3-Acetylthiophene supplier | CasNO.1468-83-3

Name
3-Acetylthiophene
EINECS 215-996-4
CAS No. 1468-83-3
Article Data35
CAS DataBase
Density 1.142 g/cm³
Solubility
Melting Point 57-62 °C(lit.)
Formula C₆H₆OS
Boiling Point 190.5 °C at 760 mmHg
Molecular Weight 126.179
Flash Point 69 °C
Transport Information UN 2811
Appearance white to light yellow crystal powder
Safety 22-24/25-36/37-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 1-thiophen-3-ylethanone;Methyl 3-thienyl ketone;Ethanone, 1-(3-thienyl)-;3-Acetyl Thiophene;
PSA 45.31000
LogP 1.95070

Synthetic route

: 67237-53-0
3-ethynylthiophene

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With C22H20AuN3O2P(1+)*CF3O3S(1-); water; silver trifluoromethanesulfonate; acetic acid at 100℃; for 10h;	93%
With water; silver trifluoromethanesulfonate for 7h; Heating;	90%
With water for 8h; Reflux;	87%

: 10486-61-0
3-thienyl iodide

: 6213-94-1
trimethylsiloxyethene

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; triphenylphosphine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20 - 100℃; for 2h; Heck Reaction; Microwave irradiation; regioselective reaction;	86%

: 14861-60-0
1-(thiophen-3-yl)ethan-1-ol

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With trimethylaluminum In toluene at 20℃; for 0.5h; Oppenauer oxidation;	84%
With tert.-butylnitrite; oxygen; 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine; acetic acid In acetonitrile at 20℃; for 4.5h; Irradiation;	71%
With dipropylene glycol dimethyl ether; oxygen at 120℃;

: 872-31-1
3-Bromothiophene

: 111-34-2
-butyl vinyl ether

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
Stage #1: 3-Bromothiophene; -butyl vinyl ether With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate In various solvent(s) at 125℃; for 30h; Regioselective Heck arylation; Stage #2: With hydrogenchloride In various solvent(s) for 1h;	82%

: 6165-69-1
Thien-3-ylboronic acid

: 105-56-6
ethyl 2-cyanoacetate

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 60℃; for 5h;	80%

: 40018-26-6
1,4-dithiane-2,5-diol

: 4652-27-1
4-methoxy-3-buten-2-one

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
Stage #1: 1,4-dithiane-2,5-diol; 4-methoxy-3-buten-2-one; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50 - 67℃; for 3 - 10h; Stage #2: hydrogenchloride In water; acetonitrile at 60℃; for 2.5 - 3.5h; Product distribution / selectivity;	79%
at 110℃; for 30h; Product distribution / selectivity;	21%
hydrogenchloride In water; toluene at 65℃; for 3h; Product distribution / selectivity;	20 %Chromat.

: 3437-95-4
2-Iodothiophene

: 201230-82-2
carbon monoxide

: 594-27-4
tetramethylstannane

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With MCM-41-supported bidentate phosphine palladium(0) complex In N,N-dimethyl-formamide at 70℃; under 760.051 Torr; for 10h; Stille carbonylative cross-coupling;	75%

...Expand

: 1795-01-3
3-ethylthiophene

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In water; acetonitrile at 50℃; for 15h; Electrolysis;	74%
With sodium anthraquinonesulfonate; air In water; acetonitrile at 20℃; for 18h; Irradiation;	91 %Chromat.

: 40018-26-6
1,4-dithiane-2,5-diol

: 2802-08-6
(E)-4-(dimethylamino)but-3-en-2-one

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In tetrahydrofuran at 65℃; for 16h;	58%

: 40018-26-6
1,4-dithiane-2,5-diol

: 1190-91-6
4-dimethylamino-3-buten-2-one

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
at 110℃; for 30h; Product distribution / selectivity;	9%
hydrogenchloride In water; toluene at 90℃; for 10h; Product distribution / selectivity;	32 %Chromat.
potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; Product distribution / selectivity;	17 %Chromat.

: 41507-35-1
3-thiophene carboxylic acid chloride

: 506-82-1
dimethylcadmium

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With diethyl ether

: 36157-40-1
3-acetyl-2,5-dichlorothiophene

A: 1468-83-3
1-(thiophen-3-yl)-ethanone

B: 58119-67-8
1-(5-Chlor-3-thienyl)-ethanon

C: 81557-66-6
3-acetyl-2-chlorothiophene

Conditions

Conditions	Yield
With sodium tetrahydroborate; hydrogen; calcium oxide; palladium In ethanol at 20℃; under 760 Torr; Rate constant; other temperature, other solvent, other acceptor;

...Expand

: 917-54-4
methyllithium

: 73540-75-7
3-thiophenecarboxylic acid,N,N-diethylamide

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With lanthanum(lll) triflate 1.) THF, -78 deg C then up to 0 deg C, 2.) -78 up to 0 deg C, 30 min; Yield given. Multistep reaction;

(+-)-1-<3>thienyl-ethanol: (+-)-1-<3>thienyl-ethanol

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

(+-)-1-<3>thienyl-ethanol: (+-)-1-<3>thienyl-ethanol

A: 13679-64-6
3-vinylthiophene

B: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With potassium hydrogensulfate at 250℃;

: 132387-75-8
1-butoxy-1-(3-thienyl)ethene

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide at 20℃; for 0.5h;
With hydrogenchloride In water for 0.5h;

: C8H10O2S

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With hydrogenchloride In water; ethyl acetate at 20℃;

: 2-(3-thienyl)propanal

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With sodium hydroxide; silver(l) oxide In ethanol at 40℃;

: 14861-60-0
1-(thiophen-3-yl)ethan-1-ol

: 115510-91-3
1-(thien-2-yl)ethanol

A: 1468-83-3
1-(thiophen-3-yl)-ethanone

B: 88-15-3
2-Acetylthiophene

Conditions

Conditions	Yield
With manganese(IV) oxide In toluene Heating / reflux;

...Expand

: 52-90-4
L-Cysteine

: 50-81-7
ascorbic acid

A: 1940-01-8
[1,2,5,6]tetrathiocane

B: 1468-83-3
1-(thiophen-3-yl)-ethanone

C: 24295-03-2
2-Acetylthiazole

D: 251-41-2
thieno[3,2-b]thiophene

E: 23654-92-4
3,5-dimethyl-1,2,4-trithiolane

F: 867253-51-8
3-(vinylthio)thiophene

: 4,6-dimethyl-1,2,3-trithiane

: 4,6-dimethyl-1,2,3-trithiane

: cis-3,5-diethyl-1,2,4-trithiolane

: trans-3,5-diethyl-1,2,4-trithiolane

Conditions

Conditions	Yield
at 141℃; for 2h; pH=9; aq. phosphate buffer;

...Expand

: 188290-36-0
thiophene

: 108-24-7
acetic anhydride

A: 1468-83-3
1-(thiophen-3-yl)-ethanone

B: 88-15-3
2-Acetylthiophene

Conditions

Conditions	Yield
With Hierarchical-ZSM-5 zeolite In neat (no solvent) at 59.84℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Friedel-Crafts Acylation; Green chemistry;

...Expand

: 130995-13-0
3-(trimethylsilylethynyl)thiophene

: 1468-83-3
1-(thiophen-3-yl)-ethanone

Conditions

Conditions	Yield
With iron(III) sulphate monohydrate; acetic acid at 70℃; for 16h; regioselective reaction;	98 %Chromat.

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 14861-60-0
1-(thiophen-3-yl)ethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1h; Heating;	100%
With sodium tetrahydroborate In ethanol at 20℃; for 4h; Inert atmosphere;	99.5%
With isopropyl alcohol; sodium hydroxide at 80℃; for 21h; Reagent/catalyst;	97%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 153035-65-5
(+)-(R)-1-(thiophen-3-yl)ethanol

Conditions

Conditions	Yield
With borane-THF; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; toluene at -23℃;	100%
With C38H38IrN4S2(1+)*F6P(1-); ammonium formate; 3-methyl-5-p-methoxyphenyl-1-hydropyrazole In tetrahydrofuran; water at 40℃; for 8h; enantioselective reaction;	93%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; N-(tert-butoxycarbonyl)-L-valine-(6-amido-1-O-benzyl-6-deoxy-2,3-O-isopropylidene-α-D-mannofuranose); potassium tert-butylate; lithium chloride In tetrahydrofuran; isopropyl alcohol at 20℃; for 3h; enantioselective reaction;	92%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 2-(thiophen-3-yl)pent-4-en-2-ol

Conditions

Conditions	Yield
With indium iodide In tetrahydrofuran at 40℃; for 24h;	100%
With methanol; indium (III) tris(hexamethyldisilyl) amide In toluene at 20℃; for 6h; Inert atmosphere;	81%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 59445-83-9
1-(thiophen-3-yl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃;	100%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;	92%
With sodium hydroxide; hydroxylamine hydrochloride In water at 0 - 100℃;	83%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 7732-18-5
water

: 14861-60-0
1-(thiophen-3-yl)ethan-1-ol

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether	100%

: 110-86-1
pyridine

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 1030917-93-1
1-[2-oxo-2-(thiophen-3-yl)ethyl]pyridinium iodide

Conditions

Conditions	Yield
With iodine	100%
With iodine at 140℃; for 3h;	100%
With iodine at 140℃; for 3h;	100%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 4289-20-7
1-phenyl-4-penten-1-yne

: (R,Z)-7-phenyl-2-(thiophen-3-yl)hept-4-en-6-yn-2-ol

Conditions

Conditions	Yield
With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; mesitylcopper(I) In tetrahydrofuran at -30℃; Inert atmosphere; stereoselective reaction;	100%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 925-90-6
ethylmagnesium bromide

: 2-(thiophen-3-yl)butan-2-ol

Conditions

Conditions	Yield
Stage #1: ethylmagnesium bromide With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.75h; Inert atmosphere; Stage #2: 1-(thiophen-3-yl)-ethanone In tetrahydrofuran; diethyl ether at 0℃; for 3h; Inert atmosphere;	99%
In diethyl ether at -20 - 20℃; for 1h;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 79571-33-8
3-dimethylamino-1-(thien-3-yl)-2-propen-1-one

Conditions

Conditions	Yield
Heating / reflux;	99%
In N,N-dimethyl-formamide Heating;	93%
at 160℃; for 0.25h; Microwave irradiation;	86%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 138890-86-5
2,5,5-trimethyl-2-(thiophen-3-yl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 24h; Heating / reflux;	99%
With toluene-4-sulfonic acid In toluene for 24h; Reflux; Dean Stark;	99%
With toluene-4-sulfonic acid In toluene for 36h; Reflux;	93%
With sulfuric acid In toluene for 2h; Heating;	65%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 36198-87-5
dimethyl trimethylsilyl phosphite

: 1172141-67-1
(1-thiophen-3-yl-1-trimethylsilanyloxy-ethyl)-phosphonic acid dimethyl ester

Conditions

Conditions	Yield
With C4H9O(1-)*C13H27KO6(1+) In tetrahydrofuran at 0℃; for 1h; Inert atmosphere;	99%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 17049-49-9
octylmagnesium bromide

: 1227495-94-4
2-(thiophen-3-yl)decan-2-ol

Conditions

Conditions	Yield
Stage #1: octylmagnesium bromide With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; Grignard addition; Stage #2: 1-(thiophen-3-yl)-ethanone In tetrahydrofuran; diethyl ether at 0℃; for 3h; Grignard addition;	99%
Stage #1: octylmagnesium bromide With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 0.75h; Inert atmosphere; Stage #2: 1-(thiophen-3-yl)-ethanone In tetrahydrofuran; diethyl ether at 0℃; for 3h; Inert atmosphere;	99%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 79571-33-8
3-(dimethylamino)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
In N,N-dimethyl acetamide for 18h; Reflux;	99%
In N,N-dimethyl acetamide at 120 - 125℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 104-87-0
4-methyl-benzaldehyde

: 3-(4-methylphenyl)-1-(3-thienyl)-2-propen-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	99%
With preheated fly-ash Aldol Condensation; Microwave irradiation; Sealed tube;	65%
With sodium hydroxide In ethanol at 20℃;
With sodium hydroxide In ethanol at 20℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 620-23-5
m-tolyl aldehyde

: 1245505-00-3
1-(thiophen-3-yl)-3-m-tolylprop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	99%
With sodium hydroxide In ethanol at 20℃;
With sodium hydroxide In ethanol at 20℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 104-87-0
4-methyl-benzaldehyde

: 148877-98-9
(E)-1-(thiophen-3-yl)-3-p-tolylprop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	99%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 620-23-5
m-tolyl aldehyde

: 1205545-63-6
(E)-1-(thiophen-3-yl)-3-m-tolylprop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	99%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 104-88-1
4-chlorobenzaldehyde

: (E)-3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With sodium hydroxide In ethanol Ambient temperature;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 146767-34-2
4-Methylphenylazo tert-butyl sulfide

: 146767-44-4
3-Thienyl <(4-methylphenyl)hydrazono>methyl ketone

Conditions

Conditions	Yield
With potassium tert-butylate In dimethyl sulfoxide at 25℃; Condensation;	98%
With potassium tert-butylate 2) room temp., 60 min; Yield given. Multistep reaction;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 1122-91-4
4-bromo-benzaldehyde

: (E)-3-(4-bromophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With sodium hydroxide In ethanol Ambient temperature;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 222609-67-8
(S)-1-(thiophen-3-yl)ethan-1-ol

Conditions

Conditions	Yield
With potassium tert-butylate; hydrogen; trans-RuCl2[(R)-xylbinap][(R)-daipen] In isopropyl alcohol; tert-butyl alcohol at 25℃; under 6080.41 Torr; for 5h; Catalytic hydrogenation;	98%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N-(tert-butoxycarbonyl)-L-valine-(6-thioamido-5-O-benzoyl-1-O-benzyl-6-deoxy-2,3-O-isopropylidene-α-D-mannofuranose); potassium tert-butylate; lithium chloride In tetrahydrofuran; isopropyl alcohol at 20℃; for 3h; enantioselective reaction;	91%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; C31H40N2O8S; sodium isopropylate; lithium chloride In tetrahydrofuran; isopropyl alcohol at 20℃; for 3h; Reagent/catalyst; Inert atmosphere; Schlenk technique; enantioselective reaction;	42%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 100-52-7
benzaldehyde

: 82833-71-4
(E)-3-phenyl-1-(3-thienyl)phenylprop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
Stage #1: 1-(thiophen-3-yl)-ethanone With sodium hydroxide In methanol at 20℃; for 0.0833333h; Stage #2: benzaldehyde In methanol at 20℃; for 16h;	61%
With potassium hydroxide In methanol at 0℃; for 3h;
With sodium hydroxide In ethanol; water at 0℃; for 0.5h;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 110853-80-0
(E)-1-(thiophen-3-yl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 60 - 65℃;	98%
With pyridine; hydroxylamine hydrochloride In ethanol at 20℃;	72%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 20h; Reflux;
With pyridine; hydroxylamine hydrochloride In ethanol at 60℃; for 1h;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 104-88-1
4-chlorobenzaldehyde

: 144080-41-1
3-(4-chlorophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With preheated fly-ash Aldol Condensation; Microwave irradiation; Sealed tube;	66%
With sodium hydroxide In ethanol at 20℃;
With sodium hydroxide In ethanol at 20℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 100-52-7
benzaldehyde

: 3-phenyl-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With preheated fly-ash Aldol Condensation; Microwave irradiation; Sealed tube;	67%
With potassium hydroxide In methanol; water at 0℃; Claisen-Schmidt Condensation;	58.4%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 123-11-5
4-methoxy-benzaldehyde

: 1245504-96-4
3-(4-methoxyphenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With sodium hydroxide In ethanol at 20℃;
With sodium hydroxide In ethanol at 20℃;
With ethanol; sodium hydroxide

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 1122-91-4
4-bromo-benzaldehyde

: 144080-42-2
3-(4-bromophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With preheated fly-ash Aldol Condensation; Microwave irradiation; Sealed tube;	66%
With sodium hydroxide In ethanol at 20℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 123-11-5
4-methoxy-benzaldehyde

: 947701-69-1
(2E)-3-(4-methoxyphenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	98%
With sodium hydroxide In ethanol; water at 20℃; Claisen-Schmidt Condensation;	92%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 3132-99-8
m-bromobenzoic aldehyde

: 1245504-98-6
3-(3-bromophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	97%
With preheated fly-ash Aldol Condensation; Microwave irradiation; Sealed tube;	65%
With sodium hydroxide In ethanol at 20℃;
With sodium hydroxide In ethanol at 20℃;

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 3132-99-8
m-bromobenzoic aldehyde

: 1205545-62-5
(E)-3-(3-bromophenyl)-1-(thiophen-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 25℃;	97%

3-Acetylthiophene Chemical Properties

Structure of 3-Acetylthiophene (CAS NO.1468-83-3):

IUPAC Name: 1-thiophen-3-ylethanone
Empirical Formula: C₆H₆OS
Molecular Weight: 126.1762
EINECS: 215-996-4
Index of Refraction: 1.54
Molar Refractivity: 34.66 cm³
Molar Volume: 110.4 cm³
Polarizability: 13.74×10^-24cm³
Surface Tension: 38.7 dyne/cm
Density: 1.142 g/cm³
Flash Point: 69 °C
Enthalpy of Vaporization: 42.67 kJ/mol
Melting Point: 57-62 °C(lit.)
Boiling Point: 190.5 °C at 760 mmHg
Vapour Pressure: 0.541 mmHg at 25°C
Sensitive: Light Sensitive
Physical Appearance: white to light yellow crystal powder
Product Categories: Thiophenes;Sulphur Derivatives;Thiophene&Benzothiophene;Heterocyclic Compounds

3-Acetylthiophene Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36/37:Wear suitable protective clothing and gloves.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

3-Acetylthiophene Specification

3-Acetylthiophene , its cas register number is 1468-83-3. It also can be called Ethanone, 1-(3-thienyl)- ; Methyl 3-thienyl ketone ; 3-Acetyl Thiophene ; 3-Acetyl Benzothiophen .

Product Name

3-Acetylthiophene

Synthetic route

3-Acetylthiophene Chemical Properties

3-Acetylthiophene Safety Profile

3-Acetylthiophene Specification

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