3-Phenylglutaric acid supplier

Name
3-Phenylglutaric acid
EINECS 224-016-4
CAS No. 4165-96-2
Article Data54
CAS DataBase
Density 1.2252 (rough estimate)
Solubility
Melting Point 140-143 ºC
Formula C11H12 O4
Boiling Point 379oC
Molecular Weight 208.214
Flash Point 185.3oC
Transport Information
Appearance Tan powder.
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Glutaricacid, 3-phenyl- (6CI,7CI,8CI); 3-Phenylglutaric acid; 3-Phenylpentanedioicacid; b-Phenylglutaric acid
PSA 74.60000
LogP 1.71960

Synthetic route

: 5394-85-4
2-phenyl-propane-1,1,3-tricarboxylic acid triethyl ester

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
In potassium hydroxide for 24h; Heating;	100%

: 496806-21-4
3-methyl-5-[3-(3-methyl-4-nitro-5-isoxazolyl)-2-phenylpropyl]-4-nitroisoxazole

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With potassium permanganate In water; acetone	71%

: 1123-49-5
3,5-dimethyl-4-nitroisoxazole

: 100-52-7
benzaldehyde

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
Stage #1: 3,5-dimethyl-4-nitroisoxazole; benzaldehyde With piperidine In tetrahydrofuran at 70 - 80℃; for 12h; Stage #2: With potassium permanganate In tetrahydrofuran; water; acetone at 20℃; Further stages.;	60%

: 493-72-1
5-phenyl-cyclohexane-1,3-dione

A: 75-25-2
Bromoform

B: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With sodium hypobromide

: 493-72-1
5-phenyl-cyclohexane-1,3-dione

A: 635-51-8, 10424-29-0
2-phenylsuccinic acid

B: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With permanganate(VII) ion

: 4360-47-8
cinnamonitrile

: 996-82-7
sodium diethylmalonate

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
durch Behandeln mit Salzsaeure;

: 996-82-7, 34727-00-9, 73177-21-6
sodium diethylmalonate

: 621-79-4, 22031-64-7
cinnamamide

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
Einw. von siedender Salzsaeure auf die entstehende Verbindung;

: 51367-64-7
3-chloro-5-phenylcyclohex-2-en-1-one

A: 635-51-8, 10424-29-0
2-phenylsuccinic acid

B: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With permanganate(VII) ion

: 78533-73-0
3-phenylglutaronitrile

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With potassium hydroxide

: 17572-39-3
2,4-diethoxycarbonyl-5-hydroxy-5-methyl-3-phenylcyclohexanone

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With potassium hydroxide

: 6768-26-9
2-phenyl-1,1,3,3-tetraethoxycarbonylpropane

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With hydrogen bromide
With hydrogenchloride
With hydrogen bromide

: 6456-84-4
diethyl 2-cyano-3-phenylpentanedioate

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With sulfuric acid

: 87894-68-6
3-phenylpent-2-enedioic acid

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With hydrogen iodide at 150℃; im geschlossenen Rohr;

: 996-82-7, 34727-00-9, 73177-21-6
sodium diethylmalonate

: 2025-40-3
ethyl benzylidenecyanoacetate

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With ethanol Erhitzen des Reaktionsprodukts mit wss. Bromwasserstoffsaeure;

: 32386-46-2
[(Z)-3-Ethoxy-1-((E)-2-ethoxy-2-ethylsulfanyl-vinyl)-3-ethylsulfanyl-allyl]-benzene

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
(acid hydrolysis);

: 106842-97-1
3-phenylpentanedioic acid monoethyl ester

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With sodium hydroxide

: 609-02-9
methyl-malonic acid dimethylester

: 103-26-4
Methyl cinnamate

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
Multistep reaction;

: 13277-74-2
diethyl 2,4‑diacetyl‑3‑phenylpentanedioate

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol Heating;
Stage #1: diethyl 2,4‑diacetyl‑3‑phenylpentanedioate With sodium hydroxide In ethanol for 2h; Reflux; Stage #2: With hydrogenchloride In ethanol; water Cooling with ice;
With potassium hydroxide In water at 80℃; for 2h;	4.89 g
With water; sodium hydroxide In ethanol at 20℃; for 21h; Reflux;

: 4160-80-9
3-phenylglutaric acid anhydride

: 7664-93-9
sulfuric acid

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
at 20℃;

: 7647-01-0
hydrogenchloride

: 102076-28-8
5-oxo-3-phenyl-5-piperidino-valeric acid

: 4165-96-2
3-phenylglutaric acid

: 7647-01-0
hydrogenchloride

: 105812-70-2
2,6-dioxo-4-phenyl-piperidine-3-carboxylic acid ethyl ester

: 4165-96-2
3-phenylglutaric acid

: 7722-84-1
dihydrogen peroxide

: 2057-01-4
2-acetyl-5-phenylcyclohexane-1,3-dione

: 4165-96-2
3-phenylglutaric acid

: 2057-01-4
2-acetyl-5-phenylcyclohexane-1,3-dione

hypobromite: hypobromite

: 4165-96-2
3-phenylglutaric acid

: 7647-01-0
hydrogenchloride

: 2,6-dioxo-1,4-diphenyl-piperidine-3-carboxylic acid ethyl ester

A: 4165-96-2
3-phenylglutaric acid

B: 62-53-3
aniline

...Expand

: 493-72-1
5-phenyl-cyclohexane-1,3-dione

aqueous permanganate: aqueous permanganate

A: 635-51-8, 10424-29-0
2-phenylsuccinic acid

B: 4165-96-2
3-phenylglutaric acid

...Expand

β-phenyl-propane-α.α.γ-tricarboxylic acid triethyl ester: β-phenyl-propane-α.α.γ-tricarboxylic acid triethyl ester

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With alkaline solution erhitzt das durch verd. Salzsaeure ausgeschiedene Oel auf 110-120grad;
With barium dihydroxide erhitzt das durch verd. Salzsaeure ausgeschiedene Oel auf 110-120grad;

2-cyano-3-phenyl-glutaric acid imide: 2-cyano-3-phenyl-glutaric acid imide

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With sulfuric acid

2-phenyl-propane-tetracarboxylic acid-(1.1.3.3)-tetramethyl ester: 2-phenyl-propane-tetracarboxylic acid-(1.1.3.3)-tetramethyl ester

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With alkaline solution Erhitzen des Reaktionsprodukts auf 130grad;

2-phenyl-propane-tricarboxylic acid-(1.1.3)-methyl ester-(1): 2-phenyl-propane-tricarboxylic acid-(1.1.3)-methyl ester-(1)

: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With potassium hydroxide at 100℃; Erhitzen des Reaktionsprodukts auf 170-185grad;

: 64-17-5
ethanol

: 4165-96-2
3-phenylglutaric acid

: 55951-74-1
diethyl 3-phenylpentanedioate

Conditions

Conditions	Yield
With sulfuric acid at 80℃; for 3h;	98%
Stage #1: 3-phenylglutaric acid With thionyl chloride at 80℃; for 1h; Stage #2: ethanol at 80℃; for 0.5h;	91.5%
With sulfuric acid at 80℃; for 3h;	74%

: 4165-96-2
3-phenylglutaric acid

: 4160-80-9
3-phenylglutaric acid anhydride

Conditions

Conditions	Yield
In acetic anhydride for 2h; Heating;	98%
With thionyl chloride for 15h; Heating;	95%
With dicyclohexyl-carbodiimide In dichloromethane at 0℃;	95%

: 4165-96-2
3-phenylglutaric acid

: 20638-52-2
4-phenyltetrahydro-2H-pyran

Conditions

Conditions	Yield
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In toluene at 60℃; for 15h; Inert atmosphere;	98%

: 4165-96-2
3-phenylglutaric acid

: 14149-31-6
4-phenylpiperidine-2,6-dione

Conditions

Conditions	Yield
With urea at 150℃; for 2h;	97%
With ammonia in Schmelze;

: 4165-96-2
3-phenylglutaric acid

: 92289-14-0
3-(4-Nitro-phenyl)-pentanedioic acid

Conditions

Conditions	Yield
Stage #1: 3-phenylglutaric acid With sulfuric acid at 0℃; for 0.333333h; Stage #2: With nitric acid at 20℃; for 3.33333h; Conversion of starting material;	94%

: 4165-96-2
3-phenylglutaric acid

: 829-27-6
3-phenylpentane-1,5-diol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 16h; Reflux; Inert atmosphere;	93%
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 25℃; for 16h; Inert atmosphere;	92%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 16h; Reflux;	90%

: 4165-96-2
3-phenylglutaric acid

: 25173-12-0
2-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetic acid

Conditions

Conditions	Yield
Stage #1: 3-phenylglutaric acid With thionyl chloride for 0.5h; Heating / reflux; Stage #2: With aluminum (III) chloride In nitrobenzene at 80℃; for 1.5h; Friedel Crafts Acylation;	90%
With PPA at 125℃; for 0.166667h;	73%
With sulfuric acid at 100℃;

: 3637-10-3
tempol

: 4165-96-2
3-phenylglutaric acid

: C29H46N2O6

Conditions

Conditions	Yield
Stage #1: tempol; 3-phenylglutaric acid With dmap In dichloromethane for 0.5h; Inert atmosphere; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at -5 - 20℃; for 8h; Inert atmosphere;	86.3%

: 2403-88-5
4-hydroxy-2,2,6,6-tetramethylpiperidine

: 4165-96-2
3-phenylglutaric acid

: C29H46N2O4

Conditions

Conditions	Yield
Stage #1: 4-hydroxy-2,2,6,6-tetramethylpiperidine; 3-phenylglutaric acid With dmap In dichloromethane for 0.5h; Inert atmosphere; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at -5 - 20℃; for 8h; Inert atmosphere;	86.2%

: 4165-96-2
3-phenylglutaric acid

: 57-13-6
urea

: 14149-31-6
4-phenylpiperidine-2,6-dione

Conditions

Conditions	Yield
at 160℃; for 3h;	79%
at 160℃; for 1h;	72%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 4165-96-2
3-phenylglutaric acid

: 1,5-bis(pentafluorophenyl)-3-phenylpentanedioate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In ethyl acetate at 0℃; for 5h;	75%

: 4165-96-2
3-phenylglutaric acid

: 20925-27-3
4-amino-2-chlorobenzonitrile

: 1427185-38-3
5-((3-chloro-4-cyanophenyl)amino)-5-oxo-3-phenylpentanoic acid

Conditions

Conditions	Yield
Stage #1: 3-phenylglutaric acid With acetic anhydride at 100℃; for 14h; Stage #2: 4-amino-2-chlorobenzonitrile With triethylamine In toluene at 80℃; for 3h;	72.9%

: 4165-96-2
3-phenylglutaric acid

: 87453-29-0
(2-fluoro-1-fluoromethyl-ethyl)-benzene

Conditions

Conditions	Yield
With xenon difluoride; hydrogen fluoride In dichloromethane at 22℃; for 12h;	60%
With xenon difluoride; hydrogen fluoride In dichloromethane at 22℃;	60%
With xenon difluoride In dichloromethane for 8h;	60%

: 4165-96-2
3-phenylglutaric acid

: 61198-49-0, 61949-75-5, 71302-21-1, 25547-53-9
4-phenyltetrahydropyran-2-one

Conditions

Conditions	Yield
Stage #1: 3-phenylglutaric acid With trifluoroacetic anhydride In dichloromethane at 0℃; for 2h; Stage #2: With sodium tetrahydroborate In tetrahydrofuran for 24h; Stage #3: With trifluoroacetic acid In dichloromethane for 16h;	60%
Multi-step reaction with 4 steps 1: AcCl / 3 h 2: 91 percent / pyridine / 2 h / Heating 3: potassium tert-butoxide; LiBH4 / tetrahydrofuran / 1 h / Heating 4: p-TsOH / toluene View Scheme
Multi-step reaction with 2 steps 1: 98 percent / acetic anhydride / 2 h / Heating 2: 19 percent / NaBH4 / tetrahydrofuran / 1 h / 0 deg C to rt View Scheme
Multi-step reaction with 2 steps 1: 95 percent / dicyclohexylcarbodiimide / CH2Cl2 / 0 °C 2: 86 percent / NaBH4 / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, 0.5 h View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / Inert atmosphere; Reflux 2: 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); {bis(salicylidene-γ-iminopropyl)methylamine}cobalt(II); 2,6-dimethoxy-p-quinone / chlorobenzene / 24 h / 80 °C View Scheme

: 4165-96-2
3-phenylglutaric acid

: 74-88-4
methyl iodide

: 132015-40-8
3-phenyl-pentanedioic acid monomethyl ester

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 16h;	55%
Stage #1: 3-phenylglutaric acid; methyl iodide With caesium carbonate In N,N-dimethyl-formamide at 0 - 25℃; for 16h; Stage #2: With sodium hydrogencarbonate In water; N,N-dimethyl-formamide pH=~ 9;

: 4165-96-2
3-phenylglutaric acid

: 7732-18-5
water

: 53597-69-6
(1,3,5-triaza-7-phosphaadamantane)

: 20667-12-3
silver(l) oxide

: 2Ag(1+)*C11H10O4(2-)*8H2O*2C6H12N3P

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	50%

...Expand

: 67-56-1
methanol

: 4165-96-2
3-phenylglutaric acid

: 19006-47-4
dimethyl 3-phenylpentanedioate

Conditions

Conditions	Yield
With sulfuric acid
sulfuric acid In toluene for 24h; Ambient temperature;
With sulfuric acid

: 463-51-4
Ketene

: 60-29-7
diethyl ether

: 4165-96-2
3-phenylglutaric acid

: 4160-80-9
3-phenylglutaric acid anhydride

...Expand

: 463-51-4
Ketene

: 4165-96-2
3-phenylglutaric acid

: 4160-80-9
3-phenylglutaric acid anhydride

Conditions

Conditions	Yield
With diethyl ether

: 4165-96-2
3-phenylglutaric acid

: 1141-24-8
3-(4-bromophenyl)pentanedioic acid

Conditions

Conditions	Yield
With bromine

: 4165-96-2
3-phenylglutaric acid

: 216586-10-6
3-phenyl-glutaroyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride
With thionyl chloride for 1h; Heating;

: 4165-96-2
3-phenylglutaric acid

: 55951-74-1
diethyl 3-phenylpentanedioate

Conditions

Conditions	Yield
With tetrachloromethane; ethanol

: 4165-96-2
3-phenylglutaric acid

: 861372-79-4
2-bromo-3-phenyl-glutaric acid dimethyl ester

Conditions

Conditions	Yield
With phosphorus pentachloride; bromine Eingiessen des Reaktionsprodukts in Methanol;

3-Phenylglutaric acid Chemical Properties

Molecular Structure of 3-Phenylglutaric acid (CAS NO.4165-96-2):

Molecular Formula: C₁₁H₁₂O₄
Molecular Weight: 208.2106
IUPAC Name: 3-Phenylpentanedioic acid
Synonyms of 3-Phenylglutaric acid (CAS NO.4165-96-2): 3-Phenylglutaric acid, 98+% ; 3-Phenylglutaricacid,97% ; Benzylsuccinic ; Pentanedioic acid, 3-phenyl-
CAS NO: 4165-96-2
Classification Code: Carboxylic Acid Monomers ; Monomers ; Polymer Science
Melting point: 140-143 °C
Index of Refraction: 1.566
Molar Refractivity: 52.83 cm³
Molar Volume: 161.7 cm³
Surface Tension: 57.5 dyne/cm
Density: 1.287 g/cm3
Flash Point: 185.3 °C
Enthalpy of Vaporization: 63.84 kJ/mol
Boiling Point: 359.4 °C at 760 mmHg
Vapour Pressure: 8.61E-06 mmHg at 25°C

3-Phenylglutaric acid Safety Profile

WGK Germany of 3-Phenylglutaric acid (CAS NO.4165-96-2): 3

Product Name

3-Phenylglutaric acid

Synthetic route

3-Phenylglutaric acid Chemical Properties

3-Phenylglutaric acid Safety Profile

Related Products

Hot Products