4,4'-OXYDIPHENOL supplier | CasNO.1965-09-9

Name
4,4'-Oxydiphenol
EINECS 217-809-1
CAS No. 1965-09-9
Article Data38
CAS DataBase
Density 1.289 g/cm³
Solubility
Melting Point 163-168 °C
Formula C₁₂H₁₀O₃
Boiling Point 379.24 °C at 760 mmHg
Molecular Weight 202.21
Flash Point 183.158 °C
Transport Information
Appearance off-white amorphous powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phenol,4,4'-oxydi- (6CI,7CI,8CI);Phenol, p,p'-oxybis- (3CI);Phenol, p,p'-oxydi-(4CI);4,4'-Dihydroxydiphenyl ether;4,4'-Dihydroxydiphenyl oxide;4,4'-Oxybiphenol;4,4'-Oxybis[phenol];4,4'-Oxydiphenol;4-(4-Hydroxyphenoxy)phenol;Bis(4-hydroxyphenyl) ether;Bis(p-hydroxyphenyl)ether;Quinol ether;Specianol DPE-H;p-(p-Hydroxyphenoxy)phenol;p-Hydroxyphenyl ether;
PSA 49.69000
LogP 2.89010

Synthetic route

: 2050-47-7
4,4'-dibromodiphenyl ether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Stage #1: 4,4'-dibromodiphenyl ether With N,N′-bis(2,4,6-trimethylphenyl)oxalamide; acetophenone; sodium hydroxide In dimethyl sulfoxide at 130℃; for 7h; Stage #2: With carbon dioxide; pyrographite at 80℃; for 3h; pH=9; Reagent/catalyst; pH-value;	87%
With sodium hydroxide; copper at 210℃;
With water; sodium hydroxide Large scale;

: 101-80-4
4,4'-oxydiphenylene diamine

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Stage #1: 4,4'-oxydiphenylene diamine With sulfuric acid; sodium nitrite at 0℃; Stage #2: With sulfuric acid In nitrobenzene at 130℃; for 0.666667h; Temperature; Solvent;	81.2%
With uranyl nitrate hydrate; water; trifluoroacetic acid In acetonitrile for 48h; Irradiation; Inert atmosphere;	44%
Diazotization;
Diazotization;

: 77-95-2
D-(-)-quinic acid

A: 1965-09-9
4,4'-dihydroxydiphenyl ether

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With Amberlyst-15; air In toluene at 100℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time;	A 7% B 71%
Multi-step reaction with 2 steps 1: Amberlyst-15 / acetonitrile / 24 h / 50 °C 2: Amberlyst-15 / toluene / 17 h / 100 °C View Scheme

: 665-27-0
1,5-quinide

A: 1965-09-9
4,4'-dihydroxydiphenyl ether

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
With Amberlyst-15 In toluene at 100℃; for 17h;	A n/a B 52%

: 123-31-9
hydroquinone

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With Amberlyst-15 In toluene at 100℃; for 144h;	48%
With Dowex (50x8x400) at 120℃; for 0.416667h; Microwave irradiation;	41%
With 3-methylbutyric acid; zinc(II) chloride

: 23446-80-2
(4,4'-diacetoxydiphenyl) ether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 2h;	25%

: 2444-89-5
4,4'-dichlorodiphenyl ether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With sodium hydroxide; copper at 210℃;

: 1655-74-9
bis(4-methoxyphenyl) ether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With hydrogen bromide; acetic anhydride
With hydrogen bromide; acetic acid at 140℃;
With aluminium trichloride; xylene
With hydrogen bromide at 160℃; for 16h;

: 95-57-8
2-monochlorophenol

A: 106-44-5
p-cresol

B: 1965-09-9
4,4'-dihydroxydiphenyl ether

C: 95-48-7
ortho-cresol

D: 108-95-2
phenol

Conditions

Conditions	Yield
With potassium hydroxide In water at 440℃; under 195016 Torr; Product distribution; Further Variations:; Reagents;

...Expand

: 91378-31-3
4-(4-hydroxyphenoxy)benzaldehyde

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid Baeyer-Villiger oxidation;

: 459-57-4
4-fluorobenzaldehyde

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: K2CO3 / N,N-dimethyl-acetamide / Heating 2: mCPBA View Scheme

: 123-31-9
hydroquinone

cinchomeronic acid anhydride: cinchomeronic acid anhydride

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: K2CO3 / N,N-dimethyl-acetamide / Heating 2: mCPBA View Scheme

: 104-92-7
1-bromo-4-methoxy-benzene

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper; hydrogen / 200 °C 2: AlCl3; xylene View Scheme
Multi-step reaction with 2 steps 1: copper; copper (II)-acetate / 190 - 200 °C 2: aqueous HBr; acetic acid / 140 °C View Scheme

: 1122-93-6
potassium p-methoxyphenolate

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper; hydrogen / 200 °C 2: AlCl3; xylene View Scheme
Multi-step reaction with 2 steps 1: copper; copper (II)-acetate / 190 - 200 °C 2: aqueous HBr; acetic acid / 140 °C View Scheme

: 696-62-8
para-iodoanisole

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: copper 2: aqueous HBr; acetic acid anhydride View Scheme

: 28896-49-3
bis(4-iodophenyl) ether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With sodium hydroxide; copper; copper(I) chloride In water	33.5 g (83%)

: 77-95-2
D-(-)-quinic acid

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Amberlyst-15; air / toluene / 24 h / 100 °C 2: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hypochlorite solution; sulfuric acid / water / 3 h / 20 °C 2: Amberlyst 15 / toluene / 1.5 h / 100 °C 3: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hypochlorite solution; sulfuric acid / water / 3 h / 20 °C 2: Amberlyst-15 / 1,4-dioxane / 0.08 h / 100 °C 3: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme
Multi-step reaction with 3 steps 1: Amberlyst-15 / acetonitrile / 24 h / 50 °C 2: Amberlyst-15 / toluene / 17 h / 100 °C 3: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme

: 95639-53-5
3(R),5(R)-trihydroxycyclohexanone

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Amberlyst 15 / toluene / 1.5 h / 100 °C 2: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: Amberlyst-15 / 1,4-dioxane / 0.08 h / 100 °C 2: Amberlyst-15 / toluene / 144 h / 100 °C View Scheme

: 106-48-9
4-chloro-phenol

A: 1965-09-9
4,4'-dihydroxydiphenyl ether

B: 2474-72-8
hydroxyquinone

C: 123-31-9
hydroquinone

D: 106-51-4
p-benzoquinone

Conditions

Conditions	Yield
With xH2O*Mg0.1Zn6(Si7.9Al0.1)O20(OH)4 at 25℃; Quantum yield; Kinetics; Reagent/catalyst; Irradiation;

...Expand

: 2615-11-4
4,4'-oxydiacetophenone

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C 2: sodium hydroxide / methanol; water / 2 h View Scheme

: 101-84-8
diphenylether

: 1965-09-9
4,4'-dihydroxydiphenyl ether

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 24 h / 0 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C 3: sodium hydroxide / methanol; water / 2 h View Scheme

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 110-82-7
cyclohexane

Conditions

Conditions	Yield
With hydrogen In dodecane at 200℃; under 15001.5 Torr; for 2h;	99.9%
With rhodium contaminated with carbon; N-methyldiethanolamine trifluoromethanesulfonate; hydrogen at 120℃; under 30003 Torr; for 6h; Autoclave;	91.5%
With carbon nanotubes-supported ruthenium; hydrogen In dodecane; water at 220℃; under 37503.8 Torr; for 3h; Autoclave;	64 %Chromat.
With hydrogen at 130℃; under 15001.5 Torr; for 6h; Ionic liquid; Autoclave; Schlenk technique;	99.4 %Chromat.

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: bispropargyl ether of 4,4'-oxydiphenol

Conditions

Conditions	Yield
	97%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 18162-48-6
tert-butyldimethylsilyl chloride

: (4,4'-oxybis(4,1-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃;	96%
With 1H-imidazole; dmap In dichloromethane; N,N-dimethyl-formamide for 3h;	93%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 23446-80-2
(4,4'-diacetoxydiphenyl) ether

Conditions

Conditions	Yield
With acetic anhydride; sulfuric acid at 20℃; for 2h;	95.4%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: C12H8O3(2-)*2Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In butanone at 100℃; for 3h;	95%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 4,4′-bis(trifluorosulfonyloxy)diphenyl ether

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;	93%
Stage #1: 4,4'-dihydroxydiphenyl ether With pyridine In dichloromethane at 0℃; for 0.166667h; Inert atmosphere; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at 0℃; Inert atmosphere;	82%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 403-42-9
1-(4-fluorophenyl)ethanone

: 24190-46-3
bis[p-(p-acetylphenoxy)phenyl]ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide Heating;	89%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 7379-35-3
4-chlorpyridine hydrochloride

: 4,4'-[oxybis(4,1-phenyleneoxy)]dipyridine

Conditions

Conditions	Yield
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 140℃; for 72h; Inert atmosphere;	89%

: 50-00-0
formaldehyd

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 124-40-3
dimethyl amine

: 912474-70-5
2,5,2',5'-tetra(dimethylaminemethylene)-4,4'-dihydroxydiphenylether

Conditions

Conditions	Yield
In ethanol; water for 3h; Mannich reaction; Heating;	88%

...Expand

: 4548-45-2
2-chloro-5-nitropyridine

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 4,4'-bis(5-nitro-2-pyridinoxy)diphenyl ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 70℃; for 0.108333h; Inert atmosphere;	88%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 106-96-7
propargyl bromide

: bispropargyl ether of 4,4'-oxydiphenol

Conditions

Conditions	Yield
With potassium hydroxide In acetone for 16h; Heating;	86%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 2251-50-5
pentafluorobenzoylchloride

: 870162-42-8
4,4'-bis(2,3,4,5,6-pentafluorobenzoyloxy)diphenyl ether

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 10 - 20℃;	86%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 85-56-3
2-(4-chlorobenzoyl)benzoic acid

: C40H26O9

Conditions

Conditions	Yield
Stage #1: 4,4'-dihydroxydiphenyl ether; 2-(4-chlorobenzoyl)benzoic acid With potassium carbonate In N,N-dimethyl acetamide; toluene Heating; Stage #2: With potassium carbonate In N,N-dimethyl acetamide at 170℃; for 12h;	85%

: 629-04-9
1-Bromoheptane

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 4,4’-oxybis((heptyloxy)benzene)

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	83.6%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 112-82-3
hexadecanyl bromide

: 4-(4-(hexadecyloxy)phenoxy)phenol

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 90℃; for 24h;	82.9%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 143-15-7
1-dodecylbromide

: C24H34O3

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 90℃; for 24h;	81.5%

: 110-91-8
morpholine

: 50-00-0
formaldehyd

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 946513-72-0
3,3'-di(morpholin-4-ylmethyl)-4,4'-dihydroxy diphenyl ether

Conditions

Conditions	Yield
Stage #1: morpholine; 4,4'-dihydroxydiphenyl ether In toluene at 25℃; for 0.5h; Stage #2: formaldehyd In toluene at 80℃; for 9h; Stage #3: morpholine; formaldehyd In toluene at 80℃; for 8.16667h;	81.2%

...Expand

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 145013-05-4
tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate

A: 1073524-89-6
1,3-di(tert-butoxycarbonyl)-2-[4-(4-hydroxyphenoxy)phenyl]isourea

B: 1073524-85-2
4,4'-bis[N,N'-di(tert-butoxycarbonyl)isoureido]diphenyl ether

Conditions

Conditions	Yield
With triethylamine; mercury dichloride In dichloromethane at 0 - 20℃; for 16h;	A 77% B 5%
With triethylamine; mercury dichloride In dichloromethane at 0 - 20℃; for 21h;	A 4% B 67%

...Expand

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 459-57-4
4-fluorobenzaldehyde

: 133387-15-2
C26H18O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide Heating;	76%

: 50-00-0
formaldehyd

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 62-53-3
aniline

: 591766-84-6
C28H24N2O3

Conditions

Conditions	Yield
With water In toluene at 80℃; for 5h;	75%

...Expand

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 4,4'-oxybis(4,1-phenylene) disulfofluoridate

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; for 12h;	75%

: 125274-23-9
(E)-3-[4-[6-(2-methylprop-2-enoyloxy)hexoxy]phenyl]prop-2-enoic acid

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: CLM_005

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 20℃; for 24h;	70%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 1619-34-7
3-quinuclidinol

A: 4-[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenoxy]phenol

B: 4,4'-di(1-aza-bicyclo[2.2.2]oct-3-yloxy)-diphenyl ether

Conditions

Conditions	Yield
	A 68% B n/a
	A n/a B 7%

...Expand

: 109-04-6
2-bromo-pyridine

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 2,2'-[oxybis(4,1-phenyleneoxy)]dipyridine

Conditions

Conditions	Yield
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere;	65%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 106-89-8
epichlorohydrin

: 19389-73-2
4,4'-dihydroxydiphenyl ether diglycidyl ether

Conditions

Conditions	Yield
Stage #1: 4,4'-dihydroxydiphenyl ether With sodium hydride In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: epichlorohydrin In N,N-dimethyl-formamide at 20℃; for 21h; Inert atmosphere; Stage #3: With water In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	64%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 627-18-9
1-bromo-3-propanol

: 1059628-28-2
4,4'-(3-hydroxypropan-1-oxy)diphenyl ether

Conditions

Conditions	Yield
Stage #1: 4,4'-dihydroxydiphenyl ether With potassium carbonate In acetone at 50℃; Stage #2: 1-bromo-3-propanol In acetone Reflux;	57%

: 1965-09-9
4,4'-dihydroxydiphenyl ether

: 36530-06-0
subphthalocyanine

: 1227471-68-2
(B(N6C24H12))2O2C6H4OC6H4

Conditions

Conditions	Yield
In 1,2-dichloro-benzene at 180.5℃; for 39h; Inert atmosphere;	55%
In 1,2-dichloro-benzene (Ar) chloro boron subphthalocyanine and bisphenol in 1,2-dichlorobenzenewere heated at reflux (180.5°C) for 39 h; react. mixt. was cooled, solvent was totary evapd., purification by flash chromy. on silica (CH2Cl2 and THF);	55%

4,4'-OXYDIPHENOL Chemical Properties

IUPAC Name: 4-(4-Hydroxyphenoxy)phenol
Synonyms: Bis(4-hydroxyphenyl) ether ; 4',4-Oxidiphenol ; 4',4-Oxydiphenol ; 4',4-Dihydroxydiphenyl ether ; 4,4'-Dihydroxydiphenyl ether ; 4',4-Dihydroxyphenyl ether ; 4-Hydroxyphenyl ether
Product Categories: Aromatic Ethers;Biphenyl & Diphenyl ether;Color Former & Related Compounds;Developer;Diphenyl Ethers (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
Molecular Structure:
Molecular Formula : C₁₂H₁₀O₃
Molecular Weight: 202.21
CAS NO: 1965-09-9
EINECS : 217-809-1
Mol File: 1965-09-9.mol
Index of Refraction: 1.639
Surface Tension: 55.6 dyne/cm
Density: 1.288 g/cm³
Flash Point: 183.2 °C
Enthalpy of Vaporization: 65.18 kJ/mol
Boiling Point: 379.2 °C at 760 mmHg
Vapour Pressure: 2.72E-06 mmHg at 25°C
Melting point: 163-168 ºC
Appearance: 4',4-Oxydiphenol (CAS NO. 1965-09-9) is off-white amorphous powder.

4,4'-OXYDIPHENOL Uses

4',4-Oxydiphenol (CAS NO. 1965-09-9) is used as pharmaceutical intermediates and additives of liquid crystal .

4,4'-OXYDIPHENOL Toxicity Data With Reference

ipr-mus LD50:150 mg/kg

NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 .

4,4'-OXYDIPHENOL Consensus Reports

Reported in EPA TSCA Inventory.

4,4'-OXYDIPHENOL Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Statements 24/25
S24/25:Avoid contact with skin and eyes.
RTECS SM6040000

4,4'-OXYDIPHENOL Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store 4',4-Oxydiphenol (CAS NO. 1965-09-9) in a cool, dry place. Keep container closed when not in use.

Product Name

4,4'-Oxydiphenol

Synthetic route

4,4'-OXYDIPHENOL Chemical Properties

4,4'-OXYDIPHENOL Uses

4,4'-OXYDIPHENOL Toxicity Data With Reference

4,4'-OXYDIPHENOL Consensus Reports

4,4'-OXYDIPHENOL Safety Profile

4,4'-OXYDIPHENOL Specification

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