Product Name

  • Name

    3-(Trimethoxysilyl)-1-propanamine

  • EINECS 237-511-5
  • CAS No. 13822-56-5
  • Article Data27
  • CAS DataBase
  • Density 0.963 g/cm3
  • Solubility reacts with water
  • Melting Point < -60 °C
  • Formula C6H17NO3Si
  • Boiling Point 204.3 °C at 760 mmHg
  • Molecular Weight 179.291
  • Flash Point 49.1 °C
  • Transport Information UN 2735
  • Appearance colorless transparent liquid
  • Safety 26-45-36/37/39-25
  • Risk Codes 36/38-34
  • Molecular Structure Molecular Structure of 13822-56-5 (3-(Trimethoxysilyl)-1-propanamine)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms 3-aminopropyltr imethoxysilane;Gamma-Aminopropyltrimethoxysilane;Silane coupling Agent KH-551;3-Aminopropyl Trimethoxy Silane;(.gamma.-Aminopropyl)trimethoxysilane//3-Aminopropyltrimethoxysilane(KH-551、KBM-903、A-1110);LS 1420;Propylamine, 3-(trimethoxysilyl)-;KBE 903;1-Propanamine, 3- (trimethoxysilyl)-;Silquest A 1110;KBM 903;Dynasilan AMMO;SC 3900;N-(Trimethoxysilylpropyl)amine;
  • PSA 53.71000
  • LogP 0.91360

Synthetic route

trimethoxysilane
2487-90-3

trimethoxysilane

Triethoxysilane
998-30-1

Triethoxysilane

A

beta-amminopropyl trimethoxy silane
130530-83-5

beta-amminopropyl trimethoxy silane

B

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Conditions
ConditionsYield
A 70%
B n/a
...Expand
trimethoxysilane
2487-90-3

trimethoxysilane

Triethoxysilane
998-30-1

Triethoxysilane

A

beta-aminopropyl triethoxy silane
53218-21-6

beta-aminopropyl triethoxy silane

B

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Conditions
ConditionsYield
A 62%
B n/a
A 62%
B n/a
...Expand
3-Chloropropyltrimethoxysilan
2530-87-2

3-Chloropropyltrimethoxysilan

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Conditions
ConditionsYield
With ammonia
methanol
67-56-1

methanol

C9H23NO4Si
727425-61-8

C9H23NO4Si

A

2-ethoxy-ethanol
110-80-5

2-ethoxy-ethanol

B

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Conditions
ConditionsYield
at 20℃; Kinetics; Equilibrium constant;
...Expand
trimethoxysilane
2487-90-3

trimethoxysilane

1-amino-2-propene
107-11-9

1-amino-2-propene

A

beta-aminoisopropyltrimethoxysilane
50602-95-4

beta-aminoisopropyltrimethoxysilane

B

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Conditions
ConditionsYield
With platinum(0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex at 80℃; for 20h; Catalytic behavior; Schlenk technique; Inert atmosphere; Overall yield = 94.3 %Spectr.; regioselective reaction;
...Expand
glutaric anhydride,
108-55-4

glutaric anhydride,

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C11H23NO6Si

C11H23NO6Si

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 12h;100%
1-Bromonaphthalene
90-11-9

1-Bromonaphthalene

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Methyl 1-naphthylphosphinate
145051-67-8

Methyl 1-naphthylphosphinate

Conditions
ConditionsYield
With anilinium hypophosphorous salt; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In acetonitrile Heating;100%
5-isothiocyanato-1,10-phenanthroline
75618-99-4

5-isothiocyanato-1,10-phenanthroline

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

N-(1,10-phenanthrolin-5-yl)-N'-(3-trimethoxysilylpropyl)thiourea
909109-37-1

N-(1,10-phenanthrolin-5-yl)-N'-(3-trimethoxysilylpropyl)thiourea

Conditions
ConditionsYield
In dichloromethane; pentane at 0℃; for 0.166667h;100%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

1-[(2-oxazepan-1-yl)carbonyl]azepan-2-one
19494-73-6

1-[(2-oxazepan-1-yl)carbonyl]azepan-2-one

A

caprolactam
105-60-2

caprolactam

B

n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam

n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam

Conditions
ConditionsYield
In toluene at 75℃; for 3h;A n/a
B 100%
...Expand
acrylic acid-2-[N-methyl][(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-1-sulfonylamino]-ethyl ester
49859-70-3

acrylic acid-2-[N-methyl][(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-1-sulfonylamino]-ethyl ester

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C35H47F26N3O11S2Si

C35H47F26N3O11S2Si

Conditions
ConditionsYield
at 70℃; for 5h;100%
maleic anhydride
108-31-6

maleic anhydride

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C10H19NO6Si

C10H19NO6Si

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h;99.1%
carbon disulfide
75-15-0

carbon disulfide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C7H16NO3S2Si(1-)*Li(1+)

C7H16NO3S2Si(1-)*Li(1+)

Conditions
ConditionsYield
With lithium hydride In tetrahydrofuran for 2h; Heating;99%
carbon disulfide
75-15-0

carbon disulfide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C7H16NO3S2Si(1-)*K(1+)

C7H16NO3S2Si(1-)*K(1+)

Conditions
ConditionsYield
With potassium hydride In tetrahydrofuran for 2h; Heating;99%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

N-(3-trimethoxysilylpropyl) O-methyl carbamate
23432-62-4

N-(3-trimethoxysilylpropyl) O-methyl carbamate

Conditions
ConditionsYield
With sodium methylate In methanol at 55 - 80℃; for 3.5h; Temperature; Time;99%
With sodium methylate In methanol at 55 - 80℃; for 4h; Large scale;99%
With 8Na(1+)*12C4H10NO(1-)*2HO(1-)*2Nd(3+) In neat (no solvent) at 80℃; for 12h; Inert atmosphere; Schlenk technique; Green chemistry;90%
succinic acid anhydride
108-30-5

succinic acid anhydride

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

4-oxo-4-[3-(trimethoxysilyl)propylamino]butanoic acid
342573-66-4

4-oxo-4-[3-(trimethoxysilyl)propylamino]butanoic acid

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 5℃; for 6h; Inert atmosphere;99%
Inert atmosphere;98%
In tetrahydrofuran at 20℃; for 18h; Inert atmosphere;
Pyridine-2,3-dicarboxylic anhydride
699-98-9

Pyridine-2,3-dicarboxylic anhydride

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C13H20N2O6Si

C13H20N2O6Si

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 5℃; for 5h; Inert atmosphere;99%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

trimellitic Anhydride
552-30-7

trimellitic Anhydride

C15H21NO8Si
1204776-58-8

C15H21NO8Si

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 5℃; for 6h; Inert atmosphere;99%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

urea
57-13-6

urea

3-(trimethoxysilyl)propyl isocyanate
15396-00-6

3-(trimethoxysilyl)propyl isocyanate

Conditions
ConditionsYield
Stage #1: 3-(trimethoxysilyl)propan-1-amine; urea With Trimethyl orthoacetate In dimethyl sulfoxide at 90 - 95℃; for 9h;
Stage #2: With sulfuric acid; copper(II) oxide In dimethyl sulfoxide at 75 - 80℃; for 4.5h; pH=6.5; Concentration; Temperature; pH-value;		98.2%
Stage #1: 3-(trimethoxysilyl)propan-1-amine; urea In methanol at 180℃; under 8250.83 - 10501.1 Torr; for 12.5h;
Stage #2: With tin(ll) chloride at 195℃; under 56.2556 Torr;		92%
ethanol
64-17-5

ethanol

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

sodium hydroxide
1310-73-2

sodium hydroxide

copper dichloride

copper dichloride

A

copper sodium γ-aminopropylsiloxane

copper sodium γ-aminopropylsiloxane

B

sodium chloride
7647-14-5

sodium chloride

Conditions
ConditionsYield
In methanol; water Si-compd. dissoln. in MeOH, aq. soln. of NaOH addn., refluxing (1 h), soln. of Cu-compd. in MeOH addn., refluxing (30 min), MeOH distillation off with simultaneous addn. of EtOH; NaCl filtration off, solvent removing; elem. anal.;A 93%
B 98%
...Expand
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C3H8F4NSi(1-)*H3N*H(1+)

C3H8F4NSi(1-)*H3N*H(1+)

Conditions
ConditionsYield
With ammonium hydrogen difluoride In water at 20℃;98%
[2-(acryloyloxy)ethyl]trimethylammonium bis-(trifluoromethane)sulfonimide
827027-31-6

[2-(acryloyloxy)ethyl]trimethylammonium bis-(trifluoromethane)sulfonimide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

[2-{3-(3-trimethoxysilylpropylamino)propionyloxy}ethyl]-N,N,N-trimethylammonium bistrifluoromethanesulfonimide

[2-{3-(3-trimethoxysilylpropylamino)propionyloxy}ethyl]-N,N,N-trimethylammonium bistrifluoromethanesulfonimide

Conditions
ConditionsYield
In acetonitrile at 20℃; for 5h;97.6%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C30H26N4O5Si2
142721-70-8

C30H26N4O5Si2

C32H48N2O11Si4

C32H48N2O11Si4

Conditions
ConditionsYield
In toluene Heating;97%
carbon disulfide
75-15-0

carbon disulfide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

C7H16NO3S2Si(1-)*Na(1+)

C7H16NO3S2Si(1-)*Na(1+)

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 65℃; Product distribution; Further Variations:; Reagents; Solvents; Temperatures;97%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

Benzoyl isothiocyanate
532-55-8

Benzoyl isothiocyanate

BTU-TMS

BTU-TMS

Conditions
ConditionsYield
In dichloromethane at 5℃; Inert atmosphere;97%
In dichloromethane at 5 - 20℃; Inert atmosphere;97%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

trans-4-(4-Heptylcyclohexyl)benzoesaeurechlorid
81930-19-0

trans-4-(4-Heptylcyclohexyl)benzoesaeurechlorid

C26H45NO4Si

C26H45NO4Si

Conditions
ConditionsYield
With triethylamine In toluene at 5 - 20℃; for 17.5h;97%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

trifluoroacetic acid
76-05-1

trifluoroacetic acid

octakis-(3-aminopropyl)octasilsesquioxane trifluoroacetic acid

octakis-(3-aminopropyl)octasilsesquioxane trifluoroacetic acid

Conditions
ConditionsYield
In water at 20℃; for 2h; Inert atmosphere; Schlenk technique;97%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

bis(trifluoromethanesulfonyl)amide
82113-65-3

bis(trifluoromethanesulfonyl)amide

C24H64N8O12Si8*8C2HF6NO4S2

C24H64N8O12Si8*8C2HF6NO4S2

Conditions
ConditionsYield
In water; dimethyl sulfoxide at 25 - 100℃; for 19h;97%
2-dimethylaminoethyl isothiocyanate
7097-89-4

2-dimethylaminoethyl isothiocyanate

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

1-(2-Dimethylamino-ethyl)-3-(3-trimethoxysilyl-propyl)-thiourea
1065667-58-4

1-(2-Dimethylamino-ethyl)-3-(3-trimethoxysilyl-propyl)-thiourea

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; for 20h; Heating / reflux;96.6%
carbon disulfide
75-15-0

carbon disulfide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

3-(trimethoxysilyl)propyl isothiocyanate

3-(trimethoxysilyl)propyl isothiocyanate

Conditions
ConditionsYield
Stage #1: carbon disulfide; 3-(trimethoxysilyl)propan-1-amine In tetrahydrofuran at 0 - 5℃; for 3h; Addition;
Stage #2: With CYANAMID; triethylamine In tetrahydrofuran at 40℃; for 3h; Elimination;		96%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

3-hydroxy-1,2,3-benzotriazin-4(3H)-one ester of di-isopropylthio-acetic acid
156881-71-9

3-hydroxy-1,2,3-benzotriazin-4(3H)-one ester of di-isopropylthio-acetic acid

C14H31NO4S2Si

C14H31NO4S2Si

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 4h;96%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

5,10,15-tri(4-tert-butylphenyl)-20-[4-(succinimidyloxycarbonyl)phenyl]porphyrin

5,10,15-tri(4-tert-butylphenyl)-20-[4-(succinimidyloxycarbonyl)phenyl]porphyrin

5,10,15-tri(4-tert-butylphenyl)-20-[4-(3-trimethoxysilylpropylaminocarbonyl)phenyl]-porphyrin

5,10,15-tri(4-tert-butylphenyl)-20-[4-(3-trimethoxysilylpropylaminocarbonyl)phenyl]-porphyrin

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Schlenk technique;96%
2-bromoisobutyric acid bromide
20769-85-1

2-bromoisobutyric acid bromide

3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

2-bromo-2-methyl-N-(3-trimethoxysilyl-propyl)-propionamide

2-bromo-2-methyl-N-(3-trimethoxysilyl-propyl)-propionamide

Conditions
ConditionsYield
With triethylamine In dichloromethane for 14h;95.1%
With triethylamine In dichloromethane for 2h; Cooling with ice; Inert atmosphere;
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

p-(iodophenyl)carboxaldehyde
15164-44-0

p-(iodophenyl)carboxaldehyde

4-iodobenzylidene-3-trimethoxylsilanylpropylamine

4-iodobenzylidene-3-trimethoxylsilanylpropylamine

Conditions
ConditionsYield
In methanol for 20h; Heating;95%
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

N-phenyl-N'-[3-(trimethoxysilyl)propyl]thiourea
155159-97-0

N-phenyl-N'-[3-(trimethoxysilyl)propyl]thiourea

Conditions
ConditionsYield
With triethylamine In dichloromethane for 24h;95%
With triethylamine In chloroform at 50℃;
3-(trimethoxysilyl)propan-1-amine
13822-56-5

3-(trimethoxysilyl)propan-1-amine

butyl isothiocyanate
592-82-5

butyl isothiocyanate

N-butyl-N'-[3-(trimethoxysilyl)propyl]thiourea
127455-96-3

N-butyl-N'-[3-(trimethoxysilyl)propyl]thiourea

Conditions
ConditionsYield
With triethylamine In dichloromethane for 24h;95%

3-Aminopropyltrimethoxysilane Chemical Properties

Molecule structure of 3-Aminopropyltrimethoxysilane (CAS NO.13822-56-5):

IUPAC Name: 3-Trimethoxysilylpropan-1-amine
Molecular Formula: C6H17NO3Si
Molecular Weight: 179.29 g/mol 
Density: 0.963 g/cm3 
Melting Point: <-60 °C
Boiling Point: 204.3 °C at 760 mmHg
Flash Point: 49.1 °C
Index of Refraction: 1.422
Molar Refractivity: 47.33 cm3
Molar Volume: 186 cm3
Surface Tension: 25.4 dyne/cm 
Enthalpy of Vaporization: 44.05 kJ/mol 
Vapour Pressure: 0.265 mmHg at 25 °C 
Water Solubility: reacts
Sensitive: moisture sensitive
Stability: stable, but moisture sensitive. incompatible with water, strong acids, strong oxidizing agents. combustible.
H-Bond Donor: 1
H-Bond Acceptor: 4
Rotatable Bond Count: 6
Exact Mass: 179.09777
MonoIsotopic Mass: 179.09777
Topological Polar Surface Area: 53.7
Heavy Atom Count: 11 
Canonical SMILES: CO[Si](CCCN)(OC)OC
InChI: InChI=1S/C6H17NO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-7H2,1-3H3
InChIKey: SJECZPVISLOESU-UHFFFAOYSA-N
EINECS: 237-511-5
Product Categories: Industrial/Fine Chemicals; Amino; Amino Silanes (Silane Coupling Agents); Functional Materials; Si (Classes of Silicon Compounds); Silane Coupling Agents; Si-O Compounds; Trialkoxysilanes; Adhesion Promoters; Amino Silanes; Coupling Agents; Dispersing Agents; Surface Modifiers

3-Aminopropyltrimethoxysilane Uses

 3-Aminopropyltrimethoxysilane (CAS NO.13822-56-5) is widely used in composite materials, coatings, inks, adhesives and sealing materials. It is also used as resin modified additives and enzymes fixative.

3-Aminopropyltrimethoxysilane Safety Profile

Hazard Codes: IrritantXi, CorrosiveC
Risk Statements: 36/38-34 
R36/38:Irritating to eyes and skin. 
R34:Causes burns.
Safety Statements: 26-45-36/37/39-25 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S25:Avoid contact with eyes.
RIDADR: 3267
WGK Germany: 3
F: 1-10
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29310095

3-Aminopropyltrimethoxysilane Specification

 3-Aminopropyltrimethoxysilane (CAS NO.13822-56-5) is also named as (3-Aminopropyl)trimethoxysilane ; (gamma-Aminopropyl)trimethoxysilane ; 1-Propanamine, 3-(trimethoxysilyl)- ; 3-(Trimethoxysilyl)-1-propanamine ; 3-(Trimethoxysilyl)propylamine ; KBE 903 ; N-(Trimethoxysilylpropyl)amine ; NSC 83845 ; Propylamine, 3-(trimethoxysilyl)- ; SC 3900 ; Silane SC 3900 . 3-Aminopropyltrimethoxysilane (CAS NO.13822-56-5) is colorless transparent liquid.

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