CAS No.41661-47-6,4-Piperidinone Suppliers

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 3h;	100%
With trifluoroacetic acid In dichloromethane at 20℃;	100%
With trifluoroacetic acid In dichloromethane
With trifluoroacetic acid In 1,2-dichloro-ethane
With hydrogenchloride In 1,4-dioxane at 20℃; for 4h;	6.5 g

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogen; palladium diacetate; pyrographite In tetrahydrofuran; methanol at 25℃; under 760.051 Torr; for 12h;	99%

: 797751-17-8
4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2h;	97%

: 267666-09-1
1-((2-nitrophenyl)sulfonyl)piperidin-4-one

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With polystyrene-thiophenol; caesium carbonate; triphenylphosphine In tetrahydrofuran at 20℃; for 24h;	94%

: 74-85-1
ethene

: 4138-35-6
methyl 3-aminopropanoate

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Stage #1: ethene; methyl 3-aminopropanoate With sodium ethanolate In ethanol at 5℃; Stage #2: In N,N-dimethyl-formamide at 120℃; for 2h; Concentration; Temperature;	93.7%

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogenchloride In water at 100℃; for 10h;	90.7%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide; palladium on activated charcoal In tetrahydrofuran; water; isopropyl alcohol for 6h;	90%
With palladium on activated charcoal; ammonium formate In methanol for 0.5h; Reflux;	86%
With Pd/C; hydrogen In ethanol

: 50-00-0
formaldehyd

: 67-64-1
acetone

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With ammonia at 60 - 70℃; Green chemistry;	68%

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: 41661-47-6
piperidin-4-one

B: 4-oxo-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Conditions

Conditions	Yield
	A n/a B 38%

: 4-methoxy-1,2,3,6-tetrahydro-pyridine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogenchloride

: 75571-24-3
4-phenoxy-1,2,3,6-tetrahydro-pyridine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogenchloride

: 3518-88-5
3,3'-imino-di-propionic acid diethyl ester

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With sodium; xylene Erhitzen des entstandenen Piperidon-(4)-carbonsaeure-(3)-aethylesters mit Salzsaeure;
Multi-step reaction with 4 steps 1: potassium carbonate / water / 1.5 h / 0 - 20 °C 2: sodium / ethanol; toluene / 48 h / 20 °C / Inert atmosphere 3: hydrogenchloride / water; ethanol / 7 h / 83 - 85 °C 4: hydrogenchloride / water / 10 h / 100 °C View Scheme

: 4451-85-8
1-acetyl-4-oxo-piperidine-3-carboxylic acid ethyl ester

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With hydrogenchloride; water

: 4451-86-9
ethyl 1-benzoyl-4-oxo-3-piperidinecarboxylate

: 41661-47-6
piperidin-4-one

: C5H9(2)H2NO2

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
In water-d2 at 34℃; Equilibrium constant;

: C8H13(2)H2NO3S

A: 41661-47-6
piperidin-4-one

B: 95193-08-1
3-mercaptopropanoic acid-d2

Conditions

Conditions	Yield
With potassium carbonate In water-d2 at 34℃; Equilibrium constant; pH 2.5-3.3;

4-oxy-piperidine: 4-oxy-piperidine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 505-47-5
di(2-carboxyethyl)amine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl 2: sodium; xylene / Erhitzen des entstandenen Piperidon-(4)-carbonsaeure-(3)-aethylesters mit Salzsaeure View Scheme

: 626-61-9
4-Chloropyridine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water / 150 °C 2: sodium; alcohol 3: hydrochloric acid View Scheme

: 620-08-6
4-methoxypyridine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium; alcohol 2: hydrochloric acid View Scheme

: 4783-86-2
4-phenoxypyridine

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium; alcohol 2: hydrochloric acid View Scheme

: 101599-56-8
3,3'-benzoylimino-di-propionic acid diethyl ester

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaH; ethanol; benzene View Scheme

: 854677-97-7
3,3'-acetylimino-di-propionic acid diethyl ester

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium; ethanol; xylene 2: water; hydrochloric acid View Scheme

: 41979-39-9
4-piperidone hydrochloride

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With MP-carbonate resin In dichloromethane at 20℃; for 2h; not specified; Product distribution / selectivity;

: 4644-61-5
ethyl 4-piperidone-3-carboxylate hydrochloride

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With potassium hydroxide

: piperidin-4-one hydrochloride monohydrate

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With magnesium sulfate; sodium hydroxide In dichloromethane

: 5382-16-1
4-HYDROXYPIPERIDINE

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
With oxygen In acetonitrile at 70℃; for 2.5h; Catalytic behavior; chemoselective reaction;	75 %Chromat.

: 83783-66-8
Ethyl N-ethoxycarbonyl-3-(2-ethoxycarbonylethylamino)-propionate

: 41661-47-6
piperidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium / ethanol; toluene / 48 h / 20 °C / Inert atmosphere 2: hydrogenchloride / water; ethanol / 7 h / 83 - 85 °C 3: hydrogenchloride / water / 10 h / 100 °C View Scheme

: 41661-47-6
piperidin-4-one

: 6025-60-1
2-(1H-pyrrol-1-yl)aniline

: 59474-46-3
5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline]

Conditions

Conditions	Yield
With maleic acid In ethanol for 1h; Heating;	100%

: 41661-47-6
piperidin-4-one

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 196085-08-2
1-(4-methoxybenzenesulfonyl)-4-piperidone

Conditions

Conditions	Yield
With pyridine at 20℃; for 18h;	100%

: 41661-47-6
piperidin-4-one

: 74-88-4
methyl iodide

: 142742-59-4
N-methyl-4-piperidone hydroiodide

Conditions

Conditions	Yield
In acetone Ambient temperature;	98%

: 41661-47-6
piperidin-4-one

: 121-33-5
vanillin

: (3E,5E)-3,5-bis-(4-hydroxy-3-methoxybenzylidene)piperidin-4-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h;	98%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;	98%

: 41661-47-6
piperidin-4-one

: 1620-98-0
3,5-di-t-butyl-4-hydroxybenzaldehyde

: 3,5-bis(3,5-di-tert-butyl-4-hydroxybenz-(E)-ylidene)-4-piperidone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h;	98%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;	98%

: 41661-47-6
piperidin-4-one

: 14273-90-6
methyl 6-bromohexanoate

: C12H21NO3

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 36h; Inert atmosphere;	98%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 36h; Inert atmosphere;

: 41661-47-6
piperidin-4-one

: 75-30-9
2-iodo-propane

: 5355-68-0
1-Isopropyl-4-piperidone

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 40℃; for 8h; Temperature; Reagent/catalyst;	97.2%

: 41661-47-6
piperidin-4-one

: 501-53-1
benzyl chloroformate

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

Conditions

Conditions	Yield
Stage #1: piperidin-4-one With sodium hydroxide In water; toluene at 0℃; Cooling; Stage #2: benzyl chloroformate In water; toluene at 20℃; for 2h;	97%
With triethylamine In dichloromethane for 0.5h; Ambient temperature;

: 41661-47-6
piperidin-4-one

: 104-87-0
4-methyl-benzaldehyde

: 1009817-60-0
(3E,5E)-3,5-bis(4-methylbenzylidene)piperidin-4-one

Conditions

Conditions	Yield
With lithium perchlorate; diethylamine at 20℃;	96%

: 41661-47-6
piperidin-4-one

: 123-11-5
4-methoxy-benzaldehyde

: 919091-64-8
(3E,5E)-3,5-bis(4′-methoxybenzylidene)-piperidin-4-one

Conditions

Conditions	Yield
With lithium perchlorate; diethylamine at 20℃;	96%
With sodium hydroxide In ethanol; water at 5 - 8℃; Aldol Condensation;	11.1%

: 41661-47-6
piperidin-4-one

: 106-89-8
epichlorohydrin

A: 1310417-72-1
C8H13NO2

B: 1425504-48-8
1-(3-chloro-2-hydroxypropyl)piperidin-4-one

Conditions

Conditions	Yield
In water at 20℃; for 1h; Solvent;	A 13% B 96%

...Expand

: 41661-47-6
piperidin-4-one

: tert-butyl (3-cyano-4,6-dimethylpyridin-2-yl) carbonate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

Conditions

Conditions	Yield
In ethanol for 1h; Reflux;	96%

: 41661-47-6
piperidin-4-one

: 24424-99-5
di-tert-butyl dicarbonate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

Conditions

Conditions	Yield
With triethylamine In methanol; dichloromethane at 0 - 25℃; for 12h; Inert atmosphere;	95%
With triethylamine In dichloromethane at 20℃; for 16h;	86%
With sodium hydroxide In tetrahydrofuran for 2h; Ambient temperature;

: 41661-47-6
piperidin-4-one

: 17852-52-7, 27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 4-piperidinone 4-sulfamoylphenylhydrazone

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 3h; Heating;	95%

: 41661-47-6
piperidin-4-one

: 17852-67-4
4-(methylsulfonyl)phenylhydrazine hydrochloride

: 4-piperidinone 4-methanesulfonylphenylhydrazone monohydrochloride

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	95%

: 41661-47-6
piperidin-4-one

: 100-52-7
benzaldehyde

: 132766-61-1, 145888-81-9
3,5-dibenzylidenepiperidin-4-one

Conditions

Conditions	Yield
With lithium perchlorate; diethylamine at 20℃;	95%
With potassium hydroxide In water at 20℃; for 24h; Aldol Condensation;

: 41661-47-6
piperidin-4-one

: 14227-95-3
3-oxo-3-pyrrolidin-1-yl-propionitrile

: 1099600-09-5
(2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)pyrrolidin-1-ylmethanone

Conditions

Conditions	Yield
With sulfur; diethylamine In ethanol at 20℃;	95%

: 41661-47-6
piperidin-4-one

: 67-66-3
chloroform

: 383193-66-6
1-formyl-4-piperidone

Conditions

Conditions	Yield
With sodium ethanolate at 50℃; Riemer-Tiemann reaction; Inert atmosphere;	95%

: 41661-47-6
piperidin-4-one

: 447-61-0
2-Trifluoromethylbenzaldehyde

: N-3,5-bis-(2-(trifluoromethyl)benzylidene)piperidin-4-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 8℃; for 12h;	95%
In ethanol

: 41661-47-6
piperidin-4-one

: 137129-98-7
6-chloro-2-methylpyridine-3-carboxylic acid

: 1-(6-chloro-2-methylpyridine-3-carbonyl)piperidin-4-one

Conditions

Conditions	Yield
With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	95%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 4h; Inert atmosphere;	81%

: 41661-47-6
piperidin-4-one

: 922-67-8
propynoic acid methyl ester

: 882-33-7
diphenyldisulfane

: C15H17NO3S

Conditions

Conditions	Yield
With iodine; potassium carbonate In acetonitrile at 60℃; for 4h; regioselective reaction;	95%

...Expand

: 41661-47-6
piperidin-4-one

: 104-88-1
4-chlorobenzaldehyde

: 919091-60-4
(3E,5E)-3,5-bis(4-chlorobenzylidene)-4-piperidone

Conditions

Conditions	Yield
With lithium perchlorate; diethylamine at 20℃;	94%
With potassium hydroxide In water at 20℃; for 24h; Aldol Condensation;

: 41661-47-6
piperidin-4-one

: 105-56-6
ethyl 2-cyanoacetate

: 24237-44-3
ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Conditions

Conditions	Yield
With sulfur; triethylamine In water at 20℃; for 2h; Gewald Aminoheterocycles Synthesis;	94%
With morpholine; sulfur In ethanol at 50℃;
With morpholine; sulfur In ethanol for 6h; Gewald reaction; Inert atmosphere; Reflux;
With morpholine; octasulfur In ethanol at 20℃; for 24h;
With sulfur; triethylamine In ethanol for 12h; Gewald Aminoheterocycles Synthesis; Reflux;

: 41661-47-6
piperidin-4-one

: 2-(6-(3-(difluoromethoxy)-5-fluorophenyl)-1-((3-(trifluoromethyl)phenyl)sulfonyl)indolin-2-yl)acetic acid

: 1-(2-(6-(3-(difluoromethoxy)-5-fluorophenyl)-1-((3-(trifluoromethyl)phenyl)sulfonyl)indolin-2-yl)acetyl)piperidin-4-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 30℃;	94%

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