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Cas:619-58-9
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inquiry4-Iodobenzoic acid CAS 619-58-9 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distribu
Cas:619-58-9
Min.Order:25 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiry1. Quality Our products meet MSDS safe standard and we have ISO and other certificate so yan can get high quality products from our company. 2. Price We are the company which is the joint of trade and industry so we cao provide the competiti
Cas:619-58-9
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inquiryhigh quality Appearance:Liquid Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:619-58-9
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif
Cas:619-58-9
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:619-58-9
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Type:Manufacturers
inquiryFactory price 4-Iodobenzoic acid CAS 619-58-9 in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Fluorene,Carb
Cas:619-58-9
Min.Order:1 Gram
FOB Price: $50.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:619-58-9
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:619-58-9
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:619-58-9
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inquiry99%min White to microred crystal MP.:268 Application: Organic Synthesis Appearance: White to light red crystalline powder Product name: 4-Iodobenzoic acid Molecular Weight: 248.02
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:619-58-9
Min.Order:10 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:619-58-9
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:619-58-9
Min.Order:1 Kilogram
FOB Price: $82.0 / 90.0
Type:Trading Company
inquiry4-Iodobenzoic acid CAS:619-58-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed
Cas:619-58-9
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Cas:619-58-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 4-Iodobenzoic acid Synonyms: 4-IODOBENZOIC ACID;BENZOIC ACID, 4-IODO-;RARECHEM AL BO 0467;P-IODOBENZOIC ACID;4-iodo-benzoicaci;4-Jodbenzoesaeure;Benzoic acid, p-iodo-;p-Iodobenzenecarboxylic acid CAS: 619-58-9 MF: C7H5IO2 MW:
Cas:619-58-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHigh qualityHangzhou Keying Chem Co., Ltd. Is a comprehensive enterprise, dedicated to the development, production and marketing of chemicals. As a technology innovative and service professional enterprise, Our company mainly engages in global phar
Cas:619-58-9
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao
Cas:619-58-9
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:619-58-9
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:619-58-9
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:619-58-9
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen
Cas:619-58-9
Min.Order:1 Kilogram
FOB Price: $2.0 / 6.0
Type:Trading Company
inquiry4-iodobenzoic acid
Conditions | Yield |
---|---|
With potassium iodide for 24h; | 100% |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; water at 20℃; for 14h; Inert atmosphere; | 99% |
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 60h; Irradiation; | 82% |
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 60h; UV-irradiation; | 81.5% |
Conditions | Yield |
---|---|
Stage #1: 4-amino-benzoic acid With cation-exchange resin KU-2-8; sodium nitrite In water at 20℃; for 2.33333h; Stage #2: With potassium iodide In water at 20℃; for 10h; Further stages.; | 98% |
Stage #1: 4-amino-benzoic acid With sodium nitrite In neat (no solvent) at 0℃; for 0.133333h; Green chemistry; Stage #2: With sodium iodide In neat (no solvent) at 0 - 20℃; for 0.1h; Green chemistry; | 95% |
Stage #1: 4-amino-benzoic acid With nicotinic acid sulfate; sodium nitrite In water at 20℃; for 0.333333h; Grinding; Stage #2: With sodium iodide In water at 20℃; | 85% |
4-iodo-benzyl alcohol
4-iodobenzoic acid
Conditions | Yield |
---|---|
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; Schlenk technique; | 97% |
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication; | 93% |
With oxygen at 120℃; for 10h; Green chemistry; | 92% |
With C22H36IrNP(1+)*CF3O3S(1-); potassium hydroxide In toluene at 120℃; for 18h; | 42% |
Multi-step reaction with 2 steps 1: tert.-butylnitrite; oxygen / acetonitrile / 24 h / 25 °C / 760.05 Torr / Green chemistry 2: oxygen / acetonitrile / 12 h / 80 °C / 760.05 Torr / Green chemistry View Scheme |
4-(trimethylsilyl)benzoic acid
4-iodobenzoic acid
Conditions | Yield |
---|---|
With Iodine monochloride In tetrachloromethane 1.) RT, 30 min, 2.) reflux, 1 h; | 95% |
4-iodo-N,N-bis(pyridin-2-ylmethyl)benzamide
4-iodobenzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-iodo-N,N-bis(pyridin-2-ylmethyl)benzamide With methanol; copper(II) bis(trifluoromethanesulfonate) at 20℃; for 16h; Stage #2: With barium(II) hydroxide In methanol; water at 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In methanol; water Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With iodine; aluminium In acetonitrile at 80℃; for 18h; | 93% |
With water; sodium hydroxide In methanol |
Conditions | Yield |
---|---|
With water; palladium diacetate; potassium carbonate at 20℃; under 760.051 Torr; for 7h; | 92% |
4-carboxybenzenediazonium 4-methylbenzenesulfonate
4-iodobenzoic acid
Conditions | Yield |
---|---|
With potassium iodide In water at 20℃; for 4h; | 91% |
With potassium iodide In water for 0.333333h; paste form; |
4-carboxyphenylboronic acid
4-iodobenzoic acid
Conditions | Yield |
---|---|
With iodine; potassium carbonate In acetonitrile at 80℃; for 8h; Inert atmosphere; Schlenk technique; Sealed tube; | 89% |
4-iodobenzoic acid ethyl ester
4-iodobenzoic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide In 1,4-dioxane at 100℃; for 1.5h; | 89% |
carbon monoxide
4-iodobenzenediazonium tetrafluoroborate
4-iodobenzoic acid
Conditions | Yield |
---|---|
With sodium acetate; palladium diacetate In acetonitrile under 6619.6 Torr; for 0.25h; Ambient temperature; | 86% |
carbon dioxide
2-(4-iodophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
4-iodobenzoic acid
Conditions | Yield |
---|---|
With (1,3-bis(2,6-diisopropyl-4-(morpholinomethyl)phenyl)imidazolidin-2-ylidene)copper(I) bromide; potassium tert-butylate In tetrahydrofuran under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Reflux; Green chemistry; | 86% |
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h; | 85% |
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-iodophenyl)-1,3,2-dioxaborinane With potassium tert-butylate; silver(I) acetate; triphenylphosphine In tetrahydrofuran at 70℃; under 15201 Torr; for 16h; Inert atmosphere; Autoclave; Stage #2: With hydrogenchloride In tetrahydrofuran; water Inert atmosphere; | 79% |
Stage #1: carbon dioxide; 5,5-dimethyl-2-(4-iodophenyl)-1,3,2-dioxaborinane With copper(l) iodide; 5,5-bis(4,5-dihydrooxazol-2-yl)nonane; cesium fluoride In N,N-dimethyl-formamide at 90℃; under 760.051 Torr; for 10h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide | 76% |
4-iodo-benzyl alcohol
A
4-iodobenzoic acid
B
p-(iodophenyl)carboxaldehyde
Conditions | Yield |
---|---|
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; Schlenk technique; | A 86% B 14 %Spectr. |
4-iodobenzoic acid
Conditions | Yield |
---|---|
With potassium iodide In water at 20℃; | 77% |
Conditions | Yield |
---|---|
Stage #1: C6H4I2Zn; carbon dioxide With lithium chloride In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; for 48h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide | 70% |
Conditions | Yield |
---|---|
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); potassium methanolate In N,N-dimethyl acetamide at 70℃; for 24h; Schlenk technique; Sealed tube; | 69% |
Conditions | Yield |
---|---|
Stage #1: 4-iodo-benzyl alcohol With [RuCl2(p-cymene)(iPr2-imy)]; tricyclohexylphosphine tetrafluoroborate; potassium hydroxide In toluene for 6h; Schlenk technique; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water pH=1; | A 67% B 12% |
Conditions | Yield |
---|---|
With potassium iodide at 19.9℃; under 45003600 Torr; Product distribution; under shear deformation (360 deg); other pressures, regents, angles of rotation; | 3.73% |
Conditions | Yield |
---|---|
With potassium iodide at 19.9℃; under 45003600 Torr; Product distribution; under shear deformation (360 deg); other reagents; | 2.3% |
Conditions | Yield |
---|---|
With sulfuric acid at 180℃; | |
With potassium hydroxide |
Conditions | Yield |
---|---|
With chromium(VI) oxide; acetic acid |
Conditions | Yield |
---|---|
With water at 160℃; |
1,2-bis-(4-iodo-phenyl)-1,2-diphenyl-ethane-1,2-diol
acetyl chloride
A
4-iodobenzoic acid
B
benzoic acid
Conditions | Yield |
---|---|
at 100℃; nachfolgend Verseifen mit alkoh. Kalilauge; |
p-(iodophenyl)carboxaldehyde
A
4-iodobenzoic acid
B
4-iodo-benzyl alcohol
Conditions | Yield |
---|---|
With potassium hydroxide auch unter Zusatz von Aethanol; | |
With potassium hydroxide |
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 90℃; for 3h; Rate constant; |
methyl 4-iodobenzoate
A
benzoic acid methyl ester
B
4-iodobenzoic acid
C
benzoic acid
Conditions | Yield |
---|---|
With 1-Benzyl-1,4-dihydronicotinamide; RhCl(PPh3)3 In acetonitrile at 69.9℃; for 6h; in the dark; | A 95 % Chromat. B n/a C n/a |
p-(iodophenyl)carboxaldehyde
4-iodobenzoic acid
Conditions | Yield |
---|---|
With perchloric acid; pyridinium chlorochromate In acetic acid at 29.9 - 59.9℃; Thermodynamic data; E(a), ΔH(excit.), ΔS(excit.), ΔG(excit.); | |
With acetic acid; quinolinium chlorochromate(VI) In water at 29.85℃; Kinetics; Further Variations:; Temperatures; Oxidation; | |
With oxygen In acetonitrile at 80℃; under 760.051 Torr; for 12h; Green chemistry; | 52 mg |
Conditions | Yield |
---|---|
With sodium methylate In methanol at 30℃; Kinetics; Thermodynamic data; enthalpy-entropy relationship, ΔH(excit.), ΔS(excit.); |
Conditions | Yield |
---|---|
With acetyl chloride at 60℃; for 12h; | 100% |
With sulfuric acid for 30h; Reflux; | 99% |
With sulfuric acid Reflux; | 99% |
4-iodobenzoic acid
4-iodo-benzyl alcohol
Conditions | Yield |
---|---|
With borane-THF In tetrahydrofuran at -20 - 50℃; for 14h; Reflux; | 100% |
With borane-THF In tetrahydrofuran at 20℃; for 16h; | 99% |
With borane-THF In tetrahydrofuran at 20℃; | 99% |
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide | 100% |
100% | |
With thionyl chloride In dichloromethane for 18h; Heating; | 100% |
1-hydroxy-pyrrolidine-2,5-dione
4-iodobenzoic acid
2,5-dioxopyrrolidin-1-yl 4-iodobenzoate
Conditions | Yield |
---|---|
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 2h; Heating; | 100% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Inert atmosphere; | 100% |
With dicyclohexyl-carbodiimide In 1,4-dioxane at 24.85℃; for 24h; | 99% |
Conditions | Yield |
---|---|
With potassium phosphate monohydrate; 4,4'-di-tBu-2,2'-dipyridylpalladium(II) dichloride In methanol; water at 80℃; for 2h; Suzuki-Miyaura Coupling; | 100% |
With potassium carbonate; palladium dichloride In water at 20 - 90℃; Suzuki coupling; Inert atmosphere; | 99% |
With potassium carbonate In water at 90℃; for 0.25h; Suzuki reaction; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 90℃; Inert atmosphere; | 100% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 20 - 90℃; Inert atmosphere; | 92% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 90℃; Inert atmosphere; | 92% |
4-Methoxybenzenethiol
4-iodobenzoic acid
4-[(4-methoxyphenyl)thio]benzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 4-Methoxybenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: 4-Methoxybenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: 2-Methoxybenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 2-Methoxybenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 4-trifluoromethylbenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: 4-trifluoromethylbenzenethiol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: para-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
4-iodobenzoic acid
para-thiocresol
4-[(4-methylphenyl)thio]benzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: para-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: (5-mercapto-4-phenyl-4H-[1,2,4]triazol-3-ylmethyl)-carbamic acid tert-butyl ester With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With SPPSLRAM SynPhase Lanterns(R); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane; N,N-dimethyl-formamide at 45℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With dmap; SPPSLHMP SynPhase Lanterns(R); dacarbazine In dichloromethane; N,N-dimethyl-formamide at 50℃; for 15h; Stage #2: 2-thiocresol With borohydride polymer supported Amberlite(R) IRA400; bis(bipyridine)nickel(II) bromide In tetrahydrofuran; ethanol at 70℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane | 100% |
4-iodobenzoic acid
3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid; 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole With potassium carbonate; copper(l) iodide; dimethylaminoacetic acid In dimethyl sulfoxide at 130℃; for 3.25h; Stage #2: With hydrogenchloride In water pH=~ 2; Product distribution / selectivity; | 100% |
4-iodobenzoic acid
p-(iodophenyl)carboxaldehyde
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With borane-THF at 20℃; Inert atmosphere; Cooling with ice; Stage #2: With pyridinium chlorochromate In dichloromethane at 0 - 20℃; for 3.5h; | 100% |
Stage #1: 4-iodobenzoic acid With borane-THF Stage #2: With pyridinium chlorochromate In chloroform | 92% |
Multi-step reaction with 2 steps 1: 99 percent / BH3*THF / tetrahydrofuran / 16 h / 20 °C 2: 99 percent / MnO2 / CHCl3 / 72 h / Heating View Scheme |
4-iodobenzoic acid
N,N-dimethylammonium chloride
4-iodo-N,N-dimethylbenzamide
Conditions | Yield |
---|---|
Stage #1: N,N-dimethylammonium chloride With triethylamine In dichloromethane for 0.5h; Stage #2: 4-iodobenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; | 100% |
4-iodobenzoic acid
(1R,3R,4R,7S)-1-(4,4'-Dimethoxytrityloxymethyl)-7-hydroxy-5-(4-iodobenzoyl)-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 1-[(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione In N,N-dimethyl-formamide at 20℃; for 0.5h; | 100% |
Conditions | Yield |
---|---|
With sodium hydroxide In water at 70℃; | 100% |
With sodium hydroxide In water at 80℃; for 0.5h; |
4-iodobenzoic acid
acrylic acid
4-(2-carboxyvinyl)benzoic acid
Conditions | Yield |
---|---|
With D-glucose; palladium diacetate; triethylamine In water; acetonitrile at 100℃; for 16h; Sealed tube; | 100% |
With sodium carbonate In water at 100℃; for 24h; Mizoroki-Heck reaction; | 94.9% |
With tributyl-amine; potassium carbonate In N,N-dimethyl-formamide Heck Reaction; Green chemistry; | 73% |
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With thionyl chloride; N,N-dimethyl-formamide at 75℃; for 1h; Inert atmosphere; Stage #2: potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; | 99.9% |
Stage #1: 4-iodobenzoic acid With thionyl chloride In N,N-dimethyl-formamide at 70℃; Stage #2: potassium tert-butylate In tetrahydrofuran at 20℃; | 97% |
Stage #1: 4-iodobenzoic acid With thionyl chloride In N,N-dimethyl-formamide at 75℃; for 0.75h; Schlenk technique; Inert atmosphere; Stage #2: potassium tert-butylate In dichloromethane at 0 - 20℃; Schlenk technique; Inert atmosphere; | 92% |
Stage #1: 4-iodobenzoic acid With thionyl chloride for 1h; Reflux; Stage #2: potassium tert-butylate In tetrahydrofuran at 0℃; for 2h; | 91% |
Conditions | Yield |
---|---|
With polyphosphoric acid trimethylsilyl ester at 180℃; for 4h; | 99.78% |
With trichlorophosphate at 90℃; for 12h; | 73.5% |
With trichlorophosphate at 90℃; for 12h; | 73.5% |
1-methyl-piperazine
oxalyl dichloride
4-iodobenzoic acid
1-[(4-iodophenyl)carbonyl]-4-methylpiperazine
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide | 99.2% |
1-methyl-piperazine
4-iodobenzoic acid
1-[(4-iodophenyl)carbonyl]-4-methylpiperazine
Conditions | Yield |
---|---|
Stage #1: 4-iodobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; Stage #2: 1-methyl-piperazine With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.5h; | 99.2% |
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 5h; | 99% |
With sulfuric acid for 24h; Inert atmosphere; Reflux; | 98% |
With hydrogenchloride In water for 2h; Reflux; | 96.1% |
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