3-Aminopropylbis(trimethylsiloxy)methylsilane supplier

Name
3-Aminopropylbis(trimethylsiloxy)methylsilane
EINECS
CAS No. 42292-18-2
Article Data5
CAS DataBase
Density 0.881 g/cm³
Solubility
Melting Point
Formula C₁₀H₂₉NO₂Si₃
Boiling Point 254.405 °C at 760 mmHg
Molecular Weight 279.602
Flash Point 107.661 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Propanamine,3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]- (9CI);3-(3-Aminopropyl)heptamethyltrisiloxane;3-Aminopropylbis(trimethylsiloxy)methylsilane;3-[1,3,3,3-Tetramethyl-1-[(trimethylsilyloxy)disiloxanyl]propylamine;
PSA 35.25000
LogP 3.83750

Synthetic route

: 63672-10-6
3-(N-trimethylsilyl-3-aminopropyl)heptamethyltrisiloxane

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

Conditions

Conditions	Yield
In ethanol for 1h;	95%
With water In isopropyl alcohol

: 107-46-0
Hexamethyldisiloxane

: 3179-76-8
3-(diethoxy-methyl-silanyl)-propylamine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

Conditions

Conditions	Yield
With tetramethyl ammoniumhydroxide at 100℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;	68%

: 107-46-0
Hexamethyldisiloxane

: 3663-44-3
gamma-aminopropylmethyldimethoxysilane

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

Conditions

Conditions	Yield
With tetramethyl ammoniumhydroxide at 90℃; for 2h; Inert atmosphere;	52.9%

: 107-46-0
Hexamethyldisiloxane

: 3-(ethoxy-methoxymethyl-methyl-silanyl)-propylamine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

Conditions

Conditions	Yield
With [C5H5N+C18H38]*NTf2; oxygen at 22℃; under 750.075 Torr; Electrochemical reaction;	32%

: 1873-88-7
1,1,1,3,5,5,5-heptamethyltrisiloxan

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 54 percent / H2PtCl6*6H2O / tetrahydrofuran / 120 - 145 °C 2: 95 percent / ethanol / 1 h View Scheme
Multi-step reaction with 2 steps 1: H2PtCl6*6H2O / propan-2-ol 2: H2O / propan-2-ol View Scheme

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 207562-46-7
2,4-dichloro-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 1.5h; pH=3 - 6.5;	95%
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 1.5h; pH=3 - 6.5;	95%
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; pH=6.5;	95%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2,4-dichloro-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)-oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
With sodium carbonate In water; acetone at 0 - 10℃; for 1.5h; pH=3 - 6.5;	95%

: 2873-74-7
gloutaric dichloride

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: N1,N5-bis(3-(trimethoxysilyl)propyl)glutaramide

Conditions

Conditions	Yield
Stage #1: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With triethylamine In toluene at 0℃; for 0.5h; Inert atmosphere; Stage #2: gloutaric dichloride In toluene at 0 - 20℃; for 3.5h; Inert atmosphere;	92%

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 1077-28-7, 62-46-4
Thioctic acid

: 1026779-50-9
5-(1,2-dithiolan-3-yl)-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl}propyl)pentanamide

Conditions

Conditions	Yield
Stage #1: Thioctic acid With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With triethylamine In tetrahydrofuran for 20h;	80%

: 79-37-8
oxalyl dichloride

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 501-52-0
3-Phenylpropionic acid

: 1027627-90-2
3-phenyl-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)-propanamide

Conditions

Conditions	Yield
With sodium chloride; N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide; acetonitrile	76%

...Expand

: 16130-58-8
cyanoacetic acid chloride

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 851974-02-2
cyano-N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]acetamide

Conditions

Conditions	Yield
Stage #1: cyanoacetic acid chloride; 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; triethylamine In dichloromethane at 32℃; for 0.333333h; dropwise addition; Stage #2: for 2h; Heating / reflux;	70%

: 79-37-8
oxalyl dichloride

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 1027627-89-9
N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)benzamide

Conditions

Conditions	Yield
With sodium chloride; N-ethyl-N,N-diisopropylamine; benzoic acid In dichloromethane; ethyl acetate; N,N-dimethyl-formamide	70%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 94-09-7
p-aminoethylbenzoate

: 2,4-bis(ethyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; p-aminoethylbenzoate With potassium carbonate In water; butanone at 0 - 70℃; for 6h; Inert atmosphere; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With sodium carbonate In water; butanone at 70℃; for 4h;	70%

...Expand

: 2680-03-7
N,N-Dimethylacrylamide

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: C15H38N2O3Si3

Conditions

Conditions	Yield
In ethanol at 20℃; for 96h;	69%

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: heptamethyl-3-<3-<(pentachlorocyclotriphosphazenyl)amino>propyl>trisiloxane

Conditions

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; triethylamine In benzene for 5h; Ambient temperature;	52.6%

: ethyl 3-{4-[4-chloro-6-(methoxyphenyl)[1,3,5]triazin-2-ylamino]phenyl}-2-cyanoacrylate

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2-(ethyl 4'-ylamino-α-cyanocinnamate)-4-(4-methoxyphenyl)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
In toluene at 90℃; for 2h;	47%

: 803699-13-0
butyl 4-{4-chloro-6-[4-(2-cyano-2-methanesulfonylvinyl)phenylaminol][1,3,5]triazin-2-ylamino}benzoate

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 803699-11-8
2-(4'-ylamino-2-methanesulfonylacrylonitrile)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
In toluene at 90℃; for 2h;	26%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 619-45-4
4-methoxycarbonyl aniline

: 2,4-bis(methyl 4'-aminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 4-methoxycarbonyl aniline With potassium carbonate In water; butanone at 0 - 70℃; for 7h; Inert atmosphere; Stage #2: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine With sodium carbonate In water; butanone for 1h;	18%

...Expand

: C26H25ClN6O4

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 803699-07-2
2-(ethyl 4'-ylamino-α-cyanocinnamate)-4-(butyl 4'-ylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
In toluene at 90℃; for 2h;	12%

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 36239-09-5
ethyl chlorocarbonylacetate

: 851974-10-2
Ethyl N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]malonamide

Conditions

Conditions	Yield
Stage #1: 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; ethyl chlorocarbonylacetate; triethylamine In dichloromethane at 10℃; for 0.5h; dropwise addition; Stage #2: for 2h; Heating / reflux;

: 39619-07-3
2-methylmalonyl dichloride

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 209330-73-4
Methyl N-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-disiloxanyl]propyl]malonamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; water

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 645-45-4
hydrocinnamic acid chloride

: 1027627-90-2
3-phenyl-N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)-propanamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 98-88-4
benzoyl chloride

: 1027627-89-9
N-(3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl)benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 90-80-2
D-Glucono-1,5-lactone

: 164063-67-6
C16H39NO8Si3

Conditions

Conditions	Yield
In methanol for 6h; Reflux;	2.369 g

: 94-25-7
4-amino-benzoic acid butyl ester

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propan-1-amine

A: 2,4-bis(n-butyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

B: butyl 4-({4-{[4-(butoxycarbonyl)-phenyl]amino}-6-[(2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propyl)amino]-1,3,5-triazin-2-yl}amino)benzoate

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; 3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine; 2-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}-propan-1-amine With 2,6-dimethylpyridine In ethyl acetate at 0 - 20℃; for 2h; Stage #2: 4-amino-benzoic acid butyl ester With pyridine In ethyl acetate at 70℃; for 3h; Overall yield = 60 %; Overall yield = 49 g;

...Expand

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: C64H94N12O11Si4

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h View Scheme
Multi-step reaction with 3 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Reflux; Inert atmosphere 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h View Scheme
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux 3: hydrogenchloride / ethanol; water; isopropyl alcohol / 4 h / 20 °C / pH 7 View Scheme

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2,4-bis(ethyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: toluene / 1.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: toluene / 1.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: toluene / 1.5 h / Reflux View Scheme

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2,4-bis(n-butyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Reflux; Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: potassium carbonate / toluene / 1.33 h / Inert atmosphere; Reflux View Scheme

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2,4-bis(n-pentyl 4’-diylaminobenzoate)-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme
Multi-step reaction with 2 steps 1.1: potassium carbonate / butanone; water / 6 h / 0 - 70 °C / Inert atmosphere 1.2: 4 h / 70 °C 2.1: potassium carbonate / butanone; water / 17.5 h / 0 - 70 °C / Inert atmosphere 2.2: 5 h / 70 °C View Scheme
Multi-step reaction with 3 steps 1.1: sodium carbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2.1: toluene / 1.5 h / Reflux 3.1: potassium carbonate / butanone; water / 17.5 h / 0 - 70 °C / Inert atmosphere 3.2: 5 h / 70 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme

: 42292-18-2
3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propylamine

: 2,4-bis[(1,1,3,3-tetramethylbutyl)-4’-diylaminobenzamide]-6-{[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl-3-ylamino}-s-triazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; acetone / 1.5 h / 0 - 10 °C / pH 3 - 6.5 2: sodium hydrogencarbonate / toluene / 0.33 h / 115 °C / Microwave irradiation View Scheme

3-Aminopropylbis(trimethylsiloxy)methylsilane Specification

The systematic name of 3-Aminopropylbis(trimethylsiloxy)methylsilane is 3-{1,3,3,3-Tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propan-1-amine. With the CAS registry number 42292-18-2, it is also named as 3-(3-Aminopropyl)heptamethyltrisiloxane. The product's category is Silane Reagents. In addition, its molecular formula is C₁₀H₂₉NO₂Si₃ and its molecular weight is 279.60.

The other characteristics of 3-Aminopropylbis(trimethylsiloxy)methylsilane can be summarized as: (1)ACD/LogP: 3.07; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 5; (8)ACD/KOC (pH 7.4): 10; (9)H bond acceptors: 3; (10)H bond donors: 2; (11)Freely Rotating Bonds: 8; (12)Polar Surface Area: 44.48 Å²; (13)Index of Refraction: 1.428; (14)Molar Refractivity: 81.555 cm³; (15)Molar Volume: 317.215 cm³; (16)Polarizability: 32.331×10^-24cm³; (17)Surface Tension: 20.605 dyne/cm; (18)Density: 0.881 g/cm³; (19)Flash Point: 107.661 °C; (20)Enthalpy of Vaporization: 49.183 kJ/mol; (21)Boiling Point: 254.405 °C at 760 mmHg; (22)Vapour Pressure: 0.017 mmHg at 25 °C.

People can use the following data to convert to the molecule structure.
(1)SMILES:O([Si](C)(C)C)[Si](O[Si](C)(C)C)(CCCN)C
(2)InChI:InChI=1/C10H29NO2Si3/c1-14(2,3)12-16(7,10-8-9-11)13-15(4,5)6/h8-11H2,1-7H3
(3)InChIKey:KWQQHTNSJIJFBO-UHFFFAOYAC
(4)Std. InChI:InChI=1S/C10H29NO2Si3/c1-14(2,3)12-16(7,10-8-9-11)13-15(4,5)6/h8-11H2,1-7H3
(5)Std. InChIKey:KWQQHTNSJIJFBO-UHFFFAOYSA-N

Product Name

3-Aminopropylbis(trimethylsiloxy)methylsilane

Synthetic route

3-Aminopropylbis(trimethylsiloxy)methylsilane Specification

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