4-Bromo-3-nitrophenol supplier

Name
4-Bromo-3-nitrophenol
EINECS
CAS No. 78137-76-5
Article Data15
CAS DataBase
Density 1.881 g/cm³
Solubility
Melting Point 144-145 ºC
Formula C₆H₄BrNO₃
Boiling Point 281 ºC at 760 mmHg
Molecular Weight 218.007
Flash Point 124 ºC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Bromo-5-hydroxynitrobenzene;4-Bromo-3-nitrophenol;
PSA 66.05000
LogP 2.58610

Synthetic route

: 554-84-7
meta-nitrophenol

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
With 1-butyl-3-methylpyridinium tribromide at 20℃;	98%
With 1,3-di-n-butyl-1H-imidazol-3-ium tribromide at 20℃; for 0.133333h; Neat (no solvent); regioselective reaction;	95%
With 1,2-ethanediylbis(triphenylphosphonium) ditribromide In methanol; dichloromethane at 20℃; for 0.0833333h; Solvent; regioselective reaction;	85%
at 120 - 140℃; Einleiten von mit CO2 verduenntem Brom-Dampf;
With hydrogenchloride; carbon dioxide; bromine

: 5344-78-5
4-bromo-3-nitroanizole

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
Stage #1: 4-bromo-3-nitroanizole With boron tribromide In dichloromethane at -78 - 20℃; for 31h; Stage #2: With water In dichloromethane at 0℃;	87%
Stage #1: 4-bromo-3-nitroanizole With boron tribromide In dichloromethane at -78 - 20℃; for 31h; Stage #2: With water In dichloromethane at 0℃;	87%
With boron tribromide In dichloromethane at -78 - 20℃;	83%

: 610-81-1
4-hydroxy-2-nitroaniline

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
With hydrogen bromide Diazotization.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver und wss. HBr;
With sulfuric acid Diazotization.man versetzt mit einer konz. Kaliumbromidloesung und fuegt Kupferpulver hinzu;
Stage #1: 4-hydroxy-2-nitroaniline With hydrogen bromide; sodium nitrite In water at 0 - 10℃; for 1h; Stage #2: With hydrogen bromide; copper(I) bromide at 40 - 45℃; for 1h;	13.1 g

: 554-84-7
meta-nitrophenol

: 7726-95-6
bromine

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
at 120 - 140℃;

: 2243-69-8
4-acetamido-3-nitrophenyl acetate

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous hydrobromic acid 2: aqueous HBr / Diazotization.Behandlung der Diazoniumsalz-Loesung mit Kupfer-Pulver und wss. HBr View Scheme

: 99-09-2
3-nitro-aniline

: 78137-76-5
4-bromo-3-nitrophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Diazotization 2: 120 - 140 °C / Einleiten von mit CO2 verduenntem Brom-Dampf View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 824-94-2
p-methoxybenzyl chloride

: C14H12BrNO4

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;	100%

: 78137-76-5
4-bromo-3-nitrophenol

: 78389-90-9
vinyl zinc chloride

: 3-nitro-4-vinylphenol

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran at 100℃; for 2h;	100%

: 1112-55-6
tetravinylsilane

: 78137-76-5
4-bromo-3-nitrophenol

: 3-nitro-4-vinylphenol

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran at 80℃; for 2h;	100%

: 78137-76-5
4-bromo-3-nitrophenol

: 7486-35-3
tri-n-butyl(vinyl)tin

: 3-nitro-4-vinylphenol

Conditions

Conditions	Yield
Stage #1: 4-bromo-3-nitrophenol; tri-n-butyl(vinyl)tin With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 4h; Stage #2: With potassium fluoride In 1,4-dioxane at 20℃; for 2h;	100%

: 78137-76-5
4-bromo-3-nitrophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: (4-bromo-3-nitro)phenoxy-tert-butyl-dimethyl-silane

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3.5h;	99%

: 78137-76-5
4-bromo-3-nitrophenol

: 100-39-0
benzyl bromide

: 4514-28-7
2-Bromo-5-benzyloxy-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone; acetonitrile for 17h; Heating;	95%
With potassium carbonate In acetone	91%
With potassium carbonate In acetone; acetonitrile for 17h; Heating / reflux;	78%

: 13154-24-0
triisopropylsilyl chloride

: 78137-76-5
4-bromo-3-nitrophenol

: 1380316-20-0
(4-bromo-3-nitrophenoxy)(triisopropyl)silane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 18℃; for 20h;	95%

: 78137-76-5
4-bromo-3-nitrophenol

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: C13H9BrClNO3

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;	94.8%

: 78137-76-5
4-bromo-3-nitrophenol

: 3163-27-7
2-(bromomethyl)naphthalene

: 2-Bromo-5-(1-naphthalenylmethoxy)-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N-methyl-acetamide	92%

: 78137-76-5
4-bromo-3-nitrophenol

: (4-bromomethyl)-phenoxy-allyl acetate

: [4-(4-Bromo-3-nitro-phenoxymethyl)-phenoxy]-acetic acid allyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 22℃; for 3h;	91%

: 358-23-6
trifluoromethylsulfonic anhydride

: 78137-76-5
4-bromo-3-nitrophenol

: 4-bromo-3-nitrophenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 30℃; for 0.5h; Inert atmosphere;	90%

: 78137-76-5
4-bromo-3-nitrophenol

: 330793-01-6
(4-tert-butoxycarbonylaminophenyl)boronic acid pinacol ester

: tert-butyl (4'-hydroxy-2'-nitro-[1,1'-biphenyl]-4-yl)carbamate

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 110℃; for 12h;	72%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane at 110℃; for 12h; Reflux;	72%

: 78137-76-5
4-bromo-3-nitrophenol

: 100367-37-1
3-amino-4-bromophenol

Conditions

Conditions	Yield
With iron(III) oxide; hydrazine hydrate In ethanol for 1.5h; Reflux;	70.9%

: 14542-12-2
(1,3-thiazol-2-yl)methanol

: 78137-76-5
4-bromo-3-nitrophenol

: 2-((4-bromo-3-nitrophenoxy)methyl)thiazole

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In toluene at 0℃; Mitsunobu Displacement; Inert atmosphere; Reflux;	69%

: 121-43-7
Trimethyl borate

: 78137-76-5
4-bromo-3-nitrophenol

: C6H6BNO5

Conditions

Conditions	Yield
Stage #1: 4-bromo-3-nitrophenol With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: Trimethyl borate In tetrahydrofuran at 20℃; for 1h; Stage #3: With hydrogenchloride In tetrahydrofuran for 1h;	53%

: 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1Hpyrrole-2-carbonitrile

: 78137-76-5
4-bromo-3-nitrophenol

: 5-(4-hydroxy-2-nitrophenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Conditions

Conditions	Yield
With palladium diacetate; cesium fluoride; catacxium A In 1,4-dioxane; water at 80℃; for 1h; Suzuki Coupling; Inert atmosphere; Sealed tube;	30%

: 78137-76-5
4-bromo-3-nitrophenol

: 78-95-5
chloroacetone

: 78137-77-6
1-(4-Bromo-3-nitro-phenoxy)-propan-2-one

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide

: 78137-76-5
4-bromo-3-nitrophenol

: 100-44-7
benzyl chloride

: 4514-28-7
2-Bromo-5-benzyloxy-nitrobenzene

Conditions

Conditions	Yield
With potassium hydroxide

: 78137-76-5
4-bromo-3-nitrophenol

: [4-(tert-butyl-dimethyl-silanyloxy)-2-nitro-phenyl]-(2'-nitrophenyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / Et3N / CH2Cl2 / 3.5 h / 20 °C 2: 70 percent / rac-BINAP; Cs2CO3 / Pd2(dba)3 / toluene / 0.5 h / 160 °C / microwave irradiation View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 1026914-86-2
[4-(3-Amino-4-bromo-phenoxymethyl)-phenoxy]-acetic acid allyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / K2CO3 / dimethylformamide / 3 h / 22 °C 2: 64 percent / Na2S2O4 / tetrahydrofuran; H2O / 4 h / 22 °C View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 53820-33-0
4-Oxo-5,6,9,10-tetradehydro-4,5-secofuranoeremophilan-5,1-carbolacton

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: K2CO3, KI / dimethylformamide 2: 82 percent / TiCl3 / ethanol 3: 1.)NO(1+) / 1.) diazotation 4: AlH(C4H9)2 / toluene 5: 27 percent / Li / tetrahydrofuran 6: 10 percent / lithium butyl / -100 °C 7: 84 percent / hydrolysis View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 78137-78-7
6-amino-5-brom-3-methylbenzofuran

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: K2CO3, KI / dimethylformamide 2: 82 percent / TiCl3 / ethanol View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 78137-79-8
5-Bromo-3-methyl-benzofuran-6-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: K2CO3, KI / dimethylformamide 2: 82 percent / TiCl3 / ethanol 3: 1.)NO(1+) / 1.) diazotation View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 78137-80-1
5-Bromo-3-methyl-benzofuran-6-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: K2CO3, KI / dimethylformamide 2: 82 percent / TiCl3 / ethanol 3: 1.)NO(1+) / 1.) diazotation 4: AlH(C4H9)2 / toluene View Scheme

: 78137-76-5
4-bromo-3-nitrophenol

: 78137-81-2
1-(5-Bromo-3-methyl-benzofuran-6-yl)-3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: K2CO3, KI / dimethylformamide 2: 82 percent / TiCl3 / ethanol 3: 1.)NO(1+) / 1.) diazotation 4: AlH(C4H9)2 / toluene 5: 27 percent / Li / tetrahydrofuran View Scheme

4-Bromo-3-nitrophenol Chemical Properties

Empirical Formula: C₆H₄BrNO₃
Molecular Weight: 218.0049
Structure of Phenol,4-bromo-3-nitro- (CAS NO.78137-76-5):

Index of Refraction: 1.652
Molar Refractivity: 42.37 cm³
Molar Volume: 115.89 cm³
Polarizability: 16.797×10^-24cm³
Surface Tension: 64.376 dyne/cm
Density: 1.881 g/cm³
Flash Point: 124.074 °C
Enthalpy of Vaporization: 54.125 kJ/mol
Melting Point: 144-145 ºC
Boiling Point: 281.545 °C at 760 mmHg
Vapour Pressure: 0.002 mmHg at 25°C
Synonyms of Phenol,4-bromo-3-nitro- (CAS NO.78137-76-5): 4-Brom-3-nitrophenol

Product Name

4-Bromo-3-nitrophenol

Synthetic route

4-Bromo-3-nitrophenol Chemical Properties

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