3-Hydroxy-2-methyl-4-pyrone supplier

Name
3-Hydroxy-2-methyl-4H-pyran-4-one
EINECS 204-271-8
CAS No. 118-71-8
Article Data49
CAS DataBase
Density 1.348 g/cm³
Solubility 1.2 g/100 mL (25 °C) in water
Melting Point 160-164 °C(lit.)
Formula C₆H₆O₃
Boiling Point 284.7 °C at 760 mmHg
Molecular Weight 126.112
Flash Point 127.32 °C
Transport Information
Appearance white crystalline powder
Safety 26-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 4H-Pyran-4-one,3-hydroxy-2-methyl-;2-Methyl-3-hydroxy-4-pyranone;2-Methyl-3-hydroxy-4-pyrone;2-Methyl-3-hydroxypyran-4-one;2-Methyl-3-hydroxypyrone;3-Hydroxy-2-methyl-1,4-pyrone;3-Hydroxy-2-methyl-4-pyranone;3-Hydroxy-2-methyl-4H-pyran-4-one;3-Hydroxy-2-methyl-g-pyrone;E 636;Larixic acid;Larixin (plant growth regulator);Larixinic acid;NSC 2829;NSC 404458;Palatone;Veltol;3-Hydroxy-2-methyl-4H-pyran-4-on;Maltol;
PSA 50.44000
LogP 0.65380

Synthetic route

: methyl maltol barium

A: 118-71-8
Maltol

B: barium sulfate

Conditions

Conditions	Yield
With sodium sulfate In water at 26℃; for 3h; Temperature; Time; Concentration;	A 88.5% B 99.8%

: 1198597-46-4
C15H26O3Si

: 118-71-8
Maltol

Conditions

Conditions	Yield
With potassium acetate In water; N,N-dimethyl-formamide at 25℃; for 20h;	92%

: 152547-41-6
3-((tert-butyldimethylsilyl)oxy)-2-methyl-4H-pyran-4-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With lithium acetate In water; N,N-dimethyl-formamide at 25℃; for 8h; Inert atmosphere;	90%

: C6H8O4

: 118-71-8
Maltol

Conditions

Conditions	Yield
With sodium hydroxide In water at -5 - 30℃; pH=2 - 3;	80.5%

: 4208-64-4
1-(2-furyl)ethanol

: 118-71-8
Maltol

Conditions

Conditions	Yield
With tert-butylhypochlorite In acetic acid 1.) 25 deg C, 2 h, 2.) 90 deg C, 4 h;	75%
With chlorine In methanol; water 1.) -5 deg C; 2.) 90-95 deg C, 3.5 h;	71%
With chlorine In methanol; water at 90 - 95℃; for 3.5h; Rearrangement;	71%

: 63493-69-6
4,6-dimethoxy-2-methyl-2H-pyran-3(6H)-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With sulfuric acid at 25℃; for 0.333333h;	74%

: 67171-01-1
2-(1-hydroxyethyl)-2,3,5-trimethoxy-2,5-dihydrofuran

: 118-71-8
Maltol

Conditions

Conditions	Yield
With sulfuric acid at 25℃; for 4h;	67%
In sulfuric acid	67%
Multi-step reaction with 2 steps 1: 77 percent / formic acid / methanol / 0.17 h / 20 °C 2: 74 percent / 2M aq. H2SO4 / 0.33 h / 25 °C View Scheme

: 72690-06-3
trans-4-chloro-6-methoxy-2-methyl-2H-pyran-3(6H)-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With acetic acid for 1.5h; Heating;	66%

: 66212-70-2
4-chloro-6-methoxy-2-methyl-2H-pyran-3(6H)-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With acetic acid	65%

: 41728-10-3
6-methoxy-2-methyl-2H-pyran-3(6H)-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With chlorine In acetic acid 1.) 10 deg C, 30 min; 2.) reflux 1.5 h;	56%
With sodium hydroxide; chlorine In water; acetic acid	56%
Multi-step reaction with 2 steps 1: Cl2, triethylamine / CH2Cl2 / 1.) -10 deg C, 30 min; 2.) 10 deg C, 25 min 2: 66 percent / acetic acid / 1.5 h / Heating View Scheme

: 4208-64-4
1-(2-furyl)ethanol

A: 118-71-8
Maltol

B potassium bromide: potassium bromide

Conditions

Conditions	Yield
With sodium bromide; chlorine In tetrahydrofuran; water	A 55% B n/a

: 66187-06-2
4-bromo-6-hydroxy-2-methyl-2H-pyran-3(6H)-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
In phosphoric acid	34%

: 60546-72-7
6-ethoxy-4,5-epoxy-3-oxo-2-methyltetrahydropyran

: 118-71-8
Maltol

Conditions

Conditions	Yield
In water	9.5%

: 2592-53-2
methyl 6-deoxy-2,3-O-isopropylidene-α-L-lyxo-hexopyranoside-4-ulose

: 118-71-8
Maltol

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 1h; Ambient temperature;	60 mg

: 20847-13-6
3-(β-D-glucopyranosyloxy)-2-methyl-4H-pyran-4-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With hydrogenchloride	6 mg
With almond β-glucosidase at 37℃; for 1h; pH=7.5; aq. buffer; Enzymatic reaction;

: 20847-13-6
3-(β-D-glucopyranosyloxy)-2-methyl-4H-pyran-4-one

A: 118-71-8
Maltol

B: 50-99-7
D-glucose

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Heating;

: 553664-53-2
soyasaponin βg

A: 118-71-8
Maltol

B: 51330-27-9
soyasaponin I

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 4℃;	A 4.4 mg B 57.4 mg

: 95263-68-6
4-(α-D-glocopyranosyloxy)-2-hydroxy-2-methyl-2H-pyran-3(6H)-one

A: 118-71-8
Maltol

B: 492-61-5
β-D-glucose

Conditions

Conditions	Yield
enzymic hydrolysis;

: 87251-66-9
1-(N-L-triptophanyl)-1-deoxy-D-fructose

A: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

B: 118-71-8
Maltol

C: 3420-59-5
isomaltol

D: 244-76-8
α-carboline

E: 73-22-3
L-Tryptophan

Conditions

Conditions	Yield
In water at 95℃; under 750.06 - 450036 Torr; Rate constant; Product distribution; various pressure; ΔV*;

...Expand

: 16752-71-9
thymidine diphosphate 4-keto-6-deoxy-α-D-glucose

: 118-71-8
Maltol

Conditions

Conditions	Yield
With potassium phosphate buffer for 0.333333h; pH=3.6; Decomposition;

cellulose: cellulose

A: 118-71-8
Maltol

B: 80-71-7
2-hydroxy-3-methylcyclopent-2-en-1-one

C: 498-07-7
levoglucosan

Conditions

Conditions	Yield
With air at 400 - 450℃; Oxidation; Formation of xenobiotics;

...Expand

Eucalyptus grandis wood: Eucalyptus grandis wood

: 118-71-8
Maltol

Conditions

Conditions	Yield
Decomposition; Formation of xenobiotics; pyrolysis;

: trichloro-acetic acid 2-methyl-4-oxo-4H-pyran-3-yl ester

: 118-71-8
Maltol

Conditions

Conditions	Yield
With lithium perchlorate; potassium carbonate In acetonitrile for 1.5h; Electrolysis; Hg cathode, Pt anode, -1.0 V (vs SCE);

: 3420-58-4
isomaltol O-methyl ether

: 118-71-8
Maltol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 75 percent / NaHCO3, Br2 / methanol / 1.) -30 deg C; 2.) room temp., 2 h 2: 100 percent / NaBH4 / methanol / 15 - 25 °C 3: 67 percent / H2SO4 / 4 h / 25 °C View Scheme
Multi-step reaction with 4 steps 1: 75 percent / NaHCO3, Br2 / methanol / 1.) -30 deg C; 2.) room temp., 2 h 2: 100 percent / NaBH4 / methanol / 15 - 25 °C 3: 77 percent / formic acid / methanol / 0.17 h / 20 °C 4: 74 percent / 2M aq. H2SO4 / 0.33 h / 25 °C View Scheme

: 67171-02-2
2-acetyl-2,3,5-trimethoxy-2,5-dihydrofuran

: 118-71-8
Maltol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / NaBH4 / methanol / 15 - 25 °C 2: 67 percent / H2SO4 / 4 h / 25 °C View Scheme
Multi-step reaction with 3 steps 1: 100 percent / NaBH4 / methanol / 15 - 25 °C 2: 77 percent / formic acid / methanol / 0.17 h / 20 °C 3: 74 percent / 2M aq. H2SO4 / 0.33 h / 25 °C View Scheme

: 71280-24-5
2-methoxy-3,4-dichloro-6-methyl tetrahydropyran-5-one

: 118-71-8
Maltol

Conditions

Conditions	Yield
With sodium hydroxide In sulfuric acid

: 98-00-0
(2-furyl)methyl alcohol

: 118-71-8
Maltol

Conditions

Conditions	Yield
In tetrahydrofuran; BrCl; water

: 4208-64-4
1-(2-furyl)ethanol

A: 118-71-8
Maltol

B 3-hydroxy-2-methyl-γ -pyrone (maltol): 3-hydroxy-2-methyl-γ -pyrone (maltol)

Conditions

Conditions	Yield
In tetrahydrofuran; water; chlorine

: 2-(1-hydroxyethyl)-3-methoxy furan

: 118-71-8
Maltol

Conditions

Conditions	Yield
With chlorine In methanol; water

: 118-71-8
Maltol

: 100-39-0
benzyl bromide

: 61049-69-2
3-O-benzylmaltol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1.25h; Inert atmosphere;	100%
Stage #1: Maltol; benzyl bromide In N,N-dimethyl-formamide at 80℃; for 0.25h; Stage #2: With potassium carbonate In N,N-dimethyl-formamide for 1h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	100%

: 118-71-8
Maltol

: 100-44-7
benzyl chloride

: 61049-69-2
3-O-benzylmaltol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 5h; Reflux;	99.4%
With potassium carbonate In methanol for 1h; Reflux;	98%
With sodium hydroxide In methanol Heating / reflux;	95%

: 118-71-8
Maltol

: 74-88-4
methyl iodide

: 4780-14-7
3-methoxy-2-methyl-4-pyrone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 3h; Reflux;	99.4%
With potassium carbonate In acetone for 6h; Reflux;	99%
With potassium carbonate In acetone for 3h; Reflux;	99.4%

: 118-71-8
Maltol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 152547-41-6
3-((tert-butyldimethylsilyl)oxy)-2-methyl-4H-pyran-4-one

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0℃; Inert atmosphere;	99%
With 1H-imidazole In dichloromethane at 23℃; for 2h; Inert atmosphere;	99%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	98%

: 118-71-8
Maltol

: [ReOCl3(PPh3)2]

: [ReOCl2(3-hydroxy-2-methyl-4H-pyran-4-one(1-))(PPh3)]

Conditions

Conditions	Yield
In dichloromethane suspn. Ru colmplex and maltol in CH2Cl2 was refluxed for 4 h; soln. was kept at -15°C for 7 days, ppt. was filtered off, washedwith n-hexane and dried in vacuo; elem. anal.;	99%

: 118-71-8
Maltol

: 58479-61-1
tert-butylchlorodiphenylsilane

: C22H24O3Si

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 23℃; for 1.5h; Inert atmosphere;	99%

: 118-71-8
Maltol

: 824-94-2
p-methoxybenzyl chloride

: 3-((4-methoxybenzyl)oxy)-2-methyl-4H-pyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux;	99%
With potassium carbonate In acetone for 6h; Reflux;	97%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 5h;	65%

: 118-71-8
Maltol

: 2746-25-0
p-Methoxybenzyl bromide

: 3-((4-methoxybenzyl)oxy)-2-methyl-4H-pyran-4-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 6h; Reflux;	99%

: 118-71-8
Maltol

: 108-24-7
acetic anhydride

: 28787-36-2
2-methyl-4-oxo-4H-pyran-3-yl acetate

Conditions

Conditions	Yield
at 90℃; for 6h;	98%
With acetic acid at 80℃; for 18h; Inert atmosphere;	84%
With sodium acetate In chloroform at 125℃; under 2250.2 Torr; for 0.25h; Irradiation;	75%
at 80℃; for 6h;

: 118-71-8
Maltol

: [(hydrotris(3,5-phenylmethylpyrazolyl)borato)CoCl]

: [(hydrotris(3,5-phenylmethylpyrazolyl)borato)Co(maltolato)]

Conditions

Conditions	Yield
With (C2H5)3N In methanol; dichloromethane (C2H5)3N added to a soln. of Co complex, a soln. of ligand in MeOH added, stirred at room temp. under N2; evapd. (vac.), dissolved in C6H6, filtered, crystd. by diffusion of the soln. with pentane; elem. anal.;	98%

: 118-71-8
Maltol

: 5588-84-1
vanadium(V) oxytriisopropoxide

: 117624-61-0, 891865-72-8
(malt)2V(V)(O)(O(i)Pr)

Conditions

Conditions	Yield
In acetonitrile at -20 - 20℃;	98%

: 118-71-8
Maltol

: 75-36-5
acetyl chloride

: 28787-36-2
2-methyl-4-oxo-4H-pyran-3-yl acetate

Conditions

Conditions	Yield
In ethanol at 100℃; for 6h; Temperature;	97.02%

: 118-71-8
Maltol

: silver nitrate

: 620591-69-7
silver(I) 3-hydroxy-2-methyl-γ-pyranoate

Conditions

Conditions	Yield
With triethylamine In ethanol; triethylamine; acetonitrile byproducts: NEt3*HNO3; a soln. of γ-pyranone in Et3N and EtOH were added dropwise under N2 to a soln. of AgNO3 in MeCN-EtOH in the dark at 25°C, the mixt.was stirred for 2 h; filtd., ppt. was washed with cold EtOH, filtrate evapd. under vac.; elem. anal.;	97%

: 118-71-8
Maltol

: 144-62-7
oxalic acid

: 3-hydroxy-2-methyl-4-pyrone/oxalic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	97%

: 118-71-8
Maltol

: 69-72-7
salicylic acid

: 1325228-62-3
3-hydroxy-2-methyl-4-pyrone/salicylic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	97%

: 118-71-8
Maltol

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: C13H12O6S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.166667h;	97%

: 118-71-8
Maltol

: 18703-07-6, 74741-94-9, 162117-95-5
oxotribromobis(triphenylphosphine)rhenium(V)

: [ReOBr2(3-hydroxy-2-methyl-4H-pyran-4-one(1-))(PPh3)]

Conditions

Conditions	Yield
In dichloromethane suspn. Ru colmplex and maltol in CH2Cl2 was refluxed for 4 h; soln. was kept at -15°C for 7 days, ppt. was filtered off, washedwith n-hexane and dried in vacuo; elem. anal.;	96%

: 118-71-8
Maltol

: 617-48-1
malic acid

: 3-hydroxy-2-methyl-4-pyrone/malic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	96%

: 118-71-8
Maltol

: 98-11-3
benzenesulfonic acid

: 3,4-dihydroxy-2-methylpyrylium benzenesulfonate

Conditions

Conditions	Yield
In methanol for 1h; Reflux;	96%

: 118-71-8
Maltol

: 17184-19-9
3-hydroxy-2-methylpyrid-4-one

Conditions

Conditions	Yield
Stage #1: Maltol With ammonium hydroxide at 40℃; for 2h; Stage #2: With ammonium carbonate at 40℃; for 10h; Reagent/catalyst; Temperature; Reflux;	95.7%
With ammonia In water for 10h; Reflux;	85%
With ammonia In water for 10h; Reflux;	79%

: 118-71-8
Maltol

: 61049-69-2
3-O-benzylmaltol

Conditions

Conditions	Yield
by a literature procedure;	95%

: 118-71-8
Maltol

: ferric trimaltol

Conditions

Conditions	Yield
Stage #1: Maltol With sodium hydroxide In water pH=11.6 - 13.5; Stage #2: With iron(III) chloride In water pH=7.1; Product distribution / selectivity;	95%
With ferric citrate; sodium carbonate In water at 20℃; pH=~ 9 - 11.6; Product distribution / selectivity;
With iron(II) gluconate; potassium hydroxide In water at 20℃; pH=~ 9 - 11.6; Product distribution / selectivity; Heating / reflux;
With sodium hydroxide; sodium iron(II) citrate In water Product distribution / selectivity;
With sodium hydroxide; sodium ferric citrate In water at 20℃; pH=~ 9 - 11.6; Product distribution / selectivity;

: 118-71-8
Maltol

: 7440-31-5
tin

: 130294-04-1
bis(3-hydroxy-2-methyl-4-pyronato)tin(II)

Conditions

Conditions	Yield
In toluene; acetonitrile Electrolysis; electrochemical oxidation of Sn (anode metal) in a CH3CN:toluene (1:1) soln. containing Et4NClO4 of 3-hydroxy-2-methyl-4-pyrone over a period of 1-2 h under N2; filtn., reducing of volume of soln., cooling, drying in vac., washing of yellow solid (EtOH), elem. anal.;	95%

: 118-71-8
Maltol

: 849585-22-4
LACTIC ACID

: 1325228-66-7
3-hydroxy-2-methyl-4-pyrone/lactic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	95%

: 118-71-8
Maltol

: 333-27-7
methyl trifluoromethanesulfonate

: 3-hydroxy-4-methoxy-2-methylpyrylium trifluoromethanesulfonate

Conditions

Conditions	Yield
In dichloromethane for 4h; Reflux; Inert atmosphere;	95%
In dichloromethane for 4h; Reflux;	54%

: 118-71-8
Maltol

: 107-30-2
chloromethyl methyl ether

: 181647-78-9
3-Methoxymethoxy-2-methyl-pyran-4-one

Conditions

Conditions	Yield
With diisopropylamine Ambient temperature;	94%

: 118-71-8
Maltol

: 3840-30-0
5-(chloromethyl)-1,2,3-trimethoxybenzene

: 2-methyl-3-(3,4,5-trimethoxy-benzyloxy)-pyran-4-one

Conditions

Conditions	Yield
tetra(n-butyl)ammonium hydroxide In dichloromethane; water Etherification; Heating;	94%
Stage #1: Maltol With tetra(n-butyl)ammonium hydroxide In water at 20℃; for 1h; Stage #2: 5-(chloromethyl)-1,2,3-trimethoxybenzene In dichloromethane for 24h; Heating;

: 118-71-8
Maltol

: 75-75-2
methanesulfonic acid

: 3,4-dihydroxy-2-methylpyrylium methanesulfonate

Conditions

Conditions	Yield
In methanol for 1h; Reflux;	94%

: 118-71-8
Maltol

: 79-14-1
glycolic Acid

: 3-hydroxy-2-methyl-4-pyrone/glycolic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	93%

3-Hydroxy-2-methyl-4-pyrone Specification

The 3-Hydroxy-2-methyl-4-pyrone, with the CAS registry number 118-71-8 and EINECS registry number 204-271-8, has the systematic name of 3-hydroxy-2-methyl-4H-pyran-4-one. It is a kind of White crystalline powder with a fragrant caramel-butterscotch odor, and belongs to following the proudct categories: Food & Feed Additives; Heterocycles; Food & Flavor Additives. It can be found in the bark of larch tree, in pine needles, and in roasted malt and so on.isolated from Passiflora incarnata; possesses depressant properties in mice; potentiates hexobarbital-induced narcosis & inhibits spontaneous motor activity. It is soluble in hot water, chloroform, and other polar solvents. And the molecular formula of this chemical is C₆H₆O₃.

The physical properties of 3-Hydroxy-2-methyl-4-pyrone are as followings:
(1)ACD/LogP: 0.07; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.07; (4)ACD/LogD (pH 7.4): 0.029; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 25.982; (8)ACD/KOC (pH 7.4): 23.677; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 46.53 Å²; (13)Index of Refraction: 1.561; (14)Molar Refractivity: 30.292 cm³; (15)Molar Volume: 93.546 cm³; (16)Polarizability: 12.009×10^-24cm³; (17)Surface Tension: 51.792 dyne/cm; (18)Density: 1.348 g/cm³; (19)Flash Point: 127.32 °C; (20)Enthalpy of Vaporization: 60.778 kJ/mol; (21)Boiling Point: 284.7 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation of 3-Hydroxy-2-methyl-4-pyrone:
(1) It can be extracted from natural products, because it is a naturally occurring organic compound; (2)It can be prepared by pyromucic aldehyde; (3)Semi-synthesis: It can be prepared by kojic acid, and after a series of oxidation, decarboxylation, formaldehyde reaction, reduction, distillation and recrystallization, you can get the product.

Uses of 3-Hydroxy-2-methyl-4-pyrone:
It is a fragrance molecule used in flavor enhancers and fragrances.usually used as a flavor enhancer. It is also used to impart a sweet aroma to fragrances because of its odor of cotton candy and caramel.

Safety Information of 3-Hydroxy-2-methyl-4-pyrone:
You should be cautious while dealing with 3-Hydroxy-2-methyl-4-pyrone. It irritates to eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Cc1c(c(=O)cco1)O;
(2)InChI: InChI=1/C6H6O3/c1-4-6(8)5(7)2-3-9-4/h2-3,8H,1H3;
(3)InChIKey: XPCTZQVDEJYUGT-UHFFFAOYAH.

The toxicity data of 3-Hydroxy-2-methyl-4-pyrone is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
chicken	LD50	oral	3720mg/kg (3720mg/kg)	Toxicology and Applied Pharmacology. Vol. 15, Pg. 604, 1969.
guinea pig	LD50	oral	1410mg/kg (1410mg/kg)	Dow Chemical Company Reports. Vol. -, Pg. -, 1967.
mouse	LD16	intraperitoneal	1400mg/kg (1400mg/kg)	Russian Pharmacology and Toxicology Vol. 38, Pg. 213, 1975.
mouse	LD50	oral	550mg/kg (550mg/kg)	FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 56, 1967.
mouse	LD50	subcutaneous	820mg/kg (820mg/kg)	Chemical and Pharmaceutical Bulletin. Vol. 22, Pg. 1008, 1974.
rabbit	LD	skin	> 5gm/kg (5000mg/kg)	Food and Cosmetics Toxicology. Vol. 13, Pg. 841, 1975.
rabbit	LD50	oral	1620mg/kg (1620mg/kg)	Dow Chemical Company Reports. Vol. -, Pg. -, 1967.
rat	LD50	oral	1410mg/kg (1410mg/kg)	FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 56, 1967.

Product Name

3-Hydroxy-2-methyl-4H-pyran-4-one

Synthetic route

3-Hydroxy-2-methyl-4-pyrone Specification

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