4,4'-(Hexafluoroisopropylidene)diphenol supplier

Name
Hexafluorobisphenol A
EINECS 216-036-7
CAS No. 1478-61-1
Article Data13
CAS DataBase
Density 1.447 g/cm³
Solubility Insoluble in water.
Melting Point 160-163 °C(lit.)
Formula C₁₅H₁₀F₆O₂
Boiling Point 344.1 °C at 760 mmHg
Molecular Weight 336.234
Flash Point 161.9 °C
Transport Information
Appearance White to off-white powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phenol,4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]di- (6CI,7CI);1,1,1,3,3,3-Hexafluoro-2,2-bis(4-hydroxyphenyl)propane;2,2-Bis(4-hydroxyphenyl)hexafluoropropane;BIS-AF;Bisphenol AE;Cheminox BAF;GP 21;Hexafluorobisphenol A;Hexafluoroisopropylidenebis(4-hydroxybenzene);NSC152522;
PSA 40.46000
LogP 4.50850

Synthetic route

: 428-59-1
Hexafluoropropene oxide

: 108-95-2
phenol

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

Conditions

Conditions	Yield
With TiClF3; SbF4Cl; hydrogen fluoride for 12h; Reagent/catalyst; Autoclave;	97.3%
With hydrogen fluoride; antimonypentachloride; titanium tetrachloride at 55℃; for 12h; Reagent/catalyst; Autoclave;	97.5%

: 684-16-2
Hexafluoroacetone

: 108-95-2
phenol

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

Conditions

Conditions	Yield
With hydrogen fluoride In melt at 10 - 100℃; for 2h; Temperature; Autoclave;	95%
With hydrogen fluoride
surface-bound sulfonic acid-containing material at 90℃; for 24h;

: 144820-54-2
hexachlorobisphenol A

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

Conditions

Conditions	Yield
With hydrogen fluoride; triethylamine at 10 - 100℃; for 6h; Reagent/catalyst; Temperature; Inert atmosphere;	92.8%

: 24427-67-6
heptafluoropropan-2-ol

: 108-95-2
phenol

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

Conditions

Conditions	Yield
With hydrogen fluoride at 110℃; under 7125.71 Torr; for 6h; Autoclave;	82%

: 79-37-8
oxalyl dichloride

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 335148-89-5
bisphenol AF bisoxalyl chloride adduct

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 90℃; for 6h; Heating / reflux;	100%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 870-63-3
prenyl bromide

: 4,4'-(perfluoropropane-2,2-diyl)bis(((3-methylbut-2-en-1-yl)oxy)benzene)

Conditions

Conditions	Yield
Stage #1: 4,4'-(hexafluoroisopropylidene)diphenol With potassium carbonate In acetone at 23℃; for 0.5h; Stage #2: prenyl bromide In acetone at 23℃; for 16h;	100%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 2,2-bis[4-(2,4-dinitrophenoxy)phenyl]hexafluoropropane

Conditions

Conditions	Yield
Stage #1: 4,4'-(hexafluoroisopropylidene)diphenol With potassium carbonate In N,N-dimethyl acetamide; toluene for 2h; Reflux; Stage #2: 1-chloro-2,4-dinitro-benzene at 90℃; for 5h;	98.3%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 35375-74-7
5-chloro-2-nitro-4-(trifluoromethyl)aniline

: 2,2-bis[4-(5-amino-4-nitro-2-trifluoromethylphenoxy)phenyl]hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 0.0833333h; Sonication;	98%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 108-36-1
1,3-dibromobenzene

polymer, hydroxyl-terminated; monomer(s): bisphenol A6F; 1,3-dibromobenzene: polymer, hydroxyl-terminated; monomer(s): bisphenol A6F; 1,3-dibromobenzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; potassium carbonate In N,N-dimethyl-formamide; toluene at 135 - 145℃; Ullmann reaction;	97%

: 126531-39-3
2,2-bis[4-(4-hydroxyphenyl)phenyl]propane

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 6357 g/mol, PDI 2.1; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 6357 g/mol, PDI 2.1; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 15℃; for 1h;	97%

...Expand

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 1197989-76-6
C39H26FN3

: 1197989-77-7
C93H60F6N6O2

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide; toluene at 140℃; for 24h; Inert atmosphere;	97%

: 99-54-7
3,4-dichloronitrobenzene

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 2,2-bis[4-(2-chloro-4-nitrophenoxy)phenyl]hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 2h; Sonication;	97%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 106-95-6
allyl bromide

: 82986-78-5
2,2-bis(4-allyloxyphenyl)hexafluoropropane

Conditions

Conditions	Yield
With sodium hydroxide; tetramethylammonium bromide In water; toluene at 50℃; for 10h;	95.7%
With potassium carbonate In acetone at 80℃; Inert atmosphere;

: 126531-39-3
2,2-bis[4-(4-hydroxyphenyl)phenyl]propane

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 12020 g/mol, PDI 1.6; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 12020 g/mol, PDI 1.6; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃;	95%

...Expand

: 126531-39-3
2,2-bis[4-(4-hydroxyphenyl)phenyl]propane

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 15860 g/mol, PDI 1.9; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 15860 g/mol, PDI 1.9; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 15℃; for 1h;	95%

...Expand

: 358-23-6
trifluoromethylsulfonic anhydride

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 83558-77-4
2,2-bis(4-trifluoromethanesulfonyloxyphenyl)hexafluoropropane

Conditions

Conditions	Yield
With pyridine at 0 - 20℃;	95%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: (4,4'-(perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(oxy)bis(tert-butyldimethylsilane)

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃;	95%
With 1H-imidazole; dmap In dichloromethane; N,N-dimethyl-formamide for 3h;

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 100-00-5
4-chlorobenzonitrile

: 2,2-bis(4-(4-nitrophenoxy)phenyl)hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 1h; Sonication;	95%
With bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium carbonate In water at 70℃; for 8h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;	95%
With N-phenylpicolinamide; copper In N,N-dimethyl-formamide at 25℃; for 10h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	91.87%
With copper(l) iodide; sodium t-butanolate In 1,2-dimethoxyethane at 95 - 105℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere;	90%
With potassium carbonate In N,N-dimethyl-formamide; benzene at 160℃; for 10h; Solvent; Temperature;

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 75-56-9, 16033-71-9
methyloxirane

: 124663-46-3
C21H22F6O4

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 50℃; under 7600.51 Torr; for 24h;	94%

: 4548-45-2
2-chloro-5-nitropyridine

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 2,2-bis[4-((5-nitro-2-pyridyl)oxy)phenyl]hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 7.5h; Inert atmosphere;	94%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 1635-61-6
5-chloro-2-nitroaniline

: 2,2-bis[4-(3-amino-4-nitrophenoxy)phenyl]hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 2h; Sonication;	94%
With potassium carbonate In dimethyl sulfoxide at 80℃; for 2h; Sonication;	94%
With potassium carbonate In dimethyl sulfoxide at 80℃; for 1h; Sonication;	92%

: 1,1-bis(4-hydroxyphenyl)-1-(4-((4-fluorophenyl)thio)phenyl)-2,2,2-trifluoroethane

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 383-29-9
bis(p-fluorophenyl)sulfone

poly(1,1-bis(4-hydroxyphenyl)-1-(4-((4-fluorophenyl)thio)phenyl)-2,2,2-trifluoroethane-co-4,4'-difluorodiphenylsulfone-co-hexafluorobisphenol A): poly(1,1-bis(4-hydroxyphenyl)-1-(4-((4-fluorophenyl)thio)phenyl)-2,2,2-trifluoroethane-co-4,4'-difluorodiphenylsulfone-co-hexafluorobisphenol A)

Conditions

Conditions	Yield
Stage #1: 1,1-bis(4-hydroxyphenyl)-1-(4-((4-fluorophenyl)thio)phenyl)-2,2,2-trifluoroethane; 4,4'-(hexafluoroisopropylidene)diphenol With potassium carbonate In N,N-dimethyl acetamide; toluene at 140℃; for 2h; Stage #2: bis(p-fluorophenyl)sulfone In N,N-dimethyl acetamide at 20 - 165℃; for 4h;	93%

...Expand

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 10440 g/mol, PDI 2.2; monomer(s): 4,4\-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 10440 g/mol, PDI 2.2; monomer(s): 4,4\-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 15℃; for 1h;	92%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 4755-77-5
Ethyl oxalyl chloride

: bisphenol-AF bis(ethyl oxalate)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2 - 3h;	92%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 5281-28-7
4,4'-(perfluoropropane-2,2-diyl)bis(2,6-dibromophenol)

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃;	92%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 55606-94-5
1,4-bis(4'-fluorophenyl)-buta-1,3-diyne

: 2,2-Bis<4-<(4-fluorophenyl)buta-1,3-diynyl>phenyloxyphenyl>hexafluoropropane

Conditions

Conditions	Yield
With potassium carbonate 1.) N-methyl-2-pyrrolidone, toluene, reflux, 5 h, 2.) 180 - 190 deg C, 24 h;	91%

: 126531-39-3
2,2-bis[4-(4-hydroxyphenyl)phenyl]propane

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 12140 g/mol, PDI 1.3; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 12140 g/mol, PDI 1.3; monomer(s): 2,2-bis[4-(4-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃;	91%

...Expand

: 421-83-0
trifluoromethane sulfonyl chloride

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 83558-77-4
2,2-bis(4-trifluoromethanesulfonyloxyphenyl)hexafluoropropane

Conditions

Conditions	Yield
	90%

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 106-89-8
epichlorohydrin

: 2,2'-(4,4'-(perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(oxy)-bis(methylene)dioxirane

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium hydroxide at 20℃; for 12h;	90%
Stage #1: 4,4'-(hexafluoroisopropylidene)diphenol; epichlorohydrin With N-benzyl-N,N,N-triethylammonium chloride at 80℃; for 12h; Stage #2: With sodium hydroxide In water for 5h;	50%
With sodium hydroxide In water at 95 - 100℃; for 0.5h;

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

: 189039-61-0
C15H8Br2F6O2

Conditions

Conditions	Yield
With bromine; iron In tetrachloromethane; acetic acid at 20℃; for 5.5h;	90%
With bromine

: 685561-32-4
2,2-bis[4-(3-hydroxyphenyl)phenyl]propane

: 32315-10-9
bis(trichloromethyl) carbonate

: 1478-61-1
4,4'-(hexafluoroisopropylidene)diphenol

polymer, Mn 5588 g/mol, PDI 4.9; monomer(s): 2,2-bis[4-(3-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene: polymer, Mn 5588 g/mol, PDI 4.9; monomer(s): 2,2-bis[4-(3-hydroxyphenyl)phenyl]propane; 4,4-(hexafluoroisopropylidene)diphenol; triphosgene

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 15℃; for 1h;	89%

...Expand

4,4'-(Hexafluoroisopropylidene)diphenol Chemical Properties

Molecular Formula: C₁₅H₁₀F₆O₂
Molecular Weight: 336.23
EINECS: 216-036-7
Index of Refraction: 1.506
Molar Refractivity: 69.08 cm³
Molar Volume: 232.3 cm³
Surface Tension: 35.4 dyne/cm
Density: 1.447 g/cm³
Flash Point: 161.9 °C
Enthalpy of Vaporization: 61.13 kJ/mol
Boiling Point: 344.1 °C at 760 mmHg
Vapour Pressure: 3.38E-05 mmHg at 25 °C
Melting point: 160-163 °C(lit.)
Appearance: White to off-white powder
Structure of Hexafluorobisphenol A (CAS NO.1478-61-1):

IUPAC Name: 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol
Canonical SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)O)(C(F)(F)F)C(F)(F)F)O
InChI: InChI=1S/C15H10F6O2/c16-14(17,18)13(15(19,20)21,9-1-5-11(22)6-2-9)10-3-7-12(23)8-4-10/h1-8,22-23H
InChIKey: ZFVMWEVVKGLCIJ-UHFFFAOYSA-N
Product Category of Hexafluorobisphenol A (CAS NO.1478-61-1): Organic Fluorides;Bisphenol AF type Compounds (for High-Performance Polymer Research);Functional Materials

4,4'-(Hexafluoroisopropylidene)diphenol Toxicity Data With Reference

1.		mnt-ham-lng 50 µmol/L		MUREAV Mutation Research. 390 (1997),21.
2.		orl-rat LD50:3400 mg/kg		NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0555704 .

4,4'-(Hexafluoroisopropylidene)diphenol Safety Profile

Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of F⁻.
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 2
RTECS: SN2780000
Hazard Note: Corrosive

4,4'-(Hexafluoroisopropylidene)diphenol Specification

Hexafluorobisphenol A , its cas register number is 1478-61-1. It also can be called Bisphenol AF ; Hexafluoroisopropylidenebis(4-hydroxybenzene) ; and 4,4'-(Hexafluoroisopropylidene)diphenol . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Hexafluorobisphenol A (CAS NO.1478-61-1) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Carbon monoxide, carbon dioxide, hydrogen fluoride gas.

Product Name

Hexafluorobisphenol A

Synthetic route

4,4'-(Hexafluoroisopropylidene)diphenol Chemical Properties

4,4'-(Hexafluoroisopropylidene)diphenol Toxicity Data With Reference

4,4'-(Hexafluoroisopropylidene)diphenol Safety Profile

4,4'-(Hexafluoroisopropylidene)diphenol Specification

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