4,7-Dichloroquinoline supplier

Name
4,7-Dichloroquinoline
EINECS 201-714-7
CAS No. 86-98-6
Article Data30
CAS DataBase
Density 1.407 g/cm³
Solubility insoluble in water
Melting Point 81-83 °C(lit.)
Formula C₉H₅Cl₂N
Boiling Point 292.9 °C at 760 mmHg
Molecular Weight 198.051
Flash Point 158.7 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36-22
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5-20-07-00316 (Beilstein Handbook Reference);AI3-50374;BRN 0125359;NSC 593;TL 1473;Quinoline, 4,7-dichloro-;
PSA 12.89000
LogP 3.54160

Synthetic route

: 86-99-7
7-chloro-4-hydroxylquinoline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
With trichlorophosphate for 1h; Heating;	94%
With trichlorophosphate Reflux;	89.5%
With trichlorophosphate for 2h; Heating / reflux;	88.5%

: 23833-97-8
7-chloro-4(1H)-oxoquinoline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
With trichlorophosphate for 2h; Reflux;	85%
With trichlorophosphate for 2h; Reflux;	85%
With ((1,3,5-triazine-2,4,6-triyl)tris(oxy))tris(triphenylphosphonium) chloride at 140 - 150℃; for 2h; Solvent; Ionic liquid;
With trichlorophosphate Reflux;

: 391-83-3, 183057-60-5
7-fluoro-1,4-dihydroquinolin-4-one

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
With trichlorophosphate for 1h; Reflux;	85%

: 1077-74-3
4,7-dichloroquinoline 1-oxide

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
With Eosin Y; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate In acetonitrile at 20℃; for 1h; Inert atmosphere; Irradiation; chemoselective reaction;	78%
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate In acetonitrile at 20℃; for 0.0833333h; Inert atmosphere; Irradiation; chemoselective reaction;	73%

: 4,7-dichloro-1,2,3,4-tetrahydroquinoline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
With iron oxide surrounded by nitrogen doped graphene shell immobilized on carbon support In n-heptane at 100℃; under 11251.1 Torr; for 12h; Autoclave;	62%

: 1134937-73-7
7-chloro-4-quinolinesulfonyl chloride

A: 86-98-6
4,7-dichloroquinoline

B: 1134937-74-8
7-chloro-4-quinolinesulfonamide

Conditions

Conditions	Yield
With ammonia In water at 20℃;	A 31% B 56%

: 25063-49-4
5-[(3-chloro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenyl ether / 0.08 h / 300 °C / microwave irradiation 2: POCl3 / 3 h / Heating View Scheme

: 39061-72-8
2-acetyl-5-chloroaniline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 75 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 95 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 3: 98 percent / NaI; Et3N / acetonitrile / 1 h / Heating 4: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 5: 81 percent / aq. NaOH / methanol / Heating 6: 94 percent / POCl3 / 1 h / Heating View Scheme

: 675578-62-8
N-(2-acetyl-5-chlorophenyl)-4-methylbenzenesulfonamide

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 95 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 2: 98 percent / NaI; Et3N / acetonitrile / 1 h / Heating 3: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 4: 81 percent / aq. NaOH / methanol / Heating 5: 94 percent / POCl3 / 1 h / Heating View Scheme

: 675578-63-9
N-allyl-N-p-toluenesulfonyl-2-acetyl-5-chloroaniline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 98 percent / NaI; Et3N / acetonitrile / 1 h / Heating 2: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 3: 81 percent / aq. NaOH / methanol / Heating 4: 94 percent / POCl3 / 1 h / Heating View Scheme

: 675578-65-1
N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / aq. NaOH / methanol / Heating 2: 94 percent / POCl3 / 1 h / Heating View Scheme

: 675578-64-0
N-allyl-N-p-toluenesulfonyl-2-[1-(tert-butyldimethylsilyloxy)vinyl]-5-chloroaniline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 95 percent / Cl2Ru(PCy3)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH2Cl2 / 1 h / 50 °C 2: 81 percent / aq. NaOH / methanol / Heating 3: 94 percent / POCl3 / 1 h / Heating View Scheme

: 86-47-5
4-hydroxy-7-chloro-3-quinoline-carboxylic acid

A: 86-98-6
4,7-dichloroquinoline

B N,Ndiethyl-butanediyldiamine: N,Ndiethyl-butanediyldiamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenyl ether / 1 h / Heating 2: POCl3 / 100 °C View Scheme

: 16600-22-9
7-chloro-4-hydroxyquinoline-3-carboxylic acid,ethyl ester

A: 86-98-6
4,7-dichloroquinoline

B N,Ndiethyl-butanediyldiamine: N,Ndiethyl-butanediyldiamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 2 N aq. NaOH / 1 h / Heating 2: diphenyl ether / 1 h / Heating 3: POCl3 / 100 °C View Scheme

: 3412-99-5
2-(3-chlorophenylamino)methylenemalonic acid diethyl ester

A: 86-98-6
4,7-dichloroquinoline

B N,Ndiethyl-butanediyldiamine: N,Ndiethyl-butanediyldiamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: diphenyl ether / 1 h / Heating 2: 2 N aq. NaOH / 1 h / Heating 3: diphenyl ether / 1 h / Heating 4: POCl3 / 100 °C View Scheme

: 108-42-9
3-chloro-aniline

potassium-<6-chloro-3-nitro benzoate>: potassium-<6-chloro-3-nitro benzoate>

A: 86-98-6
4,7-dichloroquinoline

B N,Ndiethyl-butanediyldiamine: N,Ndiethyl-butanediyldiamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.5 h / 165 °C 2: diphenyl ether / 1 h / Heating 3: 2 N aq. NaOH / 1 h / Heating 4: diphenyl ether / 1 h / Heating 5: POCl3 / 100 °C View Scheme

...Expand

: 86-47-5
4-hydroxy-7-chloro-3-quinoline-carboxylic acid

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 250 - 270 °C / oder in einem Gemisch von Diphenylaether und Biphenyl 2: phosphoryl chloride View Scheme

: 18000-24-3
7-chlorokynurenic acid

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: mineral oil / 270 °C 2: phosphoryl chloride View Scheme
Multi-step reaction with 2 steps 1: 1-chloro-naphthalene 2: phosphoryl chloride View Scheme

: 21640-97-1
7-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous NaOH 2: mineral oil / 270 °C 3: phosphoryl chloride View Scheme
Multi-step reaction with 3 steps 1: aqueous NaOH 2: 1-chloro-naphthalene 3: phosphoryl chloride View Scheme

: 16600-22-9
7-chloro-4-hydroxyquinoline-3-carboxylic acid,ethyl ester

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous NaOH 2: 250 - 270 °C / oder in einem Gemisch von Diphenylaether und Biphenyl 3: phosphoryl chloride View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide; water / diphenylether / 0.5 h 2: paraffin oil / 0.83 h / 230 °C 3: trichlorophosphate / Reflux View Scheme

: 3412-99-5
2-(3-chlorophenylamino)methylenemalonic acid diethyl ester

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: aqueous NaOH 3: 250 - 270 °C / oder in einem Gemisch von Diphenylaether und Biphenyl 4: phosphoryl chloride View Scheme
Multi-step reaction with 2 steps 1: dowtherm / 4 h 2: trichlorophosphate / 6 h / Reflux View Scheme
Multi-step reaction with 4 steps 1: diphenylether / Reflux 2: sodium hydroxide; ethanol / Reflux 3: diphenylether / Reflux 4: trichlorophosphate / 2 h / Reflux View Scheme

: 108-42-9
3-chloro-aniline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: acetic acid / Erhitzen des Reaktionsprodukts in Paraffinoel auf 250grad 2: aqueous NaOH 3: mineral oil / 270 °C 4: phosphoryl chloride View Scheme
Multi-step reaction with 5 steps 3: aqueous NaOH 4: 250 - 270 °C / oder in einem Gemisch von Diphenylaether und Biphenyl 5: phosphoryl chloride View Scheme
Multi-step reaction with 4 steps 1: acetic acid / Erhitzen des Reaktionsprodukts in Paraffinoel auf 250grad 2: aqueous NaOH 3: mineral oil / 270 °C 4: phosphoryl chloride View Scheme

: 108-42-9
3-chloro-aniline

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Stage #1: 3-chloro-aniline; diethyl 2-ethoxymethylenemalonate Heating; Stage #2: With trichlorophosphate

: 26892-97-7, 53977-12-1
7-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide / 1 h / Reflux 2: diphenylether / 0.5 h / Reflux 3: trichlorophosphate / 1 h / Reflux View Scheme

: 183057-56-9, 63463-20-7
7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenylether / 0.5 h / Reflux 2: trichlorophosphate / 1 h / Reflux View Scheme

: 372-19-0
meta-fluoroaniline

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 2 h / 100 °C 2: diphenylether / 0.25 h / Reflux 3: sodium hydroxide / 1 h / Reflux 4: diphenylether / 0.5 h / Reflux 5: trichlorophosphate / 1 h / Reflux View Scheme

: C14H16FNO4

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: diphenylether / 0.25 h / Reflux 2: sodium hydroxide / 1 h / Reflux 3: diphenylether / 0.5 h / Reflux 4: trichlorophosphate / 1 h / Reflux View Scheme

: 7-chloro-4(1H)-oxoquinoline-3-carboxylic acid

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenylether / Reflux 2: trichlorophosphate / 2 h / Reflux View Scheme

: 54132-35-3
ethyl 7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

: 86-98-6
4,7-dichloroquinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; ethanol / Reflux 2: diphenylether / Reflux 3: trichlorophosphate / 2 h / Reflux View Scheme

: 86-98-6
4,7-dichloroquinoline

: 646-19-5
heptane-1,7-diamine

: 102882-13-3
N-(7-chloro-[4]quinolyl)-heptanediyldiamine

Conditions

Conditions	Yield
Inert atmosphere;	100%
In pentan-1-ol at 120℃; for 16h;	80%
With N-ethyl-N,N-diisopropylamine In pentan-1-ol for 18h; Heating;	80%

: 86-98-6
4,7-dichloroquinoline

: 107-15-3
ethylenediamine

: 5407-57-8
N-(7-chloroquinolin-4-yl)ethylenediamine

Conditions

Conditions	Yield
at 80 - 140℃; for 13h;	100%
at 80 - 135℃; for 4h; neat (no solvent);	100%
In neat (no solvent) at 110℃;	100%

: 86-98-6
4,7-dichloroquinoline

: 106-40-1
4-bromo-aniline

: N-(4-bromophenyl)-7-chloroquinolin-4-amine

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	100%
for 0.166667h; microwave irradiation;	95%
With ethanol

: 110-85-0
piperazine

: 86-98-6
4,7-dichloroquinoline

: 837-52-5
7-chloro-4-piperazinylquinoline

Conditions

Conditions	Yield
In isopropyl alcohol at 100℃; for 20h;	100%
With triethylamine at 130℃; for 4h; Inert atmosphere;	98%
With potassium carbonate In isopropyl alcohol for 36h; Reflux;	95%

: 86-98-6
4,7-dichloroquinoline

: 373-44-4
1,8-diaminooctan

: 1025956-25-5
N-(7-chloroquinolin-4-yl)octane-1,8-diamine

Conditions

Conditions	Yield
Inert atmosphere;	100%
at 80 - 140℃; for 2.75h; Microwave irradiation;	69%
at 80 - 135℃; for 4h;	51%

: 86-98-6
4,7-dichloroquinoline

: 646-25-3
diaminodecane

: 1026600-71-4
N-(7-chloroquinolin-4-yl)decane-1,10-diamine

Conditions

Conditions	Yield
Inert atmosphere;	100%
at 80 - 135℃; for 4h;	60%
1.) 80 deg C, 1 h, 2.) 135-145 deg C, 3 h;

: 86-98-6
4,7-dichloroquinoline

: 2783-17-7
1,12-Diaminododecane

: 1026678-59-0
N1-(7-Chloro-quinolin-4-yl)-dodecane-1,12-diamine

Conditions

Conditions	Yield
Inert atmosphere;	100%
1.) 80 deg C, 1 h, 2.) 135-145 deg C, 3 h;

: 86-98-6
4,7-dichloroquinoline

: 109-76-2
Trimethylenediamine

: 7597-14-0
N-(7-chloroquinolin-4-yl)propane-1,3-diamine

Conditions

Conditions	Yield
In neat (no solvent) at 110℃;	100%
Inert atmosphere;	100%
In isopropyl alcohol at 100℃; for 20h;	98%

: 86-98-6
4,7-dichloroquinoline

: 110-60-1
1,4-diaminobutane

: 53186-45-1
N1-(7-chloroquinolin-4-yl)butane-1,4-diamine

Conditions

Conditions	Yield
Inert atmosphere;	100%
at 95℃; for 1h; Microwave irradiation;	100%
In isopropyl alcohol at 100℃; for 20h;	99%

: 86-98-6
4,7-dichloroquinoline

: 1701-93-5
silver thiocyanate

: 884647-32-9
7-chloro-4-isothiocyanatoquinoline

Conditions

Conditions	Yield
In toluene at 110℃; for 12h;	100%
In toluene at 115℃; for 18h;	89%
In toluene at 90 - 120℃; for 18h;	68%
In toluene for 12h; Heating;
In toluene at 120℃; for 18h;

: 86-98-6
4,7-dichloroquinoline

: 156-87-6
propan-1-ol-3-amine

: 60548-22-3
3-[(7-chloroquinolin-4-yl)amino]propan-1-ol

Conditions

Conditions	Yield
Inert atmosphere;	100%
With triethylamine In ethanol at 90℃;	99%
With triethylamine In N,N-dimethyl-formamide at 60 - 120℃; for 24h;	96%

: 927408-15-9
5-amino-4'-trifluoromethyl-biphenyl-3-ol

: 86-98-6
4,7-dichloroquinoline

: 927407-98-5
5-(7-chloro-quinolin-4-ylamino)-4'-trifluoromethyl-biphenyl-3-ol

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	100%

: 86-98-6
4,7-dichloroquinoline

: 62-53-3
aniline

: 83674-18-4
(7-chloroquinolin-4-yl)-phenyl-amine

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	100%
In neat (no solvent) at 120℃; under 1500.15 Torr; for 0.166667h; Microwave irradiation;	96%
for 0.116667h; microwave irradiation;	95%

: 86-98-6
4,7-dichloroquinoline

: 873850-11-4
7-amino-3-ethylquinazolin-4(3H)-one

: 1414781-94-4
C19H15ClN4O

Conditions

Conditions	Yield
In ethanol for 48h; Reflux;	100%

: 86-98-6
4,7-dichloroquinoline

: 1414782-02-7
7-amino-3-propylquinazolin-4(3H)-one

: 1414781-95-5
C20H17ClN4O

Conditions

Conditions	Yield
In ethanol for 48h; Reflux;	100%

: 86-98-6
4,7-dichloroquinoline

: 591755-15-6
7-amino-3-benzylquinazolin-4(3H)-one

: 1414781-96-6
C24H17ClN4O

Conditions

Conditions	Yield
In ethanol for 48h; Reflux;	100%

: 86-98-6
4,7-dichloroquinoline

: 104-94-9
4-methoxy-aniline

: 6059-31-0
7-chloro-N-(4-methoxyphenyl)quinolin-4-amine

Conditions

Conditions	Yield
With trifluoroacetic acid In 1,1,2-Trichloro-1,2,2-trifluoroethane for 8.53333h; Inert atmosphere; Reflux;	99%
With phenol at 120℃; for 0.5h;	98%
for 0.25h; microwave irradiation;	78%
With silica gel-loaded acidic ionic liquid IL/TFA at SiO2 In 1-methyl-pyrrolidin-2-one at 70℃;	36.8%
With hydrogenchloride

: 86-98-6
4,7-dichloroquinoline

: 141-43-5
ethanolamine

: 91066-18-1
3-(7-chloroquinolin-4-ylamino)propyl alcohol

Conditions

Conditions	Yield
With triethylamine In ethanol at 90℃;	99%
at 130 - 140℃; for 24h;	97%
In neat (no solvent) at 130℃;	95%

: 86-98-6
4,7-dichloroquinoline

: 1198-40-9
4-amino-7-chloroquinoline

Conditions

Conditions	Yield
With ammonium carbonate; phenol at 110 - 165℃;	99%
With ammonia In phenol at 170℃; for 2h;	92%
With ammonia; phenol at 150℃; for 2h;	89%

: 86-98-6
4,7-dichloroquinoline

: 123-30-8
4-amino-phenol

: 4-((4-hydroxyphenyl)amino)-7-chloroquinolinium chloride

Conditions

Conditions	Yield
In ethanol Reflux;	99%
With hydrogenchloride; potassium iodide In ethanol for 12h; Heating;

: 86-98-6
4,7-dichloroquinoline

: 124-40-3
dimethyl amine

: 22072-07-7
7-chloro-4-N,N-dimethylamino-quinoline

Conditions

Conditions	Yield
In water; acetonitrile at 50℃; for 48h;	99%
In water; acetonitrile at 50℃; for 48h;	90%
With acetic acid at 130 - 135℃; for 3h;	40%

: 86-98-6
4,7-dichloroquinoline

: 591-27-5
m-Hydroxyaniline

: 154179-33-6
4-(3'-hydroxyphenyl)amino-7-chloroquinoline

Conditions

Conditions	Yield
In ethanol Reflux;	99%
for 0.25h; microwave irradiation;	75%
With hydrogenchloride; potassium iodide In ethanol Heating;

: 288-32-4
1H-imidazole

: 86-98-6
4,7-dichloroquinoline

: 54666-24-9
7-chloro-4-(1H-imidazol-1-yl)quinoline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 2h; Inert atmosphere; Green chemistry;	99%
for 0.0333333h; microwave irradiation;	85%

: 86-98-6
4,7-dichloroquinoline

: 111-29-5
1 ,5-pentanediol

: 1033132-57-8
O-(7-chloro-4-quinolyl)-1,5-pentanediol

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol at 80℃; for 18h; Inert atmosphere;	99%

: 86-98-6
4,7-dichloroquinoline

: 504-63-2
trimethyleneglycol

: 1033132-54-5
O-(7-chloro-4-quinolyl)-1,3-propanediol

Conditions

Conditions	Yield
With potassium tert-butylate In tert-butyl alcohol at 80℃; for 18h; Inert atmosphere;	99%
With potassium tert-butylate In tert-butyl alcohol at 80℃; for 18h;

: 86-98-6
4,7-dichloroquinoline

: 79287-36-8
5-amino-4'-chloro<1,1'-biphenyl>-2-ol

: 1101170-94-8
4’-chloro-5-[(7-chloro-4-quinolinyl)amino]-[1,1’-biphenyl]-2-ol

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 10h; Reflux;	99%
With hydrogenchloride In ethanol; water for 4h; Inert atmosphere; Reflux;	87%

: 86-98-6
4,7-dichloroquinoline

: 333-27-7
methyl trifluoromethanesulfonate

: 1255923-14-8
4,7-dichloro-1-methylquinolinium triflate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 18h;	99%
In toluene at 20℃; for 24h;	65%

: 86-98-6
4,7-dichloroquinoline

: 348-54-9
2-Fluoroaniline

: 7-chloro-4-[(2-fluorophenyl)amino]quinolinium chloride

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 86-98-6
4,7-dichloroquinoline

: 95-51-2
2-Chloroaniline

: 7-chloro-4-[(2-chlorophenyl)amino]quinolinium chloride

Conditions

Conditions	Yield
In ethanol Reflux;	99%

: 86-98-6
4,7-dichloroquinoline

: 106-40-1
4-bromo-aniline

: 4-[(4-bromophenyl)amino]-7-chloroquinolinium chloride

Conditions

Conditions	Yield
In ethanol Reflux;	99%

4,7-Dichloroquinoline Chemical Properties

IUPAC Name: 4,7-Dichloroquinoline
Synonyms of 4,7-Dichloroquinoline (CAS NO.86-98-6): 5-20-07-00316 (Beilstein Handbook Reference) ; AI3-50374 ; BRN 0125359 ; EINECS 201-714-7 ; NSC 593 ; TL 1473 ; Quinoline, 4,7-dichloro-
CAS NO: 86-98-6
Classification Code: Mutation data
Molecular Formula of 4,7-Dichloroquinoline (CAS NO.86-98-6): C₉H₅Cl₂N
Molecular Weight: 198.0487
Molecular Structure:

Melting Point: 81-83 °C
Polar Surface Area: 12.89 Å²
Index of Refraction: 1.66
Molar Refractivity: 51.97 cm³
Molar Volume: 140.6 cm³
Surface Tension: 51.5 dyne/cm
Density of 4,7-Dichloroquinoline (CAS NO.86-98-6): 1.407 g/cm³
Flash Point: 158.7 °C
Enthalpy of Vaporization: 51.11 kJ/mol
Boiling Point: 292.9 °C at 760 mmHg
Vapour Pressure: 0.00313 mmHg at 25°C

4,7-Dichloroquinoline Uses

4,7-DICHLOROQUINOLINE(86-98-6) is used as a drug chloroquine phosphate intermediate.

4,7-Dichloroquinoline Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	subcutaneous	80mg/kg (80mg/kg)		National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. 30101, Pg. 8, 1945.

4,7-Dichloroquinoline Consensus Reports

Reported in EPA TSCA Inventory.

4,7-Dichloroquinoline Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-22
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S22: Do not breathe dust.
WGK Germany: 3
RTECS: VB4200000
Hazard Note: Irritant
HS Code: 29334910
Poison by subcutaneous route. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.

Product Name

4,7-Dichloroquinoline

Synthetic route

4,7-Dichloroquinoline Chemical Properties

4,7-Dichloroquinoline Uses

4,7-Dichloroquinoline Toxicity Data With Reference

4,7-Dichloroquinoline Consensus Reports

4,7-Dichloroquinoline Safety Profile

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