)-2,2,2-trichloroacetamide

Conditions

Conditions	Yield
With trifluoroacetic acid at 0 - 25℃; for 48h;	98%

: 54-96-6
3,4-diaminopyridine

: 64-18-6
formic acid

: 272-97-9
Imidazo<4,5-c>pyridin

Conditions

Conditions	Yield
at 140℃; for 48h;	97%
Heating;	87%
for 12h; Reflux;	48%

: 54-96-6
3,4-diaminopyridine

: 76423-99-9
S,S-Dimethyl N-(2-benzothiazolyl)-carbonimidodithioate

: 103588-27-8
2-(2-benzothiazolylamino)-imidazo<4,5-c>pyridine

Conditions

Conditions	Yield
In various solvent(s) Heating;	97%

: 54-96-6
3,4-diaminopyridine

: 109-52-4
valeric acid

: 133239-95-9
2-n-butyl-imidazo<4,5-c>pyridine

Conditions

Conditions	Yield
With PPA at 160℃; for 3h;	97%

: 54-96-6
3,4-diaminopyridine

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 2,3-bis(p-methoxyphenyl)pyrido<3,4-b>pyrazine

Conditions

Conditions	Yield
With zirconium oxide salicylaldehyde-(3-aminopropyl)trimethoxysilane imine complex modified SBA-15 In water for 5h; Reflux;	97%
With SBA-15 mesoporous silica supported Fe(III)-Schiff base In water for 2h; Reflux;	95%
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	94%

: 54-96-6
3,4-diaminopyridine

: 84-11-7
9,10-phenanthrenequinone

: 215-66-7
dibenzo[f,h]pyrido[2,3-b]quinoxaline

Conditions

Conditions	Yield
With Cu(II)-Schiff base/SBA-15 In water for 2h; Reflux;	97%

: 54-96-6
3,4-diaminopyridine

: 65-85-0
benzoic acid

: 75007-92-0
2-phenyl-3H-imidazo[4,5-c]pyridine

Conditions

Conditions	Yield
With PPA at 190℃; for 3h;	96%
With PPA; Polyphosphoric acid (PPA) at 200℃; for 3.5h;	84%
With polyphosphoric acid at 190℃; for 5h;

: 54-96-6
3,4-diaminopyridine

: 65-85-0
benzoic acid

: 75007-92-0
2-Phenyl-1H-imidazo<4,5-c>pyridine

Conditions

Conditions	Yield
With PPA at 190℃; for 3h;	96%
With PPA at 180℃; for 3.5h;	90%
With polyphosphoric acid at 190℃; for 5h;

: 54-96-6
3,4-diaminopyridine

: 445-29-4
o-fluoro-benzoic acid

: 2-(2-fluorophenyl)-1H-imidazo[4,5-c]pyridine

Conditions

Conditions	Yield
With polyphosphoric acid at 150℃; for 18h;	96%
With PPA at 190℃; for 4h;

: 54-96-6
3,4-diaminopyridine

: 407-25-0
trifluoroacetic anhydride

: N,N'-3,4-pyridinediylbis(2,2,2-trifluoroacetamide) trifluoroacetic acid

Conditions

Conditions	Yield
In dichloromethane at 20 - 35℃; Sonication;	96%

: 54-96-6
3,4-diaminopyridine

: 100-39-0
benzyl bromide

: 1-benzyl-4-imino-1,4-dihydropyridin-3-amine hydrobromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; Large scale;	96%
In acetonitrile at 15 - 25℃; Large scale;	96%

: 54-96-6
3,4-diaminopyridine

: 619-58-9
4-iodobenzoic acid

: C12H8IN3

Conditions

Conditions	Yield
With polyphosphoric acid at 130℃; for 16h;	95.1%

: 54-96-6
3,4-diaminopyridine

: 104-88-1
4-chlorobenzaldehyde

: 1094703-76-0
(E)-N(3)-(4-chlorobenzylidene)pyridine-3,4-diamine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux; regioselective reaction;	95%

: 54-96-6
3,4-diaminopyridine

: 555-16-8
4-nitrobenzaldehdye

: 1094703-82-8
(E)-N(3)-(4-nitrobenzylidene)pyridine-3,4-diamine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux; regioselective reaction;	95%

3,4-DIAMINOPYRIDINE Chemical Properties

Molecular Structure of 3,4-DIAMINOPYRIDINE(54-96-6):

IUPAC Name:pyridine-3,4-diamine
Molecular Formula:C₅H₇N₃
Molecular Weight:109.129180 g/mol
Appearance:light brown crystalline powder
Melting Point:216-218 °C(lit.)
Density:1.251 g/cm³
Flash Point:204.9 °C
Enthalpy of Vaporization:61.61 kJ/mol
Boiling Point:369.3 °C at 760 mmHg
Vapour Pressure:1.2E-05 mmHg at 25 °C
Water Solubility:8.292e+005 mg/L at 25 °C
Merck:14,2986
BRN:110232
EINECS:200-220-9
Synonyms of 3,4-DIAMINOPYRIDINE(54-96-6):
3,4-diamino-pyridin;3,4-pyridinediamine;4,5-diaminopyridine;diamino-3,4pyridine;TIMTEC-BB SBB004341;PYRIDINE-3,4-DIAMINE;DIAMINOPYRIDINE(3,4-);ASINEX-REAG BAS 01447204
Categories of 3,4-DIAMINOPYRIDINE(54-96-6):
Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Pyridines;Boronic Acid

3,4-DIAMINOPYRIDINE Toxicity Data With Reference

1.	ipr-mus LD50:20 mg/kg	JMCMAR Journal of Medicinal Chemistry. 8 (1965),296.
2.	scu-mus LD50:35 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 150 (1964),413.
3.	ivn-mus LD50:13 mg/kg	APFRAD Annales Pharmaceutiques Francaises. 26 (1968),345.
4.	orl-bwd LD50:75 mg/kg	AECTCV Archives of Environmental Contamination and Toxicology. 12 (1983),355.

3,4-DIAMINOPYRIDINE Safety Profile

Safety Information of 3,4-DIAMINOPYRIDINE(54-96-6):
Hazard Codes:T+,T

,Xi

Risk Statements:25-26-36/37/38
Safety Statements:26-28-36/37/39-45-37/39-28A-36
RIDADR:UN 2811 6.1/PG 2
WGK Germany:3
RTECS:US7600000
F:10-23
Hazard Note:Irritant
HazardClass:6.1
PackingGroup:I
HS Code:29333999
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.

3,4-DIAMINOPYRIDINE Specification

First Aid Measures of 3,4-DIAMINOPYRIDINE(54-96-6):
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid immediately. Wash mouth out with water.
Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Storage of 3,4-DIAMINOPYRIDINE(54-96-6):
Store in a cool, dry place. Store in a tightly closed container.

Product Name

3,4-Diaminopyridine

Synthetic route

3,4-DIAMINOPYRIDINE Chemical Properties

3,4-DIAMINOPYRIDINE Toxicity Data With Reference

3,4-DIAMINOPYRIDINE Safety Profile

3,4-DIAMINOPYRIDINE Specification

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