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inquiry1-chloro-6-Methyl-5-nitroisoquinoline CAS:943606-84-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryBoiling point 377.6±37.0 °C(Predicted) density 1.419±0.06 g/cm3(Predicted) pka 0.67±0.50(Predicted) Superiority We can c
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry1-chloro-6-Methyl-5-nitroisoquinoline Application:1-chloro-6-Methyl-5-nitroisoquinoline
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri
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inquiryWuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process
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inquiry1-chloro-6-Methyl-5-nitroisoquinolineAppearance:as detail Storage:Room temperature Package:as required Application:943606-84-6 Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology
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Type:Manufacturers
inquiryHenan Sunlake Enterprise Corporation Our Advantages 1, Any inquiry about ch
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Min.Order:1 Kilogram
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Type:Trading Company
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Cas:943606-84-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry6-methyl-5-nitroisoquinoline 2-oxide
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
With trichlorophosphate In chloroform at 70℃; for 3h; | 96% |
With trichlorophosphate In 1,2-dichloro-ethane at 70℃; for 3h; | 86% |
With trichlorophosphate In 1,2-dichloro-ethane Reflux; | 55% |
With trichlorophosphate In 1,2-dichloro-ethane Reflux; | 55% |
With trichlorophosphate In 1,2-dichloro-ethane at 70℃; | 0.88 g |
6-methyl-5-nitroisoquinoline
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
With trichlorophosphate In 1,2-dichloro-ethane Reflux; | 55% |
With trichlorophosphate In 1,2-dichloro-ethane for 7h; Reflux; | 55% |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme |
6-methylisoquinoline N-oxide
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
With potassium nitrate; trichlorophosphate In chloroform; sulfuric acid |
6-methylisoquinoline
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium nitrate; sulfuric acid / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 3 h / 0 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme |
4-methyl-benzaldehyde
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: chloroform / 90 °C 2.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C 2.2: 0 °C / Reflux 3.1: sulfuric acid; potassium nitrate / 0 °C 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 5.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 0 - 20 °C / Reflux 2.1: potassium nitrate; sulfuric acid / 0 °C 3.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 12 h / 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 3 h / 0 °C 3.1: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: chloroform / 90 °C 1.2: 24 h / 0 - 20 °C 1.3: 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: chloroform / 22 - 65 °C 1.2: 23 h / -3 - 20 °C 1.3: 10.5 h / 52 °C 2.1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C View Scheme |
(2,2-Dimethoxy-ethyl)-[1-p-tolyl-meth-(Z)-ylidene]-amine
1-chloro-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C 1.2: 0 °C / Reflux 2.1: sulfuric acid; potassium nitrate / 0 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux View Scheme |
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere; | 99.4% |
1-chloro-6-methyl-5-nitroisoquinoline
3-(methylsulfonamido)aniline
N-(3-((6-methyl-5-nitroisoquinolin-1-yl)amino)phenyl)methanesulfonamide
Conditions | Yield |
---|---|
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube; | 99% |
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube; | 99% |
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere; | 98.4% |
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere; | 95.4% |
1-chloro-6-methyl-5-nitroisoquinoline
4-chloro-aniline
N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine
Conditions | Yield |
---|---|
In isopropyl alcohol at 90℃; Sealed tube; | 95% |
In isopropyl alcohol at 90℃; Sealed tube; | 95% |
1-chloro-6-methyl-5-nitroisoquinoline
3-trifluoromethylaniline
6-methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinoline-1-amine
Conditions | Yield |
---|---|
In isopropyl alcohol at 90℃; for 12h; | 94% |
In isopropyl alcohol at 90℃; Sealed tube; | 94% |
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation; | 79% |
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation; | 79% |
In isopropyl alcohol at 180℃; for 0.416667h; microwave; | 79% |
1-chloro-6-methyl-5-nitroisoquinoline
4-chloro-3-trifluoromethyl-aniline
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere; | 93.3% |
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere; | 91.9% |
1-chloro-6-methyl-5-nitroisoquinoline
5-amino-1-chloro-6-methylisoquinoline
Conditions | Yield |
---|---|
With hydrogen In tetrahydrofuran at 20℃; under 2250.23 Torr; for 18h; chemoselective reaction; | 90.1% |
With hydrogenchloride; iron In ethanol; water for 5h; Reflux; | 83% |
With tin(ll) chloride In ethanol; dichloromethane at 70℃; for 16h; | 40% |
1-chloro-6-methyl-5-nitroisoquinoline
4-Aminobenzonitrile
4-(6-methyl-5-nitroisoquinolin-1-ylamino)benzonitrile
Conditions | Yield |
---|---|
Stage #1: 1-chloro-6-methyl-5-nitroisoquinoline; 4-Aminobenzonitrile In isopropyl alcohol at 22℃; Stage #2: With trifluoroacetic acid In isopropyl alcohol at 80℃; for 17h; | 88% |
1-chloro-6-methyl-5-nitroisoquinoline
6-methyl-5-nitroisoquinolin-1(2H)-one
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran Heating / reflux; | 87% |
With hydrogenchloride; water In tetrahydrofuran for 14h; Reflux; | 87% |
With hydrogenchloride In tetrahydrofuran; water for 14h; Heating / reflux; | 87% |
1-chloro-6-methyl-5-nitroisoquinoline
4-chloro-aniline
N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine hydrochloride
Conditions | Yield |
---|---|
In isopropyl alcohol at 170℃; for 0.266667h; Microwave irradiation; | 84% |
1-chloro-6-methyl-5-nitroisoquinoline
1-methoxy-6-methyl-5-nitroisoquinoline
Conditions | Yield |
---|---|
With sodium methylate In methanol | 74% |
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere; | 73.7% |
1-chloro-6-methyl-5-nitroisoquinoline
tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate
tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube; | 54% |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube; | 54% |
1-chloro-6-methyl-5-nitroisoquinoline
N-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methyl-5-nitroisoquinolin-1-amine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; | 53% |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube; | 53% |
1-chloro-6-methyl-5-nitroisoquinoline
2-amino-4-(trifluoromethyl)pyridine
6-methyl-5-nitro-N-(4-(trifluoromethyl)pyridin-2-yl)isoquinolin-1-amine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; Sealed tube; | 42% |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; | 42% |
1-chloro-6-methyl-5-nitroisoquinoline
5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); lithium hexamethyldisilazane; DavePhos In 1,4-dioxane at 150℃; for 0.5h; Microwave irradiation; Sealed tube; | 32.8% |
1-chloro-6-methyl-5-nitroisoquinoline
(R)-1-(4-chlorophenyl)ethylamine
(R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine
Conditions | Yield |
---|---|
With trifluoroacetic acid In isopropyl alcohol at 140℃; for 1h; microwave; |
1-chloro-6-methyl-5-nitroisoquinoline
A
5-amino-1-chloro-6-methylisoquinoline
B
5-amino-6-methylisoquinoline
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran at 37℃; under 2250.23 - 3000.3 Torr; for 15h; | A 84.4 %Chromat. B 15.6 %Chromat. |
1-chloro-6-methyl-5-nitroisoquinoline
N1-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methylisoquinoline-1,5-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C 2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux View Scheme |
1-chloro-6-methyl-5-nitroisoquinoline
4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C 2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux 3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide View Scheme |
1-chloro-6-methyl-5-nitroisoquinoline
N-(3-((5-amino-6-methylisoquinolin-1-yl)amino)phenyl)methanesulfonamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux View Scheme |
1-chloro-6-methyl-5-nitroisoquinoline
4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux 3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux 3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h View Scheme |
1-chloro-6-methyl-5-nitroisoquinoline
tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube 2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux View Scheme |
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