3-METHYL-2-PYRAZOLIN-5-ONE supplier

Name
3-Methyl-2-pyrazolin-5-one
EINECS 203-565-3
CAS No. 108-26-9
Article Data114
CAS DataBase
Density 1.33 g/cm³
Solubility Ethanol: slightly soluble
Melting Point 220-224 ºC
Formula C4H6 N2 O
Boiling Point 309.7oC at 760 mmHg
Molecular Weight 98.1044
Flash Point 141.1oC
Transport Information
Appearance pale white crystal powder
Safety Moderately toxic by unspecified route. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms 2-Pyrazolin-5-one,3-methyl- (6CI,7CI,8CI); 2,4-Dihydro-5-methyl-3H-pyrazol-3-one;3-Methyl-1H-4,5-dihydropyrazol-5-one; 3-Methyl-2-pyrazolin-5-one;3-Methyl-5-oxo-2-pyrazoline; 3-Methyl-D2-pyrazol-5-one
PSA 41.46000
LogP -0.35340

Synthetic route

: 141-97-9
ethyl acetoacetate

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With hydrazine In tetrahydrofuran; ethanol at 0 - 60℃; for 26h; Inert atmosphere;	100%
With hydrazine hydrate at 20℃; for 0.0333333h; Knorr Pyrazole Synthesis;	100%
With hydrazine for 0.00833333h;	94%

: hydrazine hydrate

: 141-97-9
ethyl acetoacetate

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With barium(II) hydroxide In water at 26℃; for 0.75h; Green chemistry;	100%

: 105-45-3
acetoacetic acid methyl ester

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With hydrazine hydrate In methanol at 50℃; for 3h; Temperature; Inert atmosphere;	97.3%
With hydrazine In ethanol

: 27991-08-8
N-acetoacetylphenylhydroxyloamine

A: 4329-75-3
N,N'-bis(isonicotinoyl)hydrazine

B: 100-65-2
N-Phenylhydroxylamine

C: 108-26-9
3-methyl-2-pyrazoline-5-one

D: 495-48-7
azoxybenzene

Conditions

Conditions	Yield
With isoniazid; triethylamine In chloroform for 24h; Heating; Further byproducts given;	A 39.5% B 32.7% C 90% D 22%

...Expand

: 27991-08-8
N-acetoacetylphenylhydroxyloamine

: 54-85-3
isoniazid

A: 4329-75-3
N,N'-bis(isonicotinoyl)hydrazine

B: 100-65-2
N-Phenylhydroxylamine

C: 143997-57-3
N-hydroxy-N-phenylisonicotinamide

D: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
triethylamine In chloroform for 24h; Heating; Further byproducts given;	A 39.5% B 32.7% C 23% D 90%

...Expand

: 54-85-3
isoniazid

A: 4329-75-3
N,N'-bis(isonicotinoyl)hydrazine

B: 100-65-2
N-Phenylhydroxylamine

C: 143997-57-3
N-hydroxy-N-phenylisonicotinamide

D: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With N,O-diacetylphenylhydroxylamine; triethylamine In chloroform for 24h; Heating; Further byproducts given;	A 39.5% B 32.7% C 23% D 90%

...Expand

: 141-97-9
ethyl acetoacetate

N2H4*H2O: N2H4*H2O

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In ethanol Condensation; Cyclization;	87%

: 116206-94-1
ethyl 2-acetyl-4,4,5,5,6,6,7,7,7-nonafluoro-3-oxoheptanoate

: 100-63-0
phenylhydrazine

A: 77146-67-9
2,2,3,3,4,4,5,5,5-Nonafluoro-pentanoic acid N'-phenyl-hydrazide

B: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In diethyl ether at -30 - -25℃; for 1h;	A 84% B n/a

...Expand

: 115479-07-7
2-Acetyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-3-oxo-nonanoic acid ethyl ester

: 100-63-0
phenylhydrazine

A: 77146-68-0
2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptanoic acid N'-phenyl-hydrazide

B: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In diethyl ether at -30 - -25℃; for 1h;	A 79% B n/a

...Expand

: 141-97-9
ethyl acetoacetate

: 269727-55-1
N-d-pseudoephedrinylacetic acid hydrazide

A: 108-26-9
3-methyl-2-pyrazoline-5-one

B: 206256-43-1
(5S,6S)-4,5-dimethyl-6-phenyl-2-morpholone

Conditions

Conditions	Yield
In isopropyl alcohol for 10h; Condensation; cyclization; elimination; Heating;	A n/a B 68%

...Expand

: 100-63-0
phenylhydrazine

: 603-69-0
ethyl 2-acetylacetoacetate

A: 108-26-9
3-methyl-2-pyrazoline-5-one

B: 114-83-0
1-acetyl-2-phenylhydrazine

Conditions

Conditions	Yield
In diethyl ether at -30 - -25℃;	A n/a B 64%

...Expand

: 141-97-9
ethyl acetoacetate

: 269727-54-0
N-l-ephedrinylacetic acid hydrazide

A: 130753-28-5
(5S,6R)-4,5-dimethyl-6-phenylmorpholin-2-one

B: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In isopropyl alcohol for 10h; Condensation; cyclization; elimination; Heating;	A 62% B n/a

...Expand

resin-OCOCH2COMe: resin-OCOCH2COMe

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With hydrazine In dichloromethane at 20℃; for 19h;	50%

: 115479-07-7
2-Acetyl-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-3-oxo-nonanoic acid ethyl ester

: 100-63-0
phenylhydrazine

A: 77146-68-0
2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptanoic acid N'-phenyl-hydrazide

B: 119403-56-4
5-Methyl-1-phenyl-3-tridecafluorohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

C: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In ethanol at -30 - -25℃; for 1h;	A n/a B 27% C n/a

...Expand

: 896109-93-6
ethyl 2-(1-adamantylcarbonyl)-3-oxobutanoate

A: 496938-13-7
3-(1-adamantyl)-4,5-dihydro-1H-pyrazol-5-one

B: 17846-15-0
adamantane-1-carbohydrazide

C: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol Cooling;	A 25% B 24% C 11%

...Expand

: 116206-94-1
ethyl 2-acetyl-4,4,5,5,6,6,7,7,7-nonafluoro-3-oxoheptanoate

: 100-63-0
phenylhydrazine

A: 77146-67-9
2,2,3,3,4,4,5,5,5-Nonafluoro-pentanoic acid N'-phenyl-hydrazide

B: 119403-55-3
5-Methyl-3-nonafluorobutyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

C: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In ethanol at -30 - -25℃; for 1h;	A n/a B 14% C n/a

...Expand

: 89179-80-6
3-methyl-5-oxo-3-pyrazolin-1-carboxamide

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 5204-15-9
ethyl 3-(acetyl hydrazono)butanoate

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
geht allmaehlich in 3-Methyl-pyrazolon-(5) ueber;

: 5982-65-0
N-carboxiamino-hidrazona del acetilacetato de etilo

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
at 120℃;

: 3075-23-8
S-ethyl acetothioacetate

A: 4344-87-0
1,2-dihydro-5-methyl-3H-pyrazol-3-one

B: 78024-98-3
5-Hydroxy-5-methyl-pyrazolidin-3-one

C: 108-26-9
3-methyl-2-pyrazoline-5-one

D: 75-08-1
ethanethiol

Conditions

Conditions	Yield
With hydrazine In methanol; water at 30℃; not separated;
With hydrazine In methanol; water at 30℃; Rate constant; Kinetics; Mechanism;

...Expand

: 160808-62-8
ethyl acetoacetate (Z)-semicarbazone

A: 110-21-4
hydrazodicarboxamide

B: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
In water for 1h; Heating;	A 0.30 g B 0.12 g

: 7664-93-9
sulfuric acid

: 3201-21-6
3-ethoxy-5-methyl-1H-pyrazole

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
at 140 - 150℃;

: 89179-80-6
3-methyl-5-oxo-3-pyrazolin-1-carboxamide

: 7732-18-5
water

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 35290-52-9
2-[amino(thioxo)methyl]-5-methyl-2,3-dihydro-1H-3-pyrazolone

: 7732-18-5
water

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 7732-18-5
water

: 141-97-9
ethyl acetoacetate

: 7803-57-8
hydrazine hydrate

: 108-26-9
3-methyl-2-pyrazoline-5-one

...Expand

: 35290-52-9
2-[amino(thioxo)methyl]-5-methyl-2,3-dihydro-1H-3-pyrazolone

concentrated alcoholic KOH-solution: concentrated alcoholic KOH-solution

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 35290-52-9
2-[amino(thioxo)methyl]-5-methyl-2,3-dihydro-1H-3-pyrazolone

concentrated aqueous KOH-solution: concentrated aqueous KOH-solution

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 64-17-5
ethanol

: 520-45-6
Dehydracetic acid

hydrazine hydrate (2 mol ): hydrazine hydrate (2 mol )

: 108-26-9
3-methyl-2-pyrazoline-5-one

Conditions

Conditions	Yield
at 120℃; im Druckrohr;

...Expand

: 110-89-4
piperidine

: 141-97-9
ethyl acetoacetate

: 937-39-3
2-phenylacetylhydrazine

A: 793-25-9
1,2-di(phenylacetyl)hydrazine

B: 108-26-9
3-methyl-2-pyrazoline-5-one

C 1-phenacetyl-3-methyl-pyrazolone-(5): 1-phenacetyl-3-methyl-pyrazolone-(5)

Conditions

Conditions	Yield
at 20℃;

...Expand

: β-[(3-methyl-pyrazolone-(5)-carbonyl-(1))-amino]-crotonic acid ethyl ester

: 7732-18-5
water

A: 7664-41-7
ammonia

B: 141-97-9
ethyl acetoacetate

C: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

D: 108-26-9
3-methyl-2-pyrazoline-5-one

...Expand

: 2-(4,6-dimethyl-3-cyano-2-pyridinylthio)benzenediazonium nitrate

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 4-[(4',6'-dimethyl-3'-cyano-2'-pyridinylthio)-2-phenylhydrazono]-5-methyl-2,4-dihydropyrazole-3-one

Conditions

Conditions	Yield
Stage #1: 2-(4,6-dimethyl-3-cyano-2-pyridinylthio)benzenediazonium nitrate; 3-methyl-2-pyrazoline-5-one for 0.0833333h; grinding; Stage #2: With trimethylamine at 20℃; under 375.038 Torr; for 12h; Further stages.;	100%

: 70-11-1
α-bromoacetophenone

: 108-26-9
3-methyl-2-pyrazoline-5-one

: (5-methyl-2H-pyrazol-3-yl) (2-oxo-2-phenylethyl) ether

Conditions

Conditions	Yield
Stage #1: α-bromoacetophenone; 3-methyl-2-pyrazoline-5-one at 20℃; for 1h; ball-milling; Stage #2: With sodium carbonate Further stages.;	100%

: 100-52-7
benzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(phenyl)methyl]propanedinitrile

Conditions

Conditions	Yield
In water at 60℃; for 0.25h; Green chemistry;	100%
With ethanol; sodium acetate at 20℃; for 0.5h; Green chemistry;	83%

...Expand

: 3132-99-8
m-bromobenzoic aldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 1032011-01-0
[(3-bromophenyl)(5-hydroxy-3-methyl-1H-pyrazol-4-yl)methyl]malononitrile

Conditions

Conditions	Yield
With ethanol; sodium acetate at 20℃; for 1h; Green chemistry;	99%

...Expand

: 91-56-5
indole-2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Solvent; Green chemistry;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 5-fluoro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 17630-76-1
5-chloroindole 2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 5-chloro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 20780-76-1
5-iodoisatin

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-5-iodoindolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 611-09-6
5-nitroisatin

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-5-nitroindolin-2-one

Conditions

Conditions	Yield
With water at 20℃; Green chemistry;	99%

: 39755-95-8
5-methoxyisatine

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-5-methoxyindolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 169037-23-4
5-trifluoromethoxy-1H-indole-2,3-dione

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-5-(trifluoromethoxy)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-1-methylindolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 723-89-7
1-phenyl-indole-2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-1-phenylindolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 104-88-1
4-chlorobenzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 89607-39-6
6‐amino‐3‐methyl‐ 4‐(4‐chlorophenyl)‐1,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile

Conditions

Conditions	Yield
With MgFeCrO4 In ethanol; water for 0.0833333h; Catalytic behavior; Solvent; Time; Reflux;	98%
With H3PO4/Al2O3 In neat (no solvent) at 100℃; for 0.1h; Reagent/catalyst; Green chemistry;	97%
With C8H19N2(1+)*HO(1-) In ethanol; water for 0.0833333h; Solvent; Microwave irradiation;	95%

...Expand

: 100-52-7
benzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 81000-11-5
6-amino-1,4-dihydro-3-methyl-4-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 1h; Reagent/catalyst; Temperature; Time; Solvent; Green chemistry;	98%
Stage #1: benzaldehyde; malononitrile In ethanol; water at 20℃; for 0.25h; UV-irradiation; Green chemistry; Stage #2: 3-methyl-2-pyrazoline-5-one In ethanol; water at 20℃; for 0.75h; UV-irradiation; Green chemistry;	98%
With H3PO4/Al2O3 In neat (no solvent) at 100℃; for 0.116667h; Catalytic behavior; Reagent/catalyst; Temperature; Green chemistry;	97%

...Expand

: 6363-87-7
1-amino-9,10-dioxo-9,10-dihydro-anthracene-2-carbaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 107124-90-3
1-amino-2-<(3-methyl-5-oxo-2-pyrazolin-4-ylidene)methyl>anthraquinone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 2h; Heating;	98%

: 104-88-1
4-chlorobenzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 4-((5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-chlorophenyl)-methyl)-3-methyl-1H-pyrazol–5–ol

Conditions

Conditions	Yield
With phosphotungstic acid In ethanol for 0.25h; Reagent/catalyst; Temperature; Solvent; Time; Reflux; Green chemistry;	98%
With Santa Barbara Amorphous modified with propylsulfonic acid groups In neat (no solvent) at 120℃; for 0.0666667h; Catalytic behavior; Solvent; Green chemistry;	95%
With sodium dodecyl-sulfate In water for 1h; Heating;	83.7%
In glycerol at 80℃; for 0.05h; Green chemistry;

: 17630-76-1
5-chloroindole 2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 296800-64-1, 713129-95-4
6'‑amino‑3'‑methyl‑2‑oxo‑1'H‑spiro[5‑chloro‑indoline‑3,4'‑pyrano[2,3‑c]pyrazole]‑5'‑carbonitrile

Conditions

Conditions	Yield
With bovine serum albumin In ethanol; water at 20℃; for 0.25h; Enzymatic reaction;	98%
With N-Sulfonic acid modified poly(styrene-co-maleic anhydride) In ethanol for 0.416667h; Reflux; Green chemistry; regioselective reaction;	97%
With potassium carbonate In water at 20℃; for 0.166667h;	87.3%

...Expand

: 18711-13-2
4,7-dichloroisatin

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 4,7-dichloro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	98%

: 104-87-0
4-methyl-benzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 4-((5-hydroxy-3-methyl-1H-pyrazol-4-yl)(p-tolyl)methyl)-3-methyl-1H-pyrazol-5-ol

Conditions

Conditions	Yield
With 1,4-diazabicyclo[2.2.2]octane hydroacetate In water at 80℃; for 0.0833333h; Green chemistry;	98%
With phosphotungstic acid In ethanol for 1h; Reflux; Green chemistry;	96%
With Santa Barbara Amorphous modified with propylsulfonic acid groups In neat (no solvent) at 120℃; Green chemistry;	87%
In glycerol at 80℃; for 0.0333333h; Green chemistry;

: 868-54-2
1,1,3-tricyano-2-amino-1-propene

: 90-02-8
salicylaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 2,4-diamino-5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile

Conditions

Conditions	Yield
With triethylamine In propan-1-ol at 98℃; for 1h; Solvent; Reagent/catalyst;	98%
With triethylamine In propan-1-ol at 98℃; for 1h; Catalytic behavior; Reagent/catalyst; Solvent;	98%

...Expand

: 555-16-8
4-nitrobenzaldehdye

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 89607-34-1
6‐amino‐3‐methyl‐4‐(4‐nitrophenyl)‐1,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile

Conditions

Conditions	Yield
With H3PO4/Al2O3 In neat (no solvent) at 100℃; for 0.0833333h; Reagent/catalyst; Green chemistry;	97%
With piperidine In ethanol at 20℃; for 0.166667h; Green chemistry;	90%
In ethanol; water for 0.333333h; Reflux; Green chemistry;	88%

...Expand

: 555-16-8
4-nitrobenzaldehdye

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 89607-34-1, 879451-69-1
6-amino-2,4-dihydro-4-(4-nitrophenyl)-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With propylamine functionalized nanoporous silica In ethanol at 20℃; for 0.25h; Green chemistry;	97%
With 2-carboxy-N,N-diethylethanaminium acetate In neat (no solvent) at 60℃; for 0.1h;	93%
With 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In ethanol; water for 1h; Reflux;	93%

...Expand

: 104-88-1
4-chlorobenzaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: [(4-chlorophenyl)(5-hydroxy-3-methyl-1H-pyrazol-4-yl)methyl]malononitrile

Conditions

Conditions	Yield
With ethanol; sodium acetate at 20℃; for 1h; Time; Green chemistry;	97%

...Expand

: 874-42-0
2,4-dichlorobenzaldeyhde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 297162-27-7, 671771-00-9
6-amino-3-methyl-4-(2,4-dichlorophenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With H3PO4/Al2O3 In neat (no solvent) at 100℃; for 0.0833333h; Reagent/catalyst; Green chemistry;	97%
Stage #1: 2,4-dichlorobenzaldeyhde; malononitrile With triethylamine In ethanol at 80℃; for 0.0333333h; Stage #2: 3-methyl-2-pyrazoline-5-one In ethanol at 80℃; for 0.25h;	8%
With C8H19N2(1+)*HO(1-) In water for 0.0833333h; Microwave irradiation;
In water at 20℃; for 2.5h; Green chemistry;
With aspirin In neat (no solvent) at 80℃; for 0.666667h; Green chemistry;

...Expand

: 6954-91-2
11H-Indeno[1,2-b]quinoxaline-11-one

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 109-77-3
malononitrile

: 1427302-77-9, 1449513-91-0
3'-amino-7'-methyl-2-oxo-2H,5H'-spiro[(11H)-indeno(1',2'-b)quinoxalin-11,1'-pyrano[2,3-c]pyrazole]-2'-carbonite

Conditions

Conditions	Yield
With triethylamine In ethanol for 1h; Mechanism; Reflux;	97%

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: 1121-60-4
pyridine-2-carbaldehyde

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 4,4'-(pyridin-2-ylmethylene)bis(3-methyl-1H-pyrazol-5-ol)

Conditions

Conditions	Yield
With phosphotungstic acid In ethanol for 1h; Reflux; Green chemistry;	97%

3-METHYL-2-PYRAZOLIN-5-ONE Chemical Properties

The Molecular formula of 3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9): C₄H₆N₂O
The Molecular Weight of 3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9): 98.1
The Molecular Weight of 3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9):

EINECS: 203-565-3
Melting point: 220-224 °C
Index of Refraction: 1.599
Molar Refractivity: 25.2 cm³
Molar Volume: 73.7 cm³
Polarizability: 9.99 10^-24 cm³
Surface Tension: 45.6 dyne/cm
Density: 1.33 g/cm³
Appearance: Yellowish powder
Synonyms: TIMTEC-BB SBB004372;3-Methyl-pyrazolon-(5);52-Pyrazolin-5-one, 3-methyl-;3-METHYL-4,5-DIHYDRO-1H-PYRAZOL-5-ONE;3-METHYL-5-PYRAZOLONE;3-methyl-2-pyrazolin-5-on;-Methyl-2,4-dihydro-3H-pyrazol-3-one;AURORA KA-6219;

3-METHYL-2-PYRAZOLIN-5-ONE Uses

3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9) is used as intermediate for the manufacture of dyestuffs as well as for agrochemicals.

3-METHYL-2-PYRAZOLIN-5-ONE Toxicity Data With Reference

unr-rat LDLo:600 mg/kg

BCPCA6 Biochemical Pharmacology. 14 (1965),1325.

3-METHYL-2-PYRAZOLIN-5-ONE Consensus Reports

Reported in EPA TSCA Inventory.

3-METHYL-2-PYRAZOLIN-5-ONE Safety Profile

Moderately toxic by unspecified route. When heated to decomposition it emits toxic vapors of NO_x.
The Risk Statements information of 3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 3-METHYL-2-PYRAZOLIN-5-ONE(108-26-9):
24/25: Avoid contact with skin and eyes
RTECS: UQ9451500

Product Name

3-Methyl-2-pyrazolin-5-one

Synthetic route

3-METHYL-2-PYRAZOLIN-5-ONE Chemical Properties

3-METHYL-2-PYRAZOLIN-5-ONE Uses

3-METHYL-2-PYRAZOLIN-5-ONE Toxicity Data With Reference

3-METHYL-2-PYRAZOLIN-5-ONE Consensus Reports

3-METHYL-2-PYRAZOLIN-5-ONE Safety Profile

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