3,4-Dichlorobenzyl chloride supplier

Name
1,2-Dichloro-4-(chloromethyl)benzene
EINECS 203-033-0
CAS No. 102-47-6
Article Data11
CAS DataBase
Density 1.386 g/cm³
Solubility
Melting Point -3 °C
Formula C₇H₅Cl₃
Boiling Point 241 °C at 760 mmHg
Molecular Weight 195.476
Flash Point 160.2 °C
Transport Information UN 3265 8/PG 2
Appearance Clear to yellowish liquid
Safety 26-36/37/39-45
Risk Codes 34-36/37
Molecular Structure
Hazard Symbols C
Synonyms Toluene,a,3,4-trichloro- (7CI,8CI);1,2-Dichloro-4-(chloromethyl)benzene;3,4,a-Trichlorotoluene;3,4-Dichloro-1-(chloromethyl)benzene;3,4-Dichlorophenylmethyl chloride;4-Chloromethyl-1,2-dichlorobenzene;NSC 406893;a,3,4-Trichlorotoluene;
PSA 0.00000
LogP 3.73220

Synthetic route

: 95-75-0
3,4-Dichlorotoluene

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride; dibenzoyl peroxide
With chlorine
With chlorine

: 100-44-7
benzyl chloride

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
With iodine beim Chlorieren;

: 50-00-0
formaldehyd

: 95-50-1
1,2-dichloro-benzene

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) chloride

: 107-30-2
chloromethyl methyl ether

: 95-50-1
1,2-dichloro-benzene

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
With sulfuric acid

: 1805-32-9
3,4-dichlorobenzyl alcohol

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene for 0.0833333h; Ambient temperature;
With thionyl chloride In dichloromethane at 0 - 20℃; for 3h;
With thionyl chloride at 60℃; for 2h;

: 6287-38-3
3,4-dichlorobenzaldehyde

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4 / methanol / Ambient temperature 2: SOCl2 / toluene / 0.08 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 3 h / 0 - 20 °C View Scheme

: 51-44-5
3,4-dichlorbenzoic acid

: 102-47-6
3,4-Dichlorophenylmethyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C 2: thionyl chloride / 2 h / 60 °C View Scheme

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 99613-63-5
1-(azidomethyl)-3,4-dichlorobenzene

Conditions

Conditions	Yield
With sodium azide In dimethyl sulfoxide at 20℃;	100%
With sodium azide In dimethyl sulfoxide at 20℃;	100%
With sodium azide In dimethyl sulfoxide at 20℃; Product distribution / selectivity;	100%

: 1252801-64-1
O7-demethyl glaziovianin A

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 7-((3,4-dichlorobenzyl)oxy)-3-(4,7-dimethoxybenzo[d][1,3]dioxol-5-yl)-6-methoxy-4H-chromen-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 18h; Reflux;	100%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 111-42-2
2,2'-iminobis[ethanol]

: 60876-94-0
2-[(2-Hydroxy-ethyl)-(3,4-dichloro-benzyl)-amino]-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 8h; Heating;	99%
	99%
	99%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 43115-48-6
6-methanesulphonyl-2(3H)-benzoxazolone

: 483288-06-8
3-(3,4-dichlorobenzyl)-6-methanesulphonyl-2(3H)-benzoxazolone

Conditions

Conditions	Yield
Stage #1: 6-methanesulphonyl-2(3H)-benzoxazolone With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 1h; Stage #2: 3,4-Dichlorophenylmethyl chloride In N,N-dimethyl-formamide at 70℃; for 2h;	98%

: 91-56-5
indole-2,3-dione

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	98%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 3179-31-5
3-mercapto-1,2,4-triazole

: 3-(3,4-dichloro-benzylsulfanyl)-4H-[1,2,4]triazole

Conditions

Conditions	Yield
Stage #1: 3-mercapto-1,2,4-triazole With sodium In methanol; 1,2-dimethoxyethane at 20℃; for 0.166667h; Stage #2: 3,4-Dichlorophenylmethyl chloride In methanol; 1,2-dimethoxyethane at 20℃; for 4h;	97%

: 1100795-02-5
N'-[5-chloro-2-(1-naphthylthio)phenyl]-N,N-dimethylpropan-1,3-diamine

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1100795-11-6
3-({5-chloro-2-[1-naphthylthio]phenyl}amino)-N-(3,4-dichlorobenzyl)-N,N-dimethylpropan-1-ammonium chloride

Conditions

Conditions	Yield
In acetone at 120℃; for 0.333333h; Inert atmosphere; Microwave irradiation;	97%

: 695-96-5
2-bromo-4-chlorophenol

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1-bromo-5-chloro-2-(3,4-dichlorobenzyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone at 60℃; for 24h; Inert atmosphere;	95%

: 1-(2-benzoyl-4-chlorophenyl)-3-[(2S)-2-methylpyrrolidine-2-carbonyl]urea

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: (S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With potassium hydroxide In dichloromethane at 10 - 30℃;	95%

: 100-97-0
hexamethylenetetramine

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 96433-36-2
N-(3,4-dichlorobenzyl)hexamethylenetetramine chloride

Conditions

Conditions	Yield
In ethyl acetate at 15 - 75℃; for 6h; Solvent; Temperature;	94.8%

: 487-89-8
Indole-3-carboxaldehyde

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 90815-02-4
1-(3,4-dichlorobenzyl)-1H-indole-3-carbaldehyde

Conditions

Conditions	Yield
With sodium hydride 1.) DMF, 2.) DMF, room temp., 15 h;	93%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;
With potassium carbonate In N,N-dimethyl-formamide at 80℃;
With sodium hydride In acetonitrile at 20℃; for 4h;
With potassium carbonate In N,N-dimethyl-formamide at 80℃;

: 621-59-0
isovanillin

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 3-(3,4-dichloro-benzyloxy)-4-methoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetonitrile Heating;	93%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 22841-91-4
8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione

: 8-chloro-3-((3,4-dichlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 0.25h; Microwave irradiation;	93%
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 0.25h; Microwave irradiation;	81%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 536-74-3
phenylacetylene

: C15H11Cl2N3

Conditions

Conditions	Yield
With sodium azide In water at 70℃; for 7h; Huisgen Cycloaddition; Green chemistry; regioselective reaction;	93%

: 4-bromo-2,6-naphthyridin-1-(2H)-one

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: C15H9BrCl2N2O

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;	93%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 5294-61-1
N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

: 2-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 25℃; for 10h;	93%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 93679-82-4
3-Diethylamino-2,3-dihydro-isoindol-1-one

: 2-(3,4-Dichloro-benzyl)-3-diethylamino-2,3-dihydro-isoindol-1-one

Conditions

Conditions	Yield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In water; benzene at 60℃; for 0.25h;	92%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 147-85-3
L-proline

: 511544-19-7
(S)-N-(3,4-dichlorobenzyl)proline

Conditions

Conditions	Yield
Stage #1: 3,4-Dichlorophenylmethyl chloride; L-proline With potassium hydroxide In isopropyl alcohol at 40℃; for 6h; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 0 - 5℃; pH=5 - 6;	92%
Stage #1: 3,4-Dichlorophenylmethyl chloride; L-proline With isopropyl alcohol; potassium hydroxide at 40℃; Stage #2: With hydrogenchloride	85%
With potassium hydroxide In isopropyl alcohol at 20℃; for 15h;	70%
Stage #1: L-proline With potassium hydroxide In isopropyl alcohol at 39 - 42℃; for 0.333333h; Stage #2: 3,4-Dichlorophenylmethyl chloride In isopropyl alcohol at 39 - 45℃; for 4h;

: 232599-02-9
1-benzhydryl-3-(4-chlorobenzyloxy)azetidine

: 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 232599-04-1
3-(3,4-Dichlorobenzyloxy)-1-(diphenylmethyl)azetidine

Conditions

Conditions	Yield
	92%

...Expand

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 534-13-4
N,N-dimethylthiourea

: C10H12Cl2N2S

Conditions

Conditions	Yield
In ethanol for 10h; Reflux;	92%

: 28620-12-4
6-nitro-2(3H)-benzothiazolone

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: C14H8Cl2N2O3S

Conditions

Conditions	Yield
With potassium hydroxide In water; acetone for 24h; Reflux;	92%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 161468-22-0
2-cyano-1,5,6,7-tetrahydro-4H-indol-4-one

: 1-(3,4-dichlorobenzyl)-4-oxo-4,5,6,7-tetrahydroindole-2-carbonitrile

Conditions

Conditions	Yield
With potassium iodide; potassium carbonate In N,N-dimethyl-formamide	91%

: 2581-34-2
3-methyl-4-nitrophenol

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1335101-86-4
1,2-dichloro-4-[(3-methyl-4-nitrophenoxy)methyl]benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 100℃;	91%

: 201230-82-2
carbon monoxide

: 1679-18-1
4-Chlorophenylboronic acid

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1-(4-chloro-phenyl)-2,3-bis-(3,4-dichloro-phenyl)-propan-1-one

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; sodium phosphate; sodium iodide at 100℃; for 6h;	91%

...Expand

: 109-57-9
Allylthiourea

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: C11H12Cl2N2S*ClH

Conditions

Conditions	Yield
In ethanol Reflux;	90%

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 128564-78-3
(E)-3-(pyridin-4-ylmethylene)indolin-2-one

: 1621102-59-7
(E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile at 60 - 70℃;	90%

: 3-(5-((3,4-dichlorobenzyl)sulfanyl)-1,3,4-oxadiazol-2-yl)-5-nitrophenyl acetate

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 3-(5-((3,4-dichlorobenzyl)sulfanyl)-1,3,4-oxadiazol-2-yl)-5-nitrophenol

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 1h; Reflux;	90%

: 107-83-5
2-Methylpentane

: 4993-93-5
4-nitro-1H-indole-2-carboxylic acid ethyl ester

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 220677-29-2
Ethyl N-(3,4-dichlorobenzyl)-4-nitroindole-2-carboxylate

Conditions

Conditions	Yield
With potassium iodide; potassium carbonate In N,N-dimethyl-formamide	89%
With potassium iodide; potassium carbonate In N,N-dimethyl-formamide	89%

...Expand

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 1274494-85-7
1-(3,4-dichlorobenzyl)-3,5-dimethyl-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 3,5-dimethyl-1H-pyrazole With potassium hydroxide In dimethyl sulfoxide at 80℃; for 1h; Inert atmosphere; Stage #2: 3,4-Dichlorophenylmethyl chloride In dimethyl sulfoxide at 20℃; for 2h; Inert atmosphere;	89%

: 2-(piperidine-1ylcarbonyl)-6,7-dihydropyrazole[1,5-a]pyrazin-4(5H)-one

: 102-47-6
3,4-Dichlorophenylmethyl chloride

: 5-(3,4-dichlorobenzyl)-2-(piperidin-1-ylcarbonyl)-6,7-dihydropyrazolo{1,5-a}pyrazin-4(5H)-one

Conditions

Conditions	Yield
Stage #1: 2-(piperidine-1ylcarbonyl)-6,7-dihydropyrazole[1,5-a]pyrazin-4(5H)-one With sodium hydride at 0 - 20℃; for 0.25h; Stage #2: 3,4-Dichlorophenylmethyl chloride at 0 - 20℃; for 15h;	89%

3,4-Dichlorobenzyl chloride Chemical Properties

IUPAC Name: 1,2-Dichloro-4-(chloromethyl)benzene
Following is the structure of 3,4-Dichlorobenzyl chloride (CAS NO.102-47-6):

Molecular formula: C₇H₅Cl₃
Molecular Weight: 195.47
EINECS: 203-033-0
Index of Refraction: 1.563
Molar Refractivity: 45.8 cm³
Molar Volume: 141 cm³
Density: 1.386 g/cm³
Flash Point: 160.2 °C
Melting point: -3 °C
Polarizability: 18.15 10^-24cm³
Surface Tension: 39.8 dyne/cm
Enthalpy of Vaporization: 45.86 kJ/mol
Boiling Point: 241 °C at 760 mmHg
Vapour Pressure: 0.057 mmHg at 25 °C
Appearance of 3,4-Dichlorobenzyl chloride (CAS NO.102-47-6): Clear to yellowish liquid
Canonical SMILES: C1=CC(=C(C=C1CCl)Cl)Cl
InChI: InChI=1S/C7H5Cl3/c8-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2
InChIKey: YZIFVWOCPGPNHB-UHFFFAOYSA-N

3,4-Dichlorobenzyl chloride Uses

3,4-Dichlorobenzyl chloride (CAS NO.102-47-6) is used as an intermediate in the production of a number of products, including agricultural chemicals, dyes and pigments and pharmaceuticals.

3,4-Dichlorobenzyl chloride Toxicity Data With Reference

3,4-Dichlorobenzyl chloride (CAS NO.102-47-6) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

3,4-Dichlorobenzyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34-36/37
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN: 3265 8/PG 2
WGK Germany: 3
F: 19
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29036990

3,4-Dichlorobenzyl chloride Specification

3,4-Dichlorobenzyl chloride , its cas register number 102-47-6. It also can be called 1,2-Dichloro-4-(chloromethyl)benzene ; AI3-14887 ; NSC 406893 ; and alpha,3,4-Trichlorotoluene .
3,4-Dichlorobenzyl chloride (CAS NO.102-47-6) is moisture sensitive. It should avoid the condition like incompatible materials, exposure to moist air or water. It is not compatible with water, bases, alcohols, aluminum, amines, iron, steel, Attacks some plastics, rubber and coatings. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, carbon monoxide, carbon dioxide. However, its hazardous polymerization may occur.

Product Name

1,2-Dichloro-4-(chloromethyl)benzene

Synthetic route

3,4-Dichlorobenzyl chloride Chemical Properties

3,4-Dichlorobenzyl chloride Uses

3,4-Dichlorobenzyl chloride Toxicity Data With Reference

3,4-Dichlorobenzyl chloride Safety Profile

3,4-Dichlorobenzyl chloride Specification

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