4'-Ethoxy-2'-hydroxyacetophenone supplier

Name
4'-ETHOXY-2'-HYDROXYACETOPHENONE
EINECS
CAS No. 37470-42-1
Article Data22
CAS DataBase
Density 1.127 g/cm³
Solubility
Melting Point 40-45 °C(lit.)
Formula C₁₀H₁₂O₃
Boiling Point 314.7 °C at 760 mmHg
Molecular Weight 180.203
Flash Point 124 °C
Transport Information
Appearance
Safety 26-36
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Acetophenone, 4'-ethoxy-2'-hydroxy- (6CI);1-(4-Ethoxy-2-hydroxyphenyl)ethanone;2-Acetyl-5-ethoxyphenol;4-Ethoxy-2-hydroxyacetophenone;
PSA 46.53000
LogP 1.99350

Synthetic route

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 75-03-6
ethyl iodide

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone at 80℃; for 6h;	97%
With potassium carbonate In N,N-dimethyl-formamide for 4h;	63%

: 64-67-5
diethyl sulfate

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 2h; Reflux;	78%
In acetone at 20℃; for 25h; Reflux;

: 74-96-4
ethyl bromide

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 13h; Reflux;	73.5%
With potassium carbonate In acetone for 24h; Heating; Yield given;

: 74-96-4
ethyl bromide

: 89-84-9
2',4'-dihydroxy-4-acetophenone

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 829-20-9
2',4'-dimethoxyacetophenone

Conditions

Conditions	Yield
With potassium carbonate

...Expand

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With water; silver nitrate und Erwaermen des erhaltenen Silber-Salzes mit Aethyljodid in Aceton;

: 110690-86-3
7-ethoxy-2-methyl-chromen-4-one

: 141-52-6
sodium ethanolate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 7-ethoxy-2-ethyl-chromen-4-one

: 141-52-6
sodium ethanolate

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 802294-64-0
propionic acid

...Expand

: 93321-62-1
7-ethoxy-2-phenyl-4H-chromen-4-one

: 141-52-6
sodium ethanolate

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 65-85-0
benzoic acid

...Expand

: 7-ethoxy-2-benzyl-chromen-4-one

: 141-52-6
sodium ethanolate

A: 103-82-2
phenylacetic acid

B: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

...Expand

: 7-ethoxy-2-(4-methoxy-phenyl)-chromen-4-one

: 141-52-6
sodium ethanolate

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 100-09-4
4-methoxybenzoic acid

...Expand

: 7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

: 141-52-6
sodium ethanolate

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 10435-55-9
4-ethoxy-2-hydroxybenzoic acid

C: 134-11-2
2-ethoxybenzoic acid

...Expand

: 7-ethoxy-2-(3-ethoxy-phenyl)-chromen-4-one

: 141-52-6
sodium ethanolate

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 621-51-2
3-ethoxybenzoic acid

...Expand

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 75-03-6
ethyl iodide

A: 22924-18-1
2′,4′-diethoxyacetophenone

B: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate

...Expand

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 75-03-6
ethyl iodide

A: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

B: 829-20-9
2',4'-dimethoxyacetophenone

Conditions

Conditions	Yield
With potassium carbonate

...Expand

: 93321-62-1
7-ethoxy-2-phenyl-4H-chromen-4-one

A: 621-34-1
O-ethyl resorcinol

B: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

C: 65-85-0
benzoic acid

D carbon dioxid; acetophenone: carbon dioxid; acetophenone

Conditions

Conditions	Yield
Kalischmelze;

...Expand

: 108-46-3
recorcinol

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: zinc(II) chloride; hydrogenchloride / diethyl ether / 0.5 h / 0 °C 2: water / 2 h / Reflux 3: potassium carbonate / acetone / 2 h / Reflux View Scheme

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 5-ethoxy-2-ethyl-phenol

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In methanol for 24h;	97%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 52191-14-7
2-(2-acetylphenoxy)-1-bromoethane

: 635538-05-5
1-(2-acetylphenoxy)-2-(2-acetyl-5-ethoxyphenoxy)ethane

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	88%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: spiro[chromane-2,1'-cyclohexane]-4,4'-dione

: 7-ethoxydispiro[chromane-2,1'-cyclohexane-4',2''-chromane]-4,4''-dione

Conditions

Conditions	Yield
With pyrrolidine In ethanol at 80℃; for 10h; Kabe Chromanone Synthesis;	85%

: 110-91-8
morpholine

: 50-00-0
formaldehyd

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

A: 1064287-95-1
1-[4-ethoxy-2-hydroxy-5-(morpholinomethyl)phenyl]ethanone

B: 1064287-96-2
1-[4-ethoxy-2-hydroxy-3-(morpholinomethyl)phenyl]ethanone

Conditions

Conditions	Yield
In ethanol; water at 120℃; Mannich reaction;	A 83% B 6%

...Expand

: 1757-42-2, 6195-92-2
3-methyl-cyclopentanone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 1069133-20-5
(1'S,3'R)-7-ethoxy-3'-methylspiro[chroman-2,1'-cyclopentan]-4-one

Conditions

Conditions	Yield
Stage #1: 3-methyl-cyclopentanone; 1-(4-ethoxy-2-hydroxyphenyl)ethanone With cis-Hyp(tBu)-Thr(tBu)-TentaGel In methanol at 20℃; for 1h; Stage #2: In methanol at 110℃; for 0.183333h; Microwave irradiation; optical yield given as %ee; enantioselective reaction;	83%

: 3002-81-1
5, 6-dimethyl-1,10-phenanthroline

: terbium(III) nitrate hexahydrate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: Tb(2-hydroxy-4-ethoxyacetophenone)3*5,6-dimethyl-1,10-phenanthroline

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 55℃; for 0.2h; pH=7 - 8;	82%

...Expand

: 51490-01-8
1-(3,4,5-trimethoxyphenyl)-2-bromoethanone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 1193107-64-0
(6-ethoxy-3-methylbenzofuran-2-yl)(3,4,5-trimethoxyphenyl)methanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 18h; Reflux;	81%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 1239890-34-6
O-2-acetyl-5-ethoxyphenyl N,N-dimethylcarbamothioate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In N,N-dimethyl-formamide at 50℃; for 5h; Inert atmosphere;	81%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 583-60-8
2-Methylcyclohexanone

: 1069133-30-7
C17H22O3

Conditions

Conditions	Yield
Stage #1: 1-(4-ethoxy-2-hydroxyphenyl)ethanone; 2-Methylcyclohexanone With cis-Hyp(tBu)-Thr(tBu)-TentaGel In methanol at 20℃; for 1h; Stage #2: In methanol at 110℃; for 0.183333h; Microwave irradiation; optical yield given as %ee; enantioselective reaction;	80%

: 366-18-7
[2,2]bipyridinyl

: terbium(III) nitrate hexahydrate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: Tb(2-hydroxy-4-ethoxyacetophenone)3*2,2-bipyridyl

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 55℃; for 0.2h; pH=7 - 8;	79%

...Expand

: 1757-42-2, 6195-92-2
3-methyl-cyclopentanone

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 1069133-19-2
C16H20O3

Conditions

Conditions	Yield
Stage #1: 3-methyl-cyclopentanone; 1-(4-ethoxy-2-hydroxyphenyl)ethanone With trans-Hyp(tBu)-Thr(tBu)-TentaGel In methanol at 20℃; for 1h; Stage #2: In methanol at 110℃; for 0.183333h; Microwave irradiation; optical yield given as %ee; enantioselective reaction;	78%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 100-52-7
benzaldehyde

: 93321-62-1
7-ethoxy-2-phenyl-4H-chromen-4-one

Conditions

Conditions	Yield
With pyrrolidine; iodine In dimethyl sulfoxide at 150℃; for 12h;	78%

: 7570-45-8
N-ethyl-3-carbazolealdehyde

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: (E)-1-(4-ethoxy-2-hydroxyphenyl)-3-(9-ethyl-9H-carbazol-3-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide for 0.133333h; Claisen-Schmidt Condensation; Microwave irradiation;	78%
With potassium hydroxide Claisen-Schmidt Condensation; Sealed tube; Microwave irradiation; Green chemistry;	78%
Claisen-Schmidt Condensation;

: 66-71-7
1,10-Phenanthroline

: terbium(III) nitrate hexahydrate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: Tb(2-hydroxy-4-ethoxyacetophenone)3*1,10-phenanthroline

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 55℃; for 0.2h; pH=7 - 8;	78%

...Expand

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 583-60-8
2-Methylcyclohexanone

: 1069133-29-4
(1'R,2'S)-7-ethoxy-2'-methylspiro[chroman-2,1'-cyclohexan]-4-one

Conditions

Conditions	Yield
Stage #1: 1-(4-ethoxy-2-hydroxyphenyl)ethanone; 2-Methylcyclohexanone With trans-Hyp(tBu)-Thr(tBu)-TentaGel In methanol at 20℃; for 1h; Stage #2: In methanol at 110℃; for 0.183333h; Microwave irradiation; optical yield given as %ee; enantioselective reaction;	76%

: terbium(III) nitrate hexahydrate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 1662-01-7
bathophenanthroline

: Tb(2-hydroxy-4-ethoxyacetophenone)3*bathophenanthroline

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 55℃; for 0.2h; pH=7 - 8;	72%

...Expand

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 111244-98-5
7-ethoxy-3,4-dimethyl-coumarin

Conditions

Conditions	Yield
at 180℃; for 10h;	66%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 6-ethoxy-7-iodobenzo[d]oxazol-2(3H)-one

Conditions

Conditions	Yield
With sodium azide; iodine; sodium hydrogencarbonate In N,N-dimethyl-formamide at 100℃; for 2h;	66%

: terbium(III) nitrate hexahydrate

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 7732-18-5
water

: Tb(2-hydroxy-4-ethoxyacetophenone)3*2H2O

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 50 - 55℃; for 0.2h; pH=7 - 8;	65%

...Expand

: 98-03-3
thiophene-2-carbaldehyde

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 1364733-90-3
7-ethoxy-3-hydroxy-2-(thiophen-2-yl)-4H-chromen-4-one

Conditions

Conditions	Yield
Stage #1: thiophene-2-carbaldehyde; 1-(4-ethoxy-2-hydroxyphenyl)ethanone With methanol; sodium hydroxide for 3h; Reflux; Stage #2: With dihydrogen peroxide at 20℃;	55%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 2,2-diazido-6-ethoxy-5,7-diiodobenzofuran-3(2H)-one

Conditions

Conditions	Yield
With sodium azide; iodine; sodium hydrogencarbonate In water at 100℃; for 2h;	54%

: 5381-20-4
benzothiophene-3-carboxaldehyde

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: (E)-3-(benzo[b]thiophen-3-yl)-1-(4-ethoxy-2-hydroxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; Claisen-Schmidt Condensation;	52%

: 110-91-8
morpholine

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 2-(4-ethoxy-2-hydroxyphenyl)-1-morpholinoethanethione

Conditions

Conditions	Yield
With sulfur at 130℃; for 16h;	52%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 100-52-7
benzaldehyde

: 7-ethoxy-3-hydroxy-2-phenyl-4H-chromen-4-one

Conditions

Conditions	Yield
Stage #1: 1-(4-ethoxy-2-hydroxyphenyl)ethanone; benzaldehyde With methanol; sodium hydroxide for 3h; Reflux; Stage #2: With dihydrogen peroxide at 20℃;	50%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 87199-17-5
4-formylphenylboronic acid,

: 1364733-22-1
7-ethoxy-3-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions

Conditions	Yield
Stage #1: 1-(4-ethoxy-2-hydroxyphenyl)ethanone; 4-formylphenylboronic acid, With methanol; sodium hydroxide for 3h; Reflux; Stage #2: With dihydrogen peroxide at 20℃;	40%

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 100-52-7
benzaldehyde

: 70668-35-8
4'-ethoxy-2'-hydroxy-trans-chalcone

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water at 20℃; for 24h; Aldol Condensation;	20%

: 75-15-0
carbon disulfide

: 37470-42-1
1-(4-ethoxy-2-hydroxyphenyl)ethanone

: 173210-12-3
7-Ethoxy-4-hydroxy-2H-1-benzopyran-2-thione

Conditions

Conditions	Yield
With potassium tert-butylate In benzene Ambient temperature;	18%

4'-Ethoxy-2'-hydroxyacetophenone Specification

The Ethanone, 1-(4-ethoxy-2-hydroxyphenyl)- is an organic compound with the formula C₁₀H₁₂O₃. The systematic name of this chemical is 1-(4-ethoxy-2-hydroxyphenyl)ethanone. With the CAS registry number 37470-42-1, it is also named as 4'-Ethoxy-2'-hydroxyacetophenone. The product's categories are Aromatic Acetophenones & Derivatives (substituted); C10; Carbonyl Compounds; Ketones.

Physical properties about Ethanone, 1-(4-ethoxy-2-hydroxyphenyl)- are: (1)ACD/LogP: 2.69; (2)ACD/LogD (pH 5.5): 2.69; (3)ACD/LogD (pH 7.4): 2.69; (4)ACD/BCF (pH 5.5): 65.08; (5)ACD/BCF (pH 7.4): 64.84; (6)ACD/KOC (pH 5.5): 691.29; (7)ACD/KOC (pH 7.4): 688.74; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 35.53 Å²; (12)Index of Refraction: 1.531; (13)Molar Refractivity: 49.47 cm³; (14)Molar Volume: 159.9 cm³; (15)Polarizability: 19.61×10^-24cm³; (16)Surface Tension: 40.7 dyne/cm; (17)Density: 1.126 g/cm³; (18)Flash Point: 124 °C; (19)Enthalpy of Vaporization: 57.81 kJ/mol; (20)Boiling Point: 314.7 °C at 760 mmHg; (21)Vapour Pressure: 0.000247 mmHg at 25°C.

Uses of Ethanone, 1-(4-ethoxy-2-hydroxyphenyl)-: it can be used to produce 7-ethoxy-3,4-dimethyl-coumarin at temperature of 180 °C. The reaction time is 10 hours. The yield is about 66%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccc(OCC)cc1O)C
(2)InChI: InChI=1/C10H12O3/c1-3-13-8-4-5-9(7(2)11)10(12)6-8/h4-6,12H,3H2,1-2H3
(3)InChIKey: VBLALYJSGGGWHU-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C10H12O3/c1-3-13-8-4-5-9(7(2)11)10(12)6-8/h4-6,12H,3H2,1-2H3
(5)Std. InChIKey: VBLALYJSGGGWHU-UHFFFAOYSA-N

Product Name

4'-ETHOXY-2'-HYDROXYACETOPHENONE

Synthetic route

4'-Ethoxy-2'-hydroxyacetophenone Specification

Related Products

Hot Products