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Shanghai Biobond Pharmaceutical Co.,Ltd

This product has been produced in large scale in our factory with GMP condition 1、high quality; 2、the related compounds have been study in detail; 3、Process of the product is the mature process; Appearance:off-white solid Storage:protecte

N-(2,6-dimethylphenyl)-1-piperazineacetamide

Cas:5294-61-1

Min.Order:10 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Manufacturer/High quality/Best price/In stock

Cas:5294-61-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Cas:5294-61-1

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-(2,6-Dimethylphenyl)-1-piperazineacetamide

Cas:5294-61-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Win-Win chemical Co.Ltd

Stock products, own laboratory Product number 37367 English Name N-(2,6-Diphenylmethyl)-1-piperazine acetylamine CAS Number 5294-61-1 Purity 98%

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Cas no.5294-61-1 98%

Cas:5294-61-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 5294-61-1 -- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had establi

TIANFUCHEM-- 5294-61-1 -- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine in stock

Cas:5294-61-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best quality CAS 5294-61-1 with best price

Cas:5294-61-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine/ LIDE PHARMA- Factory supply / Best price

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1

Cas:5294-61-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine CAS:5294-61-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine CAS:5294-61-1

Cas:5294-61-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:5294-61-1

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1

Cas:5294-61-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 1-[N-(2, 6-Dimethylphenyl) Carbamoylmethyl]Piperazine

Cas:5294-61-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: N-(2,6-Diphenylmethyl)-1-Piperazine Acetylamine CAS No.:5294-61-1 Molecule Formula:C14H21N3O Molecule Weight:247.34 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

Best Quality N-(2,6-Diphenylmethyl)-1-Piperazine Acetylamine with good supplier

Cas:5294-61-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

N-(2,6-dimethylphenyl)-1-piperazineacetamide

Cas:5294-61-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1

Cas:5294-61-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Synonyms: N-(2,6-dimethylphenyl)-2-piperazin-1-yl-ethanamide;1-Piperazineacetamide, N-(2,6-dimethylphenyl)-;N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide 97%;1-[(2,6-DIMETHYLANIL

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Manufactuered in China best quality

Cas:5294-61-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1

Cas:5294-61-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke N-(2,6-Diphenylmethyl)-1-piperazine acetylamine

Cas:5294-61-1

Min.Order:1 Kilogram

FOB Price: $200.0 / 300.0

Type:Lab/Research institutions

inquiry

Synthetic route

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
In water at 80 - 110℃; for 7h;95%
piperazine
110-85-0

piperazine

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In water at 20 - 60℃; for 3h;85%
In ethanol at 80℃; for 3h; Product distribution / selectivity;77%
In methanol at 25℃; Reflux; Large scale reaction;71%
tert-butyl 4-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)piperazine-1-carboxylate
1324752-00-2

tert-butyl 4-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)piperazine-1-carboxylate

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0℃; for 3h;72%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

2,6-dimethylphenyl isonitrile
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
With 2-(hydroxymethyl)benzoic acid In methanol Ugi Condensation; Reflux;70%
piperazine hexahydrate
142-63-2

piperazine hexahydrate

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
In ethanol for 3h; Reflux;63%
piperazine
110-85-0

piperazine

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

A

2,2'-(piperazine-1,4-diyl)bis(N-(2,6-dimethylphenyl)acetamide)

2,2'-(piperazine-1,4-diyl)bis(N-(2,6-dimethylphenyl)acetamide)

B

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
In methanol at 25℃; Reflux; Large scale reaction;A 34.6%
B 21%
With hydrogenchloride In isopropyl alcohol at 80℃; for 21h; Inert atmosphere;
Stage #1: piperazine With hydrogenchloride In water at 10 - 30℃; Inert atmosphere; Large scale;
Stage #2: 2-chloro-N-(2,6-dimethylphenyl)acetamide In water at 80℃; for 2h; Solvent; Time; Concentration; Inert atmosphere; Large scale;
A n/a
B 5.12 kg
With sodium carbonate In tetrahydrofuran at 20℃; for 72h;
diisopropylamine
108-18-9

diisopropylamine

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
In ethanol
2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol
With N-ethyl-N,N-diisopropylamine In ethanol
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 4 h / 25 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 0 °C
View Scheme
2,6-dimethylaniline
87-62-7

2,6-dimethylaniline

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / dichloromethane / 1.5 h / 10 - 15 °C / Large scale reaction
2: methanol / 25 °C / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate / dichloromethane / 1.5 h / 10 - 15 °C / Large scale reaction
2: methanol / 25 °C / Reflux; Large scale reaction
View Scheme
Multi-step reaction with 2 steps
1: water / 2 h / 20 °C
2: water / 7 h / 80 - 110 °C
View Scheme
piperazine monophosphate

piperazine monophosphate

2-chloro-N-(2,6-dimethylphenyl)acetamide
1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
In water Reflux;
N-(2,6-dimethylphenyl)-4-formyl-1-piperazineacetamide
159484-66-9

N-(2,6-dimethylphenyl)-4-formyl-1-piperazineacetamide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Conditions
ConditionsYield
With sodium hydroxide In water at 80℃; for 8h; pH=10; Reagent/catalyst;
2-isothiocyanato-4,5-dimethoxybenzonitrile
43091-89-0

2-isothiocyanato-4,5-dimethoxybenzonitrile

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

3,4-Dimethoxy-6-<4-(2,6-dimethylacetanilido)piperazin-1-yl>thiocarbamido-benzonitrile
122001-69-8

3,4-Dimethoxy-6-<4-(2,6-dimethylacetanilido)piperazin-1-yl>thiocarbamido-benzonitrile

Conditions
ConditionsYield
In ethyl acetate for 20h;100%
(R)-(-)-epichlorohydrin
51594-55-9

(R)-(-)-epichlorohydrin

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

(R)-2-(4-(3-chloro-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
1427177-24-9

(R)-2-(4-(3-chloro-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
In water at 15℃; for 1h;97%
(S)-epichlorohydrin
67843-74-7

(S)-epichlorohydrin

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

(S)-2-(4-(3-chloro-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
1427177-25-0

(S)-2-(4-(3-chloro-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
In water at 15℃; for 1h;96%
1-chloromethyl-4-fluorobenzene
352-11-4

1-chloromethyl-4-fluorobenzene

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-(4-fluorobenzyl)piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-(4-fluorobenzyl)piperazin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 10h;94%
3,4-Dichlorophenylmethyl chloride
102-47-6

3,4-Dichlorophenylmethyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

2-(4-(3,4-dichlorobenzyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 10h;93%
2-fluorobenzyl chloride
345-35-7

2-fluorobenzyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-(2-fluorobenzyl)piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-(2-fluorobenzyl)piperazin-1-yl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 10h;93%
p-bromobenzyl chloride
589-17-3

p-bromobenzyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-(4-bromobenzyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

2-(4-(4-bromobenzyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 10h;92%
2-chloro-6 fluorobenzyl chloride
55117-15-2

2-chloro-6 fluorobenzyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)-N-(2,6- dimethylphenyl)acetamide

2-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)-N-(2,6- dimethylphenyl)acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 10h;91%
4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-((4-methoxyphenyl)sulfonyl)piperazin-1-yl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 8h;91%
2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-[4-(2-cyanobenzyl)piperazin-1-yl]acetamide
185407-95-8

N-(2,6-dimethylphenyl)-2-[4-(2-cyanobenzyl)piperazin-1-yl]acetamide

Conditions
ConditionsYield
With triethylamine In toluene for 3h; Heating;90%
4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

2-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 8h;90%
4-bromobenzenesulfonyl chloride
98-58-8

4-bromobenzenesulfonyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-((4-bromophenyl)sulfonyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

2-(4-((4-bromophenyl)sulfonyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 8h;90%
4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-((4-nitrophenyl)sulfonyl)piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-((4-nitrophenyl)sulfonyl)piperazin-1-yl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 8h;89%
N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

1-bromo-3-(2-methoxyphenoxy)-2-propyl alcohol

1-bromo-3-(2-methoxyphenoxy)-2-propyl alcohol

Ranolazine
95635-55-5

Ranolazine

Conditions
ConditionsYield
With potassium carbonate In ethanol; toluene for 3h; Solvent; Reagent/catalyst; Time; Temperature; Reflux;87.4%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-tosylpiperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-(4-tosylpiperazin-1-yl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 8h;87%
3-(bromomethyl)benzonitrile
28188-41-2

3-(bromomethyl)benzonitrile

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

N-(2,6-dimethylphenyl)-2-[4-(3-cyanobenzyl)piperazin-1-yl]acetamide
185407-96-9

N-(2,6-dimethylphenyl)-2-[4-(3-cyanobenzyl)piperazin-1-yl]acetamide

Conditions
ConditionsYield
With triethylamine In toluene for 3h; Heating;85%
2-(2-methoxy-phenoxymethyl)-oxirane
2210-74-4

2-(2-methoxy-phenoxymethyl)-oxirane

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Ranolazine
95635-55-5

Ranolazine

Conditions
ConditionsYield
With Sulfated tungstate at 70℃; for 2h; Green chemistry;85%
In methanol at 60℃; for 5h; Solvent;85%
In methanol; toluene at 65℃; for 9h;69.8%
benzonitrile
100-47-0

benzonitrile

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-benzylpiperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
55340-20-0

2-(4-benzylpiperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With borane-ammonia complex; C16H29Cl2CoN2P at 20℃; for 13h; Schlenk technique; Inert atmosphere; chemoselective reaction;82%
1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol
25772-81-0

1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

Ranolazine
95635-55-5

Ranolazine

Conditions
ConditionsYield
With potassium carbonate In methanol; toluene for 4.5h; Solvent; Reagent/catalyst; Temperature; Reflux;80.1%
1-(2-benzyloxyphenoxy)-2,3-propylene oxide
22530-53-6

1-(2-benzyloxyphenoxy)-2,3-propylene oxide

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

1-[3-(2-benzyloxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine
1209000-03-2

1-[3-(2-benzyloxyphenoxy)-2-hydroxypropyl]-4-[N-(2,6-dimethylphenyl)aminocarbonylmethyl]piperazine

Conditions
ConditionsYield
In methanol; toluene at 65℃; for 9h;74.7%
epichlorohydrin
106-89-8

epichlorohydrin

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
1427177-23-8

(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
With palladium on activated charcoal In water at 20℃; for 2h;72.8%
With sodium dodecyl-sulfate In water at 15℃; for 12h; Green chemistry;70%
In water at 15℃; for 1h;
1-(4-methoxy-2-(ethylene oxide-2-ylmethoxy)phenyl)ethanone
49645-95-6

1-(4-methoxy-2-(ethylene oxide-2-ylmethoxy)phenyl)ethanone

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-(4-(3-(2-acetyl-5-methoxyphenoxy)-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

2-(4-(3-(2-acetyl-5-methoxyphenoxy)-2-hydroxypropyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide

Conditions
ConditionsYield
In ethanol at 20℃;72.4%
2-chloro-6,7-dimethoxyquinazolin-4-amine
23680-84-4

2-chloro-6,7-dimethoxyquinazolin-4-amine

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

2-<4-(2,6-Dimethylacetanilide)piperazin-1-yl>-4-amino-6,7-dimethoxyquinazoline hydrochloride

2-<4-(2,6-Dimethylacetanilide)piperazin-1-yl>-4-amino-6,7-dimethoxyquinazoline hydrochloride

Conditions
ConditionsYield
In i-Amyl alcohol for 2.5h; Heating;70%
3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

CVT-2512

CVT-2512

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol at 65℃;66.2%
epichlorohydrin
106-89-8

epichlorohydrin

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

1,3-bis{4-[(2,6-dimethylphenyl)aminocarbonylmethyl]-piperazin-1-yl}propan-2-ol
1213269-66-9

1,3-bis{4-[(2,6-dimethylphenyl)aminocarbonylmethyl]-piperazin-1-yl}propan-2-ol

Conditions
ConditionsYield
In acetone for 15h; Reflux;45%

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