3-Aminopentane supplier | CasNO.616-24-0

Name
3-Aminopentane
EINECS 210-471-6
CAS No. 616-24-0
Article Data38
CAS DataBase
Density 0.757 g/cm³
Solubility soluble in water
Melting Point -70°C (estimate)
Formula C₅H₁₃N
Boiling Point 92.1 °C at 760 mmHg
Molecular Weight 87.1649
Flash Point 2.2 °C
Transport Information UN 2733
Appearance Clear colorless to faintly yellow liquid
Safety 16-26-27-36/37/39-45
Risk Codes 11-34-22
Molecular Structure
Hazard Symbols F,C
Synonyms Propylamine,1-ethyl- (6CI,7CI,8CI);1-Ethylpropylamine;3-Aminopentane;3-Pentylamine;NSC165575;Propylamine, 1-ethyl- (8CI);
PSA 26.02000
LogP 1.83400

Synthetic route

: 96-22-0
pentan-3-one

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With ammonia; hydrogen In methanol at 30℃; for 15h; Autoclave;	97%
With platinum on silica; ammonia; hydrogen at 140 - 290℃;
With ammonia; water; nickel at 50 - 60℃; under 5148.6 Torr; Hydrogenation;

: 1188-11-0
3-pentanone oxime

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With ethanol; nickel Hydrogenation;
With ethanol; sodium
With ethanol; sodium
With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 140℃; for 4h;
Multi-step reaction with 2 steps 1: 1) sodium; 2) hydrochloric acid / 1) methanol, reflux; 2) water, reflux 2: potassium hydroxide View Scheme

: 1188-11-0
3-pentanone oxime

A: 29681-36-5
di(pentan-3-yl)amine

B: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With hydrogen; nickel at 200℃;

: 584-02-1
2-pentanol

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With ammonia; thorium dioxide at 350 - 380℃;
Multistep reaction;

: 584-02-1
2-pentanol

A: 29681-36-5
di(pentan-3-yl)amine

B: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With nickelsilicate powder; ammonia; hydrogen at 190℃;

: 1114-38-1
2-ethylbutanamide

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With alkali hypobromite

: 1530-17-2
diethyl ketone azine

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With hydrogen; nickel at 160 - 170℃;
With ethanol; aluminium amalgam at 160 - 170℃;

: 540-69-2
ammonium formate

: 64-19-7
acetic acid

: 96-22-0
pentan-3-one

: 616-24-0
3-aminopentane

...Expand

: 540-69-2
ammonium formate

: 96-22-0
pentan-3-one

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With acetic acid

: 96-22-0
pentan-3-one

A: 29681-36-5
di(pentan-3-yl)amine

B: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With ammonia; hydrogen; platinum at 25℃; under 3040 Torr;

: 925-90-6
ethylmagnesium bromide

: 107-12-0
propiononitrile

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With diethyl ether Erwaermen des Reaktionsgemisches mit Lithiumalanat in Tetrahydrofuran;

: 88-09-5
2-Ethylbutanoic acid

: 616-24-0
3-aminopentane

: 71847-22-8
C17H22NOP

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran

: 5398-26-5
pentan-3-amine hydrochloride

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With potassium hydroxide Yield given;

: ammonium hydroxide

: 96-22-0
pentan-3-one

hydrogen: hydrogen

nickel: nickel

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
at 100 - 110℃; under 15200 Torr;

...Expand

pentyl-(3)-magnesium halide: pentyl-(3)-magnesium halide

monochloroamine: monochloroamine

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
With diethyl ether

: 7664-41-7
ammonia

: 96-22-0
pentan-3-one

hydrogen: hydrogen

platinum: platinum

A: 29681-36-5
di(pentan-3-yl)amine

B: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
under 2280 Torr;

...Expand

: 1114-38-1
2-ethylbutanamide

alkali hypobromite: alkali hypobromite

: 616-24-0
3-aminopentane

: 64-17-5
ethanol

: 1530-17-2
diethyl ketone azine

amalgamated aluminium: amalgamated aluminium

: 616-24-0
3-aminopentane

...Expand

: 1530-17-2
diethyl ketone azine

hydrogen: hydrogen

nickel: nickel

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
at 160 - 170℃;

...Expand

: 584-02-1
2-pentanol

: 7664-41-7
ammonia

ThO2: ThO2

: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
at 350 - 380℃;

...Expand

: 1188-11-0
3-pentanone oxime

hydrogen: hydrogen

nickel: nickel

A: 616-24-0
3-aminopentane

B di--amine: di--amine

Conditions

Conditions	Yield
at 200℃;

...Expand

: N-ethyl-N-(1-ethyl-propyl)-hydroxylamine

: 7758-99-8
copper(II) sulfate

A: 75-07-0
acetaldehyde

B: 616-24-0
3-aminopentane

C: 96-22-0
pentan-3-one

D ethyl-sec-n-pentyl-amine: ethyl-sec-n-pentyl-amine

Conditions

Conditions	Yield
Produkt 5:NH3;

...Expand

: 109-66-0
pentane

A: 110-58-7
1-pentanamine

B: 625-30-9
2-pentylamine

C: 616-24-0
3-aminopentane

Conditions

Conditions	Yield
Stage #1: pentane With cerium(III) chloride; 1,1,1-trichloroethanol; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride In acetonitrile at 20℃; for 12h; Irradiation; Inert atmosphere; Sealed tube; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Stage #3: With hydrogen In methanol for 12h; Reagent/catalyst;

...Expand

: 616-24-0
3-aminopentane

: 156868-71-2
C15H17FN2O4

: N-(1-ethylpropyl)-3',4'-dihydro-5',7'-dinitrospiro-6'-amine

Conditions

Conditions	Yield
In dichloromethane for 24h; Heating;	100%
In dichloromethane Arylation;	86%

: 616-24-0
3-aminopentane

: 181058-08-2
1,3,5-tris(bromomethyl)-2,4,6-triethylbenzene

: 1,3,5-tris(N-(1-ethylpropyl)aminomethyl)-2,4,6-triethylbenzene

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; for 16h;	100%

: 441056-87-7
8-chloro-3-(4-methoxy-2-methylphenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacene

: 616-24-0
3-aminopentane

: (1-ethyl-propyl)-[3-(4-methoxy-2-methylphenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 90℃; for 4h;	100%
at 140℃; for 1h;

: 1064783-32-9
5-chloro-3-fluoro-4-iodopicolinonitrile

: 616-24-0
3-aminopentane

: 1064783-33-0
5-chloro-4-iodo-3-(pentan-3-ylamino)picolinonitrile

Conditions

Conditions	Yield
at 80℃; for 1h;	100%

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: 616-24-0
3-aminopentane

: 1338932-00-5
(5-chloropyrazolo[1,5-a]pyrimidin-7-yl)(1-ethylpropyl)amine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃;	100%

: 61098-38-2
5,7-dichloro-6-methylpyrazolo[1,5-a]pyrimidine

: 616-24-0
3-aminopentane

: 1338932-01-6
(5-chloro-6-methylpyrazolo[1,5-a]pyrimidin-7-yl)(1-ethylpropyl)amine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃;	100%

: 122-78-1
phenylacetaldehyde

: 616-24-0
3-aminopentane

: (1-Ethyl-propyl)-phenethyl-amine

Conditions

Conditions	Yield
Stage #1: phenylacetaldehyde; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 66-99-9
β-naphthaldehyde

: 616-24-0
3-aminopentane

: 1042512-10-6
C16H21N

Conditions

Conditions	Yield
Stage #1: β-naphthaldehyde; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 459-57-4
4-fluorobenzaldehyde

: 616-24-0
3-aminopentane

: (1-ethyl-propyl)-(4-fluoro-benzyl)-amine

Conditions

Conditions	Yield
Stage #1: 4-fluorobenzaldehyde; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 487-89-8
Indole-3-carboxaldehyde

: 616-24-0
3-aminopentane

: 356094-69-4
C14H20N2

Conditions

Conditions	Yield
Stage #1: Indole-3-carboxaldehyde; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 108-91-8
cyclohexylamine

: 616-24-0
3-aminopentane

: 356531-67-4
N-[(4-fluorophenyl)methyl]cyclohexanamino

Conditions

Conditions	Yield
Stage #1: cyclohexylamine; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 100-52-7
benzaldehyde

: 616-24-0
3-aminopentane

: N-benzyl-1-ethylpropylamine

Conditions

Conditions	Yield
Stage #1: benzaldehyde; 3-aminopentane In methanol at 64℃; for 3h; Borch Reduction; Stage #2: With sodium cyanoborohydride In methanol; ethanol at 20 - 64℃; for 5h; Borch Reduction;	100%

: 367-80-6
ethyl 4-fluoro-3-nitrobenzoate

: 616-24-0
3-aminopentane

: 1586791-34-5
4-(1-ethylpropylamino)-3-nitrobenzoic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: 367-80-6
ethyl 4-fluoro-3-nitrobenzoate

: 616-24-0
3-aminopentane

: 4-(1-ethyl-propylamino)-3-nitro-benzoic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: methyl 2-bromo-5-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3-fluorobenzoate

: 616-24-0
3-aminopentane

: methyl 2-bromo-3-fluoro-5-((4-(pentan-3-ylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzoate

Conditions

Conditions	Yield
With triethylamine In ethanol at 80℃; for 6h;	100%

: 1-(2-(benzyloxy)ethyl)-3-(3-(5-(ethoxycarbonyl)oxazol-2-yl)phenyl)-1H-pyrazole-5-carboxylic acid

: 616-24-0
3-aminopentane

: ethyl 2-(3-(1-(2-(benzyloxy)ethyl)-5-(pentan-3-ylcarbamoyl)-1H-pyrazol-3-yl)phenyl)oxazole-5-carboxylate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In ethyl acetate at 20℃; for 18h;	100%

: 75-36-5
acetyl chloride

: 616-24-0
3-aminopentane

: 23601-99-2
3-N-acetylaminopentane

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	99.5%

: 31599-61-8
3,4-dimethyliodobenzene

: 616-24-0
3-aminopentane

: 56038-89-2
N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 90℃; for 6h; Reagent/catalyst; Temperature; Buchwald-Hartwig Coupling;	99.5%

: 615-60-1
4-chloro-1,2-dimethylbenzene

: 616-24-0
3-aminopentane

: 56038-89-2
N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In toluene at 80℃; for 6h; Temperature; Reagent/catalyst; Buchwald-Hartwig Coupling;	98.9%

: 616-24-0
3-aminopentane

: 255837-23-1
3,4-dimethylphenyl trifluoromethanesulfonate

: 56038-89-2
N-(1-ethylpropyl)-3,4-dimethyl-benzenamine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; sodium carbonate; sodium t-butanolate In toluene at 90℃; for 6h; Reagent/catalyst; Buchwald-Hartwig Coupling;	98.4%

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: 616-24-0
3-aminopentane

: 110590-81-3
N,N'-bis(1-ethylpropyl)-3,4:9,10-perylenebis(dicarboximide)

Conditions

Conditions	Yield
With 1H-imidazole at 110℃; for 24h;	98%
With 1H-imidazole at 140℃; for 5h; Inert atmosphere;	96%
With 1H-imidazole at 200℃; for 2h;	92%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 616-24-0
3-aminopentane

: 688315-30-2
tert-butyl (1-ethylpropylamino)acetate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h;	98%

: 1100261-90-2
ethyl 4,8-dibromo-2-methylquinoline-5-carboxylate

: 616-24-0
3-aminopentane

: 1100261-92-4
8-bromo-4-(1-ethylpropyl)-2-methylpyrrolo[2,3,4-de]quinolin-5(4H)-one

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 100℃; for 7h;	98%

: 89281-22-1
5,7-dichloro-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

: 616-24-0
3-aminopentane

: 1338932-09-4
(5-chloro-6-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)(1-ethylpropyl)amine

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃;	98%

: 616-24-0
3-aminopentane

: 156868-72-3
6-fluoro-1,2,3,4-tetrahydro-1-methyl-1-(1-methylethyl)-5,7-dinitronaphthalene

: N-(1-ethylpropyl)-5,6,7,8-tetrahydro-5-methyl-5-(1-methylethyl)-1,3-dinitro-5,5-dipropyl-2-naphthalenamine

Conditions

Conditions	Yield
In dichloromethane for 24h; Heating;	97%
In dichloromethane Arylation;	97%

: 616-24-0
3-aminopentane

: 530-62-1
1,1'-carbonyldiimidazole

: 823235-98-9
N,N'-bis(1-ethylpropyl)urea

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 70℃; for 3h;	97%
In toluene at 20℃;	43.7%

: 53067-27-9
1,1,1-tris(cyanoethoxymethyl)propane

: 616-24-0
3-aminopentane

: 922733-75-3
(3-{2,2-bis-[3-(1-ethyl-propylamino)-propoxymethyl]-butoxy}-propyl)-(1-ethyl-propyl)-amine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 6000.48 Torr; for 48h;	97%

: 616-24-0
3-aminopentane

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 935856-05-6
4-bromo-N-(1-ethyl-propyl)-3-fluoro-benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide for 16h;	97%
With PS-carbodiimide In dichloromethane at 20℃; for 16h;

3-Aminopentane Specification

The 3-Pentanamine, with the CAS registry number 616-24-0, is also known as 1-Ethylpropylamine. Its EINECS number is 210-471-6. This chemical's molecular formula is C₅H₁₃N and molecular weight is 87.16. What's more, its IUPAC name is pentan-3-amine. It is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place.

Physical properties of 3-Pentanamine are: (1)ACD/LogP: 1.28; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.82; (4)ACD/LogD (pH 7.4): -1.65; (5)ACD/BCF (pH 5.5): 1; (6)ACD/KOC (pH 5.5): 1; (7)#H bond acceptors: 1; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 3.24 Å²; (11)Index of Refraction: 1.413; (12)Molar Refractivity: 28.7 cm³; (13)Molar Volume: 115.1 cm³; (14)Surface Tension: 25 dyne/cm; (15)Density: 0.757 g/cm³; (16)Flash Point: 2.2 °C; (17)Enthalpy of Vaporization: 33.19 kJ/mol; (18)Boiling Point: 92.1 °C at 760 mmHg; (19)Vapour Pressure: 52.4 mmHg at 25°C.

Uses of 3-Pentanamine: it can be used to produce (1-ethyl-propyl)-(9-methyl-9H-purin-6-yl)-amine by heating. It will need reagent N,N-diisopropylethylamine and solvent ethanol. The yield is about 77%.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable, so you should keep it away from sources of ignition - No smoking. It is harmful if swallowed. It can cause burns. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. You must take off immediately all contaminated clothing. When using it, you need wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCC(CC)N
(2)InChI: InChI=1S/C5H13N/c1-3-5(6)4-2/h5H,3-4,6H2,1-2H3
(3)InChIKey: PQPFFKCJENSZKL-UHFFFAOYSA-N

Product Name

3-Aminopentane

Synthetic route

3-Aminopentane Specification

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