3,5-Dimethoxyaniline supplier

Name
3,5-Dimethoxyaniline
EINECS 233-616-5
CAS No. 10272-07-8
Article Data36
CAS DataBase
Density 1.096 g/cm³
Solubility insoluble in water
Melting Point 54-57 ºC
Formula C₈H₁₁NO₂
Boiling Point 178 ºC (20 mmHg)
Molecular Weight 153.181
Flash Point 135 ºC
Transport Information UN 2811
Appearance White crystal or Colorless liquid
Safety 26-36-36/37/39-22
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 3,5-Dimethoxy-phenylamine;3,5-Dimethoxybenzeneamine;Benzenamine, 3,5-dimethoxy-;3，5-dimethoxy aniline;5-Aminoresorcinol dimethylether;
PSA 44.48000
LogP 1.86720

Synthetic route

: 85862-68-6
1-azido-3,5-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With sodium tetrahydroborate; palladium In water for 1.5h; Inert atmosphere;	99%
With sodium sulfide; water for 0.5h; Reflux;	96%
With ammonium hydroxide at 90℃; for 0.5h;	90%
With triethylamine; tris[tert-butyl]phosphonium tetrafluoroborate In tetrahydrofuran; water at 20℃; for 15h; Staudinger Azide Reduction;	94 %Spectr.

: 85657-94-9
N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With water; potassium carbonate In methanol for 20h; Ambient temperature;	94%

: 106018-88-6
2-Trimethylsilanyl-ethanesulfonic acid (3,5-dimethoxy-phenyl)-amide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h;	93%

: 7051-16-3
1-chloro-3,5-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	93%
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In water; dimethyl sulfoxide at 110℃; for 24h; Inert atmosphere;	88%
With ammonium hydroxide; potassium phosphate; copper(l) iodide; N1,N2-bis(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Schlenk technique;	88%

: 79257-61-7
N-(3,5-dimethoxy-phenyl)-acetamide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Stage #1: N-(3,5-dimethoxy-phenyl)-acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere; chemoselective reaction;	86%
With alkaline solution

: 192182-54-0
3,5-dimethoxyphenylboronic acid

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	82%

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,5-dimethoxybenzene With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -78℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;	78%
With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Sealed tube;	68%
With ammonia; sodium; ferric nitrate

: 25245-27-6
1-iodo-3,5-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With ammonium hydroxide; copper(l) iodide; N,N'-bis(3,5-dimethoxyphenyl)cyclopentane-1,1-dicarboxamide; caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Inert atmosphere; Sealed tube;	75%

: 500-99-2
3,5-dimethoxyphenol

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Stage #1: 3,5-dimethoxyphenol With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4; Reagent/catalyst; Solvent;	75%

: 1132-21-4
3,5-dimethoxybenzoic acid

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran; toluene at 20℃; for 2h;	43%
Stage #1: 3,5-dimethoxybenzoic acid With diphenylphosphoranyl azide; triethylamine In toluene at 80℃; Stage #2: With sodium hydroxide In tetrahydrofuran for 2h;	43%

: 710311-79-8
N-hydroxy-3,5-dimethoxybenzamide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Stage #1: N-hydroxy-3,5-dimethoxybenzamide With acetic anhydride; potassium carbonate In dimethyl sulfoxide at 50℃; for 2h; Lossen Rearrangement; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 0℃;	3%
Stage #1: N-hydroxy-3,5-dimethoxybenzamide With potassium carbonate In dimethyl sulfoxide at 90℃; for 3h; Lossen Rearrangement; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; for 0.0833333h;

: 17715-69-4
1-Bromo-2,4-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With ammonia; sodium amide in fluessiges NH3;

: 16147-07-2
1,3-dimethoxy-5-nitrobenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With hydrogenchloride; tin
With hydrogenchloride; tin; tin(ll) chloride at 40℃; Reagens 5: Essigsaeure;
With ethanol; nickel Hydrogenation;
With hydrogen; palladium on activated charcoal In ethyl acetate

: 17213-58-0
3,5-dimethoxybenzamide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With sodium hypobromide at -15℃;
Yield given;
With sodium hypochlorite; sodium hydroxide at 80℃; for 5h;	4.1 g

: 17275-82-0
ethyl 3,5-dimethoxybenzoate

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 78 percent / hydrazine hydrate / 2 h / Heating 2: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C 3: 93 percent / toluene / 2.5 h / Heating 4: 8.7 g / sodium hydroxide (20percent) / 60 °C View Scheme

: 99-10-5
3,5-Dihydroxybenzoic acid

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 84 percent / sodium hydroxide / heating View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 55 °C 2.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C 2.2: 2 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / acetone / 55 °C 2.1: triethylamine; diphenylphosphoranyl azide / toluene / 80 °C 2.2: 2 h View Scheme

: 75996-26-8
azido(3,5-dimethoxyphenyl)methanone

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 93 percent / toluene / 2.5 h / Heating 2: 8.7 g / sodium hydroxide (20percent) / 60 °C View Scheme
Multi-step reaction with 2 steps 1: CH2Cl2 / 60 h / Heating 2: 94 percent / H2O, K2CO3 / methanol / 20 h / Ambient temperature View Scheme

: 51707-38-1
3,5-dimethoxy-benzoic acid hydrazide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 63 percent / sodium nitrite, hydrochloric acid (2M), acetic acid (glacial) / H2O / 1 h / -10 °C 2: 93 percent / toluene / 2.5 h / Heating 3: 8.7 g / sodium hydroxide (20percent) / 60 °C View Scheme

: 17213-57-9
3,5-dimethoxybenzoyl chloride

: 10272-07-8
3,5-Dimethoxyaniline

: 54132-76-2
3,5-dimethoxyphenyl isocyanate

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 8.7 g / sodium hydroxide (20percent) / 60 °C View Scheme
With benzoic acid; sodium hydroxide In tetrahydrofuran at 20℃; for 0.5h; Curtius Rearrangement;

: 20734-67-2
3,5-dihydroxyphenylamine

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous dioxane 2: aqueous NaOH 3: aq.-ethanolic alkaline solution View Scheme

: 73164-69-9
N-(3,5-dihydroxyphenyl)acetamide

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous NaOH 2: aq.-ethanolic alkaline solution View Scheme

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: liquid ammonia 2: aqueous sodium hypobromite / -15 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C 2: triethylamine; diphenyl phosphoryl azide / 80 °C 3: sodium hydroxide; benzoic acid / tetrahydrofuran / 0.5 h / 20 °C View Scheme

: 500-99-2
3,5-dimethoxyphenol

ammonium chloride (NH4Cl): ammonium chloride (NH4Cl)

: 5150-42-5
2,3-dimethoxyphenol

: 1972-28-7
diethylazodicarboxylate

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran

...Expand

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / acetonitrile / 20 °C 2: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C 3: triethylamine; diphenyl phosphoryl azide / 80 °C 4: sodium hydroxide; benzoic acid / tetrahydrofuran / 0.5 h / 20 °C View Scheme

: 7051-16-3
1-chloro-3,5-dimethoxybenzene

A: 1445972-42-8
bis(3,5-dimethoxyphenyl)amine

B: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 50℃; for 24h; Inert atmosphere; Overall yield = 81 %;

: C15H23NO3

A: 628-62-6
heptanamide

B: 10272-07-8
3,5-Dimethoxyaniline

Conditions

Conditions	Yield
With phosphoric acid; ammonia In ethylene glycol at 145℃; for 5h;	A 95 %Spectr. B 84 %Spectr.

: 24424-99-5
di-tert-butyl dicarbonate

: 10272-07-8
3,5-Dimethoxyaniline

: 384793-29-7
(3,5-dimethoxyphenyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; Inert atmosphere;	100%
Stage #1: 3.5-dimethoxyaniline With triethylamine In dichloromethane at 20℃; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃;	99%
at 90℃; for 3h;	98%

: 79-22-1
methyl chloroformate

: 10272-07-8
3,5-Dimethoxyaniline

: 83015-12-7
methyl N-(3,5-dimethoxyphenyl)carbamate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	100%
With pyridine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	94%
In toluene for 2h; Acylation; Heating;	81%

: 190728-25-7
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

: 32315-10-9
bis(trichloromethyl) carbonate

: 144-55-8
sodium hydrogencarbonate

: 10272-07-8
3,5-Dimethoxyaniline

: N-(3,5-Dimethoxyphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

Conditions

Conditions	Yield
With triethylamine In toluene	100%

...Expand

: 10272-07-8
3,5-Dimethoxyaniline

: 920-46-7
Methacryloyl chloride

: 134354-28-2
N-(3,5-dimethoxyphenyl)-2-methylacrylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%
In dichloromethane at 0 - 20℃;
In dichloromethane at 0 - 20℃;
In dichloromethane at 0 - 20℃;
With dmap; triethylamine In dichloromethane at 0 - 20℃;

: 598-21-0
2-Bromoacetyl bromide

: 10272-07-8
3,5-Dimethoxyaniline

: 2-bromo-N-(3,5-dimethoxyphenyl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1.25h; Inert atmosphere;	100%
at -77℃;

: 4-(prop-2-yn-1-ylcarbamoyl)benzoic acid

: 10272-07-8
3,5-Dimethoxyaniline

: 4-(3,5-dimethoxyphenylaminocarbonyl)-N-(prop-2-yn-1-yl)benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃; Inert atmosphere;	99.9%

: 58518-08-4
1,1,1-trifluoro-4-phenylbut-3-yn-2-one

: 10272-07-8
3,5-Dimethoxyaniline

: 129633-19-8
(Z)-4-(3,5-Dimethoxy-phenylamino)-1,1,1-trifluoro-4-phenyl-but-3-en-2-one

Conditions

Conditions	Yield
In methanol Ambient temperature;	99%

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 10272-07-8
3,5-Dimethoxyaniline

: 161139-70-4
2-[(3,5-dimethoxyphenyl)amino]-1-(4-fluorophenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In neat (no solvent) at 20℃; for 2h;	99%
With sodium hydrogencarbonate In ethanol for 4h; Heating;

: 81051-55-0, 53256-20-5
(Z)-ethyl 3-(methylamino)-3-phenylacrylate

: 10272-07-8
3,5-Dimethoxyaniline

: (Z)-3-(3,5-Dimethoxy-phenylamino)-3-phenyl-acrylic acid ethyl ester

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane for 30h; Heating;	99%

: 84761-77-3
2-formylphenyl triflate

: 10272-07-8
3,5-Dimethoxyaniline

: 111043-16-4
1,3-dimethoxyacridine

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; XPhos In toluene at 105℃; for 13h; Mechanism; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere;	99%

: 67-64-1
acetone

: 10272-07-8
3,5-Dimethoxyaniline

: 108103-33-9
N-isopropyl-3,5-dimethoxyaniline

Conditions

Conditions	Yield
With acetic acid; zinc at 20 - 60℃; for 2.5h;	99%

: 174265-12-4
2-bromo-5-chlorobenzaldehyde

: 10272-07-8
3,5-Dimethoxyaniline

: 7-chloro-1,3-dimethoxyacridine

Conditions

Conditions	Yield
Stage #1: 3.5-dimethoxyaniline With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In toluene at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-bromo-5-chlorobenzaldehyde In toluene at 80℃; for 12h; Inert atmosphere;	99%

: 84459-32-5
2-bromo-5-nitrobenzaldehyde

: 10272-07-8
3,5-Dimethoxyaniline

: 1,3-dimethoxy-7-nitroacridine

Conditions

Conditions	Yield
Stage #1: 3.5-dimethoxyaniline With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In toluene at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-bromo-5-nitrobenzaldehyde In toluene at 80℃; for 12h; Inert atmosphere;	99%

: 360575-28-6
2-bromo-6-fluorobenzaldehyde

: 10272-07-8
3,5-Dimethoxyaniline

: 8-fluoro-1,3-dimethoxyacridine

Conditions

Conditions	Yield
Stage #1: 3.5-dimethoxyaniline With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In toluene at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 2-bromo-6-fluorobenzaldehyde In toluene at 80℃; for 12h; Inert atmosphere;	99%

: 6630-33-7
ortho-bromobenzaldehyde

: 10272-07-8
3,5-Dimethoxyaniline

: 111043-16-4
1,3-dimethoxyacridine

Conditions

Conditions	Yield
Stage #1: 3.5-dimethoxyaniline With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In toluene at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: ortho-bromobenzaldehyde In toluene at 80℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere;	99%
Stage #1: 3.5-dimethoxyaniline With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate In toluene at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: ortho-bromobenzaldehyde In toluene at 80℃; for 12h; Reagent/catalyst;	99%

: 20469-65-2
1-bromo-3,5-dimethoxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

: tris(3,5-dimethoxyphenyl)amine

Conditions

Conditions	Yield
With chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium (II); sodium t-butanolate In tetrahydrofuran at 70℃; for 24h; Inert atmosphere; Schlenk technique;	99%
With chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium (II); sodium t-butanolate In tetrahydrofuran at 60℃; for 19h; Inert atmosphere;	81%
With chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium (II); sodium t-butanolate In tetrahydrofuran at 60℃; Inert atmosphere;	75%

: 40891-33-6
3,5-dimethoxyaniline hydrochloride

: 119-52-8
4,4'-dimethoxybenzoin

: 10272-07-8
3,5-Dimethoxyaniline

: 4,6-dimethoxy-2,3-di(4-methoxyphenyl)indole

Conditions

Conditions	Yield
at 130 - 140℃; for 1h;	99%

...Expand

: 869294-86-0
ethyl 6-iodo-4-oxo-3,4-dihydroquinazoline-2-carboxylate

: 10272-07-8
3,5-Dimethoxyaniline

: N-(3,5-dimethoxyphenyl)-4-oxo-6-iodo-3,4-dihydroquinazoline-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 3.5-dimethoxyaniline With trimethylaluminum In n-heptane; 1,2-dichloro-ethane at 0 - 20℃; for 0.5h; Stage #2: ethyl 6-iodo-4-oxo-3,4-dihydroquinazoline-2-carboxylate In n-heptane; 1,2-dichloro-ethane for 2h; Reflux;	99%

: 7-nitro-4-chloro-1H-indole-2-carboxylic acid ethyl ester

: 10272-07-8
3,5-Dimethoxyaniline

: 4-((3,5-dimethoxyphenyl)amino)-7-nitro-1H-indole-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In water; toluene for 4h; Reflux; Inert atmosphere;	99%

: 943606-84-6
1-chloro-6-methyl-5-nitroisoquinoline

: 10272-07-8
3,5-Dimethoxyaniline

: C18H17N3O4

Conditions

Conditions	Yield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;	98.4%

: 108-24-7
acetic anhydride

: 10272-07-8
3,5-Dimethoxyaniline

: 79257-61-7
N-(3,5-dimethoxy-phenyl)-acetamide

Conditions

Conditions	Yield
With pyridine at 0 - 20℃;	98%
In toluene at 20℃; for 15h; Time; Inert atmosphere;	98%
In toluene at 25℃; for 20h;	97%

: 485-47-2
indan-1,2,3-trione hydrate

: 10272-07-8
3,5-Dimethoxyaniline

: 5,5a,10,10a-Tetrahydro-5a,10a-dihydroxy-4-(2-hydroxy-1,3-dioxoindanyl)-1,3-dimethoxyindeno<1,2-b>indol-10-one

Conditions

Conditions	Yield
In acetic acid for 16h; Ambient temperature;	98%

: 107-18-6
allyl alcohol

: 10272-07-8
3,5-Dimethoxyaniline

: N-allyl-3,5-dimethoxyaniline

Conditions

Conditions	Yield
With titanium(IV) isopropylate; MS 4 Angstroem; palladium diacetate; triphenylphosphine In benzene at 80℃; for 3h; Alkylation; N-allylation;	98%

: 106-38-7
para-bromotoluene

: 10272-07-8
3,5-Dimethoxyaniline

: 255835-89-3
N-(4-tolyl)-3,5-dimethoxyaniline

Conditions

Conditions	Yield
With C60H86O4P2Pd2(2+)*2BF4(1-); sodium t-butanolate In 1,4-dioxane at 80℃; for 1h;	98%
With sodium t-butanolate; 1,1'-bis(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)palladium In toluene at 90℃; for 5h;

: 10272-07-8
3,5-Dimethoxyaniline

: 407-25-0
trifluoroacetic anhydride

: 85657-94-9
N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h;	98%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;	98%
With triethylamine In toluene at 15 - 20℃; for 1.5h; Temperature; Solvent;	85.4%
With triethylamine In toluene at 18 - 25℃; for 2h;
With triethylamine In dichloromethane at 20℃; for 2.5h; Cooling with ice;

: 383-63-1
ethyl trifluoroacetate,

: 10272-07-8
3,5-Dimethoxyaniline

: 85657-94-9
N-(3,5-dimethoxyphenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With dmap In tetrahydrofuran for 48h; Heating / reflux;	98%
With dmap In tetrahydrofuran for 48h; Reflux;	98%

3,5-Dimethoxyaniline Chemical Properties

Formula：C₈H₁₁NO₂
Molecular Weight：153.18
Appearance：Beige crystals
Solubility in water：Soluble
Melting Point：66 – 68
Boiling Point：303
3,5-Dimethoxyaniline`s Synonyms：BENZENAMINE, 3,5-DIMETHOXY-;3,5-DIMETHOXYANILINE;3,5-DIMETHOXYPHENYLAMINE;5-AMINORESORCINOL DIMETHYL ESTER;5-AMINORESORCINOL DIMETHYL ETHER;AKOS 91392;3,5-dimethoxy-benzenamin;3,5-dimethoxy-Benzenamine
Molecular Structure:

3,5-Dimethoxyaniline Toxicity Data With Reference

3,5-Dimethoxyaniline may cause gastrointestinal irritation with nausea, vomiting and diarrhea. respiratory tract irritation and skin or eyes irritation. The toxicological properties of this substance have not been fully investigated

3,5-Dimethoxyaniline Consensus Reports

Stability:Stable under normal temperatures and pressures
First Aid Measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical ai
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling：Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

3,5-Dimethoxyaniline Safety Profile

Hazard Codes: Xn, Xi
Risk Statements: 22-36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-22
WGK Germany: 3
Hazard Note: Irritant
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.

3,5-Dimethoxyaniline Specification

Flash Point: 142
Fire Fighting: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.
Personal Protection: Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Product Name

3,5-Dimethoxyaniline

Synthetic route

3,5-Dimethoxyaniline Chemical Properties

3,5-Dimethoxyaniline Toxicity Data With Reference

3,5-Dimethoxyaniline Consensus Reports

3,5-Dimethoxyaniline Safety Profile

3,5-Dimethoxyaniline Specification

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