3,5-Dichloroaniline supplier

Name
3,5-Dichloroaniline
EINECS 210-948-9
CAS No. 626-43-7
Article Data68
CAS DataBase
Density 1.401 g/cm³
Solubility water: 0.6 g/L (26 ºC)
Melting Point 49 ºC
Formula C₆H₅Cl₂N
Boiling Point 260.6 ºC at 760 mmHg
Molecular Weight 162.018
Flash Point 118.3 ºC
Transport Information UN 3442 6.1/PG 2
Appearance white to brown crystals
Safety 28-36/37-45-60-61
Risk Codes 23/24/25-33-50/53
Molecular Structure
Hazard Symbols T,N,Xi
Synonyms Aniline,3,5-dichloro- (7CI,8CI);3,5-Dichlorobenzenamine;3,5-Dichlorophenylamine;
PSA 26.02000
LogP 3.15680

Synthetic route

: 39943-56-1
3,5-dichlorophenylhydrazine

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
aluminum nickel In methanol; water	100%

palladium on active charcoal: palladium on active charcoal

aluminium bromide (AlBr3): aluminium bromide (AlBr3)

: 634-91-3
3,4,5-trichloroaniline

: 120-82-1
1,2,4-Trichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With hydrogen	100%

...Expand

: 634-83-3
2,3,4,5-tetrachloroaniline

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With stannous chloride In aniline	100%

palladium on active charcoal: palladium on active charcoal

: 634-91-3
3,4,5-trichloroaniline

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
aluminium bromide (AlBr3) In dodecane; water	99.5%

: 634-83-3
2,3,4,5-tetrachloroaniline

: 108-95-2
phenol

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
palladium/charcoal In tantalum; hydrogen	99%

: 634-91-3
3,4,5-trichloroaniline

A: 108-42-9
3-chloro-aniline

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
	A 97.9% B n/a

: 18487-39-3
2,3,5-trichloroaniline

: 7440-05-3
palladium

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide	96.8%

: 618-62-2
3,5-dichloro-1-nitrobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With C36H56Cl3CrN2O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; chemoselective reaction;	96%
With hydrogen In methanol; ethyl acetate at 60℃; for 0.333333h; Flow reactor; Green chemistry; chemoselective reaction;	93%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,10-Phenanthroline; isopropyl alcohol; potassium hydroxide at 100℃; for 15h; Inert atmosphere; Schlenk technique;	81%

: 117-18-0
2,3,5,6-Tetrachloronitrobenzene

: 108-95-2
phenol

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
palladium/charcoal In tantalum	94%

: 108-70-3
1,3,5-trichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With ammonium sulfate; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; ammonia; sodium t-butanolate; tert-butyl XPhos In 1,4-dioxane at 100℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere;	93%
With lithium amide; ammonia at -50℃;
With ammonia

: 1-azido-3,5-dichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With D-glucose; potassium hydroxide In water at 85℃; for 0.166667h; Green chemistry; chemoselective reaction;	90%

: benzo-phenone imine

: 108-70-3
1,3,5-trichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
Stage #1: benzo-phenone imine; 1,3,5-trichlorobenzene With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis(diphenylphosphino) ferrocene at 136℃; for 3h; Heating / reflux; Stage #2: With hydrogenchloride In water; xylene at 70℃; for 0.75h;	88%

: 1228378-57-1
2-azido-N-(3,5-dichlorophenyl)-N-methyl-2-phenylacetamide

A: 83490-71-5
N‑methyl‑2‑oxo‑2‑phenylacetamide

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With phosphate potassium salt; oxygen; copper diacetate In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 9h;	A 53% B 29%

: 19752-55-7
1-bromo-3,5-dichlorobenzene

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 24h; Inert atmosphere;	48%

: 611-06-3
2,4-dichloronitrobenzene

A: 60930-56-5
3,3',5,5'-tetrachloroazoxybenzene

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With pyridine; hydrogen sulfide

: 5980-23-4
3,5-dichlorobenzamide

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With sodium hypobromide

: 85011-63-8
β-D-galactopyranosylmethyl 3,5-dichlorophenyltriazene

A: 13964-15-3
2,6-anhydro-L-glycero-L-galacto-heptitol

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With Mg(2+)-free lacZ-β-galactosidase; sodium EDTA buffer at 25℃; Rate constant;

: C14H19Cl2N3O5

A: 81972-21-6
(2S,3R,4R,5R,6R)-2-(2-Hydroxy-ethyl)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With Mg(2+)-free lacZ-β-galactosidase; sodium EDTA buffer at 25℃; Rate constant;

: 85013-24-7
n-propyl-3,5-dichlorophenyltriazene

A: 103322-03-8
Propane-1-diazonium

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With potassium chloride; tris hydrochloride In acetonitrile at 25℃; different pH-s, other reagents;

: 119421-08-8
(3,5-Dichloro-phenylsulfinamoyl)-acetic acid tert-butyl ester

A: 104311-66-2
sodium t-butoxycarbonylmethanesulphinate

B: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With potassium chloride In ethanol; water at 19.9℃; Rate constant; Mechanism; pH 9.30;

: 62584-33-2
3-(3,5-dichloro-phenyl)-ureidoacetic acid

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With Pseudomonas paucimobilis; water In various solvent(s) at 30℃; for 200h; pH=6.5; Kinetics; Further Variations:; Reagents; Hydrolysis; Microbiological reaction;

: 36734-19-7
Iprodione

A: 62584-33-2
3-(3,5-dichloro-phenyl)-ureidoacetic acid

B: 75-31-0
isopropylamine

C: 626-43-7
3,5-Dichloroaniline

D: 27387-87-7
3-(3',5'-Dichlorophenyl)imidazolidine-2,4-dione

Conditions

Conditions	Yield
With Pseudomonas fluoerescens; water In various solvent(s) at 30℃; for 200h; pH=6.5; Kinetics; Further Variations:; Reagents; Hydrolysis; Microbiological reaction;

...Expand

: 152723-53-0, 152723-54-1
3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione

A: 626-43-7
3,5-Dichloroaniline

B: N-(3,5-Dichlorophenyl)-2-hydroxy-2-methylbut-3-enanilide

C: 2-<<(3,5-dichlorophenyl)carbamoyl>oxy>-2-methyl-3-butenoic acid

Conditions

Conditions	Yield
With buffer pH 4.5 at 35℃; Product distribution;

...Expand

: 152723-53-0, 152723-54-1
3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione

A: 34893-92-0
3,4-dichlorophenyl isocyanate

B: 626-43-7
3,5-Dichloroaniline

C: 24261-46-9
3-(3,5-Dichlorophenyl)-5-methyl-5-methyl-oxazolidine-2,4-dione

Conditions

Conditions	Yield
humic acids In water for 8.33333h; Kinetics; Product distribution; Further Variations:; Solvents; Catalysts; wave length; Decomposition; UV-irradiation;

...Expand

: 152723-53-0, 152723-54-1
3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
In methanol; water for 0.166667h; Decomposition; UV-irradiation; formation of xenobiotics;

: 152723-53-0, 152723-54-1
3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione

A: 2150-88-1
methyl N-(3-chlorophenyl)carbamate

B: 51422-77-6
(3-methoxyphenyl)carbamic acid methyl ester

C: 83015-12-7
methyl N-(3,5-dimethoxyphenyl)carbamate

D: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
In methanol; water for 0.166667h; Kinetics; Product distribution; Further Variations:; Solvents; Catalysts; time; wave length; Decomposition; UV-irradiation;

...Expand

diazotized 2,6-dichloro-4-nitro-aniline: diazotized 2,6-dichloro-4-nitro-aniline

: 626-43-7
3,5-Dichloroaniline

Conditions

Conditions	Yield
With phosphoric acid; sulfuric acid; acetic acid anschliessend mit NaHPO2 und Cu2O in H2O;

: 79-04-9
chloroacetyl chloride

: 626-43-7
3,5-Dichloroaniline

: 33560-48-4
2-chloro-N-(3,5-dichlorophenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 0 - 25℃;	100%
With triethylamine In dichloromethane at 20℃; for 5h;	99%

: 4083-64-1
Tosyl isocyanate

: 626-43-7
3,5-Dichloroaniline

: 128924-49-2
C14H12Cl2N2O3S

Conditions

Conditions	Yield
In dichloromethane	100%

: 271-89-6
1-benzofurane

: 626-43-7
3,5-Dichloroaniline

: 298-12-4
Glyoxilic acid

: 1,3-dichloro-5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid

Conditions

Conditions	Yield
indium(III) triflate In acetonitrile at 50℃; for 0.191667h; Product distribution / selectivity; Microwave irradiation;	100%
montmorillonit KSF In acetonitrile at 50℃; for 0.191667h; Product distribution / selectivity; Microwave irradiation;	79%
ytterbium(III) triflate In acetonitrile at 50℃; for 0.191667h; Product distribution / selectivity; Microwave irradiation;	77%

...Expand

: 100124-06-9
4-dibenzofurylboronic acid

: 626-43-7
3,5-Dichloroaniline

: 298-12-4
Glyoxilic acid

: 745013-41-6
(dibenzofuran-4-yl)-(3,5-dichlorophenylamino)acetic acid

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

...Expand

: 7360-03-4
N,N',N''-triethylborazine

: 626-43-7
3,5-Dichloroaniline

: 93819-47-7
(BHN(3,5-Cl2-C6H3))3

Conditions

Conditions	Yield
	100%

: 598-21-0
2-Bromoacetyl bromide

: 626-43-7
3,5-Dichloroaniline

: 57339-11-4
2-bromo-N-(3,5-dichlorophenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1.25h; Inert atmosphere;	100%
In dichloromethane at 20℃; for 0.666667h;	65%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;

: 105-36-2
ethyl bromoacetate

: 626-43-7
3,5-Dichloroaniline

: 501008-39-5
ethyl 2-((3,5-dichlorophenyl)amino)acetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 80℃; for 16h;	100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 90℃; for 24h;	88%
In ethanol Reflux;
With potassium carbonate Reflux;

: 626-43-7
3,5-Dichloroaniline

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 296275-16-6
4-nitro-benzenesulfonic acid-(3,5-dichloro-anilide)

Conditions

Conditions	Yield
With pyridine at 20℃;	99%
With pyridine
With pyridine

: 933-88-0
ortho-toluoyl chloride

: 626-43-7
3,5-Dichloroaniline

: 97146-53-7
1-(3,5-dichlorophenyl)-3-(o-tolyl)urea

Conditions

Conditions	Yield
Stage #1: ortho-toluoyl chloride With pyridine; trimethylsilylazide In N,N-dimethyl-formamide at 20℃; Curtius rearrangement; Microflow reaction; Inert atmosphere; Stage #2: 3,5-Dichloroaniline With acetic acid In N,N-dimethyl-formamide at 110℃; Microflow reaction; Inert atmosphere;	99%

: 626-43-7
3,5-Dichloroaniline

: 62-53-3
aniline

Conditions

Conditions	Yield
With ammonium formate In water; isopropyl alcohol at 20℃; for 3h;	99%
With Raney aluminium-nickel alloy; water; sodium hydroxide In dimethoxymethane at 25℃; for 17h;

: 124-38-9
carbon dioxide

: 626-43-7
3,5-Dichloroaniline

: 75-56-9, 16033-71-9
methyloxirane

A: 57-55-6
propylene glycol

B: 3-(3,5-dichlorophenyl)-5-methyloxazolidin-2-one

Conditions

Conditions	Yield
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave;	A n/a B 99%

...Expand

: 858235-96-8
(4-chloro-quinazolin-2-yl)-(3-piperidino-propyl)-amine

: 626-43-7
3,5-Dichloroaniline

: 76005-31-7
N4-(3,5-Dichloro-phenyl)-N2-(3-piperidin-1-yl-propyl)-quinazoline-2,4-diamine; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In isopropyl alcohol for 3h; Heating;	98%

: 1402920-06-2
2-methylamino-4-mexylamino-6-chloro-1,3,5-triazine

: 626-43-7
3,5-Dichloroaniline

: 1402920-22-2
C18H18Cl2N6

Conditions

Conditions	Yield
In 1,4-dioxane for 72h; Reflux;	98%

: 532-55-8
Benzoyl isothiocyanate

: 626-43-7
3,5-Dichloroaniline

: 425660-07-7
N-benzoyl-N’-(3,5-dichlorophenyl)thiourea

Conditions

Conditions	Yield
In tetrahydrofuran at 60 - 65℃; for 0.166667h; Microwave irradiation;	98%
In acetone at 40 - 50℃;	92%
In acetone
In acetone

: 54-47-7
pyridoxal 5'-phosphate

: 626-43-7
3,5-Dichloroaniline

: C14H13Cl2N2O5P

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	98%

: 108-24-7
acetic anhydride

: 626-43-7
3,5-Dichloroaniline

: 342043-37-2
2-nitro-3,5-dichloroacetanilide

Conditions

Conditions	Yield
Stage #1: acetic anhydride; 3,5-Dichloroaniline With acetic acid at 12 - 40℃; Large scale; Stage #2: With nitric acid at 12℃; Large scale;	97.8%

: 911681-37-3
tert-butyl 4-(2-chloroquinazolin-4-ylamino)piperidine-1-carboxylate

: 626-43-7
3,5-Dichloroaniline

: C24H27Cl2N5O2

Conditions

Conditions	Yield
Stage #1: tert-butyl 4-(2-chloroquinazolin-4-ylamino)piperidine-1-carboxylate; 3,5-Dichloroaniline In 1,4-dioxane at 120℃; for 10h; Stage #2: With potassium carbonate In water	97%

: 108-31-6
maleic anhydride

: 626-43-7
3,5-Dichloroaniline

: 55198-61-3
(Z)-4-((3,5-dichlorophenyl)amino)-4-oxobut-2-enoic acid

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 2.5h;	97%
With acetic acid at 20℃; for 0.166667h;

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 626-43-7
3,5-Dichloroaniline

: 219499-66-8
4-(3,5-dichloroanilino)-2,6-dichloro-1,3,5-triazine

Conditions

Conditions	Yield
With sodium hydroxide In acetone at -20 - 0℃; for 2h;	96%

3,5-Dichloroaniline Specification

The 3,5-Dichloroaniline, with the CAS registry number 626-43-7, is also known as Benzenamine, 3,5-dichloro-. It belongs to the product categories of Anilines, Aromatic Amines and Nitro Compounds; Amines; C2 to C6; Nitrogen Compounds; Alpha Sort; Aromatics Pesticides & Metabolites; Chemical Class; D; DAlphabetic; DIA - DIC. Its EINECS registry number is 210-948-9. This chemical's molecular formula is C₆H₅Cl₂N and molecular weight is 162.02. What's more, its IUPAC name is the same with its product name.

Physical properties about 3,5-Dichloroaniline are: (1)ACD/LogP: 2.70; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.7; (4)ACD/LogD (pH 7.4): 2.7; (5)ACD/BCF (pH 5.5): 66.78; (6)ACD/BCF (pH 7.4): 66.85; (7)ACD/KOC (pH 5.5): 704.04; (8)ACD/KOC (pH 7.4): 704.71; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.613; (14)Molar Refractivity: 40.27 cm³; (15)Molar Volume: 115.6 cm³; (16)Surface Tension: 48.3 dyne/cm; (17)Density: 1.401 g/cm³; (18)Flash Point: 118.3 °C; (19)Enthalpy of Vaporization: 49.83 kJ/mol; (20)Boiling Point: 260.6 °C at 760 mmHg; (21)Vapour Pressure: 0.0121 mmHg at 25 °C.

Preparation of 3,5-Dichloroaniline: this chemical can be prepared by 1,3,5-Trichlorobenzene.

3,5-Dichloroaniline can be prepared by 1,3,5-Trichlorobenzene.

Uses of 3,5-Dichloroaniline: (1) this chemical is used as intermediate of pesticide and pharmaceutical. It is also used as a raw material for agricultural pesticides. It can also be used for synthetic herbicides, plant growth regulator; (2) it is used to produce other chemicals. For example, it can react with Isothiocyanatobenzene to get N-(3,5-Dichloro-phenyl)-N'-phenyl-thiourea. The reaction occurs with solvent ethanol and other condition of heating for 2 hours. The yield is 75 %.

3,5-Dichloroaniline can react with Isothiocyanatobenzene to get N-(3,5-Dichloro-phenyl)-N'-phenyl-thiourea.

When you are dealing with this chemical, you should be very careful. This chemical may present an immediate or delayed danger to one or more components of the environment. It is toxic by inhalation, in contact with skin and if swallowed. It is very toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment. So you should wear suitable protective clothing and gloves. This material and its container must be disposed of as hazardous waste and you should avoid releasing to the environment. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1cc(N)cc(Cl)c1
(2) InChI: InChI=1S/C6H5Cl2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
(3) InChIKey: UQRLKWGPEVNVHT-UHFFFAOYSA-N

Product Name

3,5-Dichloroaniline

Synthetic route

3,5-Dichloroaniline Specification

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