4-Amino-1-boc-piperidine supplier

Name
4-Amino-1-Boc-piperidine
EINECS 1312995-182-4
CAS No. 87120-72-7
Article Data53
CAS DataBase
Density 1.041 g/cm³
Solubility Insoluble in water.
Melting Point 50 °C
Formula C₁₀H₂₀N₂O₂
Boiling Point 277.3 °C at 760 mmHg
Molecular Weight 200.281
Flash Point 121.5 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 22-26-36/37/39
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 1,1-Dimethylethyl4-amino-1-piperidinecarboxylate;1-(t-Butoxycarbonyl)-4-aminopiperidine;1-tert-Butoxycarbonyl-4-aminopiperidine;4-Amino-1-(tert-butyloxycarbonyl)piperidine;4-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;4-Amino-1-tert-butoxycarbonylpiperidine;4-Amino-N-Boc-piperidine;4-Aminopiperidine-1-carboxylic acid tert-butyl ester;N-Boc-4-aminopiperidine;N-tert-Butoxycarbonyl-4-aminopiperidine;[N-(tert-Butoxycarbonyl)piperidin-4-yl]amine;tert-Butyl4-aminopiperidine-1-carboxylate;
PSA 55.56000
LogP 1.98280

Synthetic route

: 206273-87-2
4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In ethanol under 5320.36 Torr;	98%
With hydrogen; palladium 10% on activated carbon In ethanol	98%
With hydrogen; palladium on activated charcoal In methanol

: 150008-24-5
tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With hydrogen; Raney nickel In ethanol under 2585.81 Torr;	98%
With Raney nickel In methanol at 20℃; for 4h;	83%
With hydrogen; 5% rhodium on activated aluminium oxide In methanol at 50℃;

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With hydroxylamine hydrochloride; sodium carbonate In water at 23℃; for 14h; Stage #2: With hydrogen; Raney Ni In ethanol under 2585.81 Torr; for 3.5h; Solid phase;	96%
In ammonia-saturated methanol; aluminum nickel	95.4%
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one With titanium(IV) isopropylate; ammonia In ethanol at 25℃; for 6h; Stage #2: With sodium tetrahydroborate In ethanol at 25℃; for 3h; Further stages.;	88%

: C18H24F3N3O2

A: 434-45-7
1,1,1-trifluoroacetophenone

B: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With chloro-trimethyl-silane; lithium chloride	A n/a B 90%

: C18H24F3N3O2

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With chloro-trimethyl-silane; lithium chloride In N,N-dimethyl-formamide at 60℃; for 12h;	90%

: 13035-19-3
4-aminopiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Stage #1: 4-aminopiperidine; di-tert-butyl dicarbonate In 4-methyl-2-pentanone at 0 - 20℃; for 0.5h; Inert atmosphere; Reflux; Stage #2: With water In isopropyl alcohol at 50℃;	85%
In dichloromethane at 0℃; for 5h;	71.9%
Stage #1: 4-aminopiperidine With benzaldehyde In toluene for 3h; Heating / reflux; Stage #2: di-tert-butyl dicarbonate In toluene at 20℃;
With triethylamine In 1,4-dioxane; water
With triethylamine In 1,4-dioxane; water

: 153198-06-2
tert-butyl 4-(2,2,2-trifluoroacetamido)piperidine-1-carboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With ammonium hydroxide In methanol for 2h; Heating;	81%
With ammonium hydroxide In methanol for 6h; Heating;	5.75 g
With sodium bicarbonate; potassium carbonate In methanol

: tert-butyl 4-[(2,4-dimethoxyphenyl)methylamino]piperidine-1-carboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 25℃; for 16h;	81%

: 873088-90-5
1,1-dimethylethyl 4-[bis(phenylmethyl)amino]-1-piperidinecarboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With hydrogen; palladium(II) hydroxide In tetrahydrofuran; ethanol at 23℃; under 760.051 Torr; for 6h; Inert atmosphere;	77%

: 180695-80-1
tert-butyl 4-azidopiperidine-1-carboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With ammonium hydroxide; triphenylphosphine In 1,4-dioxane; methanol at 27 - 28℃; for 0.5h;	44%
With hydrogen; palladium on activated charcoal In methanol under 2068.59 Torr;
palladium-carbon In methanol
palladium-carbon In methanol; hexane; ethyl acetate

: 1044183-50-7
4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With acetic acid for 48h;	160 mg
With potassium hydrogensulfate for 1.5h;	4.76 g
With sodium hydrogen sulfate; water for 2h;
With potassium hydrogensulfate; water In tert-butyl methyl ether at 20℃; for 4h; Inert atmosphere;	6.0 g

: 1029643-92-2
N-phenylmethylidenepiperidinyl-4-amine

A: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

B (polystyrene-BAL)-NH-CH2-C6H4-p-NO2: (polystyrene-BAL)-NH-CH2-C6H4-p-NO2

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene / 12 h / 25 °C 2: 4.76 g / aq. KHSO4 / 1.5 h View Scheme

: 13035-19-3
4-aminopiperidine

A: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

B (polystyrene-BAL)-NH-CH2-C6H4-p-NO2: (polystyrene-BAL)-NH-CH2-C6H4-p-NO2

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene / 4 h / Heating 2: toluene / 12 h / 25 °C 3: 4.76 g / aq. KHSO4 / 1.5 h View Scheme

: 1029643-92-2
N-phenylmethylidenepiperidinyl-4-amine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 48 h / 20 °C 2: 160 mg / aq. AcOH / 48 h View Scheme
Multi-step reaction with 2 steps 1: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere 2: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere View Scheme

: 13035-19-3
4-aminopiperidine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Na2SO4 / CH2Cl2 / 24 h / 20 °C 2: Et3N / CH2Cl2 / 48 h / 20 °C 3: 160 mg / aq. AcOH / 48 h View Scheme
Multi-step reaction with 3 steps 1: toluene / 5.5 h / Inert atmosphere; Reflux 2: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere 3: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere View Scheme

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

A: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

B 4-pyrimidinyl-halide: 4-pyrimidinyl-halide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaHB(OAc)3 / 1,2-dichloro-ethane 2: H2 / Pd/C / methanol View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 94 percent / Et3N / CH2Cl2 / 12 h / 20 °C 2: H2 / Pd(OH)2/C / methanol / 12 h / 2585.81 Torr 3: CH2Cl2 / 6 h 4: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 94 percent / Et3N / CH2Cl2 / 0.25 h / 0 °C 2: H2 / Pearlman's catalyst / methanol / 48 h / 3102.9 Torr 3: 82 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature 4: 81 percent / 37percent aq. NH4OH / methanol / 2 h / Heating View Scheme

: 97181-51-6
4-trifluoromethylcarbonylamino piperidine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH2Cl2 / 6 h 2: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 82 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature 2: 81 percent / 37percent aq. NH4OH / methanol / 2 h / Heating View Scheme

: 97181-50-5
N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2 / Pd(OH)2/C / methanol / 12 h / 2585.81 Torr 2: CH2Cl2 / 6 h 3: 5.75 g / aq. NH3 / methanol / 6 h / Heating View Scheme
Multi-step reaction with 3 steps 1: H2 / Pearlman's catalyst / methanol / 48 h / 3102.9 Torr 2: 82 percent / Et3N / CH2Cl2 / 2 h / Ambient temperature 3: 81 percent / 37percent aq. NH4OH / methanol / 2 h / Heating View Scheme

: 90633-18-4
4-bromo-1H-piperidine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C 3: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: DIPEA / CH2Cl2 2: NaN3 / dimethylformamide / 20 °C 3: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 16 h / 20 °C 2: palladium on activated charcoal; ammonia; hydrogen / methanol / 20 °C View Scheme

: 180695-79-8
tert-butyl 4-bromo-1-piperidinecarboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaN3 / dimethylformamide / 20 °C 2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme

H2 NOH.HCl: H2 NOH.HCl

: 7732-18-5
water

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 497-19-8
sodium carbonate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
In tetrahydrofuran; EtOH (abs); ethanol
In tetrahydrofuran; EtOH (abs); ethanol

...Expand

H2 NOH HCl: H2 NOH HCl

: 7732-18-5
water

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 497-19-8
sodium carbonate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
In tetrahydrofuran; EtOH (abs); ethanol
In tetrahydrofuran
In tetrahydrofuran; EtOH (abs); ethanol

...Expand

H2NOH HCl: H2NOH HCl

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran; water

: C17H24N2O2

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Stage #1: C17H24N2O2 With potassium hydrogensulfate In water for 1.5h; Stage #2: With potassium hydroxide In water pH=10;

: 13035-19-3
4-aminopiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 100-52-7
benzaldehyde

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Stage #1: 4-aminopiperidine; benzaldehyde In toluene for 3h; Heating / reflux; Stage #2: di-tert-butyl dicarbonate In toluene at 20℃;

...Expand

: 41661-47-6
piperidin-4-one

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 16 h / 20 °C 2: palladium on activated charcoal; ammonia; hydrogen / methanol / 20 °C View Scheme

: 6295-57-4
2-benzthiazole thioacetic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 701236-99-9
N-(1-tert-butoxycarbonylpiperidin-4-yl)-(2-benzothiazolylthio)acetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 20℃; for 20h;	100%

: 3140-73-6
2-chloro-4,6-dimethoxy-1 ,3,5-triazine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 951004-60-7
4-(4,6-dimethoxy-[1,3,5]triazin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In acetonitrile at 160℃; for 0.333333h; microwave irradiation;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 122805-79-2
(2-formylthiophen-3-yl)carbamic acid ethyl ester

: 2-[[[1-(1,1-dimethylethoxycarbonyl)-4-piperidinyl]amino]methyl]-3-(ethoxycarbonylamino)-thiophene

Conditions

Conditions	Yield
	100%

: 1656-44-6
2,4-dinitrobenzenesulfonyl chloride

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 812690-24-7
tert-butyl 4-{[(2,4-dinitrophenyl)sulfonyl]amino}piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 2,4-dinitrobenzenesulfonyl chloride; 1-(tert-butoxycarbonyl)-4-aminopiperidine With lutidine In dichloromethane at 0 - 20℃; for 18.5h; Stage #2: With potassium hydrogensulfate; water for 0.5h; pH=2.5 - 3;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 68282-52-0
2,4-dimethyl-1H-imidazole-5-carbaldehyde

: Tert-butyl 4-[(2,4-dimethylimidazol-5-yl)methylamino]piperidin-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 0 - 20℃; Cooling with ice;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 79-04-9
chloroacetyl chloride

: 865432-01-5
tert-butyl 4-(2-chloroacetamido)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere;	90%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h;	89%

: 92972-48-0
2,4-dichlorothiazole-5-carboxaldehyde

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 866329-10-4
4-{[(2,4-dichloro-thiazol-5-yl)methyl]-amino}-piperidine-1-carboxylic acid t-butyl ester

Conditions

Conditions	Yield
Stage #1: 2,4-dichlorothiazole-5-carboxaldehyde; 1-(tert-butoxycarbonyl)-4-aminopiperidine With acetic acid In 1,2-dichloro-ethane at 21 - 26℃; for 1.5h; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20 - 27℃; for 4.46667h;	100%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 18h;	62%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 68282-52-0
2,5(4)-dimethyl-1H-imidazole-4(5)-carboxaldehyde

: 701298-75-1
tert-butyl 4-{[(2,4-dimethyl-1H-imidazol-5-yl)methyl]amino}piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In methanol at 20℃; for 2h;	100%
Stage #1: 1-(tert-butoxycarbonyl)-4-aminopiperidine; 2,5(4)-dimethyl-1H-imidazole-4(5)-carboxaldehyde With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 15h; Stage #2: With water; potassium carbonate	100%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 932700-82-8
tert-butyl 4-((5-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 18h;	93.2%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 80℃; for 1h;
With potassium carbonate In dimethyl sulfoxide at 20℃; Inert atmosphere;

: 932375-18-3
4-fluoro-2-methyl-5-nitro-benzonitrile

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 932375-19-4
1,1-dimethylethyl 4-[(4-cyano-5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃;	100%

: 1009-35-4
4-fluoro-3-nitrobenzonitrile

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 320406-05-1
tert-butyl 4-((4-cyano-2-nitrophenyl)amino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 72h;	100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 27℃; Cooling with ice;

: 125568-71-0
methyl 2,4-difluoro-5-nitrobenzoate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1037833-97-8
tert-butyl 4-{[5-fluoro-4-(methoxycarbonyl)-2-nitrophenyl]amino}piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 72h;	100%

: 104-87-0
4-methyl-benzaldehyde

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 359877-52-4
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate

Conditions

Conditions	Yield
Stage #1: 4-methyl-benzaldehyde; 1-(tert-butoxycarbonyl)-4-aminopiperidine In ethanol for 4h; Reflux; Stage #2: With sodium tetrahydroborate; ethanol at 20℃; for 24h;	100%
Stage #1: 4-methyl-benzaldehyde; 1-(tert-butoxycarbonyl)-4-aminopiperidine In ethanol for 4h; Heating / reflux; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 24h; Stage #3: With water In ethanol	100%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 35034-22-1
2-methylimidazole-4(5)-carbaldehyde

: 1034411-58-9
tert-butyl4-{[(2-methyl-1H-imidazol-5-yl)methyl]amino}piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In methanol at 20℃; for 2h;	100%

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 884308-82-1
4-(3-trifluoromethylbenzenesulfonylamino)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h;	100%

: 1143624-55-8
4,6-bis-benzyloxy-5'-isopropyl-2'-methoxybiphenyl-3-carboxylic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1143624-64-9
4-[(4,6-bis-benzyloxy-5'-isopropyl-2'-methoxybiphenyl-3-carbonyl)amino]piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 16588-74-2
3,5-ditrifluoromethylisocyanate

: 1275064-22-6
tert-butyl 4-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)piperidine-1-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1233952-63-0
4-(4-nitrobenzenesulfonylamino)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;

: 1365839-19-5
N-(6-chloro-4-((cis-2,6-dimethylmorpholino)methyl)pyridin-2-yl)thiazolo[5,4-b]pyridin-2-amine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1365839-20-8
1,1-dimethylethyl 4-{[4-{[cis-2,6-dimethyl-4-morpholinyl]methyl}-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyridinyl]amino}-1-piperidinecarboxylate

Conditions

Conditions	Yield
With lithium hexamethyldisilazane; (NHC)Pd(allyl)Cl In tetrahydrofuran at 80℃; for 1h; Microwave irradiation; Inert atmosphere;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 82820-87-9
2,4-dibromobutanoyl chloride

: 1365998-53-3
tert-butyl 4-(2,4-dibromobutanamido)piperidin-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-(tert-butoxycarbonyl)-4-aminopiperidine; 2,4-dibromobutanoyl chloride With triethylamine In dichloromethane at 0℃; Stage #2: With sodium hydrogencarbonate In dichloromethane Product distribution / selectivity;	100%
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;
With triethylamine In tetrahydrofuran at 20℃; for 0.5h;

: 1245649-52-8
1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1315495-05-6
4-(1-benzenesulphonyl-5-nitro-1H-pyrrolo[2,3-b]pyridine-4ylamino)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 2h; Reflux;	100%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol Inert atmosphere; Heating;

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 5332-06-9
4-bromobutanenitrile

: 4-(3-cyano-propylamino)-piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 48h; Reflux;	100%

: 3-(6-chloropyridin-3-yl)-6-fluoro-1-(phenylsulfonyl)-1H-indole

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1-(5-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)pyridin-2-yl)piperidin-4-amine

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 180℃; for 2h; Time; Microwave irradiation;	100%

: 4-((4-(4-(trifluoromethoxy)phenyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzoic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: N-(1-Boc-4-piperidyl)-4-((4-(6-(trifluoromethoxy)pyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;	100%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 57489-77-7
5,7-dichloropyrazolo[1,5-a]pyrimidine

: tert-butyl 4-(5-chloropyrazolo[1,5-a]pyrimidin-7-ylamino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 100℃; for 12h;	100%
With triethylamine In acetonitrile at 100℃; for 12h;

: 4-((4-(6-methoxy-3-pyridyl)-5-trifluoromethylpyrimidin-2-yl)amino)benzoic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: tert-butyl 4-(4-{[4-(6-methoxypyridin-3-yl)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamido)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 15h;	100%

: 331-41-9
2-(4-chloro-3-fluorophenoxy)acetic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: tert-butyl 4-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-(4-chloro-3-fluorophenoxy)acetic acid; 1-(tert-butoxycarbonyl)-4-aminopiperidine With HATU In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	100%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 12h;

: 59394-30-8
6-chloro-2-quinolinecarboxylic acid

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: tert-butyl 4-[(6-chloroquinoline-2-carbonyl)amino]piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 6-chloro-2-quinolinecarboxylic acid; 1-(tert-butoxycarbonyl)-4-aminopiperidine With HATU In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	100%

: N-(2,4-dimethoxybenzyl)-5-fluoro-N-(6-fluoropyridin-2-yl)-4-(trifluoromethyl)pyridine-2-sulfonamide

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: tert-butyl 4-((6-(N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)sulfamoyl)-4-(trifluoromethyl)pyridin-3-yl)amino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 70℃; for 2h;	100%

4-Amino-1-boc-piperidine Specification

The 4-Amino-1-boc-piperidine is the chemical compound with the formula C₁₀H₂₀N₂O₂. Its molecular weight is 200.28. It is white to light yellow crystal powder. With cas registry number of 87120-72-7, it belongs to the categories of (1)Amino acid; (2)Amines; (3)blocks; (4)Amines and Anilines; (5)Piperidines, Piperidones,Piperazines; (6)pharmacetical; (7)Pyrans, Piperidines & Piperazines; (8)API intermediates; (9)Piperidines; (10)Piperazine; (11)Pyrans, Piperidines & Piperazines.

Physical properties of 4-Amino-1-boc-piperidine are: (1) ACD/LogP: 1.09 ; (2) # of Rule of 5 Violations: 0 ; (3) ACD/LogD (pH 5.5): ; (4) ACD/LogD (pH 7.4): ; (5) ACD/BCF (pH 5.5): 1 ; (6) ACD/BCF (pH 7.4): 1 ; (7) ACD/KOC (pH 5.5): 1 ; (8) ACD/KOC (pH 7.4): 1.004 ; (9) #H bond acceptors: 4 ; (10) #H bond donors: 2 ; (11) #Freely Rotating Bonds: 3 ; (12) Index of Refraction: 1.484 ; (13) Molar Refractivity: 54.993 cm³ ; (14) Molar Volume: 192.269 cm³ ; (15) Surface Tension: 37.816 dyne/cm ; (16) Density: 1.042 g/cm³ ; (17) Flash Point: 121.509 °C ; (18) Enthalpy of Vaporization: 51.586 kJ/mol ; (19) Boiling Point: 277.303 °C at 760 mmHg ; (20) Vapour Pressure: 0.005 mmHg at 25°C.

Preparation of 4-Amino-1-boc-piperidine : This chemical can be prepared by 4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester .

The reaction will use reagent aq. NH₃,solvent Methanol and other conditions like heating. The reaction time is about 6 hours. Yield is about 5.75 g.

Uses of 4-Amino-1-boc-piperidine : It is used to prepare other chemicals. Here is a example below.

The reaction occurs at the temperature of 120 ℃ using reagents of K₂CO₃, KI, solvent of dimethylformamide for 24 hours. The yield is 58%.

When you are using this chemical, please be cautious about it as the following:
This chemical is sensitive to CO₂. It is harmful by inhalation, in contact with skin and if swallowed and irritating to eyes, respiratory system and skin. Wear suitable protective clothing, gloves and eye/face protection before use it. During use it, do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Keep it under argon.

You can still convert the following datas into molecular structure:
(1) SMILES:CC(C)(C)OC(=O)N1CCC(CC1)N;
(2) InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3;
(3) InChIKey:LZRDHSFPLUWYAX-UHFFFAOYAC

Product Name

4-Amino-1-Boc-piperidine

Synthetic route

4-Amino-1-boc-piperidine Specification

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