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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1-chloro-6-Methyl-5-nitroisoquinoline CAS943606-84-6

Cas:943606-84-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

1-chloro-6-Methyl-5-nitroisoquinoline CAS:943606-84-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

1-chloro-6-Methyl-5-nitroisoquinoline CAS:943606-84-6

Cas:943606-84-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Chloro-6-methyl-5-nitro-isoquinoline

Cas:943606-84-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Boiling point 377.6±37.0 °C(Predicted) density 1.419±0.06 g/cm3(Predicted) pka 0.67±0.50(Predicted) Superiority We can c

1-Chloro-6-methyl-5-nitro-isoquinoline

Cas:943606-84-6

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Chloro-6-methyl-5-nitro-isoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1-Chloro-6-methyl-5-nitro-isoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-Chloro-6-methyl-5-nitro-isoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1-chloro-6-Methyl-5-nitroisoquinoline Application:1-chloro-6-Methyl-5-nitroisoquinoline

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

943606-84-6

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Newgreat Chemical Co., Ltd

Wuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

1-chloro-6-Methyl-5-nitroisoquinolineAppearance:as detail Storage:Room temperature Package:as required Application:943606-84-6 Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-chloro-6-methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Other

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Isoquinoline, 1-chloro-6-methyl-5-nitro-

Cas:943606-84-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Kaixiang Photoelectric Technology Co., Ltd

Superiority 1.Powerful & d team 2.Capacity for mass production,from grams to tons; 3.Various kinds of advanced equipment in the laboratory and factory; 4.Strict QC standard to meet the demand of customers,advanced equipment for analysi

1-chloro-6-methyl-5-nitroisoquinoline CAS NO.943606-84-6

Cas:943606-84-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

Henan Sunlake Enterprise Corporation Our Advantages 1, Any inquiry about ch

1-chloro-6-Methyl-5-nitroisoquinoline

Cas:943606-84-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization..Company has strong ability of research and development

1-chloro-6-Methyl-5-nitroisoquinoline/943606-84-6

Cas:943606-84-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-methyl-5-nitroisoquinoline 2-oxide
943606-83-5

6-methyl-5-nitroisoquinoline 2-oxide

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
With trichlorophosphate In chloroform at 70℃; for 3h;96%
With trichlorophosphate In 1,2-dichloro-ethane at 70℃; for 3h;86%
With trichlorophosphate In 1,2-dichloro-ethane Reflux;55%
With trichlorophosphate In 1,2-dichloro-ethane Reflux;55%
With trichlorophosphate In 1,2-dichloro-ethane at 70℃;0.88 g
6-methyl-5-nitroisoquinoline
188121-31-5

6-methyl-5-nitroisoquinoline

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane Reflux;55%
With trichlorophosphate In 1,2-dichloro-ethane for 7h; Reflux;55%
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
2: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
2: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C
2: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C
View Scheme
6-methylisoquinoline N-oxide
70810-28-5

6-methylisoquinoline N-oxide

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
With potassium nitrate; trichlorophosphate In chloroform; sulfuric acid
6-methylisoquinoline
42398-73-2

6-methylisoquinoline

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; potassium nitrate / 0 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
3: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium nitrate; sulfuric acid / 0 °C
2: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; potassium nitrate / 3 h / 0 °C
2: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; potassium nitrate / 0 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
3: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C
3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C
View Scheme
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: chloroform / 90 °C
2.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C
2.2: 0 °C / Reflux
3.1: sulfuric acid; potassium nitrate / 0 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
5.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: chloroform / 90 °C
1.2: 24 h / 0 - 20 °C
1.3: 0 - 20 °C / Reflux
2.1: potassium nitrate; sulfuric acid / 0 °C
3.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: chloroform / 90 °C
1.2: 24 h / 0 - 20 °C
1.3: 12 h / 0 °C / Reflux
2.1: sulfuric acid; potassium nitrate / 3 h / 0 °C
3.1: trichlorophosphate / 1,2-dichloro-ethane / 7 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: chloroform / 90 °C
1.2: 24 h / 0 - 20 °C
1.3: 0 °C / Reflux
2.1: sulfuric acid; potassium nitrate / 0 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: chloroform / 22 - 65 °C
1.2: 23 h / -3 - 20 °C
1.3: 10.5 h / 52 °C
2.1: sulfuric acid; potassium nitrate / 1.5 h / 0 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 °C
4.1: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 70 °C
View Scheme
(2,2-Dimethoxy-ethyl)-[1-p-tolyl-meth-(Z)-ylidene]-amine
54879-70-8

(2,2-Dimethoxy-ethyl)-[1-p-tolyl-meth-(Z)-ylidene]-amine

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: chloroformic acid ethyl ester; triethyl phosphite / chloroform / 24 h / 0 - 20 °C
1.2: 0 °C / Reflux
2.1: sulfuric acid; potassium nitrate / 0 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
4.1: trichlorophosphate / 1,2-dichloro-ethane / Reflux
View Scheme
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

m-aminobenzenesulfonamide
98-18-0

m-aminobenzenesulfonamide

C16H14N4O4S

C16H14N4O4S

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;99.4%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

3-(methylsulfonamido)aniline
37045-73-1

3-(methylsulfonamido)aniline

N-(3-((6-methyl-5-nitroisoquinolin-1-yl)amino)phenyl)methanesulfonamide
1446113-45-6

N-(3-((6-methyl-5-nitroisoquinolin-1-yl)amino)phenyl)methanesulfonamide

Conditions
ConditionsYield
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube;99%
In isopropyl alcohol at 120℃; for 1.5h; Sealed tube;99%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

3,5-Dimethoxyaniline
10272-07-8

3,5-Dimethoxyaniline

C18H17N3O4

C18H17N3O4

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;98.4%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

3-acetylenephenylamine
54060-30-9

3-acetylenephenylamine

C18H13N3O2

C18H13N3O2

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;95.4%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-chloro-aniline
106-47-8

4-chloro-aniline

N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine
1191460-78-2

N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine

Conditions
ConditionsYield
In isopropyl alcohol at 90℃; Sealed tube;95%
In isopropyl alcohol at 90℃; Sealed tube;95%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

6-methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinoline-1-amine
943606-86-8

6-methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinoline-1-amine

Conditions
ConditionsYield
In isopropyl alcohol at 90℃; for 12h;94%
In isopropyl alcohol at 90℃; Sealed tube;94%
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation;79%
In isopropyl alcohol at 180℃; for 0.416667h; Microwave irradiation;79%
In isopropyl alcohol at 180℃; for 0.416667h; microwave;79%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-chloro-3-trifluoromethyl-aniline
320-51-4

4-chloro-3-trifluoromethyl-aniline

C17H11ClF3N3O2

C17H11ClF3N3O2

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;93.3%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

m-trifluoromethoxyaniline
1535-73-5

m-trifluoromethoxyaniline

C17H12F3N3O3

C17H12F3N3O3

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 18h; Inert atmosphere;91.9%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

5-amino-1-chloro-6-methylisoquinoline
1093101-44-0

5-amino-1-chloro-6-methylisoquinoline

Conditions
ConditionsYield
With hydrogen In tetrahydrofuran at 20℃; under 2250.23 Torr; for 18h; chemoselective reaction;90.1%
With hydrogenchloride; iron In ethanol; water for 5h; Reflux;83%
With tin(ll) chloride In ethanol; dichloromethane at 70℃; for 16h;40%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-Aminobenzonitrile
873-74-5

4-Aminobenzonitrile

4-(6-methyl-5-nitroisoquinolin-1-ylamino)benzonitrile
1093101-45-1

4-(6-methyl-5-nitroisoquinolin-1-ylamino)benzonitrile

Conditions
ConditionsYield
Stage #1: 1-chloro-6-methyl-5-nitroisoquinoline; 4-Aminobenzonitrile In isopropyl alcohol at 22℃;
Stage #2: With trifluoroacetic acid In isopropyl alcohol at 80℃; for 17h;
88%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

6-methyl-5-nitroisoquinolin-1(2H)-one
943606-85-7

6-methyl-5-nitroisoquinolin-1(2H)-one

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran Heating / reflux;87%
With hydrogenchloride; water In tetrahydrofuran for 14h; Reflux;87%
With hydrogenchloride In tetrahydrofuran; water for 14h; Heating / reflux;87%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-chloro-aniline
106-47-8

4-chloro-aniline

N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine hydrochloride
1191385-24-6

N-(4-chlorophenyl)-6-methyl-5-nitroisoquinolin-1-amine hydrochloride

Conditions
ConditionsYield
In isopropyl alcohol at 170℃; for 0.266667h; Microwave irradiation;84%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

1-methoxy-6-methyl-5-nitroisoquinoline
260049-39-6

1-methoxy-6-methyl-5-nitroisoquinoline

Conditions
ConditionsYield
With sodium methylate In methanol74%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

2,4-difluorophenylamine
367-25-9

2,4-difluorophenylamine

C16H11F2N3O2

C16H11F2N3O2

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 20 - 90℃; for 16h; Inert atmosphere;73.7%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate
769961-14-0

tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate

tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate
1446113-47-8

tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;54%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;54%
4-chloro-3-((dimethylamino)methyl)aniline

4-chloro-3-((dimethylamino)methyl)aniline

1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

N-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methyl-5-nitroisoquinolin-1-amine
1446113-42-3

N-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methyl-5-nitroisoquinolin-1-amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h;53%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 130℃; for 3h; Sealed tube;53%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

2-amino-4-(trifluoromethyl)pyridine
106447-97-6

2-amino-4-(trifluoromethyl)pyridine

6-methyl-5-nitro-N-(4-(trifluoromethyl)pyridin-2-yl)isoquinolin-1-amine
1446113-36-5

6-methyl-5-nitro-N-(4-(trifluoromethyl)pyridin-2-yl)isoquinolin-1-amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; Sealed tube;42%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃;42%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine
118430-73-2

5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine

C18H21N5O2

C18H21N5O2

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); lithium hexamethyldisilazane; DavePhos In 1,4-dioxane at 150℃; for 0.5h; Microwave irradiation; Sealed tube;32.8%
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

(R)-1-(4-chlorophenyl)ethylamine
27298-99-3

(R)-1-(4-chlorophenyl)ethylamine

(R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine
1093101-68-8

(R)-N-(1-(4-chlorophenyl)ethyl)-6-methyl-5-nitroisoquinolin-1-amine

Conditions
ConditionsYield
With trifluoroacetic acid In isopropyl alcohol at 140℃; for 1h; microwave;
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

A

5-amino-1-chloro-6-methylisoquinoline
1093101-44-0

5-amino-1-chloro-6-methylisoquinoline

B

5-amino-6-methylisoquinoline
188120-79-8

5-amino-6-methylisoquinoline

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In tetrahydrofuran at 37℃; under 2250.23 - 3000.3 Torr; for 15h;A 84.4 %Chromat.
B 15.6 %Chromat.
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

N1-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methylisoquinoline-1,5-diamine
1446113-43-4

N1-(4-chloro-3-((dimethylamino)methyl)phenyl)-6-methylisoquinoline-1,5-diamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C
2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube
2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux
View Scheme
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
1446112-11-3

4-amino-N-(1-((4-chloro-3-((dimethylamino)methyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C
2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
View Scheme
Multi-step reaction with 3 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube
2: hydrogenchloride; iron / water; ethanol / 1 h / Reflux
3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide
View Scheme
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

N-(3-((5-amino-6-methylisoquinolin-1-yl)amino)phenyl)methanesulfonamide
1446113-46-7

N-(3-((5-amino-6-methylisoquinolin-1-yl)amino)phenyl)methanesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube
2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube
2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux
View Scheme
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide
1446112-26-0

4-amino-N-(6-methyl-1-((3-(methylsulfonamido)phenyl)amino)isoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube
2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
View Scheme
Multi-step reaction with 3 steps
1: isopropyl alcohol / 1.5 h / 120 °C / Sealed tube
2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux
3: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
View Scheme
1-chloro-6-methyl-5-nitroisoquinoline
943606-84-6

1-chloro-6-methyl-5-nitroisoquinoline

tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate
1446113-48-9

tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube
2: iron; hydrogenchloride / water; ethanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / 130 °C / Sealed tube
2: hydrogenchloride; iron / water; ethanol / 3 h / Reflux
View Scheme

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